Dr Cortina Chen

University position

Research Associate

Departments

Department of Clinical Biochemistry

Institutes

Institute of Metabolic Science

Research Theme

Cellular and Molecular Neuroscience

Interests

My research has focused on stress as a mechanism for increasing nitric oxide production which has been implicated in the aetiology of stress-related and other neuropathological conditions. I then joined the Neuroinflammation Laboratory at The University of Queensland (Australia) to studied the underlying neuroinflammatory pathogenesis of dipeptide repeat proteins in C9orf72-linked MND. By utilising several inflammatory-related transgenic mouse lines lacking one of the innate immune C3a/C5a/C5L2 receptors of the complement cascade, I have focused on characterising the involvement of these inflammatory components in mediating central stress responsiveness.

I am currently within the WT-MRC Institute of Metabolic Science to study the cellular and molecular mechanisms underlying diseases of the brain such as obesity and neurodegeneration using pluripotent stem cell-derived cellular co-culture models.

Research Focus

Keywords

redox biology

stress

hypothalamus

energy homeostasis

Clinical conditions

Alzheimer's disease

Stress

Equipment

Behavioural analysis

Cell culture

Enzyme assays

Collaborators

No collaborators listed

Associated News Items


Key publications

Spiers, J.G., Chen, H.-J.C., Bourgognon, J.M., Steinert, J.R. (2019), “Dysregulation of stress systems and nitric oxide signaling underlies neuronal dysfunction in Alzheimer’s disease” Free Radic Biol Med 2(134): 468-483

Publications

2020

Chen, H.-J.C., Yip, T., Lee, J.K., Juliani, J, Sernia, C., Hill, A.F., Lavidis, N.A., Spiers, J.G. (2020), “Restraint stress alters expression of glucocorticoid bioavailability mediators, suppresses Nrf2, and promotes oxidative stress in liver tissue” Antioxidants 9(9), doi: 10.3390/antiox9090853

2019

Chen, H.-J.C., Lee, J.K., Yip, T, Sernia, C., Lavidis, N.A., Spiers, J.G. (2019), “Sub-acute restraint stress progressively increases oxidative/nitrosative stress and inflammatory markers while transiently upregulating antioxidant gene expression in the rat hippocampus” Free Radic Biol Med 130: 446-457

Spiers, J.G., Chen, H.-J.C. (2019), “Chronic sleep disruption potentiates locus coeruleus tauopathy in a mouse model of Alzheimer’s disease” Journal of Neuroscience 39(25): 4844-4846

2018

Chen, H.-J.C., Spiers, J.G., Sernia, C., Lavidis, N.A. (2018), “Inhibition of fatty acid amide hydrolase by PF-3845 alleviates nitrergic and proinflammatory response in the rat hippocampus following acute stress” Int J Neuropsychopharmacol 21(8):786-795

2017

Colthorpe, K., Abraha, H.M., Zimbardi, K., Ainscough, L., Spiers, J.G., Chen, H.-J.C., Lavidis, N.A. (2017), “Assessing critical evidence evaluation skills of undergraduate science students in inquiry-based laboratory classes” Adv Physiol Edu 41(1): 154-162

Spiers, J.G., Chen, H.-J.C., Steyn, F.J., Lavidis, N.A., Woodruff, T.M., Lee, J.D. (2017), “Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system” Stress 20(1): 59-67

2016

Chen, H.-J.C., Spiers, J.G., Sernia, C., Lavidis, N.A. (2016), “. Acute restraint stress induces specific changes in nitric oxide production and inflammatory markers in the rat hippocampus and striatum” Free Radic Biol Med 90: 219-229

Spiers, J.G., Chen, H.-J.C., Cuffe, J.S.M., Sernia, C., Lavidis, N.A. (2016), “Acute restraint stress induces rapid changes in central redox status and protective antioxidant genes in rats” Psychoneuroendocrinology 67: 104-112

2015

Chen, H.-J.C., Spiers, J.G., Sernia, C., Lavidis, N.A. (2015), “Response of the nitrergic system to activation of the neuroendocrine stress axis” Front Neurosci doi: 10.3389/fnins.2015.00003

Spiers, J.G., Chen, H.-J.C., Sernia, C., Lavidis, N.A. (2015), “Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress” Front Neurosci doi: 10.3389/fnins.2014.00456

2014

Chen, H.-J.C., Spiers, J.G., Sernia, C., Anderson, S.T., Lavidis, N.A. (2014), “Reactive nitrogen species contribute to the rapid onset of redox changes induced by acute immobilization stress in rats” Stress 17(6): 520-527

Spiers, J.G., Chen, H.-J.C., Lavidis, N.A (2014), “Stress alleviating plant-derived ‘green odors’: behavioral, neurochemical and neuroendocrine perspectives in laboratory animals” Phytochemistry Reviews 14(5): 713-725

Spiers, J.G., Chen, H.-J.C., Sernia, C., Lavidis, N.A. (2014), “A combination of plant-derived odors reduces corticosterone and oxidative indicators of stress” Chem Senses 39(7): 563-569

2013

Spiers, J.G., Chen, H.J., Bradley, A.J., Anderson, S.T., Sernia, C., Lavidis, N.A. (2013), “Acute restraint stress induces rapid and prolonged changes in erythrocyte and hippocampal redox status” Psychoneuroendocrinology 38: 2511-2519