Clara Mutschler University positionPhD student DepartmentsDepartment of Clinical Neurosciences InstitutesCambridge Centre for Brain Repair Research ThemeInterestsMy research focusses on the interaction of Schwann cells and neurons after peripheral nervous system injury. After injury, axons degenerate and Schwann cells transform into repair Schwann cells, which digest myelin using myelinophagy, attract macrophages, and support neuronal survival and axonal regeneration. Both axon degeneration and this repair phenotype are regulated by cell intrinsic molecular pathways, but their interaction and the Schwann cell injury response are incompletely understood. I am working on further characterising this injury response, and on understanding the transcriptional changes in Schwann cells after nerve injury. I work with a range of models, including an in vitro coculture model, mice, and zebrafish. Research Focus
EquipmentCalcium imaging Cell culture Confocal microscopy Fluorescence microscopy Immunohistochemistry Live imaging Microscopy RNA sequencing |