Dr Eric Harshfield

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Neurology Unit

Email

eh457@medschl.cam.ac.uk

Home page

http://www.neurology.cam.ac.uk/neurolo... (personal home page)

Research Theme

Clinical and Veterinary Neuroscience

Interests

My current research primarily focuses on utilising epidemiological, clinical, genetic, and imaging data to investigate relationships between vascular risk, stroke, and dementia. Specific projects that I have been involved in include identifying (1) the role of genetic and haematological traits on stroke and its subtypes, and (2) the role of lipids in markers of small vessel disease.

Research Focus

Keywords

genetics

epidemiology

vascular

stroke

dementia

Clinical conditions

Alzheimer's disease

Cardiovascular diseases

Cerebrovascular disorders

Dementia

Depressive disorders

Genetic disorders

Stroke

Equipment

Cross-sectional and cohort studies

Genetics

Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)

Randomised control trials

Recombinant protein expression

Collaborators

Cambridge

Will Astle

Hugh Markus

Willem Ouwehand

Matthew Traylor

Associated News Items


    Key publications

    van der Laan SW, Harshfield EL, Hemerich D, Stacey D, Wood AM, Asselbergs FW (2018), “From lipid locus to drug target through human genomics” Cardiovasc Res 114(9):1258-1270

    Burgess S, Harshfield E (2016), “Mendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the future” Curr Opin Endocrinol Diabetes Obes 23(2):124-30

    Publications

    2017

    Stacey D, Fauman EB, Ziemek D, Sun BB, Harshfield EL, Wood AM, Butterworth AS, Suhre K, Paul DS (2017), “ProGeM: a framework for the prioritisation of candidate causal genes at molecular quantitative trait loci” bioRxiv 230094

    2016

    Harshfield EL, Stacey D, Paul DS, Koulman A, Wood AM, Butterworth AS, Fauman E, Griffin JL, Danesh J, Saleheen D (2016), “Genomics of lipid metabolism: identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease [Abstract]” Genet Epidemiol 40(7):614-615

    2015

    Chowdhury R, Alam DS, Fakir II, Adnan SD, Naheed A, Tasmin I, Monower MM, Hossain F, Hossain FM, Rahman MM, Afrin S, Roy AK, Akter M, Sume SA, Biswas AK, Pennells L, Surendran P, Young RD, Spackman SA, Hasan K, Harshfield E, Sheikh N, Houghton R, Saleheen D, Howson JM, Butterworth AS; Cardiology Research Group, Raqib R, Majumder AA, Danesh J, Di Angelantonio E (2015), “The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design” Eur J Epidemiol 30(7):577-87

    Harshfield E, Chowdhury R, Harhay MN, Bergquist H, Harhay MO (2015), “Association of hypertension and hyperglycaemia with socioeconomic contexts in resource-poor settings: the Bangladesh Demographic and Health Survey” Int J Epidemiol 44(5):1625-36

    2014

    Chowdhury R, Harshfield E, Roy S, Flora MS, Akram KA, Bhuiya A, Ahsan H (2014), “Life, health, and safety of industrial workers in bangladesh: should they be driven by economic rationale or moral imperative?” J Occup Environ Med 56(4):e12-3

    2012

    Harshfield E, Lantagne D, Turbes A, Null C (2012), “Evaluating the sustained health impact of household chlorination of drinking water in rural Haiti” Am J Trop Med Hyg 87(5):786-95