Dr Deep Adhya
Dr Deep Adhya is pleased to consider applications from prospective PhD students.
Autism Research Centre and MRC Cambridge Stem Cell Institute
Cellular and Molecular Neuroscience
We have recently shown that the in-vitro neural tube structure, the ‘neural rosette’ is affected in autism induced pluripotent stem cell (iPSC) derived neurons. This suggests that an autism diagnosis has genetic and epigenetic influences affecting atypical iPSC neural differentiation (Adhya et al 2021). We are currently studying gene regulatory pathways that cause atypical neural rosette formation in autism, focussing on the role of histone modifications and transcriptional activation. Specifically, we are investigating the role of the MLL/SET protein family on early neurodevelopment. We are also studying effects of genes and epigenome on neuronal outcomes using a 3D cerebral organoid approach. Finally, we are looking at the role of autism-associated sex chromosomal genes and sex hormones on transcriptional and epigenetic processes during 3D cerebral organoid development.
Single cell transcriptomics
Associated News Items
Adhya D, Chennell G, Crowe JA, Valencia-Alarcón EP, Seyforth J, Hosny NA, Yasvoina MV, Forster R, Baron-Cohen S, Vernon AC, Srivastava DP. (2021), “Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids.” Mol Autism Jan 22;12(1):4
Adhya D, Swarup V, Nagy R, Dutan L, Shum C, Valencia-Alarcón EP, Jozwik KM, Mendez MA, Horder J, Loth E, Nowosiad P, Lee I, Skuse D, Flinter FA, Murphy D, McAlonan G, Geschwind DH, Price J, Carroll J, Srivastava DP, Baron-Cohen S. (2021), “Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals.” Biol Psychiatry Mar 1;89(5):486-496.
Adhya D, Annuario E, Lancaster MA, Price J, Baron-Cohen S, Srivastava DP. (2018), “Understanding the role of steroids in typical and atypical brain development: Advantages of using a "brain in a dish" approach.” J Neuroendocrinol Feb;30(2):e12547