Miss Carolina Duro

Interests

Doctorate Project exploring the topic: Role of MAST3 in neurodevelopment and disease.

Project aims:

1) Generate novel mouse models that recapitulate disease-causing mutations presented in human patients;

(2) Phenotypical, behavioral, and anatomical characterization of the mouse lines;

(3) Investigation of the molecular mechanisms underlying MAST3-disease-related phenotypes and unravel the function of this protein during brain development.

Collectively, my doctorate will shed light on how MAST3 contributes to neurodevelopment and will provide comprehension of the pathophysiological mechanisms associated with MAST3 mutations, ultimately helping in understanding the genetic architecture required to build a human brain.

Research Focus

Equipment

Behavioural analysis

Cell culture

Confocal microscopy

Electroencephalography (EEG)

Electrophysiological recording techniques

Fluorescence microscopy

Immunohistochemistry

Magnetic resonance imaging (MRI)