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Research Focus

Keywords

  • Functional Genomics
  • Genomics
  • Human Genetics
  • Bioinformatics
  • Clinical Conditions

  • Diabetes
  • Equipment & Techniques

  • Computational modelling
  • Statistical analysis
  • Cross-sectional and cohort studies
  • Cell culture
  • Calcium imaging
  • Fluorescence microscopy
  • Confocal microscopy
  • Other
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    Dr Brian Lam

    University Position
    Senior Research Associate
    Dr Brian Lam is pleased to consider applications from prospective PhD students.

    Interests

    Human genetic variations and their central effects on energy homeostasis.

    Key Publications

    Prevalence of deleterious variants in MC3R in patients with constitutional delay of growth and puberty.

    DOI: http://doi.org/10.1210/clinem/dgad373
    Journal: J Clin Endocrinol Metab
    E-pub date: 17 Nov 2023
    Authors: K Duckett, A Williamson, JWR Kincaid, K Rainbow, LJ Corbin, HC Martin, RY Eberhardt, QQ Huang, ME Hurles, W He, R Brauner, A Delaney, L Dunkel, RP Grinspon, JE Hall, JN Hirschhorn, SR Howard, AC Latronico, AAL Jorge, K McElreavey, V Mericq, PM Merino, MR Palmert, L Plummer, RA Rey, RC Rezende, SB Seminara, K Salnikov, I Banerjee, BYH Lam, JRB Perry, NJ Timpson, P Clayton, Y-M Chan, KK Ong, S O'Rahilly

    A program of successive gene expression in mouse one-cell embryos.

    DOI: http://doi.org/10.1016/j.celrep.2023.112023
    Journal: Cell Rep
    E-pub date: 28 Feb 2023
    Authors: M Asami, BYH Lam, M Hoffmann, T Suzuki, X Lu, N Yoshida, MK Ma, K Rainbow, M Gužvić, MD VerMilyea, GSH Yeo, CA Klein, ACF Perry

    HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.

    DOI: http://doi.org/10.1038/s42255-022-00657-y
    Journal: Nat Metab
    E-pub date: 1 Oct 2022
    Authors: L Steuernagel, BYH Lam, P Klemm, GKC Dowsett, CA Bauder, JA Tadross, TS Hitschfeld, A Del Rio Martin, W Chen, AJ de Solis, H Fenselau, P Davidsen, I Cimino, SN Kohnke, D Rimmington, AP Coll, A Beyer, GSH Yeo, JC Brüning

    Human embryonic genome activation initiates at the one-cell stage.

    DOI: http://doi.org/10.1016/j.stem.2021.11.012
    Journal: Cell Stem Cell
    E-pub date: 3 Feb 2022
    Authors: M Asami, BYH Lam, MK Ma, K Rainbow, S Braun, MD VerMilyea, GSH Yeo, ACF Perry

    A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing.

    DOI: http://doi.org/10.1016/j.molmet.2021.101240
    Journal: Mol Metab
    E-pub date: 1 Nov 2021
    Authors: GKC Dowsett, BYH Lam, JA Tadross, I Cimino, D Rimmington, AP Coll, J Polex-Wolf, LB Knudsen, C Pyke, GSH Yeo

    MC3R links nutritional state to childhood growth and the timing of puberty.

    DOI: http://doi.org/10.1038/s41586-021-04088-9
    Journal: Nature
    E-pub date: 1 Nov 2021
    Authors: BYH Lam, A Williamson, S Finer, FR Day, JA Tadross, A Gonçalves Soares, K Wade, P Sweeney, MN Bedenbaugh, DT Porter, A Melvin, KLJ Ellacott, RN Lippert, S Buller, J Rosmaninho-Salgado, GKC Dowsett, KE Ridley, Z Xu, I Cimino, D Rimmington, K Rainbow, K Duckett, S Holmqvist, A Khan, X Dai, EG Bochukova, Genes & Health Research Team, RC Trembath, HC Martin, AP Coll, DH Rowitch, NJ Wareham, DA van Heel, N Timpson, RB Simerly, KK Ong, RD Cone, C Langenberg, JRB Perry, GS Yeo, S O'Rahilly

    Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.

    DOI: http://doi.org/10.1038/s41591-021-01349-y
    Journal: Nat Med
    E-pub date: 1 Jun 2021
    Authors: KH Wade, BYH Lam, A Melvin, W Pan, LJ Corbin, DA Hughes, K Rainbow, J-H Chen, K Duckett, X Liu, J Mokrosiński, A Mörseburg, S Neaves, A Williamson, C Zhang, IS Farooqi, GSH Yeo, NJ Timpson, S O'Rahilly

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

    DOI: http://doi.org/10.1007/s00125-016-4033-1
    Journal: Diabetologia
    E-pub date: 1 Oct 2016
    Authors: AE Adriaenssens, B Svendsen, BYH Lam, GSH Yeo, JJ Holst, F Reimann, FM Gribble

    Publications

    Dax1 modulates ERα-dependent hypothalamic estrogen sensing in female mice.

    DOI: http://doi.org/10.1038/s41467-023-38618-y
    Journal: Nat Commun
    E-pub date: 29 May 2023
    Authors: JM Ramos-Pittol, I Fernandes-Freitas, A Milona, SM Manchishi, K Rainbow, BYH Lam, JA Tadross, A Beucher, WH Colledge, I Cebola, KG Murphy, I Miguel-Aliaga, GSH Yeo, WS Dhillo, BM Owen

    The initiation of mammalian embryonic transcription: to begin at the beginning.

    DOI: http://doi.org/10.1016/j.tcb.2022.08.008
    Journal: Trends Cell Biol
    E-pub date: 1 May 2023
    Authors: ACF Perry, M Asami, BYH Lam, GSH Yeo

    Clearance of variant Creutzfeldt-Jakob disease prions in vivo by the Hsp70 disaggregase system.

    DOI: http://doi.org/10.1093/brain/awac144
    Journal: Brain
    E-pub date: 14 Sep 2022
    Authors: AM Thackray, B Lam, EE McNulty, AV Nalls, CK Mathiason, SS Magadi, WS Jackson, O Andréoletti, C Marrero-Winkens, H Schätzl, R Bujdoso

    Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

    DOI: http://doi.org/10.1101/2022.05.06.490598
    Journal:
    E-pub date: 1 Aug 2022
    Authors: S Wagner, D Brierley, A Leeson-Payne, W Jiang, R Chianese, B Lam, G Dowsett, C Cristiano, D Lyons, F Reimann, F Gribble, GSH Yeo, S Trapp, L Heisler

    New molecular techniques for exploring neuronal appetite pathways

    DOI: http://doi.org/10.1016/j.coemr.2021.100309
    Journal: Current Opinion in Endocrine and Metabolic Research
    E-pub date: 1 Feb 2022
    Authors: JA Tadross, BYH Lam, GSH Yeo

    The imprinted Igf2-Igf2r axis is critical for matching placental microvasculature expansion to fetal growth.

    DOI: http://doi.org/10.1016/j.devcel.2021.12.005
    Journal: Dev Cell
    E-pub date: 10 Jan 2022
    Authors: I Sandovici, A Georgopoulou, V Pérez-García, A Hufnagel, J López-Tello, BYH Lam, SN Schiefer, C Gaudreau, F Santos, K Hoelle, GSH Yeo, K Burling, M Reiterer, AL Fowden, GJ Burton, CM Branco, AN Sferruzzi-Perri, M Constância

    High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.

    DOI: http://doi.org/10.1210/endocr/bqab148
    Journal: Endocrinology
    E-pub date: 1 Oct 2021
    Authors: D Gupta, GKC Dowsett, BK Mani, K Shankar, S Osborne-Lawrence, NP Metzger, BYH Lam, GSH Yeo, JM Zigman

    SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation.

    DOI: http://doi.org/10.1038/s42255-021-00440-5
    Journal: Nat Metab
    E-pub date: 1 Sep 2021
    Authors: G Bidault, S Virtue, K Petkevicius, HE Jolin, A Dugourd, A-C Guénantin, J Leggat, B Mahler-Araujo, BYH Lam, MK Ma, M Dale, S Carobbio, A Kaser, PG Fallon, J Saez-Rodriguez, ANJ McKenzie, A Vidal-Puig

    Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.

    DOI: http://doi.org/10.1016/j.celrep.2021.109362
    Journal: Cell Rep
    E-pub date: 13 Jul 2021
    Authors: S Kohnke, S Buller, D Nuzzaci, K Ridley, B Lam, H Pivonkova, MA Bentsen, KM Alonge, C Zhao, J Tadross, S Holmqvist, T Shimizu, H Hathaway, H Li, W Macklin, MW Schwartz, WD Richardson, GSH Yeo, RJM Franklin, RT Karadottir, DH Rowitch, C Blouet

    Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.

    DOI: http://doi.org/10.1371/journal.pgen.1009069
    Journal: PLoS Genet
    E-pub date: 1 Oct 2020
    Authors: CM Hammerle, I Sandovici, GV Brierley, NM Smith, WE Zimmer, I Zvetkova, HM Prosser, Y Sekita, BYH Lam, M Ma, WN Cooper, A Vidal-Puig, SE Ozanne, G Medina-Gómez, M Constância

    Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.

    DOI: http://doi.org/10.1038/s42255-020-0214-9
    Journal: Nat Metab
    E-pub date: 1 Jun 2020
    Authors: M Vacca, J Leslie, S Virtue, BYH Lam, O Govaere, D Tiniakos, S Snow, S Davies, K Petkevicius, Z Tong, V Peirce, MJ Nielsen, Z Ament, W Li, T Kostrzewski, DJ Leeming, V Ratziu, MED Allison, QM Anstee, JL Griffin, F Oakley, A Vidal-Puig

    Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells.

    DOI: http://doi.org/10.1210/endocr/bqaa032
    Journal: Endocrinology
    E-pub date: 1 Apr 2020
    Authors: T Georgescu, D Lyons, B Doslikova, AP Garcia, O Marston, LK Burke, R Chianese, BYH Lam, GSH Yeo, JJ Rochford, AS Garfield, LK Heisler

    Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease

    DOI: http://doi.org/10.1042/BCJ20190872
    Journal: Biochemical Journal
    E-pub date: 28 Feb 2020
    Authors: A Thackray, B Lam, A Shahira Binti Ab Razak, G Yeo, R Bujdoso

    Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

    DOI: http://doi.org/10.1016/j.molmet.2019.09.001
    Journal: Mol Metab
    E-pub date: 1 Nov 2019
    Authors: LJ Billing, P Larraufie, J Lewis, A Leiter, J Li, B Lam, GS Yeo, DA Goldspink, RG Kay, FM Gribble, F Reimann

    Nutritional signals rapidly activate oligodendrocyte differentiation in the adult hypothalamic median eminence

    DOI: http://doi.org/10.1101/751198
    Journal:
    E-pub date: 1 Aug 2019
    Authors: S Kohnke, B Lam, S Buller, C Zhao, D Nuzzaci, J Tadross, S Holmqvist, K Ridley, H Hathaway, W Macklin, GSH Yeo, RJM Franklin, D Rowitch, C Blouet

    Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.

    DOI: http://doi.org/10.7554/eLife.45282
    Journal: Elife
    E-pub date: 26 Jun 2019
    Authors: J López-Tello, V Pérez-García, J Khaira, LC Kusinski, WN Cooper, A Andreani, I Grant, E Fernández de Liger, BY Lam, M Hemberger, I Sandovici, M Constancia, AN Sferruzzi-Perri

    Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

    DOI: http://doi.org/10.2337/db18-0883
    Journal: Diabetes
    E-pub date: 1 May 2019
    Authors: GP Roberts, P Larraufie, P Richards, RG Kay, SG Galvin, EL Miedzybrodzka, A Leiter, HJ Li, LL Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, RH Hardwick, F Reimann, FM Gribble

    Discovering maximal motif cliques in large heterogeneous information networks

    DOI: http://doi.org/10.1109/ICDE.2019.00072
    Journal: Proceedings - International Conference on Data Engineering
    E-pub date: 1 Apr 2019
    Authors: J Hu, R Cheng, KCC Chang, A Sankar, Y Fang, BYH Lam

    Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

    DOI: http://doi.org/10.1101/374579
    Journal:
    E-pub date: 1 Aug 2018
    Authors: G Roberts, P Larraufie, P Richards, R Kay, S Galvin, E Miedzybrodzka, A Leiter, H Joyce Li, L Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, R Hardwick, F Reimann, F Gribble

    Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

    DOI: http://doi.org/10.1172/JCI97007
    Journal: J Clin Invest
    E-pub date: 1 Mar 2018
    Authors: J Polex-Wolf, BY Lam, R Larder, J Tadross, D Rimmington, F Bosch, VJ Cenzano, E Ayuso, MK Ma, K Rainbow, AP Coll, S O'Rahilly, GS Yeo

    Selective rab11 transport and the intrinsic regenerative ability of CNS axons.

    DOI: http://doi.org/10.7554/eLife.26956
    Journal: Elife
    E-pub date: 8 Aug 2017
    Authors: H Koseki, M Donegá, BY Lam, V Petrova, S van Erp, GS Yeo, JC Kwok, C Ffrench-Constant, R Eva, JW Fawcett

    Genetically improved BarraCUDA.

    DOI: http://doi.org/10.1186/s13040-017-0149-1
    Journal: BioData Min
    E-pub date: 1 Aug 2017
    Authors: WB Langdon, BYH Lam

    Genetic improvement of GPU software

    DOI: http://doi.org/10.1007/s10710-016-9273-9
    Journal: Genetic Programming and Evolvable Machines
    E-pub date: 1 Mar 2017
    Authors: WB Langdon, BYH Lam, M Modat, J Petke, M Harman

    Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity.

    DOI: http://doi.org/10.1016/j.cell.2015.12.025
    Journal: Cell
    E-pub date: 28 Jan 2016
    Authors: K Dalgaard, K Landgraf, S Heyne, A Lempradl, J Longinotto, K Gossens, M Ruf, M Orthofer, R Strogantsev, M Selvaraj, TT-H Lu, E Casas, R Teperino, MA Surani, I Zvetkova, D Rimmington, YCL Tung, B Lam, R Larder, GSH Yeo, S O'Rahilly, T Vavouri, E Whitelaw, JM Penninger, T Jenuwein, C-L Cheung, AC Ferguson-Smith, AP Coll, A Körner, JA Pospisilik

    A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

    DOI: http://doi.org/10.1210/en.2015-1301
    Journal: Endocrinology
    E-pub date: 1 Nov 2015
    Authors: A Adriaenssens, BYH Lam, L Billing, K Skeffington, S Sewing, F Reimann, F Gribble

    Microarray, qPCR, and KCNJ5 sequencing of aldosterone-producing adenomas reveal differences in genotype and phenotype between zona glomerulosa- and zona fasciculata-like tumors.

    DOI: http://doi.org/10.1210/jc.2011-2965
    Journal: J Clin Endocrinol Metab
    E-pub date: 1 May 2012
    Authors: EAB Azizan, BYH Lam, SJ Newhouse, J Zhou, RE Kuc, J Clarke, L Happerfield, A Marker, GJ Hoffman, MJ Brown

    BarraCUDA – a fast short read sequence aligner using graphics processing units.

    DOI: http://doi.org/10.1186/1756-0500-5-27
    Journal: BMC Res Notes
    E-pub date: 13 Jan 2012
    Authors: P Klus, S Lam, D Lyberg, MS Cheung, G Pullan, I McFarlane, GS Yeo, BY Lam

    Transcriptome analysis of embryonic and adult sensory axons reveals changes in mRNA repertoire localization.

    DOI: http://doi.org/10.1261/rna.2386111
    Journal: RNA
    E-pub date: 1 Jan 2011
    Authors: LF Gumy, GSH Yeo, Y-CL Tung, KH Zivraj, D Willis, G Coppola, BYH Lam, JL Twiss, CE Holt, JW Fawcett

    Identification of the global transcriptomic response of the hypothalamic arcuate nucleus to fasting and leptin.

    DOI: http://doi.org/10.1111/j.1365-2826.2010.02026.x
    Journal: J Neuroendocrinol
    E-pub date: 31 Aug 2010
    Authors: Z Jovanovic, YCL Tung, BYH Lam, S O'Rahilly, GSH Yeo

    CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.

    DOI: http://doi.org/10.1111/j.1471-4159.2009.06521.x
    Journal: J Neurochem
    E-pub date: 1 Feb 2010
    Authors: BYH Lam, W Zhang, DC-H Ng, M Maruthappu, HL Roderick, S Chawla

    Inverse regulation of plasticity-related immediate early genes by calcineurin in hippocampal neurons.

    DOI: http://doi.org/10.1074/jbc.M901121200
    Journal: J Biol Chem
    E-pub date: 1 May 2009
    Authors: BYH Lam, W Zhang, N Enticknap, E Haggis, MZ Cader, S Chawla

    Artificial neural networks and decision tree model analysis of liver cancer proteomes.

    DOI: http://doi.org/10.1016/j.bbrc.2007.06.172
    Journal: Biochem Biophys Res Commun
    E-pub date: 14 Sep 2007
    Authors: JM Luk, BY Lam, NPY Lee, DW Ho, PC Sham, L Chen, J Peng, X Leng, PJ Day, S-T Fan