Dr Franziska Knolle


University position

Research Associate

Departments

Department of Psychiatry

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience

Interests

I am interested in investigating the underlying mechanisms of predictive processing. Especially, I wish to explore how dysfunctional predictive processing might lead to various symptoms of psychiatric and neurological disorders, such as delusions or hallucinations. Brain structures I am particularly interested in in that respect are the basal ganglia and the cerebellum. I am using EEG and fMRI as well as behavioural paradigms to explore these topics.

Research Focus

Keywords

Predictive processing

Cerebellum

Prediction error

Speech

Cognition

Clinical conditions

Depressive disorders

Huntington's disease

Obsessive compulsive disorder

Schizophrenia

Stroke

Equipment

Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Paul Fletcher

Jenny Morton

Graham Murray

United Kingdom

Sebastian McBride

International

Sonja Kotz

Erich Schroeger

Associated News Items


Publications

in press

Ermakova AO, Gileadi N, Knolle F, Justicia Diaz A, Anderson R, Fletcher PC, Moutoussis M, Murray GK (in press), “Cost evaluation during decision making in patients at early stages of psychosis” Computational Psychiatry

2018

Ermakova*, A.O., Knolle*, F., Justicia, A., Bullmore, E.T., Jones, P.J., Robbins, T.W., Fletcher, P.C., & Murray, G.K. (2018), “Abnormal reward prediction error signalling in antipsychotic naïve individuals with first episode psychosis or clinical risk for psychosis.” Neuropsychopharmacology 43, 1691–1699

Haarsma J, Knolle F, Griffin J, Taverne H, Mada M, Goodyer I, Neuroscience in Psychiatry Network, Fletcher, PC, Murray GK (2018), “Influence of prior beliefs on perception in early psychosis: effects of illness stage and hierarchical level of belief” bioRxiv 421891

Knolle* F, Ermakova* AO, Justicia A., Fletcher PC, Bunseck N, Düzel E & Murray GK. (2018), “Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study” Translational Psychiatry 8:196

2017

Knolle F, McBride SD, Stewart JE, Goncalves R Morton, AJ (2017), “A stop-signal task for sheep: Introduction and validation of a direct measure for the stop-signal reaction time” Animal Cognition 20(4):615-626

Knolle F, Vallotton C, Ayoub C (2017), “Deficit or difference? Effects of early maltreatment on children’s language skills and use of grammatical negations.” Journal of Child and Family Studies 1-12

Knolle, F., Goncalves, R. & Morton, J. (2017), “Sheep recognise familiar and unfamiliar human faces from two-dimensional images.” Royal Society Open Science 4: 171228

Murray*, G.K., Knolle*, F., Ersche, K.D., Craig, K.J., Abbott, S., Shabbir, S.S., Suckling, J., Sahakian, B.J., Bullmore, E.T., Robbins, T.W. (2017), “Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder” bioRxiv 225938

2013

Knolle F, Schröger E, Kotz SA (2013), “Cerebellar contribution to the prediction of self-initiated sounds.” Cortex 49(9), 2449-2461

Knolle F, Schröger E, Kotz SA (2013), “Prediction errors in self- and externally-generated deviants.” Biological Psychology 92(2), 410-416

2012

Knolle F (2012), “Knowing what's next: The role of the cerebellum in generating predictions. ” PhD Thesis, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig ISBN: 978-3-941504-26-4

Knolle F, Schröger E, Baess P, Kotz SA (2012), “The cerebellum generates motor-to-auditory predictions: ERP lesion evidence” Journal of Cognitive Neuroscience 24(3), 698-706