Dr Emilio Fernandez-Egea


My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Clozapine Clinic Lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trust). We study treatment resistant schizophrenia from different angles, including studies on biomarkers (metabolism, immunity and inflammation), clinical epidemiology, interaction between physical and mental health and clinical trials with new interventions (both pharmacological and non-pharmacological).

Our main lines of research are:

1) the link between metabolic abnormalities and schizophrenia,

2) the understanding of negative symptoms and,

3) uncommon antipsychotic-induced side effects (i.e. compulsive behaviour).

Clozapine Research Team Logo
Clozapine Research Team Logo
View image full-size (1355x679 pixels)

Research Focus







Clinical conditions



Behavioural analysis


Cognitive testing

Cross-sectional and cohort studies

Randomised control trials


No collaborators listed

Associated News Items

Key publications

Fernandez-Egea E, Garcia-Rizo C, Zimbron J, Kirkpatrick B (2013), “Diabetes or prediabetes in newly diagnosed patients with nonaffective psychosis? A historical and contemporary view.” Schizophr Bull 39(2):266-7 Details

Fernandez-Egea E, Bernardo M, Donner T, Conget I, Parellada E, Justicia A, Esmatjes E, Garcia-Rizo C, Kirkpatrick B (2009), “Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.” Br J Psychiatry 194(5):434-8 Details

Fernandez-Egea E, Bernardo M, Heaphy CM, Griffith JK, Parellada E, Esmatjes E, Conget I, Nguyen L, George V, Stöppler H, Kirkpatrick B (2009), “Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis.” Schizophr Bull 35(2):437-42 Details



Garcia-Portilla MP, Garcia-Alvarez L, Mané A, Garcia-Rizo C, Sugranyes G, Bergé D, Bernardo M, Fernández-Egea E, Bobes J (2015), “The negative syndrome of schizophrenia: Three -underlying components are better than two.” Schizophr Res Details

Garcia-Rizo C, Fernandez-Egea E, Bernardo M, Kirkpatrick B (2015), “The thrifty psychiatric phenotype.” Acta Psychiatr Scand 131(1):18-20 Details

Paterson LM, Flechais RS, Murphy A, Reed LJ, Abbott S, Boyapati V, Elliott R, Erritzoe D, Ersche KD, Faluyi Y, Faravelli L, Fernandez-Egea E, Kalk NJ, Kuchibatla SS, McGonigle J, Metastasio A, Mick I, Nestor L, Orban C, Passetti F, Rabiner EA, Smith DG, Suckling J, Tait R, Taylor EM, Waldman AD, Robbins TW, Deakin JW, Nutt DJ, Lingford-Hughes AR, ICCAM Platform (2015), “The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.” J Psychopharmacol Details

Sahakian BJ, Bruhl AB, Cook J, Killikelly C, Savulich G, Piercy T, Hafizi S, Perez J, Fernandez-Egea E, Suckling J, Jones PB (2015), “The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people.” Philos Trans R Soc Lond B Biol Sci 370(1677) Details

Worbe Y, Palminteri S, Savulich G, Daw ND, Fernandez-Egea E, Robbins TW, Voon V (2015), “Valence-dependent influence of serotonin depletion on model-based choice strategy.” Mol Psychiatry Details

Worbe Y, Savulich G, de Wit S, Fernandez-Egea E, Robbins TW (2015), “Tryptophan Depletion Promotes Habitual over Goal-Directed Control of Appetitive Responding in Humans.” Int J Neuropsychopharmacol Details


Ellison-Wright I, Nathan PJ, Bullmore ET, Zaman R, Dudas RB, Agius M, Fernandez-Egea E, Müller U, Dodds CM, Forde NJ, Scanlon C, Leemans A, McDonald C, Cannon DM (2014), “Distribution of tract deficits in schizophrenia.” BMC Psychiatry 14(1):99 Details

Garcia-Rizo C, Kirkpatrick B, Fernandez-Egea E, Oliveira C, Meseguer A, Grande I, Undurraga J, Vieta E, Bernardo M (2014), “"Is bipolar disorder an endocrine condition?" Glucose abnormalities in bipolar disorder.” Acta Psychiatr Scand 129(1):73-4 Details

Horga G, Fernández-Egea E, Mané A, Font M, Schatz KC, Falcon C, Lomeña F, Bernardo M, Parellada E (2014), “Brain Metabolism during Hallucination-Like Auditory Stimulation in Schizophrenia.” PLoS One 9(1):e84987 Details

Mané A, García-Rizo C, Garcia-Portilla MP, Bergé D, Sugranyes G, Garcia-Alvarez L, Bernardo M, Bobes J, Fernandez-Egea E (2014), “Spanish adaptation and validation of the Brief Negative Symptoms Scale.” Compr Psychiatry Details

Worbe Y, Savulich G, Voon V, Fernandez-Egea E, Robbins TW (2014), “Serotonin Depletion Induces 'Waiting Impulsivity' on the Human Four Choice Serial Reaction Time Task: Cross-Species Translational Significance.” Neuropsychopharmacology Details


Batalla A, Garcia-Rizo C, Castellví P, Fernandez-Egea E, Yücel M, Parellada E, Kirkpatrick B, Martin-Santos R, Bernardo M (2013), “Screening for substance use disorders in first-episode psychosis: Implications for readmission.” Schizophr Res Details

Fernandez-Egea E, Scoriels L, Theegala S, Giro M, Ozanne SE, Burling K, Jones PB (2013), “Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers.” Prog Neuropsychopharmacol Biol Psychiatry Details

Garcia-Rizo C, Fernandez-Egea E, Miller BJ, Oliveira C, Justicia A, Griffith JK, Heaphy CM, Bernardo M, Kirkpatrick B (2013), “Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression.” Brain Behav Immun 28:49-53 Details

Kaser M, Soltesz F, Lawrence P, Miller S, Dodds C, Croft R, Dudas RB, Zaman R, Fernandez-Egea E, Müller U, Dean A, Bullmore ET, Nathan PJ (2013), “Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia.” PLoS One 8(12):e83255 Details

Kirkpatrick B, Miller B, García-Rizo C, Fernandez-Egea E (2013), “Schizophrenia.” Clin Schizophr Relat Psychoses :1-23 Details


Fernandez-Egea E, Parellada E, Sugranyes G, Horga G, Lomeña F, Falcon C, Pavia J, Bernardo M (2012), “Left amygdalar activation in deficit syndrome compared with non-deficit subjects with schizophrenia during the control task in a facial emotion recognition paradigm.” Psychiatry Res Details

Garcia-Rizo C, Fernandez-Egea E, Oliveira C, Justicia A, Bernardo M, Kirkpatrick B (2012), “Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features.” Psychiatry Res Details

Pérez Pintor L, Valldeoriola F, Fernández-Egea E, Sánchez R, Rami L, Tolosa E, Muñiz A, Martí MJ, Bernardo M (2012), “Use of Electroconvulsive Therapy in Parkinson Disease With Residual Axial Symptoms Partially Unresponsive to L-Dopa: A Pilot Study.” J ECT Details

Pons I Villanueva A, Romero A, Goti J, Fernandez-Egea E, Undurruaga J, Carne X, Bernardo M (2012), “Should obesity be a limiting factor for clozapine treatment?” Rev Psiquiatr Salud Ment Details


Fernandez-Egea E, García-Rizo C, Miller B, Parellada E, Justicia A, Bernardo M, Kirkpatrick B (2011), “Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With Nonaffective Psychosis: A Test of the Accelerated Aging Hypothesis.” Psychosom Med Details

Fernandez-Egea E, Miller B, Garcia-Rizo C, Bernardo M, Kirkpatrick B (2011), “Metabolic effects of olanzapine in patients with newly diagnosed psychosis.” J Clin Psychopharmacol 31(2):154-9 Details

Garcia-Rizo C, Fernandez-Egea E, Oliveira C, Justicia A, Parellada E, Bernardo M, Kirkpatrick B (2011), “Prolactin concentrations in newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis.” Schizophr Res Details

Horga G, Parellada E, Lomeña F, Fernández-Egea E, Mané A, Font M, Falcón C, Konova AB, Pavia J, Ros D, Bernardo M (2011), “Differential brain glucose metabolic patterns in antipsychotic-naïve first-episode schizophrenia with and without auditory verbal hallucinations.” J Psychiatry Neurosci 36(1):100085 Details

Mané A, Gallego J, Lomeña F, Mateos JJ, Fernandez-Egea E, Horga G, Cot A, Pavia J, Bernardo M, Parellada E (2011), “A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients.” Psychiatry Res 194(1):79-84 Details

Segarra N, Bernardo M, Gutierrez F, Justicia A, Fernadez-Egea E, Allas M, Safont G, Contreras F, Gascon J, Soler-Insa PA, Menchon JM, Junque C, Keefe RS (2011), “Spanish validation of the Brief Assessment in Cognition in Schizophrenia (BACS) in patients with schizophrenia and healthy controls.” Eur Psychiatry 26(2):69-73 Details


Fernandez-Egea E, Parellada E, Lomeña F, Falcon C, Pavia J, Mane A, Horga G, Bernardo M (2010), “18FDG PET study of amygdalar activity during facial emotion recognition in schizophrenia.” Eur Arch Psychiatry Clin Neurosci 260(1):69-76 Details

Kirkpatrick B, Garcia-Rizo C, Tang K, Fernandez-Egea E, Bernardo M (2010), “Cholesterol and triglycerides in antipsychotic-naive patients with nonaffective psychosis.” Psychiatry Res Details

Kirkpatrick B, Miller BJ, Garcia-Rizo C, Fernandez-Egea E, Bernardo M (2010), “Is Abnormal Glucose Tolerance in Antipsychotic-Naive Patients With Nonaffective Psychosis Confounded by Poor Health Habits?” Schizophr Bull Details


Cardinal RN, Shah DN, Edwards CJ, Hughes GR, Fernández-Egea E (2009), “Psychosis and catatonia as a first presentation of antiphospholipid syndrome.” Br J Psychiatry 195(3):272 Details

Fernandez-Egea E, Bruna A, Garcia-Rizo C, Bernardo M, Kirkpatrick B (2009), “Stem cell signaling in newly diagnosed, antipsychotic-naive subjects with nonaffective psychosis.” Mol Psychiatry 14(11):989-91 Details

Fernandez-Egea E, Parellada E, Lomeña F, Falcon C, Pavia J, Mane A, Sugranyes G, Valdes M, Bernardo M (2009), “A continuous emotional task activates the left amygdala in healthy volunteers: (18)FDG PET study.” Psychiatry Res 171(3):199-206 Details

Kirkpatrick B, Fernandez-Egea E, Garcia-Rizo C, Bernardo M (2009), “Differences in glucose tolerance between deficit and nondeficit schizophrenia.” Schizophr Res 107(2-3):122-7 Details

Mané A, Falcon C, Mateos JJ, Fernandez-Egea E, Horga G, Lomeña F, Bargalló N, Prats-Galino A, Bernardo M, Parellada E (2009), “Progressive gray matter changes in first episode schizophrenia: a 4-year longitudinal magnetic resonance study using VBM.” Schizophr Res 114(1-3):136-43 Details

Sugranyes G, Flamarique I, Parellada E, Baeza I, Goti J, Fernandez-Egea E, Bernardo M (2009), “Cannabis use and age of diagnosis of schizophrenia.” Eur Psychiatry 24(5):282-6 Details


Fernandez-Egea E, Bernardo M, Parellada E, Justicia A, Garcia-Rizo C, Esmatjes E, Conget I, Kirkpatrick B (2008), “Glucose abnormalities in the siblings of people with schizophrenia.” Schizophr Res 103(1-3):110-3 Details

Fernandez-Egea E, Miller B, Bernardo M, Donner T, Kirkpatrick B (2008), “Parental history of type 2 diabetes in patients with nonaffective psychosis.” Schizophr Res 98(1-3):302-6 Details

Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR (2008), “Is schizophrenia a syndrome of accelerated aging?” Schizophr Bull 34(6):1024-32 Details

Parellada E, Lomena F, Font M, Pareto D, Gutierrez F, Simo M, Fernández-Egea E, Pavia J, Ros D, Bernardo M (2008), “Fluordeoxyglucose-PET study in first-episode schizophrenic patients during the hallucinatory state, after remission and during linguistic-auditory activation.” Nucl Med Commun 29(10):894-900 Details


Bernardo M, Fernández-Egea E, Torras A, Gutiérrez F, Ahuir M, Arango C (2007), “[Adaptation and validation into Spanish of Schedule for the Deficit Syndrome]” Med Clin (Barc) 129(3):91-3 Details

Gómez-Gil E, Fernández-Egea E, Trilla A, Almela M (2007), “[Value of screening test for syphilis in acute psychiatric inpatients]” Med Clin (Barc) 129(2):77 Details

Kirkpatrick B, Hack GD, Higginbottom E, Hoffacker D, Fernandez-Egea E (2007), “Palate and dentition in schizophrenia.” Schizophr Res 91(1-3):187-91 Details

Mateos JJ, Lomeña F, Parellada E, Mireia F, Fernandez-Egea E, Pavia J, Prats A, Pons F, Bernardo M (2007), “Lower striatal dopamine transporter binding in neuroleptic-naive schizophrenic patients is not related to antipsychotic treatment but it suggests an illness trait.” Psychopharmacology (Berl) 191(3):805-11 Details

Pintor L, Bailles E, Fernández-Egea E, Sánchez-Gistau V, Torres X, Carreño M, Rumia J, Matrai S, Boget T, Raspall T, Donaire A, Bargalló N, Setoain X (2007), “Psychiatric disorders in temporal lobe epilepsy patients over the first year after surgical treatment.” Seizure 16(3):218-25 Details


Fernández-Egea E, Ferrer del Alamo A, Torrebadell Burriel M, Carrió Ybáñez A (2006), “[Velo-cardio-facial syndrome at the psychiatry consulting-liaison service in a general hospital]” Actas Esp Psiquiatr 34(1):67-8 Details

Mateos JJ, Lomeña F, Parellada E, Font M, Fernández E, Pavia J, Prats A, Bernardo M (2006), “[Striatal dopamine transporter density decrease in first episode schizophrenic patients treated with risperidone]” Rev Esp Med Nucl 25(3):159-65 Details


Mateos JJ, Lomeña F, Parellada E, Font M, Fernandez E, Pavia J, Prats A, Pons F, Bernardo M (2005), “Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first-episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism.” Psychopharmacology (Berl) 181(2):401-6 Details


Baillés E, Pintor L, Fernandez-Egea E, Torres X, Matrai S, De Pablo J, Arroyo S (2004), “Psychiatric disorders, trauma, and MMPI profile in a Spanish sample of nonepileptic seizure patients.” Gen Hosp Psychiatry 26(4):310-5 Details

Baillès E, Pintor L, Torres X, Fernández-Egea E, de Pablo J, Arroyo S (2004), “[Psychiatric disease in patients with psychogenic non-epileptic seizures referred from an epilepsy unit in a general hospital]” Actas Esp Psiquiatr 32(2):76-81 Details

Parellada E, Lomeña F, Catafau AM, Bernardo M, Font M, Fernández-Egea E, Pavía J, Gutierrez F (2004), “Lack of sex differences in striatal dopamine D2 receptor binding in drug-naive schizophrenic patients: an IBZM-SPECT study.” Psychiatry Res 130(1):79-84 Details


Font M, Parellada E, Fernández-Egea E, Bernardo M, Lomeña F (2003), “[Functional neuroimaging of auditory hallucinations in schizophrenia]” Actas Esp Psiquiatr 31(1):3-9 Details

Gómez-Gil E, Vidal A, Panés J, Jaén J, Peri JM, Fernández-Egea E, Piqué JM (2003), “[Relationship between patient's subjective stress perception and the course of inflammatory bowel disease]” Gastroenterol Hepatol 26(7):411-6 Details


Fernández-Egea E, Gómez Gil E, Corbella Santomà B, Salamero Baró M, Blanch Andreu J, Valdés Miyar M (2002), “[Serological testing and prevalence of human immunodeficiency, hepatitis B and C viruses infections amongst acute psychiatric inpatients]” Med Clin (Barc) 119(18):690-2 Details

Gómez-Gil E, Trilla A, Corbella B, Fernández-Egea E, Luburich P, de Pablo J, Ferrer Raldúa J, Valdés M (2002), “Lack of clinical relevance of routine chest radiography in acute psychiatric admissions.” Gen Hosp Psychiatry 24(2):110-3 Details