Through an in-depth investigation of the neuronal cell biophysical properties, our program aims to Identify new targetable pathways, disrupted in dementia. In particular, we seek understanding of the role Endoplasmic Reticulum, and its structure function regulation, plays in neuronal (patho)physiology, and thus to gain insight into the dementia-underlying dysregulation of ER function. In our quests we develop, implement and combine techniques such as high tempora-spatial resolution light microscopy (super-resolution), genetically encoded biosensors, genetic manipulations of neuronal models (e.g. iPS cells based) and in vitro/in vivo biochemistry.
