Dr Daniel Sobrido-Cameán University positionResearch Associate DepartmentsHome pagehttps://www.zoo.cam.ac.uk/directo... Research ThemesInterestsDuring my PhD, I have been carrying out studies using lampreys as an animal model for spinal cord injury. Lampreys are a good model of regeneration/plasticity. But, also has some limitations. For example, their life cycle takes between 5 and 7 years from birth to sexual maturity. Therefore, it is highly impractical to generate stable mutant or transgenic lines in the laboratory. In contrast to lampreys, the fruit-fly, Drosophila, is genetically tractable and there are tools and innovations in genetic, imaging, and electrophysiological technologies that have enabled the visualization, in vivo, of dynamic processes such as dendritic growth and synapse development. For this reason, I joined to the group of Dr Matthias Landgraf, who has extensive experience in the use of drosophila as a model for the study of the development of the nervous system. In the long run, I want to harness the genetics of Drosophila to identify candidate pathways and genes involved in nervous system development. Research Focus
EquipmentBehavioural analysis Calcium imaging Confocal microscopy Fluorescence microscopy Immunohistochemistry Microscopy CollaboratorsNo collaborators listed Associated News ItemsKey publicationsSobrido-Cameán D, Oswald MCW, Bailey DMD, Mukherjee A, Landgraf M. (2023), “Activity-regulated growth of motoneurons at the neuromuscular junction is mediated by NADPH oxidases” Frontiers in Cellular Neuroscience 16: 1106593 Publications2022González-Llera L, Sobrido-Cameán D, Santos-Durán GN, Barreiro-Iglesias A (2022), “Full regeneration of descending CRH axons after a complete spinal cord injury in lampreys.” Computational and Structural Biotechnology Journal Sobrido-Cameán D, Barreiro-Iglesias A (2022), “Neural Morpholino studies shed light on the signalling pathways regulating axon regeneration in lampreys” Neural regeneration research 17(7): 1475–1477 Sobrido-Cameán D, González-Llera L, Anadón R, Barreiro-Iglesias A (2022), “Organization of the corticotropin-releasing hormone and corticotropin-releasing hormone-binding protein systems in the central nervous system of the sea lamprey Petromyzon marinus” Journal of Comparative Neurology 2021Quelle-Regaldie A, Sobrido-Cameán D, Barreiro-Iglesias A, Sobrido MJ, Sánchez L (2021), “Zebrafish models of Autosomal Dominant Ataxias” Cells 10, 421 Quelle-Regaldie A, Sobrido-Cameán D, Barreiro-Iglesias A, Sobrido MJ, Sánchez L (2021), “Zebrafish models of Autosomal Recessive and X-linked Hereditary Ataxias” Cells 10, 836 Sobrido-Cameán D, Anadón R, Barreiro-Iglesias A (2021), “Expression of urocortin 3 mRNA in the central nervous system of the sea lamprey Petromyzon marinus” Biology 10: 978. Sobrido-Cameán D, Yáñez-Guerra L, Deber A, Freire-Delgado M, Cacheiro-Vázquez R, Rodicio MC, Tostivint H, Anadón R, Barreiro-Iglesias A (2021), “Differential expression of three somatostatin genes in the central nervous system of the sea lamprey” Brain Structure and Function Sobrido-Cameán D, Yañez-Guerra LA, Deber A, Rodicio MC, Barreiro-Iglesias (2021), “Expression of kisspeptin 1 in the brain of the adult sea lamprey Petromyzon marinus” Life 11: 1174 2020Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M (2020), “Developmentally-programmed cellular senescence is conserved and widespread in zebrafish” Aging Sobrido-Cameán D, Robledo D, Romaus-Sanjurjo D, Perez-Cedrón C, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2020), “Inhibition of gamma-secretase promotes axon regeneration after a complete spinal cord injury.” Frontiers in Cell and Developmental Biology Sobrido-Cameán D, Tostivint H, Mazan S, Rodicio MC, Rodríguez-Moldes I, Candal E, Anadón R, Barreiro-Iglesias A (2020), “In situ hybridization study of the differential expression of five prosomatostatin genes in the central nervous system of the catshark Scyliorhinus canicula” Journal of Comparative Neurology 2019Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M (2019), “Cell senescence contributes to tissue regeneration in Zebrafish” Aging Cell Sobrido-Cameán D, Yáñez-Guerra LA, Robledo D, López-Varela E, Rodicio MC, Elphick MR, Anadón R, Barreiro-Iglesias A (2019), “Cholecystokinin in the central nervous system of the sea lamprey Petromyzon marinus: precursor identification and neuroanatomical relationships with other neuronal signalling systems” Brain Structure and Function Sobrido-Cameán D, Fernández-López B, Pereiro N, Lafuente A, Rodicio MC, Barreiro-Iglesias A (2019), “Taurine promotes axonal regeneration after a complete spinal cord injury in lampreys” Journal of Neurotrauma Sobrido-Cameán D, Robledo D, Sánchez L, Rodicio MC, Barreiro-Iglesias A (2019), “Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys” Disease Models and Mechanisms Sobrido-Cameán D, Yáñez-Guerra LA, Lamanna F, Conde-Fernández C, Kaessmann H, Elphick MR, Anadón R, Rodicio MC, Barreiro-Iglesias A (2019), “Galanin in an agnathan: precursor identification and localisation of expression in the brain of the sea lamprey Petromyzon marinus” Frontiers in Neuroanatomy 2018Sobrido-Cameán D, Barreiro-Iglesias A (2018), “Role of caspase-8 and Fas in cell death after spinal cord injury” Frontiers in Molecular Neuroscience Sobrido-Cameán D, Rodicio MC, Barreiro-Iglesias A (2018), “The role of serotonin in nervous system regeneration: lessons from regenerating animal models” Neural Regeneration Research Sobrido-Cameán D, Rodicio MC, Barreiro-Iglesias A (2018), “Data on the effect of a muscimol treatment in caspase activation in descending neurons of lampreys after a complete spinal cord injury” Data in Brief 2017Barreiro-Iglesias A, Fernández-López B, Sobrido-Cameán D, Anadón R (2017), “ Organization of AlphaTransducin Immunoreactive System in the Brain and Retina of Larval and Young Adult Sea Lamprey (Petromyzon marinus), and their Relationship with Other Neural Systems” Journal of Comparative Neurology Barreiro-Iglesias A, Sobrido-Cameán D, Shifman MI (2017), “Retrograde activation of the extrinsic apoptotic pathway in spinal-projecting neurons after a complete spinal cord injury in lampreys” BioMed Research International Fernández-López B, Sobrido-Cameán D, Anadón R, Rodicio MC, Barreiro-Iglesias A (2017), “Restricted co-localization of glutamate and dopamine in neurons of the adult sea lamprey brain” Journal of Anatomy Romaus-Sanjurjo, D, Fernández-López, B, Sobrido-Cameán, D, Barreiro-Iglesias, A, Rodicio, MC (2017), “Cloning of the gabaB Receptor Subunits B1 and B2 and their Expression in the Central Nervous System of the Adult Sea Lamprey” Frontiers in Neuroanatomy |