Dr Eric Harshfield

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Neurology Unit

Email

eh457@medschl.cam.ac.uk

Home page

http://www.neurology.cam.ac.uk/neurolo... (personal home page)

Research Theme

Clinical and Veterinary Neuroscience

Interests

My current research primarily focuses on utilising epidemiological, clinical, genetic, and imaging data to investigate relationships between vascular risk, stroke, and dementia. Examples of specific projects that I have been involved in include (1) investigating the causal role of haematological traits in stroke and its subtypes using Mendelian randomisation, and (2) performing a pooled individual patient analysis of clinical trials on stenting for symptomatic vertebral artery stenosis.

Research Focus

Keywords

genetics

epidemiology

vascular

stroke

dementia

Clinical conditions

Alzheimer's disease

Cardiovascular diseases

Cerebrovascular disorders

Dementia

Depressive disorders

Genetic disorders

Stroke

Equipment

Cross-sectional and cohort studies

Genetics

Magnetic resonance imaging (MRI)

Mendelian randomization

Neuropsychological testing

Positron Emission Tomography (PET)

Randomised control trials

Recombinant protein expression

Collaborators

Cambridge

Will Astle

Hugh Markus

Willem Ouwehand

Matt Sims

Matthew Traylor

United Kingdom

Cornela van Duijn Web: https://www.ndph.ox.ac.uk/team/co...

International

Ale Algra Web: https://www.umcutrecht.nl/en/Rese...

Stéphanie Debette Web: https://www.bordeaux-population-health.center/profile...

Martin Dichgans Web: https://www.mcn.uni-muenchen.de/members...

Susanna Larsson Web: https://staff.ki.se/people/...

Associated News Items


    Publications

    2020

    Harshfield EL, Georgakis MK, Malik R, Dichgans M, Markus HS (2020), “Modifiable lifestyle factors and risk of stroke: a Mendelian randomization analysis” medRxiv 2020.03.17.20037549

    Harshfield EL, Sims MC, Traylor M, Ouwehand WH, Markus HS (2020), “The role of haematological traits in risk of ischaemic stroke and its subtypes” Brain 143(1):210-221

    2019

    Chauhan G, [...], Debette S, Stroke Genetics Network (SiGN), the International Stroke Genetics Consortium (ISGC), METASTROKE, Alzheimer's Disease Genetics Consortium (ADGC), and the Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium (2019), “Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting” Neurology 92(5):e486-e503

    Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M (2019), “Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study” medRxiv 2019.12.27.19015834

    Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, Stacey D, Rasheed A, Lee JJ, Shah N, Jabeen S, Imran A, Abbas S, Hina Z, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Qureshi IH, Ishaq M, Frossard P, Danesh J, Saleheen D, Butterworth AS, Wood AM, Griffin JL (2019), “An unbiased lipid phenotyping approach to study the genetic determinants of lipids and their association with coronary heart disease risk factors” J Proteome Res 18(6):2397-2410

    Markus HS, Harshfield EL, Compter A, Küker W, Kappelle LJ, Clifton A, van der Worp HB, Rothwell P, Algra A, on behalf of the Vertebral Stenosis Trialist’s Collaboration (2019), “Stenting for symptomatic vertebral artery stenosis: a preplanned pooled individual patient data analysis” Lancet Neurol 18(7):666-673

    Stacey D, Fauman EB, Ziemek D, Sun BB, Harshfield EL, Wood AM, Butterworth AS, Suhre K, Paul DS (2019), “ProGeM: a framework for the prioritisation of candidate causal genes at molecular quantitative trait loci” Nucleic Acids Res 47(1):e3

    2018

    van der Laan SW, Harshfield EL, Hemerich D, Stacey D, Wood AM, Asselbergs FW (2018), “From lipid locus to drug target through human genomics” Cardiovasc Res 114(9):1258-1270

    2016

    Burgess S, Harshfield E (2016), “Mendelian randomization to assess causal effects of blood lipids on coronary heart disease: lessons from the past and applications to the future” Curr Opin Endocrinol Diabetes Obes 23(2):124-30

    2015

    Chowdhury R, Alam DS, Fakir II, Adnan SD, Naheed A, Tasmin I, Monower MM, Hossain F, Hossain FM, Rahman MM, Afrin S, Roy AK, Akter M, Sume SA, Biswas AK, Pennells L, Surendran P, Young RD, Spackman SA, Hasan K, Harshfield E, Sheikh N, Houghton R, Saleheen D, Howson JM, Butterworth AS; Cardiology Research Group, Raqib R, Majumder AA, Danesh J, Di Angelantonio E (2015), “The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design” Eur J Epidemiol 30(7):577-87

    Harshfield E, Chowdhury R, Harhay MN, Bergquist H, Harhay MO (2015), “Association of hypertension and hyperglycaemia with socioeconomic contexts in resource-poor settings: the Bangladesh Demographic and Health Survey” Int J Epidemiol 44(5):1625-36

    Interleukin 1 Genetics Consortium, Freitag DF, Butterworth AS, Willeit P, Howson JM, Burgess S, Kaptoge S, Young R, Ho WK, Wood AM, Sweeting M, Spackman S, Staley JR, Ramond A, Harshfield E, [...], Di Angelantonio E, Chowdhury R, Nordestgaard BG, Saleheen D, Thompson SG, Danesh J (2015), “Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis” Lancet Diabetes Endocrinol 3(4):243-53

    White IR, Rapsomaniki E, Emerging Risk Factors Collaboration (2015), “Covariate-adjusted measures of discrimination for survival data” Biometrical J 57(4):592:613

    2014

    Chowdhury R, Harshfield E, Roy S, Flora MS, Akram KA, Bhuiya A, Ahsan H (2014), “Life, health, and safety of industrial workers in bangladesh: should they be driven by economic rationale or moral imperative?” J Occup Environ Med 56(4):e12-3

    Emerging Risk Factors Collaboration, Di Angelantonio E, Gao P, Khan H, Butterworth AS, Wormser D, Kaptoge S, Kondapally Seshasai SR, Thompson A, Sarwar N, Willeit P, Ridker PM, Barr EL, Khaw KT, Psaty BM, Brenner H, Balkau B, Dekker JM, Lawlor DA, Daimon M, Willeit J, Njølstad I, Nissinen A, Brunner EJ, Kuller LH, Price JF, Sundström J, Knuiman MW, Feskens EJ, Verschuren WM, Wald N, Bakker SJ, Whincup PH, Ford I, Goldbourt U, Gómez-de-la-Cámara A, Gallacher J, Simons LA, Rosengren A, Sutherland SE, Björkelund C, Blazer DG, Wassertheil-Smoller S, Onat A, Marín Ibañez A, Casiglia E, Jukema JW, Simpson LM, Giampaoli S, Nordestgaard BG, Selmer R, Wennberg P, Kauhanen J, Salonen JT, Dankner R, Barrett-Connor E, Kavousi M, Gudnason V, Evans D, Wallace RB, Cushman M, D'Agostino RB Sr, Umans JG, Kiyohara Y, Nakagawa H, Sato S, Gillum RF, Folsom AR, van der Schouw YT, Moons KG, Griffin SJ, Sattar N, Wareham NJ, Selvin E, Thompson SG, Danesh J (2014), “Glycated hemoglobin measurement and prediction of cardiovascular disease” JAMA 311(12):1225-1233

    2012

    Harshfield E, Lantagne D, Turbes A, Null C (2012), “Evaluating the sustained health impact of household chlorination of drinking water in rural Haiti” Am J Trop Med Hyg 87(5):786-95

    2010

    Samie A, Tambani T, Harshfield E, Green E, Ramalivhana JN, Bessong PO (2010), “Antifungal activities of selected Venda medicinal plants against Candida albicans, Candida krusei and Cryptococcus neoformans isolated from South African AIDS patients” Afr J Biotechnol 9(20):2965-2976

    2009

    Harshfield E, Jemec A, Makhado O, Ramarumo E (2009), “Water purification in rural South Africa: ethical analysis and reflections on collaborative community engagement projects in engineering” Int J Serv Learn Eng 4(1):1-14