Dr Bart Nieuwenhuis

Interests

Injury to the brain and spinal cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Gene therapy is a promising tool to promote axon regeneration. My research makes contributions to the field of gene therapy and restorative neuroscience:

1 – Gene therapy: Optimising the delivery of transgenes in the brain, spinal cord, and eyes, using adeno-associated viral vectors

2 – Laser axotomy: Identification and validation of potential axon regeneration targets in CNS neurons

3 – Axon transport: Increasing the growth machinery in the axon of CNS neurons to promote regeneration

Neuron from the brain grown in a culture dish for two weeks
Neuron from the brain grown in a culture dish for two weeks
Click image to view full-size

Research Focus

Keywords

Axonal regeneration

Axonal transport

Gene therapy

Integrins

Spinal cord injury

Clinical conditions

Spinal cord injury

Equipment

Behavioral analysis

Cell culture

Fluorescence microscopy

Immunohistochemistry

Live cell imaging

Viral expression vectors

Collaborators

Cambridge

Richard Eva

James Fawcett

Keith Martin

Andrew Osborne

United Kingdom

Melissa Andrews Web: https://www.southampton.ac.uk/biosci/...

Lawrence Moon Web: http://www.lawrencemoon.co.uk/

International

Joost Verhaagen Web: https://nin.nl/about-u...

Associated News Items


    Publications

    2018

    Nieuwenhuis B, Eva R (2018), “Linking axon transport to regeneration using in vitro laser axotomy” Neural Regen Res 13(3): 410-412 PDF

    Nieuwenhuis B, Eva R (2018), “ARF6 and Rab11 as intrinsic regulators of axon regeneration” Small GTPases PDF

    Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW (2018), “Integrins promote axonal regeneration after injury of the nervous system” Biological Reviews PDF

    2014

    Mecollari V, Nieuwenhuis B, Verhaagen J (2014), “A perspective on the role of class III semaphorin signaling in central nervous system trauma.” Front Cell Neurosci 8:328 PDF Details