My PhD project aims to look at the genetic relationship of sleep and circadian rhythmicity with cerebral small vessel disease (CSVD) using bioinformatical approaches. This is interesting since abnormal sleeping patterns may be associated with glymphatic system dysfunction, which plays important roles in CSVD pathology. The molecular findings will then be translated into clinical settings by exploring potentially druggable genes with no current targets and examining their off-target effects, which are helpful from the perspective of drug development.
