Dr Danuta Lisiecka University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences InstitutesBehavioural and Clinical Neuroscience Institute and Brain Mapping Unit Research ThemesInterestsI am interested in how MRI techniques can help us understand susceptibility to psychiatric disorders and mechanisms of action of psychiatric treatments. My current research focuses on: A) neural mechanism of action of Minocycline on negative symptoms of psychosis in BeneMin study (www.benemin.org.uk). BeneMin is a multicentre CTIMP with 6 MRI sites and 15 NHS Trusts and Health Boards involved. I am an MRI coordinator of the study. B) white matter microstructure of Autism endophenotype in Structural and functional MRI of autism and broader phenotype study (http://www.autismresearchcentre.com/project_29_sandfmri). C) association between magnetic transfer and diffusion tensor measurements in white matter in NSPN study (http://www.nspn.org.uk/). D) pH of the brain in the Acid Test study. My interests also involve the role of emotional regulation in the susceptibility and resilience to major depressive disorder.  Increased activation during inhibition of negative stimuli in first degree relatives of patients with major depressive disorder Click image to view full-size Research Focus
EquipmentMagnetic resonance imaging (MRI) Neuropsychological testing Collaborators
Associated News ItemsKey publicationsLisiecka-Ford DM, Tozer DJ, Morris RG, Lawrence AJ, Barrick TR, Markus HS (in press), “Involvement of the reward network is associated with apathy in cerebral small vessel disease” Journal of Affective Disorders Lisiecka DM, Holt R, Tait R, Ford M, Lai MC, Chura LR, Baron-Cohen S, Spencer MD, Suckling J (2015), “Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence.” Transl Psychiatry 5:e529 Details Lisiecka DM, O'Hanlon E, Fagan AJ, Carballedo A, Morris D, Suckling J, Frodl T (2015), “BDNF Val66Met polymorphism in patterns of neural activation in individuals with MDD and healthy controls” J Affect Disorders 184: 239-244 Lisiecka DM, Suckling J, Barnes TR, Chaudhry IB, Dazzan P, Husain N, Jones PB, Joyce EM, Lawrie SM, Upthegrove R, Deakin B (2015), “The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care - extent and mechanism (BeneMin): study protocol for a randomised controlled trial.” Trials 16(1):580 Lisiecka DM, Carballedo A, Fagan AJ, Ferguson Y, Meaney J, Frodl T (2013), “Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression.” J Psychiatry Neurosci 38(2):117-28 Details Lisiecka DM, Carballedo A, Fagan AJ, Connolly G, Meaney J, Frodl T (2012), “Altered inhibition of negative emotions in subjects at family risk of major depressive disorder.” J Psychiatr Res 46(2):181-8 Details Lisiecka D, Meisenzahl E, Scheuerecker J, Schoepf V, Whitty P, Chaney A, Moeller HJ, Wiesmann M, Frodl T (2011), “Neural correlates of treatment outcome in major depression.” Int J Neuropsychopharmacol 14(4):521-34 Details Publications2012Amico F, Carballedo A, Lisiecka D, Fagan AJ, Boyle G, Frodl T (2012), “Functional anomalies in healthy individuals with a first degree family history of major depressive disorder.” Biol Mood Anxiety Disord 2(1):1 Details Bermingham R, Carballedo A, Lisiecka D, Fagan A, Morris D, Fahey C, Donohoe G, Meaney J, Gill M, Frodl T (2012), “Effect of genetic variant in BICC1 on functional and structural brain changes in depression.” Neuropsychopharmacology 37(13):2855-62 Details Carballedo A, Lisiecka D, Fagan A, Saleh K, Ferguson Y, Connolly G, Meaney J, Frodl T (2012), “Early life adversity is associated with brain changes in subjects at family risk for depression.” World J Biol Psychiatry 13(8):569-78 Details Chan JS, Maguinness C, Lisiecka D, Setti A, Newell FN (2012), “Evidence for crossmodal interactions across depth on target localisation performance in a spatial array.” Perception 41(7):757-73 Details Frodl T, Carballedo A, Fagan AJ, Lisiecka D, Ferguson Y, Meaney JF (2012), “Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression.” J Psychiatry Neurosci 37(1):37-45 Details Saleh K, Carballedo A, Lisiecka D, Fagan AJ, Connolly G, Boyle G, Frodl T (2012), “Impact of family history and depression on amygdala volume.” Psychiatry Res 203(1):24-30 Details 2010Frodl T, Bokde AL, Scheuerecker J, Lisiecka D, Schoepf V, Hampel H, Möller HJ, Brückmann H, Wiesmann M, Meisenzahl E (2010), “Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression.” Biol Psychiatry 67(2):161-7 Details |