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Research Focus

Keywords

  • Axon
  • Axon Damage
  • Axon & Neuronal Degeneration
  • Axon Degeneration
  • Schwann Cells
  • Molecular Biology
  • Cell Biology
  • Clinical Conditions

  • Motor neurone disease
  • Genetic disorders
  • Hereditary spastic paraplegia
  • Other 
  • Equipment & Techniques

  • Cell culture
  • Confocal microscopy
  • Enzyme assays
  • Fluorescence microscopy
  • Immunohistochemistry
  • Microscopy
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    Dr Emma Rachel Wilson

    (she/her/hers)
    University Position
    Research Associate

    Interests

    My particular interests lie in molecular neuroscience and diseases of the peripheral nervous system. I completed my PhD in Neuroscience at University College London, under the supervision of Prof. Linda Greensmith, Prof. Mary M. Reilly and Dr. Bernadett Kalmar. My thesis explored potential pathomechanisms underlying Hereditary Sensory Neuropathy type I. Subsequently, I undertook post doctoral training in the laboratory of Prof. M. Laura Feltri, at the University of Buffalo, State University of New York, where my research centred on myelin and axo-glia communication in development and disease. Currently, I am a post doctoral research scientist in Prof. Michael Coleman's laboratory at the University of Cambridge, where I am exploring programmed axonal degeneration and its relevance to human disease. More specifically, I am investigating the non-coding regions of the genes NMNAT2 and SARM1, and biomarkers of programmed axonal degeneration.

    Key Publications

    Peripheral glia diversity.

    DOI: http://doi.org/10.1111/joa.13484
    Journal: J Anat
    E-pub date: 1 Nov 2022
    Authors: CB Reed, ML Feltri, ER Wilson

    Activation of mTORC1 and c-Jun by Prohibitin1 loss in Schwann cells may link mitochondrial dysfunction to demyelination.

    DOI: http://doi.org/10.7554/eLife.66278
    Journal: Elife
    E-pub date: 14 Sep 2021
    Authors: G Della-Flora Nunes, ER Wilson, E Hurley, B He, BW O'Malley, Y Poitelon, L Wrabetz, ML Feltri

    Schwann cell interactions during the development of the peripheral nervous system.

    DOI: http://doi.org/10.1002/dneu.22744
    Journal: Dev Neurobiol
    E-pub date: 1 Jul 2021
    Authors: ER Wilson, G Della-Flora Nunes, MR Weaver, LR Frick, ML Feltri

    Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.

    DOI: http://doi.org/10.1038/s41467-021-23552-8
    Journal: Nat Commun
    E-pub date: 2 Jun 2021
    Authors: G Della-Flora Nunes, ER Wilson, LN Marziali, E Hurley, N Silvestri, B He, BW O'Malley, B Beirowski, Y Poitelon, L Wrabetz, ML Feltri

    Hereditary sensory neuropathy type 1-associated deoxysphingolipids cause neurotoxicity, acute calcium handling abnormalities and mitochondrial dysfunction in vitro.

    DOI: http://doi.org/10.1016/j.nbd.2018.05.008
    Journal: Neurobiol Dis
    E-pub date: 1 Sep 2018
    Authors: ER Wilson, U Kugathasan, AY Abramov, AJ Clark, DLH Bennett, MM Reilly, L Greensmith, B Kalmar

    Publications

    A new mouse model of Charcot-Marie-Tooth 2J neuropathy replicates human axonopathy and suggest alteration in axo-glia communication.

    DOI: http://doi.org/10.1371/journal.pgen.1010477
    Journal: PLoS Genet
    E-pub date: 1 Nov 2022
    Authors: G Shackleford, LN Marziali, Y Sasaki, A Claessens, C Ferri, NI Weinstock, AM Rossor, NJ Silvestri, ER Wilson, E Hurley, GJ Kidd, S Manohar, D Ding, RJ Salvi, ML Feltri, M D'Antonio, L Wrabetz

    Development of MRC Centre MRI calf muscle fat fraction protocol as a sensitive outcome measure in Hereditary Sensory Neuropathy Type 1.

    DOI: http://doi.org/10.1136/jnnp-2018-320198
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2019
    Authors: U Kugathasan, MRB Evans, JM Morrow, CDJ Sinclair, JS Thornton, TA Yousry, T Hornemann, S Suriyanarayanan, K Owusu-Ansah, G Lauria, R Lombardi, JM Polke, E Wilson, DLH Bennett, H Houlden, MG Hanna, JC Blake, M Laura, MM Reilly

    Spider toxin inhibits gating pore currents underlying periodic paralysis.

    DOI: http://doi.org/10.1073/pnas.1720185115
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 24 Apr 2018
    Authors: R Männikkö, ZO Shenkarev, MG Thor, AA Berkut, MY Myshkin, AS Paramonov, DS Kulbatskii, DA Kuzmin, M Sampedro Castañeda, L King, ER Wilson, EN Lyukmanova, MP Kirpichnikov, S Schorge, F Bosmans, MG Hanna, DM Kullmann, AA Vassilevski

    Correlative and integrated light and electron microscopy of in-resin GFP fluorescence, used to localise diacylglycerol in mammalian cells.

    DOI: http://doi.org/10.1016/j.ultramic.2014.02.001
    Journal: Ultramicroscopy
    E-pub date: 31 Aug 2014
    Authors: CJ Peddie, K Blight, E Wilson, C Melia, J Marrison, R Carzaniga, M-C Domart, P O'Toole, B Larijani, LM Collinson