Dr Franziska Knolle

University position

Research Associate


Department of Psychiatry

Research Themes

Cognitive and Behavioural Neuroscience

Systems and Computational Neuroscience


I am interested in investigating the underlying mechanisms of predictive processing. Especially, I wish to explore how dysfunctional predictive processing might lead to various symptoms of psychiatric and neurological disorders, such as delusions or hallucinations. Brain structures I am particularly interested in in that respect are the basal ganglia and the cerebellum. I am using EEG and fMRI as well as behavioural paradigms to explore these topics.

Research Focus


Predictive processing


Prediction error



Clinical conditions

Depressive disorders

Huntington's disease

Obsessive compulsive disorder




Behavioural analysis

Computational modelling

Electroencephalography (EEG)

Magnetic resonance imaging (MRI)



Paul Fletcher

Jenny Morton

Graham Murray

United Kingdom

Sebastian McBride


Sonja Kotz

Erich Schroeger

Associated News Items



Knolle* F, Ermakova* AO, Justicia A., Fletcher PC, Bunseck N, Düzel E & Murray GK. (2018), “Altered cingulate and substantia nigra/ventral tegmental activation to novelty and emotional salience in antipsychotic naive first episode psychosis patients.” bioRxiv 263020


Ermakova AO, Gileadi N, Knolle F, Justicia Diaz A, Anderson R, Fletcher PC, Moutoussis M, Murray GK (2017), “Cost evaluation during decision making in patients at early stages of psychosis” bioRxiv 225920

Ermakova*, A.O., Knolle*, F., Justicia, A., Bullmore, E.T., Jones, P.J., Robbins, T.W., Fletcher, P.C., & Murray, G.K. (2017), “Abnormal reward prediction error signalling in antipsychotic naïve individuals with first episode psychosis or clinical risk for psychosis.” bioRxiv 214437

Knolle F, McBride SD, Stewart JE, Goncalves R Morton, AJ (2017), “A stop-signal task for sheep: Introduction and validation of a direct measure for the stop-signal reaction time” Animal Cognition 20(4):615-626

Knolle F, Vallotton C, Ayoub C (2017), “Deficit or difference? Effects of early maltreatment on children’s language skills and use of grammatical negations.” Journal of Child and Family Studies 1-12

Knolle, F., Goncalves, R. & Morton, J. (2017), “Sheep recognise familiar and unfamiliar human faces from two-dimensional images.” Royal Society Open Science 4: 171228

Murray*, G.K., Knolle*, F., Ersche, K.D., Craig, K.J., Abbott, S., Shabbir, S.S., Suckling, J., Sahakian, B.J., Bullmore, E.T., Robbins, T.W. (2017), “Dopaminergic drug treatment remediates exaggerated cingulate prediction error responses in obsessive-compulsive disorder” bioRxiv 225938


Knolle F, Schröger E, Kotz SA (2013), “Cerebellar contribution to the prediction of self-initiated sounds.” Cortex 49(9), 2449-2461

Knolle F, Schröger E, Kotz SA (2013), “Prediction errors in self- and externally-generated deviants.” Biological Psychology 92(2), 410-416


Knolle F (2012), “Knowing what's next: The role of the cerebellum in generating predictions. ” PhD Thesis, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig ISBN: 978-3-941504-26-4

Knolle F, Schröger E, Baess P, Kotz SA (2012), “The cerebellum generates motor-to-auditory predictions: ERP lesion evidence” Journal of Cognitive Neuroscience 24(3), 698-706