Dr Ed Harding

Interests

I am primarily interested in the neuronal control of energy balance and how this is altered in disease. Previously I worked on a specific type of hypothalamic neuron that connects thermoregulatory circuits to the control of NREM sleep initiation.

I have now moved to focus on the influence of obesity and associated metabolic syndromes on susceptibility to neurodegenerative disease.

Research Focus

Keywords

Metabolics

Neuroscience

Obesity

Neurodegeneration

Energy Balance

Clinical conditions

Alzheimer's disease

Diabetes

Metabolic Syndrome

Neurodegeneration

Obesity

Equipment

Behavioural analysis

Computational modelling

Confocal microscopy

Fluorescence microscopy

Immunohistochemistry

Collaborators

No collaborators listed

Associated News Items


    Key publications

    Harding EC, Franks NP, Wisden W (2020), “Sleep and thermoregulation” Current Opinion in Physiology

    Harding EC, Franks NP, Wisden W (2019), “The Temperature dependence of Sleep” Frontiers in Neuroscience 13(336)

    Harding EC, Yu X, Miao A, Andrews N,,Ma Y, Ye Z, Lignos L, Miracca G, Ba W, Yustos R, Vyssotski AL, Wisden W, Franks NP (2018), “A Neuronal Hub Binding Sleep Initiation and Body Cooling in Response to a Warm External Stimulus” Current Biology 28(14): 2263-2273

    Publications

    2020

    Yu X, Ba W, Zhao G, Ma Y, Harding EC, Ying L, Wang D, Li H, Zhang P, Shi Y, Yustos R, Vyssotski AL, Dong H, NP Franks, Wisden W (2020), “Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior” Molecular Psychiatry 1-16

    2019

    Hsieh B, Harding EC, Wisden W, Franks NP, Constandinou TG (2019), “A Miniature Neural Recording Device to Investigate Sleep and Temperature Regulation in Mice” 2019 IEEE Biomedical Circuits and Systems Conference (BioCAS)

    Ma Y, Miracca G, Yu X, Harding EC, Miao A,Yustos R, Vyssotski AL, Franks NP, Wisden W (2019), “Galanin neurons unite sleep homeostasis and α2-adrenergic sedation” Current Biology 29(19)3315-3322. e3

    Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G, Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D, Yang Q, Dong H, Franks NP, Wisden W (2019), “GABA and glutamate neurons in the VTA regulate sleep and wakefulness” Nature Neuroscience 22(1):106-119

    Yu X, Ma Y, Harding EC, Yustos R, Vyssotski AL, Franks NP, Wisden W (2019), “Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness” Sleep 42(5). pii: zsz031

    2018

    Gelegen C, Miracca G, Ran MZ, Harding EC, Ye Z, Yu X, Tossell K, Houston CM, Yustos R, Hawkins ED, Vyssotski AL, Dong HL, Wisden W, Franks NP (2018), “Excitatory Pathways from the Lateral Habenula Enable Propofol-Induced Sedation” Current Biology 28(4):580-587

    2016

    Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W. (2016), “Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons” Journal of Neuroscience 36(44):11171-11184

    2015

    Zhang Z, Ferretti V, Güntan İ, Moro A, Steinberg EA, Ye Z, Zecharia AY, Yu X, Vyssotski AL, Brickley SG, Yustos R, Pillidge ZE, Harding EC, Wisden W, Franks NP. (2015), “Neuronal ensembles sufficient for recovery sleep and the sedative actions of α2 adrenergic agonists” Nature Neuroscience 18(4):553-561

    2014

    Jégouzo SA, Harding EC, Acton O, Rex MJ, Fadden AJ, Taylor ME, Drickamer K (2014), “Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate” 2014 24(12):1291-300