Dr Ellen Tedford

Interests

I am interested in the role extracellular vesicles play in neurodegenerative diseases, primarily I work on Alzhiemer's Disease and tauopathies investigating the mechanisms that govern tau aggregation on a molecular and epigenetic level. Extracellular vesicles are shed by almost every cell type, including neurons and glia, they contain RNA, DNA and protein. This is an important part of neurophysiological communication but during neurodegenerative diseases this process is altered. To investigate the mechanisms governing this dysfunction I use human iPS cells and animal models. During my PhD, I investigated the role extracellular vesicles play in epigenetic regulation of neurons.

Research Focus

Keywords

Dementia

Extracellular vesicles

iPS

Epigenetics

Clinical conditions

Alzheimer's disease

Dementia

Parkinson's disease

Progressive supranuclear palsy

Equipment

Cell culture

Confocal microscopy

Immunohistochemistry

Microscopy

Collaborators

Cambridge

David Klenerman

Will McEwan

International

Roberta Ghidoni Web: https://moh-it.pure.elsevier.com/en/pers...

Katharina Landfester Web: https://www.mpg.de/424968/...

Associated News Items


    Key publications

    Tedford E, Badya N B, Laing C, Asaoka N, Kaneko S, Filippi B M, McConkey G A (2020), “Signals Secreted by Infection Induce Transcriptional and Epigenetic Changes in Neurons” bioRxiv 2020.11.26.399345

    Tedford E, Alsaady I, Alsaad M, Bristow G, Kohli S, Murray M, Reeves M, Vijayabaskar M S, Clapcote S J,. Wastling J, McConkey G A (2018), “Downregulation of the Central Noradrenergic System by Toxoplasma gondii Infection” Infection and Immunity 87(2): 567-98

    Publications

    2019

    Tedford E (2019), “Neurophysiological Changes During Chronic Toxoplasma gondii Infection” Thesis

    2017

    Tedford E, and McConkey G A (2017), “Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection” Pathogens