Dr Emmanuel A Stamatakis University positionStephen Erskine Fellow, Queens' College Dr Emmanuel A Stamatakis is pleased to consider applications from prospective PhD students. DepartmentsInstitutesBehavioural and Clinical Neurosciences Institute and Division of Anaesthesia Home pagehttps://sites.google.com/site/cc... (personal home page) Research ThemesInterestsMy research aims to decode complex relationships between remote and/or proximal brain regions, which form networks at rest or during goal directed behaviour. This includes work on network adaptive behaviour (reorganisation/plasticity) triggered by abrupt (e.g. trauma, stroke) or gradual structural changes (e.g. neuropsychiatric/neurodegenerative diseases, ageing), or pharmacological agents. Although I primarily work with task related networks, I am also interested in the significance of resting networks and their relationship with task networks. In this context, my research questions are: Can resting network connectivity in individuals/groups provide insights to their ability to complete certain tasks? What happens to resting network connectivity during goal directed behaviour? How does structural integrity relate to network connectivity and behaviour? How do pharmacological agents modulate network organisation at rest or during tasks?  Motor system connectivity in healthy controls and brain injured patients. Green lines - positive interactions. Red lines - negative interactions. Solid lines - significant cluster level with p < 0.05 corrected for multiple comparisons. Dotted lines - significant at voxel level with p < 0.001 uncorrected. Neurology. 2010 Jul 13;75(2):168-76. Click image to view full-size Research Focus
EquipmentBehavioural analysis Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Collaborators
Associated News ItemsKey publicationsMM Craig, B Misic, I Pappas, RM Adapa, DK Menon, EA Stamatakis, (in press), “Propofol-induced alterations in brain connectivity reflect parvalbumin interneuron distribution in the human cortex, ” British Journal of Anaesthesia I Pappas, MM Craig, DK Menon, EA Stamatakis, (2020), “ Structural optimality and neurogenetic expression mediate functional dynamics in the human brain,” Human Brain Mapping 41(8):2229-2243 TF Varley, M Craig, R Adapa, P Finoia, G Williams, J Alanson, J Pickard, DK Menon, EA. Stamatakis, (2020), “Fractal Dimension of Cortical Functional Connectivity Networks & Severity of Disorders of Consciousness,” PLoS ONE 15(2): e0223812 TF Varley, R Carhart-Harris, Leor Roseman, David K Menon, EA Stamatakis, (2020), “Serotonergic Psychedelics LSD and Psilocybin Increase the Fractal Dimension of Cortical Brain Activity in Spatial and Temporal Domains,” Neuroimage 220 117049 TF Varley†, A Luppi†, I Pappas, R Adapa, A Owen, L Naci, DK Menon, EA Stamatakis, (2020), “Consciousness & Brain Functional Complexity in Propofol Anaesthesia,” Scientific Reports 10, 1018 AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon & EA Stamatakis, (2019), “Consciousness-specific dynamic interactions of brain integration and functional diversity,” Nature Communications 10(1):4616 I Pappas, RM Adapa, DK Menon, EA Stamatakis, (2019), “Brain network disintegration during sedation is mediated by the complexity of sparsely connected regions,” Neuroimage 186:221-233 I Pappas†, L Cornelissen†, DK Menon, CB Berde, EA Stamatakis, (2019), “Delta oscillation correlates of anesthesia-induced unconsciousness in large-scale brain networks of human infants,” Anesthesiology 131(6):1239–1253 AE Manktelow, DK Menon, BJ Sahakian and EA Stamatakis, (2017), “Working memory after traumatic brain injury: the neural basis of improved performance with methylphenidate,” Frontiers in Behavioral Neuroscience 11:58. doi: 10.3389/fnbeh.2017.00058 D Vatansever, DK Menon, EA Stamatakis, (2017), “Default mode contributions to automated information processing,” PNAS 114:12821-12826 F Bravo, I Cross, S Hawkins, N Gonzalez, J Docampo, C Bruno, EA Stamatakis, (2017), “Neural mechanisms underlying valence inferences to sound: The role of the right angular gyrus,” Neuropsychologia 102:144-162 L Moreno-López, AE Manktelow, BJ Sahakian, DK Menon and EA Stamatakis (2017), “Anything goes? Regulation of the neural processes underlying response inhibition in TBI patients,” European Neuropsychopharmacology 27(2):159-169 Vatansever D Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015), “Default mode dynamics for global functional integration” Journal of Neuroscience 35(46):15254-62 Tyler LK, Marslen-Wilson WD, Randall B, Wright P, Devereux BJ, Zhuang J, Papoutsi M, Stamatakis EA (2011), “Left inferior frontal cortex and syntax: function, structure and behaviour in patients with left hemisphere damage.” Brain 134(Pt 2):415-31 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details Stamatakis EA, Adapa RM, Absalom AR, Menon DK (2010), “Changes in resting neural connectivity during propofol sedation.” PLoS One 5(12):e14224 Details Tyler LK, Shafto MA, Randall B, Wright P, Marslen-Wilson WD, Stamatakis EA (2010), “Preserving syntactic processing across the adult life span: the modulation of the frontotemporal language system in the context of age-related atrophy.” Cereb Cortex 20(2):352-64 Details Tyler LK, Wright P, Randall B, Marslen-Wilson WD, Stamatakis EA (2010), “Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function?” Brain 133(11):3396-408 Details Stamatakis EA, Marslen-Wilson WD, Tyler LK, Fletcher PC (2005), “Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivity.” Neuroimage 28(1):115-21 Details Tyler LK, Marslen-Wilson WD, Stamatakis EA (2005), “Differentiating lexical form, meaning, and structure in the neural language system.” Proc Natl Acad Sci U S A 102(23):8375-80 Details Publicationsin pressAI Luppi & EA Stamatakis, (in press), “Combining Network Topology and Information Theory to Construct Representative Brain Networks,” Network Neuroscience 2021AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis, (2021), “LSD alters dynamic integration and segregation in the human brain,” NeuroImage 227 117653 in pressL Wilson, L Horton, K Kunzmann, BJ Sahakian, VFJ Newcombe, EA Stamatakis, N von Steinbuechel, K Cunitz, A Covic, A Maas, D Van Praag, D Menon, CENTER-TBI participants and investigators, (in press), “Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury,” Journal of Neurology Neurosurgery and Psychiatry 2020D Vatansever, M Schröter, R Adapa, E Bullmore, DK Menon, EA Stamatakis, (2020), “Reorganisation of brain hubs across altered states of consciousness,” Scientific Reports 10, 3402 F Bravo, I Cross, C Hopkins, N Gonzalez, Jorge Docampo, C Bruno and EA Stamatakis, (2020), “Anterior Cingulate and Medial Prefrontal Cortex Response to Systematically Controlled Tonal Dissonance during Passive Music Listening, ” Human Brain Mapping 41(1):46–66 V Newcombe, L Spindler, T Das, S Winzeck, K Allinson, EA Stamatakis DK Menon, on behalf of the Cambridge NeuroCovid Imaging Collaborators, (2020), “Neuroanatomical substrates of generalized brain dysfunction in COVID-19, ” Intensive Care Med https://doi.org/10.1007/s00134-020-06241-w X Xu, J Dai, Y Chen, C Liu, F Xin, X Zhou, F Zhou, E A Stamatakis, S Yao, L Luo, Y Huang, J Wang, Z Zou, D Vatansever, K Kendrick, B Zhou, and B Becker, (2020), “. Intrinsic connectivity of the prefrontal cortex and striato-limbic system respectively differentiate Major Depressive from Generalized Anxiety Disorder,” Neuropsychopharmacology 0:1 – 8 2018AJ Lawrence, DJ Tozer, EA Stamatakis, HS Markus, (2018), “A comparison of functional and tractography based networks in cerebral small vessel disease,” NeuroImage: Clinical 18:425-432 CL Dorer, AE Manktelow, J Allanson, BJ Sahakian, JD Pickard; A Bateman, DK Menon, EA Stamatakis, (2018), “Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury,” Brain Injury 32:1040-1049 D Vatansever, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis, (2018), “Default Mode Network Engagement Beyond Self-Referential Internal Mentation,” Brain Connectivity 8:245-253 G Savulich, DK Menon, EA Stamatakis, JD Pickard, BJ Sahakian, (2018), “Personalised treatments for traumatic brain injury: cognitive, emotional and motivational targets,” Psychol Med 11:1-3 G Winterer, G Androsova G, O Bender, D Boraschi, F Borchers, TB Dschietzig, I Feinkohl, P Fletcher, J Gallinat, D Hadzidiakos et al., (2018), “Personalized risk prediction of postoperative cognitive impairment – rationale for the EU-funded BioCog project,” European Psychiatry 50:34-39 JA Huijben, V Volovici, MC Cnossen, IK Haitsma, N Stocchetti, AIR Maas, DK Menon, A Ercole, G Citerio, D Nelson, S Polinder, EW Steyerberg, HF Lingsma, M van der Jagt; CENTER-TBI investigators and participants, (2018), “Variation in general supportive and preventive intensive care management of traumatic brain injury: a survey in 66 neurotrauma centers participating in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study,” Crit Care 22:90 MM Craig, AE Manktelow, BJ Sahakian, DK Menon, EA Stamatakis, (2018), “Spectral diversity in default mode network connectivity reflects behavioural state” Journal of Cognitive Neuroscience 30:526-539 N Konstantinou, E Pettemeridou, EA Stamatakis, I Seimenis and F Constantinidou, (2018), “Altered Resting Functional Connectivity is Related to Cognitive Outcome in Males with Moderate-Severe Traumatic Brain Injury,” Frontiers Neurology 9:1163. doi: 10.3389/fneur.2018.01163 2017AIR Maas, DK Menon, PD Adelson, N Andelic, MJ Bell, A Belli, P Bragge, A Brazinova, A Büki, RM Chesnut, G Citerio and TBIR Participants and Investigators, (2017), “Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research,” Lancet Neurol 16:987-1048 F Bravo, I Cross, EA Stamatakis and M Rohrmeier, (2017), “Sensory cortical response to uncertainty and low salience during recognition of affective cues in musical intervals,” PLoS One 12(4):e0175991 J Lauer, L Moreno-López, A. Manktelow, EL Carroll, JG Outtrim, JP Coles, VF Newcombe, BJ Sahakian, DK Menon & EA Stamatakis, (2017), “Neural correlates of visual memory in patients with diffuse axonal injury,” Brain Injury 14:1-8 MC Cnossen, JA Huijben, M van der Jagt, V Volovici, T van Essen, S Polinder, D Nelson, A Ercole, N Stocchetti, G Citerio, WC Peul, AIR Maas, D Menon, EW Steyerberg, HF Lingsma; CENTER-TBI investigators, (2017), “. Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study,” Crit Care 21(1):233 Vatansever D, Manktelow AE, Sahakian BJ, Menon DK, Stamatakis EA (2017), “Angular Default Mode Network Connectivity Across Working Memory Load” Human Brain Mapping 38(1):41-52 2016Agarwal S, Stamatakis EA, Geva S, Warburton EA (2016), “Dominant hemisphere functional networks compensate for structural connectivity loss to preserve phonological word retrieval with aging” Brain and Behavior 27;6(9):e00495 Ahmad MF, Murphy J, Vatansever D, Stamatakis EA and Godsill S (2016), “Bayesian Inference of Task-Based Functional Brain Connectivity Using Markov Chain Monte Carlo Methods” IEEE Journal of Selected Topics in Signal Processing 10(7): 1150-1159 Chennu S, Stamatakis EA, Menon DK (2016), “The see-saw brain: recovering consciousness after brain injury” Lancet Neurol S1474-4422(16)30027-8 Moreno-Lopez L, Contreras-Rodriguez O, Soriano-Mas C, Stamatakis EA, Verdejo-Garcia A (2016), “Disrupted functional connectivity in adolescent obesity” NeuroImage: Clinical 12:262-8 Moreno-López L, Sahakian BJ, Manktelow A, Menon DK, Stamatakis EA (2016), “Depression following traumatic brain injury: A functional connectivity perspective ” Brain Injury 30(11):1319-1328 Vatansever D, Manktelow AE, Sahakian BJ, Menon DK, Stamatakis EA (2016), “Cognitive Flexibility: A Default Network and Basal Ganglia Connectivity Perspective” Brain Connectivity 6(3): 201-207 2015Barttfeld P, Bekinschtein TA, Salles A, Stamatakis EA, Adapa, R, Menon DK, Sigman M (2015), “Factoring the brain signatures of anesthesia concentration and level of arousal across individuals” NeuroImage:Clinical 9:385-91 Maas AI, Menon DK, Steyerberg EW, Citerio G, Lecky F, Manley GT, Hill S, Legrand V, Sorgner A; CENTER-TBI Participants and Investigators (2015), “Colaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study” Neurosurgery 76:67-80 Vatansever D, Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015), “Default mode network connectivity during task execution” Neuroimage 122:96-104 2014Adapa RM, Davis MH, Stamatakis EA, Absalom AR, Menon DK (2014), “Neural correlates of successful semantic processing during propofol sedation” Hum Brain Mapp 35(7):2935-49 Goon SS, Stamatakis EA, Adapa RM, Kasahara M, Bishop S, Wood DF, Wheeler DW, Menon DK, Gupta AK (2014), “Clinical decision-making augmented by simulation training: neural correlates demonstrated by functional imaging: a pilot study.” Br J Anaesth 112(1):124-32 Details Meunier D, Stamatakis EA, Tyler LK (2014), “Age-related functional reorganization, structural changes, and preserved cognition.” Neurobiol Aging 35(1):42-54 Details Zhuang J, Tyler LK, Randall B, Stamatakis EA, Marslen-Wilson WD (2014), “Optimally efficient neural systems for processing spoken language.” Cereb Cortex 24(4):908-18 Details 2013Griffiths JD, Marslen-Wilson WD, Stamatakis EA, Tyler LK (2013), “Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax.” Cereb Cortex 23(1):139-47 Details Moreno-López L, Fernández-Serrano MJ, Stamatakis EA, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2013), “[Differential association between the regional metabolism of the prefrontal cortex and limbic structures, and the time of abstinence in substance dependent individuals].” Adicciones 25(4):348-55 Details 2012Moreno-López L, Catena A, Fernández-Serrano MJ, Delgado-Rico E, Stamatakis EA, Pérez-García M, Verdejo-García A (2012), “Trait impulsivity and prefrontal gray matter reductions in cocaine dependent individuals.” Drug Alcohol Depend 125(3):208-14 Details Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2012), “Neural correlates of hot and cold executive functions in polysubstance addiction: association between neuropsychological performance and resting brain metabolism as measured by positron emission tomography.” Psychiatry Res 203(2-3):214-21 Details Moreno-López L, Stamatakis EA, Fernández-Serrano MJ, Gómez-Río M, Rodríguez-Fernández A, Pérez-García M, Verdejo-García A (2012), “Neural correlates of the severity of cocaine, heroin, alcohol, MDMA and cannabis use in polysubstance abusers: a resting-PET brain metabolism study.” PLoS One 7(6):e39830 Details Shafto M, Randall B, Stamatakis EA, Wright P, Tyler LK (2012), “Age-related neural reorganization during spoken word recognition: the interaction of form and meaning.” J Cogn Neurosci 24(6):1434-46 Details Wright P, Stamatakis EA, Tyler LK (2012), “Differentiating hemispheric contributions to syntax and semantics in patients with left-hemisphere lesions.” J Neurosci 32(24):8149-57 Details 2011Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details Papoutsi M, Stamatakis EA, Griffiths J, Marslen-Wilson WD, Tyler LK (2011), “Is left fronto-temporal connectivity essential for syntax? Effective connectivity, tractography and performance in left-hemisphere damaged patients.” Neuroimage 58(2):656-64 Details Rolheiser T, Stamatakis EA, Tyler LK (2011), “Dynamic processing in the human language system: synergy between the arcuate fascicle and extreme capsule.” J Neurosci 31(47):16949-57 Details Stamatakis EA, Shafto MA, Williams G, Tam P, Tyler LK (2011), “White matter changes and word finding failures with increasing age.” PLoS One 6(1):e14496 Details Zhuang J, Randall B, Stamatakis EA, Marslen-Wilson WD, Tyler LK (2011), “The Interaction of Lexical Semantics and Cohort Competition in Spoken Word Recognition: An fMRI Study.” J Cogn Neurosci Details 2010Green S, Ralph MA, Moll J, Stamatakis EA, Grafman J, Zahn R (2010), “Selective functional integration between anterior temporal and distinct fronto-mesolimbic regions during guilt and indignation.” Neuroimage 52(4):1720-6 Details Shafto MA, Stamatakis EA, Tam PP, Tyler LK (2010), “Word retrieval failures in old age: the relationship between structure and function.” J Cogn Neurosci 22(7):1530-40 Details 2009Acres K, Taylor KI, Moss HE, Stamatakis EA, Tyler LK (2009), “Complementary hemispheric asymmetries in object naming and recognition: a voxel-based correlational study.” Neuropsychologia 47(8-9):1836-43 Details Raposo A, Moss HE, Stamatakis EA, Tyler LK (2009), “Modulation of motor and premotor cortices by actions, action words and action sentences.” Neuropsychologia 47(2):388-96 Details Taylor KI, Stamatakis EA, Tyler LK (2009), “Crossmodal integration of object features: voxel-based correlations in brain-damaged patients.” Brain 132(Pt 3):671-83 Details 2008Bright P, Moss HE, Stamatakis EA, Tyler LK (2008), “Longitudinal studies of semantic dementia: the relationship between structural and functional changes over time.” Neuropsychologia 46(8):2177-88 Details Tyler LK, Randall B, Stamatakis EA (2008), “Cortical differentiation for nouns and verbs depends on grammatical markers.” J Cogn Neurosci 20(8):1381-9 Details 2007Bozic M, Marslen-Wilson WD, Stamatakis EA, Davis MH, Tyler LK (2007), “Differentiating morphology, form, and meaning: neural correlates of morphological complexity.” J Cogn Neurosci 19(9):1464-75 Details Bright P, Moss HE, Longe O, Stamatakis EA, Tyler LK (2007), “Conceptual structure modulates anteromedial temporal involvement in processing verbally presented object properties.” Cereb Cortex 17(5):1066-73 Details Longe O, Randall B, Stamatakis EA, Tyler LK (2007), “Grammatical categories in the brain: the role of morphological structure.” Cereb Cortex 17(8):1812-20 Details Noppeney U, Patterson K, Tyler LK, Moss H, Stamatakis EA, Bright P, Mummery C, Price CJ (2007), “Temporal lobe lesions and semantic impairment: a comparison of herpes simplex virus encephalitis and semantic dementia.” Brain 130(Pt 4):1138-47 Details Shafto MA, Burke DM, Stamatakis EA, Tam PP, Tyler LK (2007), “On the tip-of-the-tongue: neural correlates of increased word-finding failures in normal aging.” J Cogn Neurosci 19(12):2060-70 Details 2006Raposo A, Moss HE, Stamatakis EA, Tyler LK (2006), “Repetition suppression and semantic enhancement: an investigation of the neural correlates of priming.” Neuropsychologia 44(12):2284-95 Details Taylor KI, Moss HE, Stamatakis EA, Tyler LK (2006), “Binding crossmodal object features in perirhinal cortex.” Proc Natl Acad Sci U S A 103(21):8239-44 Details 2005Bright P, Moss HE, Stamatakis EA, Tyler LK (2005), “The anatomy of object processing: the role of anteromedial temporal cortex.” Q J Exp Psychol B 58(3-4):361-77 Details Moss HE, Rodd JM, Stamatakis EA, Bright P, Tyler LK (2005), “Anteromedial temporal cortex supports fine-grained differentiation among objects.” Cereb Cortex 15(5):616-27 Details Stamatakis EA, Tyler LK (2005), “Identifying lesions on structural brain images--validation of the method and application to neuropsychological patients.” Brain Lang 94(2):167-77 Details Tyler LK, Marslen-Wilson W, Stamatakis EA (2005), “Dissociating neuro-cognitive component processes: voxel-based correlational methodology.” Neuropsychologia 43(5):771-8 Details Tyler LK, Stamatakis EA, Post B, Randall B, Marslen-Wilson W (2005), “Temporal and frontal systems in speech comprehension: an fMRI study of past tense processing.” Neuropsychologia 43(13):1963-74 Details 2004Tyler LK, Bright P, Fletcher P, Stamatakis EA (2004), “Neural processing of nouns and verbs: the role of inflectional morphology.” Neuropsychologia 42(4):512-23 Details Tyler LK, Stamatakis EA, Bright P, Acres K, Abdallah S, Rodd JM, Moss HE (2004), “Processing objects at different levels of specificity.” J Cogn Neurosci 16(3):351-62 Details Tyler LK, Stamatakis EA, Jones RW, Bright P, Acres K, Marslen-Wilson WD (2004), “Deficits for semantics and the irregular past tense: a causal relationship?” J Cogn Neurosci 16(7):1159-72 Details 2003Stamatakis EA, Hetherington MM (2003), “Neuroimaging in eating disorders.” Nutr Neurosci 6(6):325-34 Details Tyler LK, Stamatakis EA, Dick E, Bright P, Fletcher P, Moss H (2003), “Objects and their actions: evidence for a neurally distributed semantic system.” Neuroimage 18(2):542-57 Details 2002Stamatakis EA, Wilson JT, Hadley DM, Wyper DJ (2002), “SPECT imaging in head injury interpreted with statistical parametric mapping.” J Nucl Med 43(4):476-83 Details 2001Stamatakis EA, Wilson JT, Wyper DJ (2001), “Spatial normalization of lesioned HMPAO-SPECT images.” Neuroimage 14(4):844-52 Details 2000Stamatakis EA, Wilson JT, Wyper DJ (2000), “Analysis of HMPAO SPECT scans in head injury using Statistical Parametric Mapping.” Behav Neurol 12(1-2):29-37 Details 1999Stamatakis EA, Glabus MF, Wyper DJ, Barnes A, Wilson JT (1999), “Validation of statistical parametric mapping (SPM) in assessing cerebral lesions: A simulation study.” Neuroimage 10(4):397-407 Details 15TF Varley, M Craig, R Adapa, P Finoia, G Williams, J Alanson, J Pickard, DK Menon, EA. Stamatakis, (15), “Fractal Dimension of Cortical Functional Connectivity Networks & Severity of Disorders of Consciousness,” PLoS One 2020 |