Dr Ellen Tedford
I am interested in the role extracellular vesicles play in neurodegenerative diseases, primarily I work on Alzhiemer's Disease and tauopathies investigating the mechanisms that govern tau aggregation on a molecular and epigenetic level. Extracellular vesicles are shed by almost every cell type, including neurons and glia, they contain RNA, DNA and protein. This is an important part of neurophysiological communication but during neurodegenerative diseases this process is altered. To investigate the mechanisms governing this dysfunction I use human iPS cells and animal models. During my PhD, I investigated the role extracellular vesicles play in epigenetic regulation of neurons.
Associated News Items
Tedford E, Badya N B, Laing C, Asaoka N, Kaneko S, Filippi B M, McConkey G A (2020), “Signals Secreted by Infection Induce Transcriptional and Epigenetic Changes in Neurons” bioRxiv 2020.11.26.399345
Tedford E, Alsaady I, Alsaad M, Bristow G, Kohli S, Murray M, Reeves M, Vijayabaskar M S, Clapcote S J,. Wastling J, McConkey G A (2018), “Downregulation of the Central Noradrenergic System by Toxoplasma gondii Infection” Infection and Immunity 87(2): 567-98
Tedford E (2019), “Neurophysiological Changes During Chronic Toxoplasma gondii Infection” Thesis
Tedford E, and McConkey G A (2017), “Neurophysiological Changes Induced by Chronic Toxoplasma gondii Infection” Pathogens