Dr Emad Sidhom


I am interested in neurodegenerative disorders, in particular Alzheimer's Disease. I work to understand the pathological mechanisms underlying neurodegenerative processes. I aim to search for the failure of synaptic repair and modify the unfolded protein response in the endoplasmic reticulum. The aim is to achieve a safe neuroprotective, disease modifying agent to slow down the progress of neurocognitive disorders.

Electroconvulsive Therapy (ECT) and other forms of neuromodulation in psychiatry is my other area of clinical interest which include research on the low pulse amplitude (< 800 mA), ultra-brief pulse (<0.5 ms) unilateral (ECT) usage to minimise the cognitive side effects of ECT while retaining its efficacy. As well as, optimising titration schedules and algorithms of ECT dosing strategies, and understanding the mechanism of action of ECT, and the mechanism by which ECT causes adverse event in order to provide safe and effective targeted delivery of ECT.

Research Focus







Clinical conditions

Alzheimer's disease


Depressive Disorders


Positron Emission Tomography (PET)



Giovanna Mallucci

Ben Underwood

Associated News Items

    Key publications

    Voysey M, Clemens SAC,Madhi SA, Weckx LY, Folegatti PM, Aley PK, Angus B, Baillie BL, Barnabas SL, Bhorat QE, Bibi S, Briner C, Cicconi P, Collins AM, Colin-Jones R, Cutland CL, Darton TC, Dheda K, Duncan CJA, Emary KRW, Ewer KJ, Fairlie L, Faust SN, Feng S, Ferreira DM, Finn A, Goodman AL, Green CM, Green CA, Heath PT, Hill C, Hill H, Hirsch I, Hodgson SHC, Izu A, Jackson S, Jenkin D, Joe CCD, Kerridge S, Koen A, Kwatra G, Lazarus R, Lawrie AM, Lelliott A, Libri V, Lillie PJ, Mallory R, Mendes AVA, Milan EP, Minassian AM, McGregor A, Morrison H, Mujadidi YF, Nana A, O’Reilly PJ, Padayachee SD, Pittella A, Plested E, Pollock KM, Ramasamy MN, Rhead S, Schwarzbold AV, Singh N, Smith A, Song R, Snape MD, Sprinz E, Sutherland RK, Tarrant R, Thomson EC, Török ME, Toshner M, Turner DPJ, Vekemans J, Villafana TL, Watson MEE, Williams CJJ, Douglas AD, Hill AVS, Lambe T, Gilbert SC, Pollard AJ on behalf of the Oxford COVID Vaccine Trial Group (2021), “Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK” Lancet 397(10269): 99-111

    Sidhom E, Welchew D (2019), “Electroconvulsive Therapy” Oxford Textbook of Inpatient Psychiatry 10.1093/med/9780198794257.003.0014

    Youssef NA, Sidhom E (2017), “Proof of concept clinical trial of feasibility course of low Amplitude Seizure Therapy (LAP-ST) in man: Less cognitive side effects with retention of efficacy” Brain Stimul. 10(2): 368-368

    Youssef NA, Sidhom E (2017), “Feasibility, safety, and preliminary efficacy of Low Amplitude Seizure Therapy (LAP-ST): A proof of concept clinical trial in man” J Affect Disord. 222(Nov): 1-6

    Sidhom E, Youssef NA (2014), “Ultra-brief pulse unilateral ECT is associated with less cognitive side effects” Brain Stimul. 7(5):768-769



    London S, Chen S, Sidhom E, Lewis J, Cardinal R, Roalf D, Underwood BR (2023), “195. Predicting Patients With Dementia Most at Risk of Needing Psychiatric Inpatient or Enhanced Community Care Using Routinely Collected Clinical Data” Biol. Psychiatry 93(9):S172-S173


    Sidhom E, O'Brien JT, Butcher AJ, Smith HL, Mallucci GR, Underwood BR (2022), “Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia ” Int. J. Mol. Sci. 23(4):2021

    Sidhom E, Padilla McS, Lewis J, White S, O'Brien JT, Mallucci GR, Underwood BR (2022), “Trazodone and patient outcomes in dementia: Limitations of naturalistic cohort data ” Int J Geriatr Psychiatry 1-3

    Treagust N, Sidhom E, Lewis J, Denman C, Knutson O, Underwood BR (2022), “The epidemiology and clinical features of personality disorders in later life; a study of secondary care data” Int J Geriatr Psychiatry 37(12)


    Aftab A, Sidhom E, Forrest A, Judge N, Underwood BR, Harkness K, Blackburn DJ. (2021), “Patient and clinician experience of providing remote memory assessment services.” Int J Geriatr Psychiatry 37(2)1-2

    Chen F, Sidhom E, Yang S, Ruiz-Mendoza E, Essem J (2021), “Case report: delayed response after electroconvulsive therapy in a patient with major depressive disorder” BMC Psychiatry 21(1):50

    Sidhom E, Omar, MH (2021), “The Nomenclature of Electroconvulsive Therapy” J ECT 37(2): 128-132

    Torok ME, Underwood BR, Toshner M, Waddington C, Sidhom E, Sharrocks K, Bousfield R, Summers C, Saunders C, McIntyre Z, Morris H, Piper J, Calderon G, Dennis S, Assari T, de Rotrou AM, Shaw A, Bradley J, O’Brien JT, Rintoul RC, Smith I, Bullmore E, Chatterjee K, and on behalf of the Cambridge COVID Vaccine Trial Team (2021), “Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom” Clin. Trials. J. 18(5): 615-621

    Underwood BR, Thomspell A, Sidhom E, Burn A (2021), “Providing memory assessment services during COVID-19” Aging and Mental Health 25(8):1373-1375


    Sidhom E (2020), “ The Depiction of ECT in Egyptian Media” Biomed J Sci & Tech Res 30(5): 23729-23731

    Sidhom E, O'Brien, J, & Underwood, B (2020), “The application of stratified medicine to dementia care” BJPsych Advances 26(4): 245-252


    Sidhom E (2015), “ The Jinn That Haunts Mental Illness” ArabPsyNet 46(summer): 134-138

    Sidhom E, Youssef NA (2015), “Brain Stimulation the 21st Century Speciality” J Psy Neuro Dis Brain Stim 1(1): 103e


    Sidhom E, Abdelfattah A, Carter J, El-Dosoky A, El-Islam M (2014), “Patients' Perspectives on Stigma of Mental Illness (An Egyptian Study in a private hospital)” Front. Psychiatry 5(166)


    Sidhom E (2013), “Towards a More Egalitarian Approach to Communicating Psychopathology” JEMH 8(1)


    Sidhom E (2012), “The impact of the uprising in Egypt on mental health in a private hospital” International Psychiatry 9(4): 102-102

    Sidhom E, Abdelfattah A, El-Dosoky AR, Carter JM, El-Islam MF (2012), “The experience of stigma among a sample of psychiatric in-patients in an Egyptian private psychiatric hospital” International Psychiatry 9(2): 49-49