I am interested in using single-molecule techniques to study soluble tau aggregates in tauopathy models, such as iPSC-derived neurons and cerebral organoids. These techniques include TIRF microscopy as well as super-resolution microscopy (dSTORM, DNA-PAINT) and SIMOA. Those methods can be used to characterise tau aggregates and their changes over time in terms of number, shape and morphology in disease models in order to identify relevant species in the aggregation process.
