Dr Benjamin Falcon
Filamentous protein assemblies in the brain characterize a large number of neurodegenerative diseases, the accumulation and spread of which is believed to underlie nerve cell degeneration. My research focuses on using electron cryo-microscopy (cryo-EM) and helical reconstruction to investigate how the structures of filamentous proteins obtained directly from human brain relate to disease. In addition, I use cellular and in vitro models to study the mechanisms of amplification and spread of filamentous tau protein, a major hallmark of Alzheimer's disease.
Electron cryo-microscopy (cryo-EM)
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