Dr Claire O'Callaghan

Claire O'Callaghan

University position

Visiting postdoctoral fellow


Department of Psychiatry


Behavioural and Clinical Neuroscience Institute



Research Theme

Cognitive and Behavioural Neuroscience


I am a clinical research fellow with a focus on neuropsychiatric symptoms in neurodegenerative conditions.

Symptoms such as apathy, depression, impulsivity and social impairments are common in neurodegenerative disease. My research takes a transdiagnostic approach across different conditions, including Parkinson’s disease, Huntington’s disease and frontotemporal dementia, to study neuropsychiatric symptoms. Drawing from both clinical and cognitive neurosciences, I aim to develop novel neuropsychological assessment tools to detect these symptoms, in combination with multimodal neuroimaging and pharmacological manipulations. Together, my goal is to refine our characterisation of these symptoms and better establish their neural basis, to ultimately improve therapeutic strategies.

Research Focus






Clinical conditions

Alzheimer's disease

Cognitive impairment


Frontotemporal dementia

Huntington's disease

Parkinson's disease


Behavioural analysis

Magnetic resonance imaging (MRI)

Neuropsychological testing



Trevor Robbins

United Kingdom

Michael Hornberger


Maxime Bertoux

John Hodges

Simon Lewis

Mac Shine

Associated News Items



Mariano LI, O’Callaghan C, Guimarães HC, Gambogi LB, Lima da Silva TB, Yassuda MS, Septímio J, Caramelli P, Teixeira AL, Hornberger M, Cruz de Souza L (2020), “Disinhibition in Frontotemporal Dementia and Alzheimer's Disease: a neuropsychological and behavioural investigation” Journal of the International Neuropsychological Society 26(2) 163-171

O’Brien J, Taylor J-P, Ballard C, Barker RA, Bradley C, Burns A, Collerton D, Dave S, Dudley R, Francis P, Gibbons A, Harris K, Lawrence V, Leroi I, McKeith I, Michaelides M, Naik C, O’Callaghan C, Olsen K, Onofrj M, Pinto R, Russell G, Swann P, Thomas A, Urwyler P, Weil RS & ffytche DH (2020), “Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management” Journal of Neurology, Neurosurgery and Psychiatry 91(5), 512-519

in press

O’Callaghan, C, Walpola IC, Shine JM (in press), “Neuromodulation of the mind-wandering brain state: the interaction between neuromodulatory tone, sharp wave-ripples and spontaneous thought” Philosophical Transactions B


Powell A, Muller AJ, O’Callaghan C, Sourty M, Shine JM, Lewis SJG (2020), “Dopamine and functional connectivity in patients with Parkinson's disease and visual hallucinations” Movement Disorders 35: 704-705

Walpola IC, Muller AJ, Hall JM, Andrews-Hanna JR, Irish M, Lewis SJG, Shine JM, O'Callaghan C (2020), “Mind-wandering in Parkinson's disease hallucinations reflects primary visual and default network coupling” Cortex 125(233-245)


Hall, JM, O’Callaghan C, Muller AJ, Ehgoetz-Martens KA, Phillips JR, Moustafa AA, Lewis SJG, Shine JM (2019), “Changes in structural network topology correlate with severity of hallucinatory behaviour in Parkinson's disease” Network Neuroscience 3(2), 521-538

Heath CJ, O’Callaghan C, Mason SL, Phillips BU, Saksida LM, Robbins TW, Barker RA, Bussey TJ, Sahakian BJ (2019), “A touchscreen motivation assessment evaluated in Huntington’s disease patients and R6/1 model mice” Frontiers in Neurology 10: 858

Irish M, Goldberg ZL, Alaeddin S, O'Callaghan C, Andrews-Hanna JR (2019), “Age-related changes in the temporal focus and self-referential content of spontaneous cognition during periods of low cognitive demand” Psychological Research 83(4):747–760

O'Callaghan C (2019), “The multifaceted nature of impulsivity in Parkinson’s disease” Brain 142 (12), 3666-3669

O'Callaghan C, Shine JM, Hodges JR, Andrews-Hanna J, Irish M (2019), “Hippocampal atrophy and intrinsic brain network dysfunction relate to alterations in mind wandering in neurodegeneration” PNAS 116: 3316-3321

O'Callaghan C, Vaghi, MM, Brummerloh B, Cardinal RN, Robbins TW (2019), “Impaired awareness of action-outcome contingency and causality during healthy ageing and following ventromedial prefrontal cortex lesions” Neuropsychologia 128:282-289 PDF

Rollins C, Garrison JR, Simons JD, Rowe JB, O’Callaghan C, Murray GK, Suckling J (2019), “Meta-analytic evidence for the plurality of mechanisms in transdiagnostic structural MRI studies of hallucination status” EClinicalMedicine 8:58-71

Shine JM, Bell PT, Matar E, Poldrack RA, Lewis SJG, Halliday GM, O’Callaghan C (2019), “Dopamine Depletion Alters Macroscopic Network Dynamics in Parkinson’s Disease” Brain 142(4), 1024-1034


Jalal B, Brühl A, O’Callaghan C, Piercy T, Cardinal RN, Ramachandran VS, & Sahakian, BJ (2018), “Novel Smartphone Interventions Improve Cognitive Flexibility and Obsessive-Compulsive Disorder Symptoms in Individuals with Contamination Fears” Scientific reports 8(1), 14923

Muller AJ, Mills JMZ, O'Callaghan C, Naismith SL, Clouston PD, Lewis SJG, Shine JM. (2018), “Informant- and self-appraisals on the Psychosis and Hallucinations Questionnaire (PsycH-Q) enhances detection of visual hallucinations in Parkinson's disease” Movement Disorders Clinical Practice 5: 607-613

O'Callaghan C & Irish M (2018), “Candidate mechanisms of spontaneous cognition as revealed by dementia syndromes” In F Fox & K Christoff (Eds), The Oxford Handbook of Spontaneous Thought: Mind-wandering, Creativity, Dreaming, and Clinical Disorders

Walton CC, Mowszowski L, Gilat M, Hall JM, O’Callaghan C, Muller AJ, Georgiades M, Szeto JYY, Ehgoetz Martens KA, Shine JM, Naismith SL & Lewis SJG. (2018), “Cognitive Training for Freezing of Gait in Parkinson’s Disease: A Randomized Controlled Trial” npj Parkinson's Disease 4(1):15


Bertoux M, O’Callaghan C, Flanagan E & Hornberger M (2017), “Frontotemporal Dementia” In N.A. Pachana (Ed.), Encyclopedia of Geropsychology. Singapore: Springer Singapore. doi:10.1007/978-981-287-080-3_311-1

Gellersen HM, Guo CC, O’Callaghan C, Tan RH, Sami S & Hornberger M (2017), “Cerebellar atrophy in neurodegeneration – a meta-analysis” Journal of Neurology, Neurosurgery and Psychiatry 88(9):780-788

Muller AJ, O'Callaghan C, Walton CC, Shine JM & Lewis, SJG (2017), “Retrospective neuropsychological profile of patients with Parkinson disease prior to developing visual hallucinations” Journal of Geriatric Psychiatry and Neurology 30(2):90-95

O'Callaghan C & Hornberger M (2017), “Towards a neurocomputational account of social dysfunction in neurodegenerative disease” Brain 140(3):e14-e14

O'Callaghan C & Lewis SJG (2017), “Cognition in Parkinson's disease” in “Non Motor Parkinson's: The Hidden Face”, edited by K Ray Chaudhuri and Nataliya Titova International Review of Neurobiology, Vol 133:557-583

O'Callaghan C, Hall JM, Tomassini A, Muller AJ, Walpola IC, Moustafa AA, Shine JM & Lewis SJG (2017), “Visual hallucinations are characterised by impaired sensory evidence accumulation: Insights from hierarchical drift diffusion modelling in Parkinson’s disease” Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2(8):680-688

O'Callaghan C, Kveraga K, Shine JM, Adams RB, Bar M (2017), “Predictions penetrate perception: Converging insights from brain, behaviour and disorder” Consciousness and Cognition 47:63-74

Wong S, Irish M, O'Callaghan C, Kumfor F, Savage G, Hodges JR, Piguet O & Hornberger M (2017), “Should I trust you? Learning and memory of social interactions in dementia” Neuropsychologia 104(Supplement C):157-167


Bertoux M, O’Callaghan C, Dubois B, Hornberger M (2016), “In two minds - executive functioning vs. theory of mind in behavioural variant frontotemporal dementia” Journal of Neurology, Neurosurgery and Psychiatry 87(3), 231-234

Hall JM, Ehgoetz Martens KA, Walton CC, O'Callaghan C, Keller PE, Lewis SJG & Moustafa AA (2016), “Diffusion alterations associated with Parkinson's disease symptomatology: A review of the literature” Parkinsonism & Related Disorders 33, 12-26

Hall JM, O'Callaghan C, Shine JM, Muller AJ, Phillips JR, Walton CC, Lewis SJG, Moustafa AA (2016), “Dysfunction in attentional processing in patients with Parkinson's disease and visual hallucinations” Journal of Neural Transmission 123(5), 503-507

Irish M, Eyre N, Dermody N, O'Callaghan C, Hodges JR, Hornberger M & Piguet O (2016), “Neural Substrates of Semantic Prospection – Evidence from the Dementias” Frontiers in Behavioral Neuroscience 10:96

O'Callaghan C, Bertoux M, Irish M, Shine JM, Wong S, Spiliopoulos L, Hodges JR, Hornberger M (2016), “Fair play: social norm compliance failures in behavioural variant frontotemporal dementia” Brain 139(1), 204-216

O'Callaghan C, Hornberger M, Balsters JH, Halliday GM, Lewis SJG, Shine JM (2016), “Cerebellar atrophy in Parkinson’s disease and its implication for network connectivity” Brain 139(3), 845-855

O'Callaghan C, Kveraga K, Shine JM, Adams RB, Bar M (2016), “Convergent evidence for top-down effects from the "predictive brain"” Behavioral and Brain Sciences 39


Bell PT, Gilat M, O'Callaghan C, Copland DA, Frank MJ, Lewis SJ, Shine JM (2015), “Dopaminergic basis for impairments in functional connectivity across subdivisions of the striatum in Parkinson's disease.” Hum Brain Mapp 36(4):1278-91 Details

Bertoux M, de Souza LC, O’Callaghan C, Greve A, Sarazin M, Dubois B Hornberger M (2015), “Social cognition: the key to distinguish behavioural variant frontotemporal dementia from Alzheimer disease regardless of amnesia?” Journal of Alzheimer’s Disease 49(4),1065-1074

Bertoux M, O'Callaghan C, Flanagan E, Hodges JR, Hornberger M (2015), “Fronto-striatal atrophy in behavioural variant frontotemporal dementia & Alzheimer’s disease” Front Neurol 6:147

Devenney E, Bartley L, Hoon C, O’Callaghan C, Kumfor F, Hornberger M, Kiernan MC, Halliday GM, Piguet O, Hodges JR. (2015), “Progression in behavioural variant frontotemporal dementia: a longitudinal study” JAMA Neurology 72(12):1501-1509

Gilat M, Shine JM, Walton CC, O’Callaghan C, Hall JM, Lewis SJG (2015), “Brain activation underlying turning in Parkinson’s disease patients with and without Freezing of Gait: a virtual reality fMRI study” Npj Parkinson's Disease 1: 15020

Hall JM, Shine JM, O’Callaghan C, Walton CC, Gilat M, Naismith SL, Lewis SJG (2015), “Freezing of Gait and its Associations in the Early and Advanced Clinical Motor Stages of Parkinson’s Disease: A Cross-Sectional Study” Journal of Parkinson’s Disease 5(4): 881-891

O'Callaghan C, Shine JM, Lewis SJ, Andrews-Hanna JR, Irish M (2015), “Shaped by our thoughts--a new task to assess spontaneous cognition and its associated neural correlates in the default network.” Brain Cogn 93:1-10 Details

Shine JM, Keogh R, O'Callaghan C, Muller AJ, Lewis SJ, Pearson J (2015), “Imagine that: elevated sensory strength of mental imagery in individuals with Parkinson's disease and visual hallucinations.” Proc Biol Sci 282(1798):20142047 Details

Shine JM, Mills JMZ, Qiu J, O'Callaghan C, Terpening ZT, Halliday GM, Naismith SL, Lewis SJG (2015), “Validation of the Psychosis and Hallucinations Questionnaire in non-demented patients with Parkinson's disease” Mov Disord Clin Pract 2(2):175-81

Shine JM, Muller AJ, O’Callaghan C, Hornberger M, Halliday GM, Lewis SJG (2015), “Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease: a task-based fMRI study” npj Parkinson’s Disease 1:15003

Szeto JYY, O’Callaghan C, Shine JM, Walton CC, Mowszowski L, Naismith SL, Halliday GM, Lewis SJG (2015), “The relationships between mild cognitive impairment and phenotype in Parkinson’s disease” Npj Parkinson's Disease 1:15015

Walton CC, O’Callaghan C, Hall JM, Gilat M, Mowszowski L, Naismith SL, Burrell JR, Shine JM, Lewis SJG (2015), “Antisaccade errors reveal cognitive control deficits in Parkinson's disease with freezing of gait” Journal of Neurology 262(12), 2745-2754

Walton CC, Shine JM, Hall JM, O'Callaghan C, Mowszowski L, Gilat M, Szeto JY, Naismith SL, Lewis SJ (2015), “The major impact of freezing of gait on quality of life in Parkinson's disease.” J Neurol 262(1):108-15 Details

Walton CC, Shine JM, Mowszowski L, Gilat M, Hall JM, O'Callaghan C, Naismith SL, Lewis SJ (2015), “Impaired cognitive control in Parkinson's disease patients with freezing of gait in response to cognitive load.” J Neural Transm 122(5):653-60 Details


Kamminga J, O'Callaghan C, Hodges JR, Irish M (2014), “Differential prospective memory profiles in frontotemporal dementia syndromes.” J Alzheimers Dis 38(3):669-79 Details

O'Callaghan C, Bertoux M, Hornberger M (2014), “Beyond and below the cortex: the contribution of striatal dysfunction to cognition and behaviour in neurodegeneration.” J Neurol Neurosurg Psychiatry 85(4):371-8 Details

O'Callaghan C, Muller AJ, Shine JM (2014), “Clarifying the role of neural networks in complex hallucinatory phenomena.” J Neurosci 34(36):11865-7 Details

O'Callaghan C, Shine JM, Lewis SJ, Hornberger M (2014), “Neuropsychiatric symptoms in Parkinson's disease: fronto-striatal atrophy contributions.” Parkinsonism Relat Disord 20(8):867-72 Details

Shine JM, O'Callaghan C, Halliday GM, Lewis SJ (2014), “Tricks of the mind: Visual hallucinations as disorders of attention.” Prog Neurobiol 116:58-65 Details


Bertoux M, Funkiewiez A, O'Callaghan C, Dubois B, Hornberger M (2013), “Sensitivity and specificity of ventromedial prefrontal cortex tests in behavioral variant frontotemporal dementia.” Alzheimers Dement 9(5 Suppl):S84-94 Details

Kloeters S, Bertoux M, O'Callaghan C, Hodges JR, Hornberger M (2013), “Money for nothing - Atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease.” Neuroimage Clin 2:263-72 Details

Nguyen T, Bertoux M, O’Callaghan C, Ahmed S, Hodges JR, Hornberger M (2013), “Grey and white matter brain network changes in frontotemporal dementia subtypes” Translational Neuroscience 4(4)410-418

O'Callaghan C, Hodges JR, Hornberger M (2013), “Inhibitory dysfunction in frontotemporal dementia: a review.” Alzheimer Dis Assoc Disord 27(2):102-8 Details

O'Callaghan C, Hornberger M (2013), “Screening for impulse control symptoms in patients with de novo Parkinson disease: a case-control study.” Neurology 81(7):694-5 Details

O'Callaghan C, Moustafa AA, de Wit S, Shine JM, Robbins TW, Lewis SJ, Hornberger M (2013), “Fronto-striatal gray matter contributions to discrimination learning in Parkinson's disease.” Front Comput Neurosci 7:180 Details

O'Callaghan C, Naismith SL, Hodges JR, Lewis SJ, Hornberger M (2013), “Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia.” Cortex 49(7):1833-43 Details

O'Callaghan C, Naismith SL, Shine JM, Bertoux M, Lewis SJ, Hornberger M (2013), “A novel bedside task to tap inhibitory dysfunction and fronto-striatal atrophy in Parkinson's disease.” Parkinsonism Relat Disord 19(9):827-30 Details


Harris IM, Murray AM, Hayward WG, O'Callaghan C, Andrews S (2012), “Repetition blindness reveals differences between the representations of manipulable and nonmanipulable objects.” J Exp Psychol Hum Percept Perform 38(5):1228-41 Details