Dr Franziska Knolle


University position

Research Associate

Departments

Department of Psychiatry

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience

Interests

I am interested in applying the framework of predictive processing to understanding psychiatric disorders, especially psychosis. I wish to explore how and if potentially dysfunctional predictive processing across various higher and lower cognitive domains might lead to psychotic symptoms, such as delusions or hallucinations. I am particularly interested in the interaction between subcortical and cortical regions. In my research, I am using fMRI and MEG/EEG as well as behavioural paradigms to explore these topics.

Research Focus

Keywords

Predictive processing

Cerebellum

Prediction error

Speech

Cognition

Clinical conditions

Obsessive compulsive disorder

Schizophrenia

Stroke

Equipment

Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)

Collaborators

Cambridge

Paul Fletcher

Graham Murray

United Kingdom

Rick Adams

International

Sonja Kotz

Christian Sorg

Associated News Items


Publications

2019

Ermakova AO, Gileadi N, Knolle F, Justicia Diaz A, Anderson R, Fletcher PC, Moutoussis M, Murray GK (2019), “Cost evaluation during decision making in patients at early stages of psychosis” Computational Psychiatry 3, 18-39

in press

Haarsma J, Knolle F, Griffin J, Taverne H, Mada M, Goodyer I, Neuroscience in Psychiatry Network, Fletcher, PC, Murray GK (in press), “Influence of prior beliefs on perception in early psychosis: effects of illness stage and hierarchical level of belief” Journal of Abnormal Psychology

2019

Knolle F, Schwartze M, Schröger E, Kotz SA (2019), “Auditory predictions and prediction errors in response to self-initiated vowels” Frontiers in Auditory Neuroscience 13, 1146

Knolle F., Garofalo, S., Viviani R., Justicia, A., Ermakova, A.O., Blank H., Williams, G.B., Arrondo, G., Ramachandra, P., ,Tudor-Sfetea, C., Bunzeck, N., Duezel, E., Robbins,T.W., Barker, R.A., and Murray, G.K. (2019), “Altered subcortical emotional salience processing differentiates Parkinson’s patients with and without psychotic symptoms” MedRxiv 19010512

Knolle, F., Goncalves, R.P., Davies, E.L., Duff, A.R., Morton, J.A. (2019), “Response-inhibition during problem solving in sheep” International Journal of Comparative Psychology 3

M Montagnese, F Knolle, J Haarsma, J Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, M Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray (2019), “Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population” bioRxiv 668939

Murray*, G.K., Knolle*, F., Ersche, K.D., Craig, K.J., Abbott, S., Shabbir, S.S., Suckling, J., Sahakian, B.J., Bullmore, E.T., Robbins, T.W. (2019), “Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder” Psychopharmacology 236: 2325.

2018

Ermakova*, A.O., Knolle*, F., Justicia, A., Bullmore, E.T., Jones, P.J., Robbins, T.W., Fletcher, P.C., & Murray, G.K. (2018), “Abnormal reward prediction error signalling in antipsychotic naïve individuals with first episode psychosis or clinical risk for psychosis.” Neuropsychopharmacology 43, 1691–1699

Knolle* F, Ermakova* AO, Justicia A., Fletcher PC, Bunseck N, Düzel E & Murray GK. (2018), “Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study” Translational Psychiatry 8:196

2017

Knolle F, McBride SD, Stewart JE, Goncalves R Morton, AJ (2017), “A stop-signal task for sheep: Introduction and validation of a direct measure for the stop-signal reaction time” Animal Cognition 20(4):615-626

Knolle F, Vallotton C, Ayoub C (2017), “Deficit or difference? Effects of early maltreatment on children’s language skills and use of grammatical negations.” Journal of Child and Family Studies 1-12

Knolle, F., Goncalves, R. & Morton, J. (2017), “Sheep recognise familiar and unfamiliar human faces from two-dimensional images.” Royal Society Open Science 4: 171228

2013

Knolle F, Schröger E, Kotz SA (2013), “Cerebellar contribution to the prediction of self-initiated sounds.” Cortex 49(9), 2449-2461

Knolle F, Schröger E, Kotz SA (2013), “Prediction errors in self- and externally-generated deviants.” Biological Psychology 92(2), 410-416

2012

Knolle F (2012), “Knowing what's next: The role of the cerebellum in generating predictions. ” PhD Thesis, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig ISBN: 978-3-941504-26-4

Knolle F, Schröger E, Baess P, Kotz SA (2012), “The cerebellum generates motor-to-auditory predictions: ERP lesion evidence” Journal of Cognitive Neuroscience 24(3), 698-706