Menu

Department
  • Psychiatry
  • Research Focus

    Keywords

  • Schizophrenia
  • Antipsychotics
  • Clozapine
  • Aetiology
  • Clinical Trials
  • Clinical Conditions

  • Schizophrenia
  • Equipment & Techniques

  • Neuropsychological testing
  • Randomised control trials
  • Statistical analysis
  • Computational modelling
  • Science Culture

  • History of Science
  • Philosophy of Science
  • Back

    Dr Emilio Fernandez-Egea

    University Position
    Associate Professor
    Affiliated Member
    Dr Emilio Fernandez-Egea is pleased to consider applications from prospective PhD students.

    Interests

    My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Cambridge Psychosis Centre and Clozapine Clinic Lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trust). We study treatment resistant schizophrenia from different angles, including studies on biomarkers (metabolism, immunity and inflammation), clinical epidemiology, interaction between physical and mental health and clinical trials with new interventions (both pharmacological and non-pharmacological). Our main lines of research are: 1) the link between metabolic abnormalities and schizophrenia, 2) the understanding of negative symptoms and, 3) uncommon antipsychotic-induced side effects (i.e. compulsive behaviour).

    Key Publications

    Birth weight, family history of diabetes and diabetes onset in schizophrenia.

    DOI: http://doi.org/10.1136/bmjdrc-2019-001036
    Journal: BMJ Open Diabetes Res Care
    E-pub date: 1 Jan 2020
    Authors: E Fernandez-Egea, R Walker, H Ziauddeen, RN Cardinal, ET Bullmore

    Publications

    Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action.

    DOI: http://doi.org/10.1136/bmjment-2023-300870
    Journal: BMJ Ment Health
    E-pub date: 1 Oct 2023
    Authors: D Pizzol, M Trott, L Butler, Y Barnett, T Ford, SA Neufeld, A Ragnhildstveit, CN Parris, BR Underwood, GF López Sánchez, M Fossey, C Brayne, E Fernandez-Egea, G Fond, L Boyer, JI Shin, S Pardhan, L Smith

    Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

    DOI: http://doi.org/10.1192/bjp.2022.191
    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2023
    Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

    Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study.

    DOI: http://doi.org/10.1017/S003329172100492X
    Journal: Psychol Med
    E-pub date: 1 May 2023
    Authors: K Parkin, S Chen, M Biria, J Plaistow, H Beckwith, I Jarratt-Barnham, N Segarra, Y Worbe, NA Fineberg, RN Cardinal, TW Robbins, E Fernandez-Egea

    Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.

    DOI: http://doi.org/10.1016/j.bpsc.2021.08.010
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Nov 2022
    Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    DOI: http://doi.org/10.1016/j.lanepe.2022.100493
    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19: A retrospective cohort study.

    DOI: http://doi.org/10.1002/gps.5610
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2021
    Authors: S Chen, PB Jones, BR Underwood, E Fernandez-Egea, P Qin, JR Lewis, RN Cardinal

    Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

    DOI: http://doi.org/10.1192/bjo.2021.1046
    Journal: BJPsych Open
    E-pub date: 1 Nov 2021
    Authors: S Chen, E Fernandez-Egea, PB Jones, JR Lewis, RN Cardinal

    The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study.

    DOI: http://doi.org/10.1097/JCP.0000000000001432
    Journal: J Clin Psychopharmacol
    E-pub date: 1 Sep 2021
    Authors: E Fernandez-Egea, S Chen, C Jenkins, C Turrion, SP Mitchell, DJF Dodwell, LM Mann, JB Deakin, ZH Syed, S Hafizi, J Zimbron, AS Praseedom, RN Cardinal

    Atomoxetine partially restores loss sensitivity in cocaine use disorder

    DOI: http://doi.org/10.1016/j.euroneuro.2021.10.016
    Journal:
    E-pub date: 1 Aug 2021
    Authors: L Cincikas, RN Cardinal, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, TW Robbins, KD Ersche

    Early versus late risk factors for deficit and nondeficit schizophrenia.

    DOI: http://doi.org/10.1016/j.rpsm.2021.03.002
    Journal: Rev Psiquiatr Salud Ment (Engl Ed)
    E-pub date: 1 Apr 2021
    Authors: S Alabaf, B Kirkpatrick, S Chen, RN Cardinal, E Fernandez-Egea

    The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services: A Controlled Interrupted Time Series Study.

    DOI: http://doi.org/10.3389/fpsyt.2020.585915
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2020
    Authors: S Chen, R She, P Qin, A Kershenbaum, E Fernandez-Egea, JR Nelder, C Ma, J Lewis, C Wang, RN Cardinal

    Risk Factors for Excess Deaths Among Older Adults Without Confirmed COVID-19 During Lockdown: A Retrospective Cohort Study

    DOI: http://doi.org/10.2139/ssrn.3672334
    Journal:
    E-pub date: 1 Aug 2020
    Authors: S Chen, P Jones, B Underwood, E Fernandez-Egea, P Qin, J Lewis, R Cardinal

    Causes of death in clozapine-treated patients in a catchment area: a 10-year retrospective case-control study.

    DOI: http://doi.org/10.1016/j.euroneuro.2020.05.011
    Journal: Eur Neuropsychopharmacol
    E-pub date: 1 Jul 2020
    Authors: E Rose, S Chen, C Turrion, C Jenkins, RN Cardinal, E Fernandez-Egea

    Noradrenergic modulation of stopping impulsivity in cocaine use disorder

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.317
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2019
    Authors: R Rodrigues, S Morein-Zamir, C Meng, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    SLC6A2 genotype variation and the modulatory effects of atomoxetine on inhibitory control in individuals with and without cocaine use disorder

    DOI: http://doi.org/10.1016/S0924-977X(17)31865-5
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2017
    Authors: AN Le, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction.

    DOI: http://doi.org/10.1016/j.nicl.2017.01.028
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2017
    Authors: JR Garrison, E Fernandez-Egea, R Zaman, M Agius, JS Simons

    Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia.

    DOI: http://doi.org/10.1016/j.euroneuro.2016.03.008
    Journal: Eur Neuropsychopharmacol
    E-pub date: 1 Jun 2016
    Authors: H Ziauddeen, C Garcia-Rizo, M Bernardo, B Kirkpatrick, SE Ozanne, PB Jones, E Fernandez-Egea

    Distribution of tract deficits in schizophrenia.

    DOI: http://doi.org/10.1186/1471-244X-14-99
    Journal: BMC Psychiatry
    E-pub date: 2 Apr 2014
    Authors: I Ellison-Wright, PJ Nathan, ET Bullmore, R Zaman, RB Dudas, M Agius, E Fernandez-Egea, U Müller, CM Dodds, NJ Forde, C Scanlon, A Leemans, C McDonald, DM Cannon

    Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia.

    DOI: http://doi.org/10.1371/journal.pone.0083255
    Journal: PLoS One
    E-pub date: 1 Aug 2013
    Authors: M Kaser, F Soltesz, P Lawrence, S Miller, C Dodds, R Croft, RB Dudas, R Zaman, E Fernandez-Egea, U Müller, A Dean, ET Bullmore, PJ Nathan

    Psychosis and catatonia as a first presentation of antiphospholipid syndrome.

    DOI: http://doi.org/10.1192/bjp.195.3.272
    Journal: Br J Psychiatry
    E-pub date: 1 Sep 2009
    Authors: RN Cardinal, DN Shah, CJ Edwards, GRV Hughes, E Fernández-Egea