Dr Paul Miller

Interests

I use electrophysiology and structural biology to understand GABA-A receptors and ligands that target them. I am also using these approaches to develop novel small molecule and antibody tools against GABA-A receptor signalling and to study these tools in physiological systems. This work encompasses developing stabilized forms of GABA-A receptors for use in pharmacological assays.

Research Focus

Equipment

Cell culture

CryoEM

Electrophysiological recording techniques

Fluorescence microscopy

FPLC/HPLC

Protein purification

Recombinant protein expression

Whole cell patch clamp

X-ray crystallography