Dr Dawn Eagle


How does the brain control impulsive and compulsive actions and stop inappropriate or unwanted behaviour? This question is relevant to many illnesses where brain function is altered (e.g,. ADHD, Parkinson's disease, OCD, schizophrenia, compulsive gambling, eating disorders and drug addiction), each of which has symptoms of excessive or unwanted impulsive/compulsive behaviour.

Models of rodent behaviour allow us to study the anatomy and pharmacology of inhibitory failure in great detail. We develop behavioural tests that can be used in rats and mice to analyse drug actions on behaviour and often these behavioural methods can translate directly to assess patients in the clinic. This may improve how new treatment strategies for these debilitating disorders are developed.

Research Focus




animal models

stop-signal task


Clinical conditions


Anxiety disorders

Attention deficit hyperactivity disorder

Eating disorders

Huntington's disease

Obsessive compulsive disorder

Parkinson's disease



Behavioural analysis



Johan Alsio

Jeff Dalley

Amy Milton

Sharon Morein

Trevor Robbins


Christelle Baunez Web: http://sites.univ-provence.fr/lnc/ind...

Associated News Items



Morein-Zamir S, Shahper S, Fineberg NA, Eisele V, Eagle DM, Urcelay GP, Robbins TW (2018), “Free operant observing in humans: a translational approach to compulsive certainty seeking” Quarterly Journal of Experimental Psychology


d’Angelo C, Eagle DM, Coman CM, Robbins TW (2017), “Role of the medial prefrontal cortex and nucleus accumbens in an operant model of checking behaviour and uncertainty” Brain and Neuroscience Advances 1


Camilla d'Angelo LS, Eagle DM, Grant JE, Fineberg NA, Robbins TW, Chamberlain SR (2014), “Animal models of obsessive-compulsive spectrum disorders.” CNS Spectr 19(1):28-49 Details

Eagle DM, Noschang C, d'Angelo LS, Noble CA, Day JO, Dongelmans ML, Theobald DE, Mar AC, Urcelay GP, Morein-Zamir S, Robbins TW (2014), “The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD.” Behav Brain Res 264:207-29 Details


Bari A, Mar AC, Theobald DE, Elands SA, Oganya KC, Eagle DM, Robbins TW (2011), “Prefrontal and monoaminergic contributions to stop-signal task performance in rats.” J Neurosci 31(25):9254-63 Details

Eagle DM, Wong JC, Allan ME, Mar AC, Theobald DE, Robbins TW (2011), “Contrasting Roles for Dopamine D1 and D2 Receptor Subtypes in the Dorsomedial Striatum but Not the Nucleus Accumbens Core during Behavioral Inhibition in the Stop-Signal Task in Rats.” J Neurosci 31(20):7349-56 Details

Mar AC, Walker AL, Theobald DE, Eagle DM, Robbins TW (2011), “Dissociable effects of lesions to orbitofrontal cortex subregions on impulsive choice in the rat.” J Neurosci 31(17):6398-404 Details


Eagle DM, Baunez C (2010), “Is there an inhibitory-response-control system in the rat? Evidence from anatomical and pharmacological studies of behavioral inhibition.” Neurosci Biobehav Rev 34(1):50-72 Details


Bari A, Eagle DM, Mar AC, Robinson ES, Robbins TW (2009), “Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats.” Psychopharmacology (Berl) 205(2):273-83 Details

Eagle DM, Lehmann O, Theobald DE, Pena Y, Zakaria R, Ghosh R, Dalley JW, Robbins TW (2009), “Serotonin depletion impairs waiting but not stop-signal reaction time in rats: implications for theories of the role of 5-HT in behavioral inhibition.” Neuropsychopharmacology 34(5):1311-21 Details

Robinson ES, Eagle DM, Economidou D, Theobald DE, Mar AC, Murphy ER, Robbins TW, Dalley JW (2009), “Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'.” Behav Brain Res 196(2):310-6 Details


Eagle DM, Bari A, Robbins TW (2008), “The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks.” Psychopharmacology (Berl) 199(3):439-56 Details

Eagle DM, Baunez C, Hutcheson DM, Lehmann O, Shah AP, Robbins TW (2008), “Stop-signal reaction-time task performance: role of prefrontal cortex and subthalamic nucleus.” Cereb Cortex 18(1):178-88 Details

Robinson ES, Eagle DM, Mar AC, Bari A, Banerjee G, Jiang X, Dalley JW, Robbins TW (2008), “Similar effects of the selective noradrenaline reuptake inhibitor atomoxetine on three distinct forms of impulsivity in the rat.” Neuropsychopharmacology 33(5):1028-37 Details


Aron AR, Durston S, Eagle DM, Logan GD, Stinear CM, Stuphorn V (2007), “Converging evidence for a fronto-basal-ganglia network for inhibitory control of action and cognition.” J Neurosci 27(44):11860-4 Details

Eagle DM, Tufft MR, Goodchild HL, Robbins TW (2007), “Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.” Psychopharmacology (Berl) 192(2):193-206 Details


Winstanley CA, Eagle DM, Robbins TW (2006), “Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies.” Clin Psychol Rev 26(4):379-95 Details


Eagle DM, Robbins TW (2003), “Inhibitory control in rats performing a stop-signal reaction-time task: effects of lesions of the medial striatum and d-amphetamine.” Behav Neurosci 117(6):1302-17 Details

Eagle DM, Robbins TW (2003), “Lesions of the medial prefrontal cortex or nucleus accumbens core do not impair inhibitory control in rats performing a stop-signal reaction time task.” Behav Brain Res 146(1-2):131-44 Details


Dalley JW, Theobald DE, Eagle DM, Passetti F, Robbins TW (2002), “Deficits in impulse control associated with tonically-elevated serotonergic function in rat prefrontal cortex.” Neuropsychopharmacology 26(6):716-28 Details


Baunez C, Humby T, Eagle DM, Ryan LJ, Dunnett SB, Robbins TW (2001), “Effects of STN lesions on simple vs choice reaction time tasks in the rat: preserved motor readiness, but impaired response selection.” Eur J Neurosci 13(8):1609-16 Details


Watts C, Brasted PJ, Eagle DM, Dunnett SB, Robbins TW (2000), “Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease.” Experimental Neurology 163:85-97


Eagle DM, Humby T, Dunnett SB, Robbins TW (1999), “Effects of regional striatal lesions on motor, motivational, and executive aspects of progressive-ratio performance in rats.” Behav Neurosci 113(4):718-31 Details

Eagle DM, Humby T, Howman M, Reid-Henry A, Dunnett SB, Robbins TW (1999), “Differential effects of ventral and regional dorsal striatal lesions on sucrose drinking and positive and negative contrst in rats.” Psychobiology 27(2):267-276