Dr Benjamin Phillips

Interests

My main research interests are the neuropharmacological and computational mechanisms that support motivation and reinforcement learning and how these systems are disrupted in neuropsychiatric and neurodegenerative diseases.

Research Focus

Keywords

Reinforcement

Motivation

Neuropharmacology

Touchscreen

Clinical conditions

Cognitive impairment

Dementia

Depressive disorders

Eating disorders

Huntington's disease

Obsessive compulsive disorder

Parkinson's disease

Schizophrenia

Equipment

Behavioural analysis

Computational modelling

Collaborators

Cambridge

Johan Alsiƶ

Timothy Bussey

Mona El-Sayed Hervig

Audrey Hay

Eosu Kim

Laura Lopez-Cruz

Claire O'Callaghan

Ole Paulsen

Trevor Robbins

Sujeong Yang

United Kingdom

John Apergis-Schoute Web: https://www2.le.ac.uk/departm...

Christopher Heath Web: http://www.open.ac.uk/people/...

Jemeen Sreedharan Web: https://kclpure.kcl.ac.uk/portal/...

International

Lisa Saksida Web: http://www.tcnlab.uwo.ca/people/...

Associated News Items


    Key publications

    Phillips BU, Dewan S, Nilsson SRO, Robbins TW, Heath CJ, Saksida LM, Bussey TJ, Alsiƶ J. (in press), “Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.” Psychopharmacology (Berl). Apr 22.

    White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S, Massenzio F, Lin Z, Andrews S, Segonds-Pichon A, Metterville J, Saksida LM, Mead R, Ribchester RR, Barhomi Y, Serre T, Coleman MP, Fallon J, Bussey TJ, Brown RH Jr, Sreedharan J. (2018), “TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.” Nat Neurosci. Apr;21(4):552-563.

    Publications

    2018

    Phillips BU, Lopez-Cruz L, Hailwood J, Saksida LM, Bussey TJ, Heath CJ. (2018), “Translational approaches to evaluating motivation in laboratory rodents: conventional and touchscreen-based procedures” Curr Opin Behav Neurosci 22:21-27

    2017

    Aitta-Aho T, Phillips BU, Pappa E, Hay YA, Harnischfeger F, Heath CJ, Saksida LM, Bussey TJ, Apergis-Schoute J. (2017), “Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling.” eNeuro. May 9;4(2). pii: ENEURO.0328-16.2017.

    Kim EW, Phillips BU, Heath CJ, Cho SY, Kim H, Sreedharan J, Song HT, Lee JE, Bussey TJ, Kim CH, Kim E, Saksida LM. (2017), “Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens.” Mol Brain. Jul 17;10(1):31.

    Phillips BU, Heath CJ, Ossowska Z, Bussey TJ, Saksida LM. (2017), “Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength. ” Learn Behav. Sep;45(3):252-262.

    2016

    Heath CJ, Phillips BU, Bussey TJ, Saksida LM. (2016), “Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System.” Curr Protoc Neurosci. Jan 4;74:8.34.1-20.