Professor David Menon University positionHead of Division of Anaesthesia DepartmentsInstitutesHome pagehttp://www.medschl.cam.ac.uk/anaesth... Research ThemesInterestsThe research program of the University Division of Anaesthesia has aimed to understand regional cerebral pathophysiology to advance the care of critically ill patients after brain injury, from initial ictus, through recovery from coma and rehabilitation, to final outcome. These aims have been realized through a series of MRC Program and Cooperative Group Grants, based in the Wolfson Brain Imaging Centre, which have formed a focus for productive collaboration with other departments in the Clinical School, and the broader neuroscience community in Cambridge. Substantial academic leadership for this research program has come from the Division of Anaesthesia, but key collaborations have included NHS colleagues in the Neurocritical Care Unit, the University Departments of Neurosurgery, Psychiatry and Experimental Psychology, and the MRC Cognition and Brain Sciences Unit.  Click image to view full-size Research Focus
EquipmentBehavioural analysis Computational modelling Computerised tomography Electroencephalography (EEG) Electrophysiological recording techniques Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Collaborators
Associated News Items
Key publicationsColes JP, Cunningham AS, Salvador R, Chatfield DA, Carpenter A, Pickard JD, Menon DK (2009), “Early metabolic characteristics of lesion and nonlesion tissue after head injury.” J Cereb Blood Flow Metab 29(5):965-75 Details Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJ, Gupta AK, Menon DK (2008), “Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.” Crit Care Med 36(1):273-81 Details Davis MH, Coleman MR, Absalom AR, Rodd JM, Johnsrude IS, Matta BF, Owen AM, Menon DK (2007), “Dissociating speech perception and comprehension at reduced levels of awareness.” Proc Natl Acad Sci U S A 104(41):16032-7 Details Publications2014Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT (2014), “Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.” J Cereb Blood Flow Metab 34(5):753-8 Details Budohoski KP, Guilfoyle M, Helmy A, Huuskonen T, Czosnyka M, Kirollos R, Menon DK, Pickard JD, Kirkpatrick PJ (2014), “The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage.” J Neurol Neurosurg Psychiatry Details Carpenter KL, Jalloh I, Gallagher CN, Grice P, Howe DJ, Mason A, Timofeev I, Helmy A, Murphy MP, Menon DK, Kirkpatrick PJ, Carpenter TA, Sutherland GR, Pickard JD, Hutchinson PJ (2014), “(13)C-labelled microdialysis studies of cerebral metabolism in TBI patients.” Eur J Pharm Sci 57:87-97 Details Dyson EW, Kolias AG, Burnstein RM, Hutchinson PJ, Garnett MR, Menon DK, Trivedi RA (2014), “Neuro-critical care: A valuable placement during foundation and early neurosurgical training.” Br J Neurosurg Details Goon SS, Stamatakis EA, Adapa RM, Kasahara M, Bishop S, Wood DF, Wheeler DW, Menon DK, Gupta AK (2014), “Clinical decision-making augmented by simulation training: neural correlates demonstrated by functional imaging: a pilot study.” Br J Anaesth 112(1):124-32 Details Helmy A, Guilfoyle MR, Carpenter KL, Pickard JD, Menon DK, Hutchinson PJ (2014), “Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a phase II randomized control trial.” J Cereb Blood Flow Metab 34(5):845-51 Details Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2014), “Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.” JAMA Neurol 71(1):23-31 Details Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon DK, Carpenter KL, Hutchinson PJ (2014), “Response to Letter Lactate Uptake Against a Concentration Gradient: Misinterpretation of Analytical Imprecision.” J Neurotrauma Details Kolias AG, Hutchinson PJ, Menon DK, Manley GT, Gallagher CN, Servadei F (2014), “Decompressive craniectomy for acute subdural hematomas.” J Neurosurg 120(5):1247-9; author reply 1249 Details Kompanje EJ, Maas AI, Menon DK, Kesecioglu J (2014), “Medical research in emergency research in the European Union member states: tensions between theory and practice.” Intensive Care Med 40(4):496-503 Details Lazaridis C, DeSantis SM, Smielewski P, Menon DK, Hutchinson P, Pickard JD, Czosnyka M (2014), “Patient-specific thresholds of intracranial pressure in severe traumatic brain injury.” J Neurosurg 120(4):893-900 Details Li LM, Menon DK, Janowitz T (2014), “Cross-sectional analysis of data from the U.S. clinical trials database reveals poor translational clinical trial effort for traumatic brain injury, compared with stroke.” PLoS One 9(1):e84336 Details Risdall JE, Carter AJ, Kirkman E, Watts SA, Taylor C, Menon DK (2014), “Endothelial Activation and Chemoattractant Expression are Early Processes in Isolated Blast Brain Injury.” Neuromolecular Med Details Sekhon MS, Griesdale DE, Robba C, McGlashan N, Needham E, Walland K, Shook AC, Smielewski P, Czosnyka M, Gupta AK, Menon DK (2014), “Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury.” Intensive Care Med Details Sharshar T, Citerio G, Andrews PJ, Chieregato A, Latronico N, Menon DK, Puybasset L, Sandroni C, Stevens RD (2014), “Neurological examination of critically ill patients: a pragmatic approach. Report of an ESICM expert panel.” Intensive Care Med 40(4):484-95 Details Veenith TV, Carter EL, Grossac J, Newcombe VF, Outtrim JG, Nallapareddy S, Lupson V, Correia MM, Mada MM, Williams GB, Menon DK, Coles JP (2014), “Use of diffusion tensor imaging to assess the impact of normobaric hyperoxia within at-risk pericontusional tissue after traumatic brain injury.” J Cereb Blood Flow Metab Details Yuh EL, Cooper SR, Mukherjee P, Yue JK, Lingsma HF, Gordon WA, Valadka AB, Okonkwo DO, Schnyer DM, Vassar MJ, Maas AI, Manley GT, Casey SS, Cheong M, Dams-O'Connor K, Hricik AJ, Inoue T, Menon DK, Morabito DJ, Pacheco JL, Puccio AM, Sinha TK (2014), “Diffusion Tensor Imaging for Outcome Prediction in Mild Traumatic Brain Injury: A TRACK-TBI Study.” J Neurotrauma Details 2013Adapa RM, Davis MH, Stamatakis EA, Absalom AR, Menon DK (2013), “Neural correlates of successful semantic processing during propofol sedation.” Hum Brain Mapp Details Clark DJ, Kolias AG, Corteen EA, Ingham SC, Piercy J, Crick SJ, Menon DK, Hutchinson PJ, RESCUE-ASDH Collaborative Group (2013), “Community consultation in emergency neurotrauma research: results from a pre-protocol survey.” Acta Neurochir (Wien) 155(7):1329-34; discussion 1334 Details Duclos C, Dumont M, Blais H, Paquet J, Laflamme E, de Beaumont L, Wiseman-Hakes C, Menon DK, Bernard F, Gosselin N (2013), “Rest-Activity Cycle Disturbances in the Acute Phase of Moderate to Severe Traumatic Brain Injury.” Neurorehabil Neural Repair 28(5):472-482 Details Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon DK, Carpenter KL, Hutchinson PJ (2013), “Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.” J Neurotrauma 30(24):2031-7 Details Klinck JR, McNeill L, Menon DK (2013), “Dysnatremia and mortality: do sweat the small stuff...” Crit Care 17(2):128 Details Li L, Brichard L, Larsen L, Menon DK, Smith RA, Murphy MP, Aigbirhio FI (2013), “Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.” J Labelled Comp Radiopharm 56(14):717-21 Details McNeill L, English SW, Borg N, Matta BF, Menon DK (2013), “Effects of institutional caseload of subarachnoid hemorrhage on mortality: a secondary analysis of administrative data.” Stroke 44(3):647-52 Details Newcombe VF, Williams GB, Outtrim JG, Chatfield D, Gulia Abate M, Geeraerts T, Manktelow A, Room H, Mariappen L, Hutchinson PJ, Coles JP, Menon DK (2013), “Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.” J Cereb Blood Flow Metab 33(6):855-62 Details Stubbs DJ, Yamamoto AK, Menon DK (2013), “Imaging in sepsis-associated encephalopathy--insights and opportunities.” Nat Rev Neurol 9(10):551-61 Details Veenith TV, Carter E, Grossac J, Newcombe VF, Outtrim JG, Lupson V, Williams GB, Menon DK, Coles JP (2013), “Inter subject variability and reproducibility of diffusion tensor imaging within and between different imaging sessions.” PLoS One 8(6):e65941 Details 2012Aries MJ, Czosnyka M, Budohoski KP, Steiner LA, Lavinio A, Kolias AG, Hutchinson PJ, Brady KM, Menon DK, Pickard JD, Smielewski P (2012), “Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury.” Crit Care Med 40(8):2456-63 Details Bishop SM, Yarham SI, Navapurkar VU, Menon DK, Ercole A (2012), “Multifractal analysis of hemodynamic behavior: intraoperative instability and its pharmacological manipulation.” Anesthesiology 117(4):810-21 Details Budohoski KP, Czosnyka M, de Riva N, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Lavinio A (2012), “The relationship between cerebral blood flow autoregulation and cerebrovascular pressure reactivity after traumatic brain injury.” Neurosurgery 71(3):652-60; discussion 660-1 Details Budohoski KP, Zweifel C, Kasprowicz M, Sorrentino E, Diedler J, Brady KM, Smielewski P, Menon DK, Pickard JD, Kirkpatrick PJ, Czosnyka M (2012), “What comes first? The dynamics of cerebral oxygenation and blood flow in response to changes in arterial pressure and intracranial pressure after head injury.” Br J Anaesth 108(1):89-99 Details Helmy A, Kirkpatrick PJ, Seeley HM, Corteen E, Menon DK, Hutchinson PJ (2012), “Fixed, dilated pupils following traumatic brain injury: historical perspectives, causes and ophthalmological sequelae.” Acta Neurochir Suppl 114:295-9 Details Hughes JL, Jones PS, Beech JS, Wang D, Menon DK, Aigbirhio FI, Fryer TD, Baron JC (2012), “A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.” Neuroimage 59(3):2007-16 Details Li LM, Kolias AG, Guilfoyle MR, Timofeev I, Corteen EA, Pickard JD, Menon DK, Kirkpatrick PJ, Hutchinson PJ (2012), “Outcome following evacuation of acute subdural haematomas: a comparison of craniotomy with decompressive craniectomy.” Acta Neurochir (Wien) 154(9):1555-61 Details 2011Carrera E, Steiner LA, Castellani G, Smielewski P, Zweifel C, Haubrich C, Pickard JD, Menon DK, Czosnyka M (2011), “Changes in cerebral compartmental compliances during mild hypocapnia in patients with traumatic brain injury.” J Neurotrauma 28(6):889-96 Details Chatfield DA, Brahmbhatt DH, Sharp T, Perkes IE, Outrim JG, Menon DK (2011), “Juguloarterial endothelin-1 gradients after severe traumatic brain injury.” Neurocrit Care 14(1):55-60 Details Geeraerts T, Coles JP, Aigbirhio FI, Pickard JD, Menon DK, Fryer TD, Hong YT (2011), “Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.” Ann Nucl Med 25(6):396-405 Details Helmy A, Carpenter KL, Menon DK, Pickard JD, Hutchinson PJ (2011), “The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production.” J Cereb Blood Flow Metab 31(2):658-70 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2011), “Traumatic brain injury alters the functional brain network mediating working memory.” Brain Inj 25(12):1170-87 Details Landt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar ?-amyloid in adults with down syndrome: safety, acceptability, and feasibility.” Arch Neurol 68(7):890-6 Details Lavinio A, Menon DK (2011), “Intracranial pressure: why we monitor it, how to monitor it, what to do with the number and what's the future?” Curr Opin Anaesthesiol 24(2):117-23 Details Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK (2011), “Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury.” Brain 134(Pt 3):759-68 Details Timofeev I, Carpenter KL, Nortje J, Al-Rawi PG, O'Connell MT, Czosnyka M, Smielewski P, Pickard JD, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2011), “Cerebral extracellular chemistry and outcome following traumatic brain injury: a microdialysis study of 223 patients.” Brain 134(Pt 2):484-94 Details Timofeev I, Czosnyka M, Carpenter KL, Nortje J, Kirkpatrick PJ, Al-Rawi PG, Menon DK, Pickard JD, Gupta AK, Hutchinson PJ (2011), “Interaction between brain chemistry and physiology after traumatic brain injury: impact of autoregulation and microdialysis catheter location.” J Neurotrauma 28(6):849-60 Details Wheeler DW, Thompson AJ, Corletto F, Reckless J, Loke JC, Lapaque N, Grant AJ, Mastroeni P, Grainger DJ, Padgett CL, O'Brien JA, Miller NG, Trowsdale J, Lummis SC, Menon DK, Beech JS (2011), “Anaesthetic impairment of immune function is mediated via GABA(A) receptors.” PLoS One 6(2):e17152 Details 2010Dickson JD, Ash TW, Williams GB, Harding SG, Carpenter TA, Menon DK, Ansorge RE (2010), “Quantitative BOLD: the effect of diffusion.” J Magn Reson Imaging 32(4):953-61 Details Guilfoyle MR, Seeley HM, Corteen E, Harkin C, Richards H, Menon DK, Hutchinson PJ (2010), “Assessing quality of life after traumatic brain injury: examination of the short form 36 health survey.” J Neurotrauma 27(12):2173-81 Details Helmy A, Timofeev I, Palmer CR, Gore A, Menon DK, Hutchinson PJ (2010), “Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury.” Acta Neurochir (Wien) 152(6):953-7 Details Hughes JL, Beech JS, Jones PS, Wang D, Menon DK, Baron JC (2010), “Mapping selective neuronal loss and microglial activation in the salvaged neocortical penumbra in the rat.” Neuroimage 49(1):19-31 Details Janowitz T, Menon DK (2010), “Exploring new routes for neuroprotective drug development in traumatic brain injury.” Sci Transl Med 2(27):27rv1 Details Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76 Details Menon DK, Schwab K, Wright DW, Maas AI, Demographics and Clinical Assessment Working Group of the International and Interagency Initiative toward Common Data Elements for Research on Traumatic Brain Injury and Psychological Health (2010), “Position statement: definition of traumatic brain injury.” Arch Phys Med Rehabil 91(11):1637-40 Details Newcombe VF, Williams GB, Scoffings D, Cross J, Carpenter TA, Pickard JD, Menon DK (2010), “Aetiological differences in neuroanatomy of the vegetative state: insights from diffusion tensor imaging and functional implications.” J Neurol Neurosurg Psychiatry 81(5):552-61 Details Stamatakis EA, Adapa RM, Absalom AR, Menon DK (2010), “Changes in resting neural connectivity during propofol sedation.” PLoS One 5(12):e14224 Details Zweifel C, Castellani G, Czosnyka M, Helmy A, Manktelow A, Carrera E, Brady KM, Hutchinson PJ, Menon DK, Pickard JD, Smielewski P (2010), “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.” J Neurotrauma 27(11):1951-8 Details 2009Absalom AR, Menon DK (2009), “BIS and spectral entropy monitoring during sedation with midazolam/remifentanil and dexmedetomidine/remifentanil.” Crit Care 13(2):137 Details Ercole A, Menon DK, O'Donnell DR (2009), “Modelling the impact of pandemic influenza A(H1N1) on UK paediatric intensive care demand.” Arch Dis Child 94(12):962-4 Details Ercole A, Taylor BL, Rhodes A, Menon DK (2009), “Modelling the impact of an influenza A/H1N1 pandemic on critical care demand from early pathogenicity data: the case for sentinel reporting.” Anaesthesia 64(9):937-41 Details Gallagher CN, Carpenter KL, Grice P, Howe DJ, Mason A, Timofeev I, Menon DK, Kirkpatrick PJ, Pickard JD, Sutherland GR, Hutchinson PJ (2009), “The human brain utilizes lactate via the tricarboxylic acid cycle: a 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study.” Brain 132(Pt 10):2839-49 Details Hutchinson PJ, O'Connell MT, Seal A, Nortje J, Timofeev I, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Carpenter KL (2009), “A combined microdialysis and FDG-PET study of glucose metabolism in head injury.” Acta Neurochir (Wien) 151(1):51-61; discussion 61 Details Menon DK (2009), “Unique challenges in clinical trials in traumatic brain injury.” Crit Care Med 37(1 Suppl):S129-35 Details Menon DK, Zahed C (2009), “Prediction of outcome in severe traumatic brain injury.” Curr Opin Crit Care 15(5):437-41 Details Wijesurendra RS, Bernard F, Outtrim J, Maiya B, Joshi S, Hutchinson PJ, Halsall DJ, Menon DK (2009), “Low-dose and high-dose synacthen tests and the hemodynamic response to hydrocortisone in acute traumatic brain injury.” Neurocrit Care 11(2):158-64 Details Zygun DA, Nortje J, Hutchinson PJ, Timofeev I, Menon DK, Gupta AK (2009), “The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.” Crit Care Med 37(3):1074-8 Details 2008Abate MG, Trivedi M, Fryer TD, Smielewski P, Chatfield DA, Williams GB, Aigbirhio F, Carpenter TA, Pickard JD, Menon DK, Coles JP (2008), “Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.” Neurocrit Care 9(3):319-25 Details Bernard F, Al-Tamimi YZ, Chatfield D, Lynch AG, Matta BF, Menon DK (2008), “Serum albumin level as a predictor of outcome in traumatic brain injury: potential for treatment.” J Trauma 64(4):872-5 Details Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD, Hutchinson PJ (2008), “Nitric oxide in acute brain injury: a pilot study of NO(x) concentrations in human brain microdialysates and their relationship with energy metabolism.” Acta Neurochir Suppl 102:207-13 Details Geeraerts T, Newcombe VF, Coles JP, Abate MG, Perkes IE, Hutchinson PJ, Outtrim JG, Chatfield DA, Menon DK (2008), “Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure.” Crit Care 12(5):R114 Details Honey GD, Corlett PR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Bullmore ET, Menon DK, Fletcher PC (2008), “Individual differences in psychotic effects of ketamine are predicted by brain function measured under placebo.” J Neurosci 28(25):6295-303 Details Lee MC, Zambreanu L, Menon DK, Tracey I (2008), “Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans.” J Neurosci 28(45):11642-9 Details Maiya B, Newcombe V, Nortje J, Bradley P, Bernard F, Chatfield D, Outtrim J, Hutchinson P, Matta B, Antoun N, Menon D (2008), “Magnetic resonance imaging changes in the pituitary gland following acute traumatic brain injury.” Intensive Care Med 34(3):468-75 Details Menon D, Harrison D (2008), “Prognostic modelling in traumatic brain injury.” BMJ 336(7641):397-8 Details Newcombe VF, Hawkes RC, Harding SG, Willcox R, Brock S, Hutchinson PJ, Menon DK, Carpenter TA, Coles JP (2008), “Potential heating caused by intraparenchymal intracranial pressure transducers in a 3-tesla magnetic resonance imaging system using a body radiofrequency resonator: assessment of the Codman MicroSensor Transducer.” J Neurosurg 109(1):159-64 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Chatfield DA, Outtrim JG, Harding SG, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2008), “Concordant biology underlies discordant imaging findings: diffusivity behaves differently in grey and white matter post acute neurotrauma.” Acta Neurochir Suppl 102:247-51 Details Nortje J, Coles JP, Menon DK (2008), “Normobaric hyperoxia-A further treatment option following traumatic brain injury?” Crit Care Med 36(5):1698 Polderman KH, Menon DK, Girbes AR (2008), “Treating intracranial hypertension in traumatic brain injury: keep it cool!” Intensive Care Med Details Reid CL, Murgatroyd PR, Wright A, Menon DK (2008), “Quantification of lean and fat tissue repletion following critical illness: a case report.” Crit Care 12(3):R79 Details Standley TD, Smith HL, Brennan LJ, Wilkins IA, Bradley PG, Barrera Groba C, Davey AJ, Menon DK, Wheeler DW (2008), “Room air dilution of heliox given by facemask.” Intensive Care Med Details Timofeev I, Dahyot-Fizelier C, Keong N, Nortje J, Al-Rawi PG, Czosnyka M, Menon DK, Kirkpatrick PJ, Gupta AK, Hutchinson PJ (2008), “Ventriculostomy for control of raised ICP in acute traumatic brain injury.” Acta Neurochir Suppl 102:99-104 Details Wheeler DW, Carter JJ, Murray LJ, Degnan BA, Dunling CP, Salvador R, Menon DK, Gupta AK (2008), “The effect of drug concentration expression on epinephrine dosing errors: a randomized trial.” Ann Intern Med 148(1):11-4 Details Wheeler DW, Degnan BA, Sehmi JS, Burnstein RM, Menon DK, Gupta AK (2008), “Variability in the concentrations of intravenous drug infusions prepared in a critical care unit.” Intensive Care Med Details 2007Absalom AR, Lee M, Menon DK, Sharar SR, De Smet T, Halliday J, Ogden M, Corlett P, Honey GD, Fletcher PC (2007), “Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers.” Br J Anaesth 98(5):615-23 Details Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA (2007), “Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo.” Exp Neurol 204(2):512-24 Details Beech JS, Wheeler DW, Reckless J, Grant AJ, Price J, Mastroeni P, Grainger DJ, Menon DK (2007), “The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro.” J Neuroimmunol 184(1-2):198-208 Details Coleman MR, Rodd JM, Davis MH, Johnsrude IS, Menon DK, Pickard JD, Owen AM (2007), “Do vegetative patients retain aspects of language comprehension? Evidence from fMRI.” Brain 130(Pt 10):2494-507 Details Coles JP, Fryer TD, Coleman MR, Smielewski P, Gupta AK, Minhas PS, Aigbirhio F, Chatfield DA, Williams GB, Boniface S, Carpenter TA, Clark JC, Pickard JD, Menon DK (2007), “Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.” Crit Care Med 35(2):568-78 Details Hutchinson PJ, O'Connell MT, Rothwell NJ, Hopkins SJ, Nortje J, Carpenter KL, Timofeev I, Al-Rawi PG, Menon DK, Pickard JD (2007), “Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra.” J Neurotrauma 24(10):1545-57 Details Jansen TC, Kompanje EJ, Druml C, Menon DK, Wiedermann CJ, Bakker J (2007), “Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not?” Intensive Care Med 33(5):894-900 Details Lavinio A, Timofeev I, Nortje J, Outtrim J, Smielewski P, Gupta A, Hutchinson PJ, Matta BF, Pickard JD, Menon D, Czosnyka M (2007), “Cerebrovascular reactivity during hypothermia and rewarming.” Br J Anaesth 99(2):237-44 Details Mannion RJ, Cross J, Bradley P, Coles JP, Chatfield D, Carpenter A, Pickard JD, Menon DK, Hutchinson PJ (2007), “Mechanism-based MRI classification of traumatic brainstem injury and its relationship to outcome.” J Neurotrauma 24(1):128-35 Details Newcombe VF, Williams GB, Nortje J, Bradley PG, Harding SG, Smielewski P, Coles JP, Maiya B, Gillard JH, Hutchinson PJ, Pickard JD, Carpenter TA, Menon DK (2007), “Analysis of acute traumatic axonal injury using diffusion tensor imaging.” Br J Neurosurg 21(4):340-8 Details Reid CL, Menon DK (2007), “Researching incapacity: Time to get our acts together.” BMJ 335(7617):415 Details Sharshar T, Carlier R, Bernard F, Guidoux C, Brouland JP, Nardi O, de la Grandmaison GL, Aboab J, Gray F, Menon D, Annane D (2007), “Brain lesions in septic shock: a magnetic resonance imaging study.” Intensive Care Med 33(5):798-806 Details Takasawa M, Beech JS, Fryer TD, Hong YT, Hughes JL, Igase K, Jones PS, Smith R, Aigbirhio FI, Menon DK, Clark JC, Baron JC (2007), “Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.” J Cereb Blood Flow Metab 27(4):679-89 Details 2006Bernard F, Menon DK, Matta BF (2006), “Corticosteroids after traumatic brain injury: new evidence to support their use.” Crit Care Med 34(2):583; author reply 584 Details Bernard F, Outtrim J, Lynch AG, Menon DK, Matta BF (2006), “Hemodynamic steroid responsiveness is predictive of neurological outcome after traumatic brain injury.” Neurocrit Care 5(3):176-9 Details Bernard F, Outtrim J, Menon DK, Matta BF (2006), “Incidence of adrenal insufficiency after severe traumatic brain injury varies according to definition used: clinical implications.” Br J Anaesth 96(1):72-6 Details Coles JP, Fryer TD, Bradley PG, Nortje J, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK (2006), “Intersubject variability and reproducibility of 15O PET studies.” J Cereb Blood Flow Metab 26(1):48-57 Details Cox AL, Coles AJ, Nortje J, Bradley PG, Chatfield DA, Thompson SJ, Menon DK (2006), “An investigation of auto-reactivity after head injury.” J Neuroimmunol 174(1-2):180-6 Details Hutchinson PJ, Corteen E, Czosnyka M, Mendelow AD, Menon DK, Mitchell P, Murray G, Pickard JD, Rickels E, Sahuquillo J, Servadei F, Teasdale GM, Timofeev I, Unterberg A, Kirkpatrick PJ (2006), “Decompressive craniectomy in traumatic brain injury: the randomized multicenter RESCUEicp study (www.RESCUEicp.com).” Acta Neurochir Suppl 96:17-20 Details Hutchinson PJ, Gimson A, Al-Rawi PG, O'Connell MT, Czosnyka M, Menon DK (2006), “Microdialysis in the management of hepatic encephalopathy.” Neurocrit Care 5(3):202-5 Details Hyam JA, Welch CA, Harrison DA, Menon DK (2006), “Case mix, outcomes and comparison of risk prediction models for admissions to adult, general and specialist critical care units for head injury: a secondary analysis of the ICNARC Case Mix Programme Database.” Crit Care 10 Suppl 2:S2 Details Lau K, Matta B, Menon DK, Absalom AR (2006), “Attitudes of anaesthetists to awareness and depth of anaesthesia monitoring in the UK.” Eur J Anaesthesiol 23(11):921-30 Details Lee MC, Absalom AR, Menon DK, Smith HL (2006), “Awake insertion of the laryngeal mask airway using topical lidocaine and intravenous remifentanil.” Anaesthesia 61(1):32-5 Details Liddell K, Bion J, Chamberlain D, Druml C, Kompanje E, Lemaire F, Menon D, Vrhovac B, Wiedermann CJ (2006), “Medical research involving incapacitated adults: implications of the EU Clinical Trials Directive 2001/20/EC.” Med Law Rev 14(3):367-417 Details Liddell K, Chamberlain D, Menon DK, Bion J, Kompanje EJ, Lemaire F, Druml C, Vrhovac B, Wiedermann CJ, Sterz F (2006), “The European Clinical Trials Directive revisited: the VISEAR recommendations.” Resuscitation 69(1):9-14 Details Liddell K, Kompanje EJ, Lemaire F, Vrhovac B, Menon DK, Bion J, Chamberlain D, Wiedermann CJ, Druml C, Working Group of the Vienna Initiative to Save European Academic Research (2006), “Recommendations in relation to the EU clinical trials directive and medical research involving incapacitated adults.” Wien Klin Wochenschr 118(5-6):183-91 Details Menon DK (2006), “Brain ischaemia after traumatic brain injury: lessons from 15O2 positron emission tomography.” Curr Opin Crit Care 12(2):85-9 Details Price CJ, Wang D, Menon DK, Guadagno JV, Cleij M, Fryer T, Aigbirhio F, Baron JC, Warburton EA (2006), “Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.” Stroke 37(7):1749-53 Details Salmond CH, DeVito EE, Clark L, Menon DK, Chatfield DA, Pickard JD, Kirkpatrick PJ, Sahakian BJ (2006), “Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors.” J Int Neuropsychol Soc 12(5):697-706 Details Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2006), “Cognitive reserve as a resilience factor against depression after moderate/severe head injury.” J Neurotrauma 23(7):1049-58 Details Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2006), “Changes over time in cognitive and structural profiles of head injury survivors.” Neuropsychologia 44(10):1995-8 Details Salmond CH, Menon DK, Chatfield DA, Williams GB, Pena A, Sahakian BJ, Pickard JD (2006), “Diffusion tensor imaging in chronic head injury survivors: correlations with learning and memory indices.” Neuroimage 29(1):117-24 Details Sardesai AM, Patel R, Denny NM, Menon DK, Dixon AK, Herrick MJ, Harrop-Griffiths AW (2006), “Interscalene brachial plexus block: can the risk of entering the spinal canal be reduced? A study of needle angles in volunteers undergoing magnetic resonance imaging.” Anesthesiology 105(1):9-13 Details Timofeev I, Kirkpatrick PJ, Corteen E, Hiler M, Czosnyka M, Menon DK, Pickard JD, Hutchinson PJ (2006), “Decompressive craniectomy in traumatic brain injury: outcome following protocol-driven therapy.” Acta Neurochir Suppl 96:11-6 Details Wheeler DW, Whittlestone KD, Salvador R, Wood DF, Johnston AJ, Smith HL, Menon DK (2006), “Influence of improved teaching on medical students' acquisition and retention of drug administration skills.” Br J Anaesth 96(1):48-52 Details 2005Balestreri M, Czosnyka M, Steiner LA, Hiler M, Schmidt EA, Matta B, Menon D, Hutchinson P, Pickard JD (2005), “Association between outcome, cerebral pressure reactivity and slow ICP waves following head injury.” Acta Neurochir Suppl 95:25-8 Details Coleman MR, Menon DK, Fryer TD, Pickard JD (2005), “Neurometabolic coupling in the vegetative and minimally conscious states: preliminary findings.” J Neurol Neurosurg Psychiatry 76(3):432-4 Details Cunningham AS, Harding S, Chatfield DA, Hutchinson P, Carpenter TA, Pickard JD, Menon DK (2005), “Metallic neurosurgical implants for cranial reconstruction and fixation: assessment of magnetic field interactions, heating and artefacts at 3.0 Tesla.” Br J Neurosurg 19(2):167-72 Details Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK (2005), “Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.” Brain 128(Pt 8):1931-42 Details Elliott L, Coleman M, Shiel A, Wilson BA, Badwan D, Menon D, Pickard J (2005), “Effect of posture on levels of arousal and awareness in vegetative and minimally conscious state patients: a preliminary investigation.” J Neurol Neurosurg Psychiatry 76(2):298-9 Details Honey GD, Honey RA, O'Loughlin C, Sharar SR, Kumaran D, Suckling J, Menon DK, Sleator C, Bullmore ET, Fletcher PC (2005), “Ketamine disrupts frontal and hippocampal contribution to encoding and retrieval of episodic memory: an fMRI study.” Cereb Cortex 15(6):749-59 Details Hutchinson PJ, Menon DK, Kirkpatrick PJ (2005), “Decompressive craniectomy in traumatic brain injury--time for randomised trials?” Acta Neurochir (Wien) 147(1):1-3 Details Hutchinson PJ, O'Connell MT, Nortje J, Smith P, Al-Rawi PG, Gupta AK, Menon DK, Pickard JD (2005), “Cerebral microdialysis methodology--evaluation of 20 kDa and 100 kDa catheters.” Physiol Meas 26(4):423-8 Details Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O'Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK (2005), “Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.” Crit Care Med 33(1):189-95; discussion 255-7 Details Lee MC, Menon DK (2005), “Sublingual drug delivery during functional magnetic resonance imaging.” Anaesthesia 60(8):821-2 Details Menon DK, Taylor BL, Ridley SA, Intensive Care Society, UK (2005), “Modelling the impact of an influenza pandemic on critical care services in England.” Anaesthesia 60(10):952-4 Details Müller U, Clark L, Lam ML, Moore RM, Murphy CL, Richmond NK, Sandhu RS, Wilkins IA, Menon DK, Sahakian BJ, Robbins TW (2005), “Lack of effects of guanfacine on executive and memory functions in healthy male volunteers.” Psychopharmacology (Berl) 182(2):205-13 Details O'Connell MT, Seal A, Nortje J, Al-Rawi PG, Coles JP, Fryer TD, Menon DK, Pickard JD, Hutchinson PJ (2005), “Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study.” Acta Neurochir Suppl 95:165-8 Details Owen AM, Coleman MR, Menon DK, Berry EL, Johnsrude IS, Rodd JM, Davis MH, Pickard JD (2005), “Using a hierarchical approach to investigate residual auditory cognition in persistent vegetative state.” Prog Brain Res 150:457-71 Details Owen AM, Coleman MR, Menon DK, Johnsrude IS, Rodd JM, Davis MH, Taylor K, Pickard JD (2005), “Residual auditory function in persistent vegetative state: a combined PET and fMRI study.” Neuropsychol Rehabil 15(3-4):290-306 Details Pickard JD, Hutchinson PJ, Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smielewski P, Chatfield DA, Aigbirhio F, Williams GB, Rice K, Clark JC, Salmond CH, Sahakian BJ, Bradley PG, Carpenter TA, Salvador R, Pena A, Gillard JH, Cunningham AS, Piechnik S, Czosnyka M, Menon DK (2005), “Imaging of cerebral blood flow and metabolism in brain injury in the ICU.” Acta Neurochir Suppl 95:459-64 Details Salmond CH, Chatfield DA, Menon DK, Pickard JD, Sahakian BJ (2005), “Cognitive sequelae of head injury: involvement of basal forebrain and associated structures.” Brain 128(Pt 1):189-200 Details Salmond CH, Menon DK, Chatfield DA, Pickard JD, Sahakian BJ (2005), “Deficits in decision-making in head injury survivors.” J Neurotrauma 22(6):613-22 Details Salvador R, Peña A, Menon DK, Carpenter TA, Pickard JD, Bullmore ET (2005), “Formal characterization and extension of the linearized diffusion tensor model.” Hum Brain Mapp 24(2):144-55 Details Salvador R, Suckling J, Coleman MR, Pickard JD, Menon D, Bullmore E (2005), “Neurophysiological architecture of functional magnetic resonance images of human brain.” Cereb Cortex 15(9):1332-42 Details Smith HL, Menon DK (2005), “Teaching difficult airway management: is virtual reality real enough?” Intensive Care Med 31(4):504-5 Details Steiner LA, Balestreri M, Johnston AJ, Coles JP, Chatfield DA, Pickard JD, Menon DK, Czosnyka M (2005), “Effects of moderate hyperventilation on cerebrovascular pressure-reactivity after head injury.” Acta Neurochir Suppl 95:17-20 Details Steiner LA, Balestreri M, Johnston AJ, Coles JP, Smielewski P, Pickard JD, Menon DK, Czosnyka M (2005), “Predicting the response of intracranial pressure to moderate hyperventilation.” Acta Neurochir (Wien) 147(5):477-83; discussion 483 Details Zygun DA, Bradley PG, Menon DK (2005), “Effect of methylene blue on middle cerebral artery flow velocity in a patient with severe sepsis following clipping of a cerebral aneurysm.” Neurocrit Care 2(1):39-42 Details 2004Bradley P, Hiler M, Menon D (2004), “Vasopressin in acute brain injury: a note of caution.” Anesth Analg 98(3):872; author reply 872-3 Details Bradley PG, Allen EK, Menon DK (2004), “Terlipressin for cerebral perfusion pressure support in a patient with septic shock.” Anaesthesia 59(6):619-20 Details Bradley PG, Harding SG, Reape-Moore K, Abeygunaratne R, Menon DK (2004), “Evaluation of infusion pump performance in a magnetic resonance environment.” Eur J Anaesthesiol 21(9):729-33 Details Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA (2004), “Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease.” Int J Biochem Cell Biol 36(4):702-13 Details Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK (2004), “Incidence and mechanisms of cerebral ischemia in early clinical head injury.” J Cereb Blood Flow Metab 24(2):202-11 Details Coles JP, Fryer TD, Smielewski P, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology.” J Cereb Blood Flow Metab 24(2):191-201 Details Coles JP, Steiner LA, Johnston AJ, Fryer TD, Coleman MR, Smieleweski P, Chatfield DA, Aigbirhio F, Williams GB, Boniface S, Rice K, Clark JC, Pickard JD, Menon DK (2004), “Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?” Brain 127(Pt 11):2479-90 Details Gelling L, Shiel A, Elliott L, Owen A, Wilson B, Menon D, Pickard J (2004), “Commentary on Oh H. and Seo W. (2003) Sensory stimulation programme to improve recovery in comatose patients. Journal of Clinical Nursing 12, 394-404.” J Clin Nurs 13(1):125-7 Details Gupta AK, Zygun DA, Johnston AJ, Steiner LA, Al-Rawi PG, Chatfield D, Shepherd E, Kirkpatrick PJ, Hutchinson PJ, Menon DK (2004), “Extracellular Brain pH and Outcome following Severe Traumatic Brain Injury.” J Neurotrauma 21(6):678-84 Details Honey RA, Honey GD, O'Loughlin C, Sharar SR, Kumaran D, Bullmore ET, Menon DK, Donovan T, Lupson VC, Bisbrown-Chippendale R, Fletcher PC (2004), “Acute ketamine administration alters the brain responses to executive demands in a verbal working memory task: an FMRI study.” Neuropsychopharmacology 29(6):1203-14 Details Johnston AJ, Steiner LA, Chatfield DA, Coles JP, Hutchinson PJ, Al-Rawi PG, Menon DK, Gupta AK (2004), “Effect of cerebral perfusion pressure augmentation with dopamine and norepinephrine on global and focal brain oxygenation after traumatic brain injury.” Intensive Care Med 30(5):791-7 Details Johnston AJ, Steiner LA, O'Connell M, Chatfield DA, Gupta AK, Menon DK (2004), “Pharmacokinetics and pharmacodynamics of dopamine and norepinephrine in critically ill head-injured patients.” Intensive Care Med 30(1):45-50 Details Liddell K, Menon DK, Zimmern R (2004), “The human tissue bill and the mental capacity bill.” BMJ 328(7455):1510-1 Details Menon D (2004), “Neurocritical care: turf label, organizational construct, or clinical asset?” Curr Opin Crit Care 10(2):91-3 Details Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD (2004), “Diffusion limited oxygen delivery following head injury.” Crit Care Med 32(6):1384-90 Details Menon DK, Wheeler DW, Wilkins IA, Phillips PD, Fletcher SJ, Penfold NW, Smith HL, Gupta AK, Matta BF (2004), “Integrated approaches to academic anaesthesia - the Cambridge experience.” Anaesthesia 59(8):785-92 Details Nortje J, Menon DK (2004), “Traumatic brain injury: physiology, mechanisms, and outcome.” Curr Opin Neurol 17(6):711-8 Details Price CJ, Menon DK, Peters AM, Ballinger JR, Barber RW, Balan KK, Lynch A, Xuereb JH, Fryer T, Guadagno JV, Warburton EA (2004), “Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study.” Stroke 35(7):1659-64 Details Steiner LA, Balestreri M, Johnston AJ, Czosnyka M, Coles JP, Chatfield DA, Smielewski P, Pickard JD, Menon DK (2004), “Sustained moderate reductions in arterial CO2 after brain trauma time-course of cerebral blood flow velocity and intracranial pressure.” Intensive Care Med 30(12):2180-7 Details Steiner LA, Johnston AJ, Czosnyka M, Chatfield DA, Salvador R, Coles JP, Gupta AK, Pickard JD, Menon DK (2004), “Direct comparison of cerebrovascular effects of norepinephrine and dopamine in head-injured patients.” Crit Care Med 32(4):1049-54 Details Urwin SC, Menon DK (2004), “Comparative tolerability of sedative agents in head-injured adults.” Drug Saf 27(2):107-33 Details Wheeler DW, Remoundos DD, Whittlestone KD, House TP, Menon DK (2004), “Calculation of doses of drugs in solution: are medical students confused by different means of expressing drug concentrations?” Drug Saf 27(10):729-34 Details Wheeler DW, Remoundos DD, Whittlestone KD, Palmer MI, Wheeler SJ, Ringrose TR, Menon DK (2004), “Doctors' confusion over ratios and percentages in drug solutions: the case for standard labelling.” J R Soc Med 97(8):380-3 Details Zygun DA, Steiner LA, Johnston AJ, Hutchinson PJ, Al-Rawi PG, Chatfield D, Kirkpatrick PJ, Menon DK, Gupta AK (2004), “Hyperglycemia and brain tissue pH after traumatic brain injury.” Neurosurgery 55(4):877-81; discussion 882 Details 2003Coles JP, Steiner LA, Martin J, Donovan T, Hutchinson PJ, Carpenter TA, Menon DK (2003), “Assessment of the Ventrix parenchymal intracranial pressure monitoring probe (NL950-P) and Monitor (NL950-100) in a 3 Tesla magnetic resonance scanner.” Anaesthesia 58(2):143-8 Details Johnston AJ, Steiner LA, Balestreri M, Gupta AK, Menon DK (2003), “Hyperoxia and the cerebral hemodynamic responses to moderate hyperventilation.” Acta Anaesthesiol Scand 47(4):391-6 Details Johnston AJ, Steiner LA, Chatfield DA, Coleman MR, Coles JP, Al-Rawi PG, Menon DK, Gupta AK (2003), “Effects of propofol on cerebral oxygenation and metabolism after head injury.” Br J Anaesth 91(6):781-6 Details Johnston AJ, Steiner LA, Gupta AK, Menon DK (2003), “Cerebral oxygen vasoreactivity and cerebral tissue oxygen reactivity.” Br J Anaesth 90(6):774-86 Details McNamara B, Ray J, Menon D, Boniface S (2003), “Raised intracranial pressure and seizures in the neurological intensive care unit.” Br J Anaesth 90(1):39-42 Details Menon DK (2003), “Procrustes, the traumatic penumbra, and perfusion pressure targets in closed head injury.” Anesthesiology 98(4):805-7 Details Minhas PS, Menon DK, Smielewski P, Czosnyka M, Kirkpatrick PJ, Clark JC, Pickard JD (2003), “Positron emission tomographic cerebral perfusion disturbances and transcranial Doppler findings among patients with neurological deterioration after subarachnoid hemorrhage.” Neurosurgery 52(5):1017-22; discussion 1022-4 Details Price CJ, Warburton EA, Menon DK (2003), “Human cellular inflammation in the pathology of acute cerebral ischaemia.” J Neurol Neurosurg Psychiatry 74(11):1476-84 Details Santarius T, Menon DK (2003), “Images in clinical medicine. Carotid-artery thrombosis secondary to basal skull fracture.” N Engl J Med 349(5):e5 Details Steiner LA, Coles JP, Czosnyka M, Minhas PS, Fryer TD, Aigbirhio FI, Clark JC, Smielewski P, Chatfield DA, Donovan T, Pickard JD, Menon DK (2003), “Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.” J Neurol Neurosurg Psychiatry 74(6):765-70 Details Steiner LA, Coles JP, Johnston AJ, Chatfield DA, Smielewski P, Fryer TD, Aigbirhio FI, Clark JC, Pickard JD, Menon DK, Czosnyka M (2003), “Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.” Stroke 34(10):2404-9 Details Steiner LA, Coles JP, Johnston AJ, Czosnyka M, Fryer TD, Smielewski P, Chatfield DA, Salvador R, Aigbirhio FI, Clark JC, Menon DK, Pickard JD (2003), “Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.” J Cereb Blood Flow Metab 23(11):1371-7 Details Steiner LA, Johnston AJ, Chatfield DA, Czosnyka M, Coleman MR, Coles JP, Gupta AK, Pickard JD, Menon DK (2003), “The effects of large-dose propofol on cerebrovascular pressure autoregulation in head-injured patients.” Anesth Analg 97(2):572-6, table of contents Details Steiner LA, Johnston AJ, Salvador R, Czosnyka M, Menon DK (2003), “Validation of a tonometric noninvasive arterial blood pressure monitor in the intensive care setting.” Anaesthesia 58(5):448-54 Details Watts C, Donovan T, Gillard JH, Antoun NM, Burnstein R, Menon DK, Carpenter TA, Fryer T, Thomas DG, Pickard JD (2003), “Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease.” Cell Transplant 12(7):697-704 Details Wheeler DW, Whittlestone KD, Smith HL, Gupta AK, Menon DK, East Anglian Peri-Operative Medicine Undergraduate Teaching Forum (2003), “A web-based system for teaching, assessment and examination of the undergraduate peri-operative medicine curriculum.” Anaesthesia 58(11):1079-86 Details Wilby MJ, Sharp M, Whitfield PC, Hutchinson PJ, Menon DK, Kirkpatrick PJ (2003), “Cost-effective outcome for treating poor-grade subarachnoid hemorrhage.” Stroke 34(10):2508-11 Details Zygun DA, Doig CJ, Gupta AK, Whiting G, Nicholas C, Shepherd E, Conway-Smith C, Menon DK (2003), “Non-neurological organ dysfunction in neurocritical care.” J Crit Care 18(4):238-44 Details 2002Chatfield DA, Zemlan FP, Day DJ, Menon DK (2002), “Discordant temporal patterns of S100beta and cleaved tau protein elevation after head injury: a pilot study.” Br J Neurosurg 16(5):471-6 Details Coles JP, Minhas PS, Fryer TD, Smielewski P, Aigbirihio F, Donovan T, Downey SP, Williams G, Chatfield D, Matthews JC, Gupta AK, Carpenter TA, Clark JC, Pickard JD, Menon DK (2002), “Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates.” Crit Care Med 30(9):1950-9 Details Gupta AK, Hutchinson PJ, Fryer T, Al-Rawi PG, Parry DA, Minhas PS, Kett-White R, Kirkpatrick PJ, Mathews JC, Downey S, Aigbirhio F, Clark J, Pickard JD, Menon DK (2002), “Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method.” J Neurosurg 96(2):263-8 Details Hutchinson PJ, Gupta AK, Fryer TF, Al-Rawi PG, Chatfield DA, Coles JP, O'Connell MT, Kett-White R, Minhas PS, Aigbirhio FI, Clark JC, Kirkpatrick PJ, Menon DK, Pickard JD (2002), “Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.” J Cereb Blood Flow Metab 22(6):735-45 Details Hutchinson PJ, O'Connell MT, Coles JP, Chatfield DA, Coleman MR, Al-Rawi PG, Kett-White CR, Gupta AK, Menon DK, Boniface SJ, Heazell M, Kirkpatrick PJ, Pickard JD (2002), “Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent.” Br J Clin Pharmacol 53(3):275-83 Details Menon DK, Day D, Kuc RE, Downie AJ, Chatfield DA, Davenport AP (2002), “Arteriojugular endothelin-1 gradients in aneurysmal subarachnoid haemorrhage.” Clin Sci (Lond) 103 Suppl 48:399S-403S Details Owen AM, Menon DK, Johnsrude IS, Bor D, Scott SK, Manly T, Williams EJ, Mummery C, Pickard JD (2002), “Detecting residual cognitive function in persistent vegetative state.” Neurocase 8(5):394-403 Details Patel HC, Menon DK, Tebbs S, Hawker R, Hutchinson PJ, Kirkpatrick PJ (2002), “Specialist neurocritical care and outcome from head injury.” Intensive Care Med 28(5):547-53 Details Rosser AE, Barker RA, Harrower T, Watts C, Farrington M, Ho AK, Burnstein RM, Menon DK, Gillard JH, Pickard J, Dunnett SB, NEST-UK (2002), “Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.” J Neurol Neurosurg Psychiatry 73(6):678-85 Details Sardesai AM, Brown NM, Menon DK (2002), “Deliberate release of biological agents.” Anaesthesia 57(11):1067-82 Details Senthuran S, Toff WD, Vuylsteke A, Solesbury PM, Menon DK (2002), “Implanted cardiac pacemakers and defibrillators in anaesthetic practice.” Br J Anaesth 88(5):627-31 Details Smielewski P, Coles JP, Fryer TD, Minhas PS, Menon DK, Pickard JD (2002), “Integrated image analysis solutions for PET datasets in damaged brain.” J Clin Monit Comput 17(7-8):427-40 Details Steiner LA, Chatfield DA, Donovan T, Coles JP, Menon DK (2002), “Assessment of the Caradyne WhisperFlow for administration of continuous positive airway pressure in a 3 Tesla magnetic resonance scanner.” Anaesthesia 57(5):470-4 Details Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD (2002), “Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury.” Crit Care Med 30(4):733-8 Details 2001Beech JS, Reckless J, Mosedale DE, Grainger DJ, Williams SC, Menon DK (2001), “Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor.” J Cereb Blood Flow Metab 21(6):683-9 Details Beech JS, Williams SC, Campbell CA, Bath PM, Parsons AA, Hunter AJ, Menon DK (2001), “Further characterisation of a thromboembolic model of stroke in the rat.” Brain Res 895(1-2):18-24 Details Bridgland IA, Menon DK (2001), “Monitoring medical devices: the need for new evaluation methodology.” Br J Anaesth 87(5):678-81 Details Menon DK (2001), “Mapping the anatomy of unconsciousness--imaging anaesthetic action in the brain.” Br J Anaesth 86(5):607-10 Details Menon DK, Matta BF, Gupta AK, Swami A (2001), “Propofol use in head-injury patients.” Lancet 357(9269):1708-9; author reply 1709-10 Details Whitfield PC, Patel H, Hutchinson PJ, Czosnyka M, Parry D, Menon D, Pickard JD, Kirkpatrick PJ (2001), “Bifrontal decompressive craniectomy in the management of posttraumatic intracranial hypertension.” Br J Neurosurg 15(6):500-7 Details Wilkins IA, Menon DK, Matta BF (2001), “Management of comatose head-injured patients: are we getting any better?” Anaesthesia 56(4):350-2 Details 2000Clatworthy MR, Edwards PD, Grant JW, Monteiro J, Menon DK (2000), “Haemothorax via an intact diaphragm.” J R Soc Med 93(12):634-6 Details Kuzumi E, Vuylsteke A, Guo X, Menon DK (2000), “Serum S100 protein as a marker of cerebral damage during cardiac surgery.” Br J Anaesth 85(6):936-7 Details Nandate K, Vuylsteke A, Ratsep I, Messahel S, Oduro-Dominah A, Menon DK, Matta BF (2000), “Effects of isoflurane, sevoflurane and propofol anaesthesia on jugular venous oxygen saturation in patients undergoing coronary artery bypass surgery.” Br J Anaesth 84(5):631-3 Details Pickard JD, Kirkpatrick PJ, Melsen T, Andreasen RB, Gelling L, Fryer T, Matthews J, Minhas P, Hutchinson PJ, Menon D, Downey SP, Kendall I, Clark J, Carpenter TA, Williams E, Persson L (2000), “Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage.” Blood Coagul Fibrinolysis 11 Suppl 1:S117-20 Details Waran V, Menon DK (2000), “Multimodality monitoring and the diagnosis of traumatic caroticocavernous fistula following head injury.” Br J Neurosurg 14(5):469-71 Details 1999Coles JP, Menon DK (1999), “Things are not as they seem.” Anaesthesia 54(1):100 Details Gupta AK, Hutchinson PJ, Al-Rawi P, Gupta S, Swart M, Kirkpatrick PJ, Menon DK, Datta AK (1999), “Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury.” Anesth Analg 88(3):549-53 Details Menon DK (1999), “Cerebral protection in severe brain injury: physiological determinants of outcome and their optimisation.” Br Med Bull 55(1):226-58 Details Menon DK, McCreath SW (1999), “5- to 8-year results of the Freeman press-fit hip arthroplasty without HA coating: a clinicoradiologic study.” J Arthroplasty 14(5):581-8 Details Menon DK, Owen AM, Pickard JD (1999), “Response from Menon, Owen and Pickard.” Trends Cogn Sci 3(2):44-46 Details Nandate K, Vuylsteke A, Crosbie AE, Messahel S, Oduro-Dominah A, Menon DK (1999), “Cerebrovascular cytokine responses during coronary artery bypass surgery: specific production of interleukin-8 and its attenuation by hypothermic cardiopulmonary bypass.” Anesth Analg 89(4):823-8 Details Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD (1999), “Redefining the functional organization of working memory processes within human lateral prefrontal cortex.” Eur J Neurosci 11(2):567-74 Details Williams EJ, Bunch CS, Carpenter TA, Downey SP, Kendall IV, Czosnyka M, Pickard JD, Martin J, Menon DK (1999), “Magnetic resonance imaging compatibility testing of intracranial pressure probes. Technical note.” J Neurosurg 91(4):706-9 Details Williams EJ, Jones NS, Carpenter TA, Bunch CS, Menon DK (1999), “Testing of adult and paediatric ventilators for use in a magnetic resonance imaging unit.” Anaesthesia 54(10):969-74 Details Williams EJ, Tam YC, Kendall IV, Carpenter TA, Menon DK (1999), “Infusion pump performance in an MR environment.” Eur J Anaesthesiol 16(7):468-72 Details 1998Bao YP, Williamson G, Tew D, Plumb GW, Lambert N, Jones JG, Menon DK (1998), “Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance.” Br J Anaesth 81(4):584-9 Details McKeating EG, Andrews PJ, Tocher JI, Menon DK (1998), “The intensive care of severe head injury: a survey of non-neurosurgical centres in the United Kingdom.” Br J Neurosurg 12(1):7-14 Details Menon DK, Owen AM, Williams EJ, Minhas PS, Allen CM, Boniface SJ, Pickard JD (1998), “Cortical processing in persistent vegetative state. Wolfson Brain Imaging Centre Team.” Lancet 352(9123):200 Details Menon DK, Summors AC (1998), “Neuroprotection (including hypothermia).” Curr Opin Anaesthesiol 11(5):485-96 Details Navapurkar VU, Skepper JN, Jones JG, Menon DK (1998), “Propofol preserves the viability of isolated rat hepatocyte suspensions under an oxidant stress.” Anesth Analg 87(5):1152-7 Details Raabe A, Menon DK, Gupta S, Czosnyka M, Pickard JD (1998), “Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury: a pilot study.” J Neurol Neurosurg Psychiatry 65(6):930-2 Details Skepper JN, Pierson RN 3rd, Young VK, Rees JA, Powell JM, Navaratnam V, Cary NR, Tew DN, Bacon PJ, Wallwork J, White DJ, Menon DK (1998), “Cytochemical demonstration of sites of hydrogen peroxide generation and increased vascular permeability in isolated pig hearts after ischaemia and reperfusion.” Microsc Res Tech 42(5):369-85 Details 1997Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD (1997), “Continuous assessment of the cerebral vasomotor reactivity in head injury.” Neurosurgery 41(1):11-7; discussion 17-9 Details Gupta AK, Menon DK, Czosnyka M, Smielewski P, Jones JG (1997), “Thresholds for hypoxic cerebral vasodilation in volunteers.” Anesth Analg 85(4):817-20 Details Gupta AK, Menon DK, Czosnyka M, Smielewski P, Kirkpatrick PJ, Jones JG (1997), “Non-invasive measurement of cerebral blood volume in volunteers.” Br J Anaesth 78(1):39-43 Details Lockwood GG, Dob DP, Bryant DJ, Wilson JA, Sargentoni J, Sapsed-Byrne SM, Harris DN, Menon DK (1997), “Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part II: Functional localization.” Br J Anaesth 79(5):586-9 Details Lockwood GG, Dob DP, Bryant DJ, Wilson JA, Sargentoni J, Sapsed-Byrne SM, Harris DN, Menon DK (1997), “Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part I: Elimination from the head.” Br J Anaesth 79(5):581-5 Details Radhakrishnan D, Menon DK (1997), “Haemodynamic effects of intravenous nimodipine following aneurysmal subarachnoid haemorrhage: implications for monitoring.” Anaesthesia 52(5):489-91 Details Young Y, Menon DK, Tisavipat N, Matta BF, Jones JG (1997), “Propofol neuroprotection in a rat model of ischaemia reperfusion injury.” Eur J Anaesthesiol 14(3):320-6 Details 1996Bacon PJ, Love SA, Gupta AK, Kirkpatrick PJ, Menon DK (1996), “Plasma antioxidant consumption associated with ischemia/reperfusion during carotid endarterectomy.” Stroke 27(10):1808-11 Details Cowley HC, Bacon PJ, Goode HF, Webster NR, Jones JG, Menon DK (1996), “Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors.” Crit Care Med 24(7):1179-83 Details Czosnyka M, Harland S, Piechnik S, Kirkpatrick P, Czosnyka Z, Menon D (1996), “Systematic overestimation of intracranial pressure measured using a Camino pressure monitor.” J Neurol Neurosurg Psychiatry 61(4):427-8 Details Czosnyka M, Smielewski P, Kirkpatrick P, Menon DK, Pickard JD (1996), “Monitoring of cerebral autoregulation in head-injured patients.” Stroke 27(10):1829-34 Details Jeevaratnam DR, Menon DK (1996), “Survey of intensive care of severely head injured patients in the United Kingdom.” BMJ 312(7036):944-7 Details Matta B, Menon D (1996), “Severe head injury in the United Kingdom and Ireland: a survey of practice and implications for management.” Crit Care Med 24(10):1743-8 Details Powell JF, Menon DK, Jones JG (1996), “The effects of hypoxaemia and recommendations for postoperative oxygen therapy.” Anaesthesia 51(8):769-72 Details 1995Burdett NG, Menon DK, Carpenter TA, Jones JG, Hall LD (1995), “Visualisation of changes in regional cerebral blood flow (rCBF) produced by ketamine using long TE gradient-echo sequences: preliminary results.” Magn Reson Imaging 13(4):549-53 Details Kirkpatrick PJ, Smielewski P, Czosnyka M, Menon DK, Pickard JD (1995), “Near-infrared spectroscopy use in patients with head injury.” J Neurosurg 83(6):963-70 Details Kirkpatrick PJ, Smielewski P, Whitfield PC, Czosnyka M, Menon D, Pickard JD (1995), “An observational study of near-infrared spectroscopy during carotid endarterectomy.” J Neurosurg 82(5):756-63 Details Menon DK, Bacon PJ, Jones JG (1995), “Nutrition and lung health.” BMJ 310(6982):805 Details Menon DK, Harris M, Sargentoni J, Taylor-Robinson SD, Cox IJ, Morgan MY (1995), “In vivo hepatic 31P magnetic resonance spectroscopy in chronic alcohol abusers.” Gastroenterology 108(3):776-88 Details Menon DK, Sargentoni J, Taylor-Robinson SD, Bell JD, Cox IJ, Bryant DJ, Coutts GA, Rolles K, Burroughs AK, Morgan MY (1995), “Effect of functional grade and etiology on in vivo hepatic phosphorus-31 magnetic resonance spectroscopy in cirrhosis: biochemical basis of spectral appearances.” Hepatology 21(2):417-27 Details 1994Menon DK, Young Y (1994), “Pharmacologically induced hypothermia for cerebral protection in humans.” Stroke 25(2):522-3 Details Menon DK, Young Y, Tew DN, Bacon PJ (1994), “New horizons in ICU sedation: exploring non-sedative effects of ICU sedation.” Clin Intensive Care 5(5 Suppl):22-6 Details 1993Bell JD, Cox IJ, Sargentoni J, Peden CJ, Menon DK, Foster CS, Watanapa P, Iles RA, Urenjak J (1993), “A 31P and 1H-NMR investigation in vitro of normal and abnormal human liver.” Biochim Biophys Acta 1225(1):71-7 Details Dagnelie PC, Bell JD, Cox IJ, Menon DK, Sargentoni J, Coutts GA, Williams SC (1993), “Effects of fish oil on phospholipid metabolism in human and rat liver studied by 31P NMR spectroscopy in vivo and in vitro.” NMR Biomed 6(2):157-62 Details Menon DK (1993), “Additional evidence against a unitary site of volatile anesthetic action.” Anesth Analg 77(3):645 Details Menon DK, Lockwood GG, Peden CJ, Cox IJ, Sargentoni J, Bell JD, Coutts GA, Whitwam JG (1993), “In vivo fluorine-19 magnetic resonance spectroscopy of cerebral halothane in postoperative patients: preliminary results.” Magn Reson Med 30(6):680-4 Details Saeed N, Menon DK (1993), “A knowledge-based approach to minimize baseline roll in chemical shift imaging.” Magn Reson Med 29(5):591-8 Details 1992Cox IJ, Menon DK, Sargentoni J, Bryant DJ, Collins AG, Coutts GA, Iles RA, Bell JD, Benjamin IS, Gilbey S (1992), “Phosphorus-31 magnetic resonance spectroscopy of the human liver using chemical shift imaging techniques.” J Hepatol 14(2-3):265-75 Details Dagnelie PC, Menon DK, Cox IJ, Bell JD, Sargentoni J, Coutts GA, Urenjak J, Iles RA (1992), “Effect of L-alanine infusion on 31P nuclear magnetic resonance spectra of normal human liver: towards biochemical pathology in vivo.” Clin Sci (Lond) 83(2):183-90 Details Menon DK, Ainsworth JG, Cox IJ, Coker RC, Sargentoni J, Coutts GA, Baudouin CJ, Kocsis AE, Harris JR (1992), “Proton MR spectroscopy of the brain in AIDS dementia complex.” J Comput Assist Tomogr 16(4):538-42 Details Menon DK, Peden CJ, Hall AS, Sargentoni J, Whitwam JG (1992), “Magnetic resonance for the anaesthetist. Part I: Physical principles, applications, safety aspects.” Anaesthesia 47(3):240-55 Details Peden CJ, Menon DK, Hall AS, Sargentoni J, Whitwam JG (1992), “Magnetic resonance for the anaesthetist. Part II: Anaesthesia and monitoring in MR units.” Anaesthesia 47(6):508-17 Details 1991Hampton KK, Chamberlain MA, Menon DK, Davies JA (1991), “Coagulation and fibrinolytic activity in Behçet's disease.” Thromb Haemost 66(3):292-4 Details Menon DK, Sandford RN, Cassidy MJ, Bell JD, Baudouin CJ, Sargentoni J (1991), “Proton magnetic resonance spectroscopy in chronic renal failure.” Lancet 337(8735):244-5 Details 1990Gill SS, Thomas DG, Van Bruggen N, Gadian DG, Peden CJ, Bell JD, Cox IJ, Menon DK, Iles RA, Bryant DJ (1990), “Proton MR spectroscopy of intracranial tumours: in vivo and in vitro studies.” J Comput Assist Tomogr 14(4):497-504 Details Menon DK, Baudouin CJ, Tomlinson D, Hoyle C (1990), “Proton MR spectroscopy and imaging of the brain in AIDS: evidence of neuronal loss in regions that appear normal with imaging.” J Comput Assist Tomogr 14(6):882-5 Details Menon DK, Sargentoni J, Peden CJ, Bell JD, Cox IJ, Coutts GA, Baudouin C, Newman CG (1990), “Proton MR spectroscopy in herpes simplex encephalitis: assessment of neuronal loss.” J Comput Assist Tomogr 14(3):449-52 Details Peden CJ, Cowan FM, Bryant DJ, Sargentoni J, Cox IJ, Menon DK, Gadian DG, Bell JD, Dubowitz LM (1990), “Proton MR spectroscopy of the brain in infants.” J Comput Assist Tomogr 14(6):886-94 Details |