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  • Neuroscience
  • Research Focus

    Keywords

  • Parkinson's Disease
  • Huntington's Disease
  • Human Stem Cells
  • Clinical Conditions

  • Parkinson's disease
  • Huntington's disease
  • Equipment & Techniques

  • Cell culture
  • Cross-sectional and cohort studies
  • Immunohistochemistry
  • Neuropsychological testing
  • Behavioural analysis
  • Randomised control trials
  • Science Culture

  • Industry Engagement
  • Open Access
  • Mentorship
  • Public Outreach
  • Teaching
  • Equality, Diversity, Inclusion and Wellbeing
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    Professor Roger Barker

    (he/him/his)
    University Position
    Professor
    Professor Roger Barker is pleased to consider applications from prospective PhD students.

    Interests

    I work on: Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers. Examining the value of different biomarkers to assess disease onset and progression. Evaluating and developing novel therapies for these conditions including ATMPs and especially stem cell therapies for Parkinson's Disease.. Studying the cell biology of neurodegenerative disorders.

    Key Publications

    SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.

    DOI: http://doi.org/10.3389/fncel.2023.1158388
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2023
    Authors: SV Fazal, C Mutschler, CZ Chen, M Turmaine, C-Y Chen, Y-P Hsueh, A Ibañez-Grau, A Loreto, A Casillas-Bajo, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanchez, P Arthur-Farraj

    B lymphocyte responses in Parkinson’s disease and their possible significance in disease progression.

    DOI: http://doi.org/10.1093/braincomms/fcad060
    Journal: Brain Commun
    E-pub date: 1 Aug 2023
    Authors: KM Scott, YT Chong, S Park, RS Wijeyekoon, S Hayat, RJ Mathews, Z Fitzpatrick, P Tyers, G Wright, J Whitby, RA Barker, MT Hu, CH Williams-Gray, MR Clatworthy

    Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.bbi.2020.01.018
    Journal: Brain Behav Immun
    E-pub date: 1 Jul 2020
    Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, W-L Kuan, JR Evans, DP Breen, G Cummins, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

    Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-322857
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, J Evans, DP Breen, RA Barker, CH Williams-Gray

    Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28015
    Journal: Mov Disord
    E-pub date: 1 Jun 2020
    Authors: RS Wijeyekoon, SF Moore, K Farrell, DP Breen, RA Barker, CH Williams-Gray

    Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.

    DOI: http://doi.org/10.1136/jnnp-2019-322702
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2020
    Authors: J O'Brien, JP Taylor, C Ballard, RA Barker, C Bradley, A Burns, D Collerton, S Dave, R Dudley, P Francis, A Gibbons, K Harris, V Lawrence, I Leroi, I McKeith, M Michaelides, C Naik, C O'Callaghan, K Olsen, M Onofrj, R Pinto, G Russell, P Swann, A Thomas, P Urwyler, RS Weil, D Ffytche

    Monocyte Function in Parkinson’s Disease and the Impact of Autologous Serum on Phagocytosis.

    DOI: http://doi.org/10.3389/fneur.2018.00870
    Journal: Front Neurol
    E-pub date: 1 Aug 2018
    Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

    The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson’s Disease.

    DOI: http://doi.org/10.3389/fneur.2018.00946
    Journal: Front Neurol
    E-pub date: 1 Aug 2018
    Authors: AJ White, RS Wijeyekoon, KM Scott, NP Gunawardana, S Hayat, IH Solim, HT McMahon, RA Barker, CH Williams-Gray

    Abnormalities of age-related T cell senescence in Parkinson’s disease.

    DOI: http://doi.org/10.1186/s12974-018-1206-5
    Journal: J Neuroinflammation
    E-pub date: 28 May 2018
    Authors: CH Williams-Gray, RS Wijeyekoon, KM Scott, S Hayat, RA Barker, JL Jones

    Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD).

    DOI: http://doi.org/10.1002/mds.26563
    Journal: Mov Disord
    E-pub date: 1 Jul 2016
    Authors: CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker, ICICLE-PD study group

    Development and external validation of a prognostic model in newly diagnosed Parkinson disease.

    DOI: http://doi.org/10.1212/WNL.0000000000002437
    Journal: Neurology
    E-pub date: 15 Mar 2016
    Authors: DC Velseboer, RMA de Bie, L Wieske, JR Evans, SL Mason, T Foltynie, B Schmand, RJ de Haan, B Post, RA Barker, CH Williams-Gray

    The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort.

    DOI: http://doi.org/10.1136/jnnp-2013-305277
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Nov 2013
    Authors: CH Williams-Gray, SL Mason, JR Evans, T Foltynie, C Brayne, TW Robbins, RA Barker

    Association of the human leucocyte antigen region with susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp.2008.162883
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2010
    Authors: M Saiki, A Baker, CH Williams-Gray, T Foltynie, RS Goodman, CJ Taylor, DAS Compston, RA Barker, SJ Sawcer, A Goris

    The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort.

    DOI: http://doi.org/10.1093/brain/awp245
    Journal: Brain
    E-pub date: 1 Nov 2009
    Authors: CH Williams-Gray, JR Evans, A Goris, T Foltynie, M Ban, TW Robbins, C Brayne, BS Kolachana, DR Weinberger, SJ Sawcer, RA Barker

    Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-009-0119-8
    Journal: J Neurol
    E-pub date: 1 Mar 2009
    Authors: CH Williams-Gray, A Goris, M Saiki, T Foltynie, DAS Compston, SJ Sawcer, RA Barker

    Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson’s disease.

    DOI: http://doi.org/10.1002/ana.21192
    Journal: Ann Neurol
    E-pub date: 31 Aug 2007
    Authors: A Goris, CH Williams-Gray, GR Clark, T Foltynie, SJG Lewis, J Brown, M Ban, MG Spillantini, A Compston, DJ Burn, PF Chinnery, RA Barker, SJ Sawcer

    Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort.

    DOI: http://doi.org/10.1093/brain/awm111
    Journal: Brain
    E-pub date: 1 Jul 2007
    Authors: CH Williams-Gray, T Foltynie, CEG Brayne, TW Robbins, RA Barker

    Publications

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project.

    DOI: http://doi.org/10.1371/journal.pone.0292180
    Journal: PLoS One
    E-pub date: 1 Aug 2023
    Authors: E-J Vollstedt, H Madoev, A Aasly, A Ahmad-Annuar, B Al-Mubarak, RN Alcalay, V Alvarez, I Amorin, G Annesi, D Arkadir, S Bardien, RA Barker, M Barkhuizen, AN Basak, V Bonifati, A Boon, L Brighina, K Brockmann, A Carmine Belin, J Carr, J Clarimon, M Cornejo-Olivas, L Correia Guedes, J-C Corvol, D Crosiers, J Damásio, P Das, P de Carvalho Aguiar, A De Rosa, J Dorszewska, S Ertan, R Ferese, J Ferreira, E Gatto, G Genç, N Giladi, P Gómez-Garre, H Hanagasi, N Hattori, F Hentati, D Hoffman-Zacharska, SN Illarioshkin, J Jankovic, S Jesús, V Kaasinen, A Kievit, P Klivenyi, V Kostic, D Koziorowski, AA Kühn, AE Lang, S-Y Lim, C-H Lin, K Lohmann, V Markovic, MH Martikainen, G Mellick, M Merello, L Milanowski, P Mir, Ö Öztop-Çakmak, MMG Pimentel, T Pulkes, A Puschmann, E Rogaeva, EM Sammler, M Skaalum Petersen, M Skorvanek, M Spitz, O Suchowersky, AH Tan, P Termsarasab, A Thaler, V Tumas, EM Valente, B van de Warrenburg, CH Williams-Gray, R-M Wu, B Zhang, A Zimprich, J Solle, S Padmanabhan, C Klein

    Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.

    DOI: http://doi.org/10.1111/bpa.13128
    Journal: Brain Pathol
    E-pub date: 1 May 2023
    Authors: W-L Kuan, M Alfaidi, CB Horne, B Vallin, S Fox, SV Fazal, CH Williams-Gray, RA Barker

    Mitochondrial haplogroups and cognitive progression in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awac327
    Journal: Brain
    E-pub date: 5 Jan 2023
    Authors: G Liu, C Ni, J Zhan, W Li, J Luo, Z Liao, JJ Locascio, W Xian, L Chen, Z Pei, J-C Corvol, J Maple-Grødem, MC Campbell, A Elbaz, S Lesage, A Brice, AY Hung, MA Schwarzschild, MT Hayes, A-M Wills, B Ravina, I Shoulson, P Taba, S Kõks, TG Beach, F Cormier-Dequaire, G Alves, O-B Tysnes, JS Perlmutter, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

    Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

    DOI: http://doi.org/10.1002/mds.29072
    Journal: Mov Disord
    E-pub date: 31 Aug 2022
    Authors: R Ye, C O'Callaghan, C Rua, FH Hezemans, N Holland, M Malpetti, PS Jones, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, J Rowe

    Genome-wide determinants of mortality and motor progression in Parkinson’s disease

    DOI: http://doi.org/10.1101/2022.07.07.22277297
    Journal:
    E-pub date: 10 Jul 2022
    Authors: MMX Tan, MA Lawton, MI Pollard, E Brown, R Real, A Martinez Carrasco, S Bekadar, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, L Hubbard, N Malek, KA Grosset, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, OA Andreassen, M Toft, A Elbaz, F Artaud, A Brice, J-C Corvol, J Aasly, MJ Farrer, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, J Hardy, MTM Hu, DG Grosset, M Shoai, L Pihlstrøm, HR Morris

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

    DOI: http://doi.org/10.1371/journal.pcbi.1010079
    Journal: PLoS Comput Biol
    E-pub date: 1 May 2022
    Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia.

    DOI: http://doi.org/10.1002/mdc3.13451
    Journal: Mov Disord Clin Pract
    E-pub date: 1 May 2022
    Authors: JA Boel, RMA de Bie, BA Schmand, JC Dalrymple-Alford, C Marras, CH Adler, JG Goldman, AI Tröster, DJ Burn, I Litvan, GJ Geurtsen, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort.

    DOI: http://doi.org/10.3233/JPD-212581
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2021
    Authors: RA Lawson, CH Williams-Gray, M Camacho, GW Duncan, TK Khoo, DP Breen, RA Barker, L Rochester, DJ Burn, AJ Yarnall, ICICLE-PD study group

    The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features.

    DOI: http://doi.org/10.3389/fnagi.2021.685594
    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2021
    Authors: WJ Griffiths, J Abdel-Khalik, SF Moore, RS Wijeyekoon, PJ Crick, E Yutuc, K Farrell, DP Breen, CH Williams-Gray, S Theofilopoulos, E Arenas, M Trupp, RA Barker, Y Wang

    Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

    DOI: http://doi.org/10.1101/2021.04.19.21255762
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Early constipation predicts faster dementia onset in Parkinson’s disease.

    DOI: http://doi.org/10.1038/s41531-021-00191-w
    Journal: NPJ Parkinsons Dis
    E-pub date: 26 May 2021
    Authors: M Camacho, AD Macleod, J Maple-Grødem, JR Evans, DP Breen, G Cummins, RS Wijeyekoon, JC Greenland, G Alves, OB Tysnes, RA Lawson, RA Barker, CH Williams-Gray

    Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28342
    Journal: Mov Disord
    E-pub date: 1 Feb 2021
    Authors: MMX Tan, MA Lawton, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, MI Pollard, L Hubbard, N Malek, KA Grosset, SL Marrinan, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, J Hardy, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, MTM Hu, DG Grosset, M Shoai, HR Morris

    Differences in the Presentation and Progression of Parkinson’s Disease by Sex.

    DOI: http://doi.org/10.1002/mds.28312
    Journal: Mov Disord
    E-pub date: 1 Jan 2021
    Authors: H Iwaki, C Blauwendraat, HL Leonard, MB Makarious, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, SJ Hutten, M Frasier, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, RJ Gibbs, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, OA Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Parkinson’s disease and spirituality.

    DOI: http://doi.org/10.3233/NRE-192947
    Journal: NeuroRehabilitation
    E-pub date: 1 Aug 2020
    Authors: C Redfern, SL Mason, RA Barker, A Coles

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.09.03.20176800
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study.

    DOI: http://doi.org/10.3233/JPD-191724
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2020
    Authors: C Martin-Ruiz, CH Williams-Gray, AJ Yarnall, JJ Boucher, RA Lawson, RS Wijeyekoon, RA Barker, C Kolenda, C Parker, DJ Burn, T Von Zglinicki, G Saretzki

    Genome-wide association studies of cognitive and motor progression in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.05.07.20084343
    Journal:
    E-pub date: 1 Aug 2020
    Authors: MMX Tan, M Lawton, E Jabbari, R Reynolds, H Iwaki, C Blauwendraat, S Kanavou, M Pollard, L Hubbard, N Malek, K Grosset, S Marrinan, N Bajaj, R Barker, D Burn, C Bresner, T Foltynie, N Wood, C Williams-Gray, J Hardy, M Nalls, A Singleton, N Williams, Y Ben-Shlomo, MTM Hu, D Grosset, M Shoai, H Morris

    Differences in the presentation and progression of Parkinson’s disease by sex

    DOI: http://doi.org/10.1101/2020.04.08.20058370
    Journal:
    E-pub date: 1 Aug 2020
    Authors: H Iwaki, C Blauwendraat, H Leonard, M Makarious, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, S Hutten, M Frasier, K-D Nguyen, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

    Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.parkreldis.2020.05.034
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Jul 2020
    Authors: N Ramsay, AD Macleod, G Alves, M Camacho, L Forsgren, RA Lawson, J Maple-Grødem, O-B Tysnes, CH Williams-Gray, AJ Yarnall, CE Counsell, Parkinson's Incidence Cohorts Collaboration, PINE Study, CamPaIGN study, PICNICS study, NYPUM Study, ParkWest Study: ParkWest Principal investigators, Study personnel, ICICLE-PD Study

    A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2019-322210
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2020
    Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, RA Barker, CH Williams-Gray

    Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?

    DOI: http://doi.org/10.1212/WNL.0000000000009107
    Journal: Neurology
    E-pub date: 17 Mar 2020
    Authors: AJ Espay, LV Kalia, Z Gan-Or, CH Williams-Gray, PL Bedard, SM Rowe, F Morgante, A Fasano, B Stecher, MA Kauffman, MJ Farrer, CS Coffey, MA Schwarzschild, T Sherer, RB Postuma, AP Strafella, AB Singleton, RA Barker, K Kieburtz, CW Olanow, A Lozano, JH Kordower, JM Cedarbaum, P Brundin, DG Standaert, AE Lang

    Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson’s Disease Cohort (ICICLE-PD).

    DOI: http://doi.org/10.3390/brainsci10020078
    Journal: Brain Sci
    E-pub date: 2 Feb 2020
    Authors: JK Dlay, GW Duncan, TK Khoo, CH Williams-Gray, DP Breen, RA Barker, DJ Burn, RA Lawson, AJ Yarnall

    DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

    DOI: http://doi.org/10.1016/j.nbd.2019.104629
    Journal: Neurobiol Dis
    E-pub date: 1 Feb 2020
    Authors: K Solti, W-L Kuan, B Fórizs, G Kustos, J Mihály, Z Varga, B Herberth, É Moravcsik, R Kiss, M Kárpáti, A Mikes, Y Zhao, T Imre, J-C Rochet, F Aigbirhio, CH Williams-Gray, RA Barker, G Tóth

    Motor complications in Parkinson’s disease: 13-year follow-up of the CamPaIGN cohort.

    DOI: http://doi.org/10.1002/mds.27882
    Journal: Mov Disord
    E-pub date: 1 Jan 2020
    Authors: H-J Kim, S Mason, T Foltynie, S Winder-Rhodes, RA Barker, CH Williams-Gray

    Genomewide association study of Parkinson’s disease clinical biomarkers in 12 longitudinal patients’ cohorts.

    DOI: http://doi.org/10.1002/mds.27845
    Journal: Mov Disord
    E-pub date: 1 Dec 2019
    Authors: H Iwaki, C Blauwendraat, HL Leonard, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, JR Gibbs, International Parkinson's Disease Genomics Consortium, KN Chitrala, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, O Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

    DOI: http://doi.org/10.1212/NXG.0000000000000348
    Journal: Neurol Genet
    E-pub date: 31 Aug 2019
    Authors: H Iwaki, C Blauwendraat, HL Leonard, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

    Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

    DOI: http://doi.org/10.1101/585836
    Journal:
    E-pub date: 1 Aug 2019
    Authors: H Iwaki, C Blauwendraat, H Leonard, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, S Hutten, N Khanh-Dung, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, KN Chitrala, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

    Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.nbd.2018.11.002
    Journal: Neurobiol Dis
    E-pub date: 1 Apr 2019
    Authors: J Lamontagne-Proulx, I St-Amour, R Labib, J Pilon, HL Denis, N Cloutier, F Roux-Dalvai, AT Vincent, SL Mason, C Williams-Gray, A-C Duchez, A Droit, S Lacroix, N Dupré, M Langlois, S Chouinard, M Panisset, RA Barker, E Boilard, F Cicchetti

    The clinical heterogeneity of Parkinson’s disease and its therapeutic implications.

    DOI: http://doi.org/10.1111/ejn.14094
    Journal: Eur J Neurosci
    E-pub date: 1 Feb 2019
    Authors: JC Greenland, CH Williams-Gray, RA Barker

    The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series.

    DOI: http://doi.org/10.1007/s00415-018-8908-6
    Journal: J Neurol
    E-pub date: 31 Aug 2018
    Authors: LM Collins, CH Williams-Gray, E Morris, P Deegan, TM Cox, RA Barker

    An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease.

    DOI: http://doi.org/10.1007/s00415-017-8647-0
    Journal: J Neurol
    E-pub date: 1 Dec 2017
    Authors: BR Underwood, ZW Green-Thompson, PJ Pugh, SE Lazic, SL Mason, J Griffin, PS Jones, JB Rowe, DC Rubinsztein, RA Barker

    Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awx285
    Journal: Brain
    E-pub date: 1 Dec 2017
    Authors: LA Robak, IE Jansen, J van Rooij, AG Uitterlinden, R Kraaij, J Jankovic, International Parkinson’s Disease Genomics Consortium (IPDGC), P Heutink, JM Shulman

    Associations between Lifestyle Factors and Parkinson’s Disease in an Urban Sri Lankan Clinic Study.

    DOI: http://doi.org/10.3823/2516
    Journal: Int Arch Med
    E-pub date: 15 Sep 2017
    Authors: R Wijeyekoon, V Suriyakumara, R Gamage, T Fernando, A Jayasuriya, D Amarasinghe, H Gunasekara, D Sirisena, D Amaratunga, C Muthukuda, RA Barker, C Williams-Gray, R De Silva

    Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2016-315099
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2017
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

    Parkinson disease: Defining PD subtypes – a step toward personalized management?

    DOI: http://doi.org/10.1038/nrneurol.2017.98
    Journal: Nat Rev Neurol
    E-pub date: 31 Aug 2017
    Authors: CH Williams-Gray, RA Barker

    Prediction of cognition in Parkinson’s disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

    DOI: http://doi.org/10.1016/S1474-4422(17)30122-9
    Journal: Lancet Neurol
    E-pub date: 31 Aug 2017
    Authors: G Liu, JJ Locascio, J-C Corvol, B Boot, Z Liao, K Page, D Franco, K Burke, IE Jansen, A Trisini-Lipsanopoulos, S Winder-Rhodes, CM Tanner, AE Lang, S Eberly, A Elbaz, A Brice, G Mangone, B Ravina, I Shoulson, F Cormier-Dequaire, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, J Marinus, CR Scherzer, HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, PDBP

    Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

    DOI: http://doi.org/10.1001/jamaneurol.2017.0469
    Journal: JAMA Neurol
    E-pub date: 1 Jul 2017
    Authors: A Witoelar, IE Jansen, Y Wang, RS Desikan, JR Gibbs, C Blauwendraat, WK Thompson, DG Hernandez, S Djurovic, AJ Schork, F Bettella, D Ellinghaus, A Franke, BA Lie, LK McEvoy, TH Karlsen, S Lesage, HR Morris, A Brice, NW Wood, P Heutink, J Hardy, AB Singleton, AM Dale, T Gasser, OA Andreassen, M Sharma, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators

    No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs.

    DOI: http://doi.org/10.1007/s12402-017-0219-8
    Journal: Atten Defic Hyperact Disord
    E-pub date: 1 Jun 2017
    Authors: JM Geissler, International Parkinson Disease Genomics Consortium members, M Romanos, M Gerlach, D Berg, C Schulte

    Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing.

    DOI: http://doi.org/10.1186/s13059-017-1147-9
    Journal: Genome Biol
    E-pub date: 30 Jan 2017
    Authors: IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, SJ Lubbe, V Drouet, S Lesage, E Majounie, JR Gibbs, MA Nalls, M Ryten, JA Botia, J Vandrovcova, J Simon-Sanchez, M Castillo-Lizardo, P Rizzu, C Blauwendraat, AK Chouhan, Y Li, P Yogi, N Amin, CM van Duijn, International Parkinson’s Disease Genetics Consortium (IPGDC), HR Morris, A Brice, AB Singleton, DC David, EA Nollen, S Jain, JM Shulman, P Heutink

    Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2016.09.001
    Journal: Neurobiol Aging
    E-pub date: 1 Dec 2016
    Authors: T Rittman, M Rubinov, PE Vértes, AX Patel, CE Ginestet, BCP Ghosh, RA Barker, MG Spillantini, ET Bullmore, JB Rowe

    α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

    DOI: http://doi.org/10.1016/j.expneurol.2016.09.003
    Journal: Exp Neurol
    E-pub date: 1 Nov 2016
    Authors: W-L Kuan, N Bennett, X He, JN Skepper, N Martynyuk, R Wijeyekoon, PV Moghe, CH Williams-Gray, RA Barker

    Specifically neuropathic Gaucher’s mutations accelerate cognitive decline in Parkinson’s.

    DOI: http://doi.org/10.1002/ana.24781
    Journal: Ann Neurol
    E-pub date: 1 Nov 2016
    Authors: G Liu, B Boot, JJ Locascio, IE Jansen, S Winder-Rhodes, S Eberly, A Elbaz, A Brice, B Ravina, JJ van Hilten, F Cormier-Dequaire, J-C Corvol, RA Barker, P Heutink, J Marinus, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

    Comparative epidemiology of incident Parkinson’s disease in Cambridgeshire, UK.

    DOI: http://doi.org/10.1136/jnnp-2015-312581
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Sep 2016
    Authors: JR Evans, G Cummins, DP Breen, T Foltynie, SL Mason, CEG Brayne, CH Williams-Gray, RA Barker

    Atomoxetine restores the response inhibition network in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/aww138
    Journal: Brain
    E-pub date: 31 Aug 2016
    Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.26592
    Journal: Mov Disord
    E-pub date: 1 Jul 2016
    Authors: DP Breen, C Nombela, R Vuono, PS Jones, K Fisher, DJ Burn, DJ Brooks, AB Reddy, JB Rowe, RA Barker

    Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention.

    DOI: http://doi.org/10.1016/j.parkreldis.2016.04.009
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Jun 2016
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, D Collerton, J-P Taylor, DJ Burn, ICICLE-PD study group

    Deletions at 22q11.2 in idiopathic Parkinson’s disease: a combined analysis of genome-wide association data.

    DOI: http://doi.org/10.1016/S1474-4422(16)00071-5
    Journal: Lancet Neurol
    E-pub date: 1 May 2016
    Authors: KY Mok, U Sheerin, J Simón-Sánchez, A Salaka, L Chester, V Escott-Price, K Mantripragada, KM Doherty, AJ Noyce, NE Mencacci, SJ Lubbe, International Parkinson's Disease Genomics Consortium (IPDGC), CH Williams-Gray, RA Barker, KD van Dijk, HW Berendse, P Heutink, J-C Corvol, F Cormier, S Lesage, A Brice, K Brockmann, C Schulte, T Gasser, T Foltynie, P Limousin, KE Morrison, CE Clarke, S Sawcer, TT Warner, AJ Lees, HR Morris, MA Nalls, AB Singleton, J Hardy, AY Abramov, V Plagnol, NM Williams, NW Wood

    The role of executive processes in working memory deficits in Parkinson’s Disease

    DOI: http://doi.org/10.1515/ppb-2016-0013
    Journal: Polish Psychological Bulletin
    E-pub date: 1 Apr 2016
    Authors: A Gruszka, D Bor, RR Barker, E Necka, AM Owen

    Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

    DOI: http://doi.org/10.1016/j.ajhg.2016.01.014
    Journal: Am J Hum Genet
    E-pub date: 3 Mar 2016
    Authors: S Lesage, V Drouet, E Majounie, V Deramecourt, M Jacoupy, A Nicolas, F Cormier-Dequaire, SM Hassoun, C Pujol, S Ciura, Z Erpapazoglou, T Usenko, C-A Maurage, M Sahbatou, S Liebau, J Ding, B Bilgic, M Emre, N Erginel-Unaltuna, G Guven, F Tison, C Tranchant, M Vidailhet, J-C Corvol, P Krack, A-L Leutenegger, MA Nalls, DG Hernandez, P Heutink, JR Gibbs, J Hardy, NW Wood, T Gasser, A Durr, J-F Deleuze, M Tazir, A Destée, E Lohmann, E Kabashi, A Singleton, O Corti, A Brice, French Parkinson's Disease Genetics Study (PDG), International Parkinson's Disease Genomics Consortium (IPDGC)

    Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

    DOI: http://doi.org/10.1002/hbm.23087
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2016
    Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Review: The spectrum of clinical features seen with alpha synuclein pathology.

    DOI: http://doi.org/10.1111/nan.12303
    Journal: Neuropathol Appl Neurobiol
    E-pub date: 1 Feb 2016
    Authors: RA Barker, CH Williams-Gray

    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

    DOI: http://doi.org/10.1038/mp.2014.107
    Journal: Mol Psychiatry
    E-pub date: 1 May 2015
    Authors: Coffee and Caffeine Genetics Consortium, MC Cornelis, EM Byrne, T Esko, MA Nalls, A Ganna, N Paynter, KL Monda, N Amin, K Fischer, F Renstrom, JS Ngwa, V Huikari, A Cavadino, IM Nolte, A Teumer, K Yu, P Marques-Vidal, R Rawal, A Manichaikul, MK Wojczynski, JM Vink, JH Zhao, G Burlutsky, J Lahti, V Mikkilä, RN Lemaitre, J Eriksson, SK Musani, T Tanaka, F Geller, J Luan, J Hui, R Mägi, M Dimitriou, ME Garcia, W-K Ho, MJ Wright, LM Rose, PK Magnusson, NL Pedersen, D Couper, BA Oostra, A Hofman, MA Ikram, HW Tiemeier, AG Uitterlinden, FJ van Rooij, I Barroso, I Johansson, L Xue, M Kaakinen, L Milani, C Power, H Snieder, RP Stolk, SE Baumeister, R Biffar, F Gu, F Bastardot, Z Kutalik, DR Jacobs, NG Forouhi, E Mihailov, L Lind, C Lindgren, K Michaëlsson, A Morris, M Jensen, K-T Khaw, RN Luben, JJ Wang, S Männistö, M-M Perälä, M Kähönen, T Lehtimäki, J Viikari, D Mozaffarian, K Mukamal, BM Psaty, A Döring, AC Heath, GW Montgomery, N Dahmen, T Carithers, KL Tucker, L Ferrucci, HA Boyd, M Melbye, JL Treur, D Mellström, JJ Hottenga, I Prokopenko, A Tönjes, P Deloukas, S Kanoni, M Lorentzon, DK Houston, Y Liu, J Danesh, A Rasheed, MA Mason, AB Zonderman, L Franke, BS Kristal, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), UK Brain Expression Consortium (UKBEC), J Karjalainen, DR Reed, H-J Westra, MK Evans, D Saleheen, TB Harris, G Dedoussis, G Curhan, M Stumvoll, J Beilby, LR Pasquale, B Feenstra, S Bandinelli, JM Ordovas, AT Chan, U Peters, C Ohlsson, C Gieger, NG Martin, M Waldenberger, DS Siscovick, O Raitakari, JG Eriksson, P Mitchell, DJ Hunter, P Kraft, EB Rimm, DI Boomsma, IB Borecki, RJ Loos, NJ Wareham, P Vollenweider, N Caporaso, HJ Grabe, ML Neuhouser, BH Wolffenbuttel, FB Hu, E Hyppönen, M-R Järvelin, LA Cupples, PW Franks, PM Ridker, CM van Duijn, G Heiss, A Metspalu, KE North, E Ingelsson, JA Nettleton, RM van Dam, DI Chasman

    Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease.

    DOI: http://doi.org/10.1038/ng.3043
    Journal: Nat Genet
    E-pub date: 1 Sep 2014
    Authors: MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, AL DeStefano, E Kara, J Bras, M Sharma, C Schulte, MF Keller, S Arepalli, C Letson, C Edsall, H Stefansson, X Liu, H Pliner, JH Lee, R Cheng, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, MA Ikram, JPA Ioannidis, GM Hadjigeorgiou, JC Bis, M Martinez, JS Perlmutter, A Goate, K Marder, B Fiske, M Sutherland, G Xiromerisiou, RH Myers, LN Clark, K Stefansson, JA Hardy, P Heutink, H Chen, NW Wood, H Houlden, H Payami, A Brice, WK Scott, T Gasser, L Bertram, N Eriksson, T Foroud, AB Singleton

    Mild cognitive impairment and Parkinson’s disease–something to remember.

    DOI: http://doi.org/10.3233/JPD-140427
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: RA Barker, CH Williams-Gray

    Parkinson’s disease mild cognitive impairment: application and validation of the criteria.

    DOI: http://doi.org/10.3233/JPD-130304
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: GJ Geurtsen, J Hoogland, JG Goldman, BA Schmand, AI Tröster, DJ Burn, I Litvan, MDS Study Group on the Validation of PD-MCI Criteria

    Which patients with Parkinson’s disease participate in clinical trials? One centre’s experiences with a new cell based therapy trial (TRANSEURO).

    DOI: http://doi.org/10.3233/JPD-140432
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2014
    Authors: SF Moore, NV Guzman, SL Mason, CH Williams-Gray, RA Barker

    The spectrum of cognitive impairment in Lewy body diseases.

    DOI: http://doi.org/10.1002/mds.25866
    Journal: Mov Disord
    E-pub date: 15 Apr 2014
    Authors: JG Goldman, C Williams-Gray, RA Barker, JE Duda, JE Galvin

    Putative cortical dopamine levels affect cortical recruitment during planning.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2013.07.016
    Journal: Neuropsychologia
    E-pub date: 1 Sep 2013
    Authors: SJ Fallon, A Hampshire, CH Williams-Gray, RA Barker, AM Owen

    From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.

    DOI: http://doi.org/10.3233/JAD-2012-129006
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2013
    Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

    The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson’s disease with a sexual dimorphism.

    DOI: http://doi.org/10.1136/jnnp-2012-304475
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2013
    Authors: S Klebe, J-L Golmard, MA Nalls, M Saad, AB Singleton, JM Bras, J Hardy, J Simon-Sanchez, P Heutink, G Kuhlenbäumer, R Charfi, C Klein, J Hagenah, T Gasser, I Wurster, S Lesage, D Lorenz, G Deuschl, F Durif, P Pollak, P Damier, F Tison, A Durr, P Amouyel, J-C Lambert, C Tzourio, C Maubaret, F Charbonnier-Beaupel, K Tahiri, M Vidailhet, M Martinez, A Brice, J-C Corvol, French Parkinson's Disease Genetics Study Group, International Parkinson's Disease Genomics Consortium (IPDGC)

    Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease.

    DOI: http://doi.org/10.1212/WNL.0b013e318294b434
    Journal: Neurology
    E-pub date: 28 May 2013
    Authors: G Hudson, M Nalls, JR Evans, DP Breen, S Winder-Rhodes, KE Morrison, HR Morris, CH Williams-Gray, RA Barker, AB Singleton, J Hardy, NE Wood, DJ Burn, PF Chinnery

    The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.

    DOI: http://doi.org/10.1136/jnnp-2012-303618
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2013
    Authors: T Rittman, BC Ghosh, P McColgan, DP Breen, J Evans, CH Williams-Gray, RA Barker, JB Rowe

    A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1093/hmg/dds492
    Journal: Hum Mol Genet
    E-pub date: 1 Mar 2013
    Authors: P Holmans, V Moskvina, L Jones, M Sharma, International Parkinson's Disease Genomics Consortium, A Vedernikov, F Buchel, M Saad, JM Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, JR Gibbs, C Schulte, A Durr, R Guerreiro, D Hernandez, A Brice, H Stefánsson, K Majamaa, T Gasser, P Heutink, NW Wood, M Martinez, AB Singleton, MA Nalls, J Hardy, HR Morris, NM Williams

    Prefrontal dopamine levels determine the balance between cognitive stability and flexibility.

    DOI: http://doi.org/10.1093/cercor/bhs025
    Journal: Cereb Cortex
    E-pub date: 1 Feb 2013
    Authors: SJ Fallon, CH Williams-Gray, RA Barker, AM Owen, A Hampshire

    Excessive daytime sleepiness and its risk factors in incident Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2012-304097
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Feb 2013
    Authors: DP Breen, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

    Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort.

    DOI: http://doi.org/10.1093/brain/aws318
    Journal: Brain
    E-pub date: 1 Feb 2013
    Authors: SE Winder-Rhodes, JR Evans, M Ban, SL Mason, CH Williams-Gray, T Foltynie, R Duran, NE Mencacci, SJ Sawcer, RA Barker

    From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps

    DOI: http://doi.org/10.3233/978-1-61499-154-0-385
    Journal: Advances in Alzheimer's Disease
    E-pub date: 1 Dec 2012
    Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

    Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson’s disease.

    DOI: http://doi.org/10.1093/hmg/dds335
    Journal: Hum Mol Genet
    E-pub date: 15 Nov 2012
    Authors: MF Keller, M Saad, J Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, F Büchel, M Sharma, JR Gibbs, C Schulte, V Moskvina, A Durr, P Holmans, LL Kilarski, R Guerreiro, DG Hernandez, A Brice, P Ylikotila, H Stefánsson, K Majamaa, HR Morris, N Williams, T Gasser, P Heutink, NW Wood, J Hardy, M Martinez, AB Singleton, MA Nalls, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

    Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.25132
    Journal: Mov Disord
    E-pub date: 1 Oct 2012
    Authors: LL Kilarski, JP Pearson, V Newsway, E Majounie, MDW Knipe, A Misbahuddin, PF Chinnery, DJ Burn, CE Clarke, M-H Marion, AJ Lewthwaite, DJ Nicholl, NW Wood, KE Morrison, CH Williams-Gray, JR Evans, SJ Sawcer, RA Barker, MM Wickremaratchi, Y Ben-Shlomo, NM Williams, HR Morris

    Addenbrooke’s Cognitive Examination-Revised for mild cognitive impairment in Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.25084
    Journal: Movement Disorders
    E-pub date: 1 Aug 2012
    Authors: P McColgan, JR Evans, DP Breen, SL Mason, RA Barker, CH Williams-Gray

    LONGITUDINAL EVALUATION OF EXCESSIVE DAYTIME SLEEPINESS AND ITS RISK FACTORS IN PARKINSON’S DISEASE

    DOI: http://doi.org/10.1136/jnnp-2011-301993.149
    Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    E-pub date: 1 Mar 2012
    Authors: DP Breen, JR Evans, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

    THE UTILITY OF THE ADDENBROOKE’S COGNITIVE EXAMINATION-REVISED (ACE-R) IN PARKINSON’S DISEASE

    DOI: http://doi.org/10.1136/jnnp-2011-301993.3
    Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    E-pub date: 1 Mar 2012
    Authors: P McColgan, J Evans, DP Breen, SL Mason, B Ghosh, T Rittman, J Rowe, P Nestor, RA Barker, CH Williams-Gray

    Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines.

    DOI: http://doi.org/10.1002/mds.24893
    Journal: Mov Disord
    E-pub date: 1 Mar 2012
    Authors: I Litvan, JG Goldman, AI Tröster, BA Schmand, D Weintraub, RC Petersen, B Mollenhauer, CH Adler, K Marder, CH Williams-Gray, D Aarsland, J Kulisevsky, MC Rodriguez-Oroz, DJ Burn, RA Barker, M Emre

    Genetic and pathological links between Parkinson’s disease and the lysosomal disorder Sanfilippo syndrome.

    DOI: http://doi.org/10.1002/mds.24029
    Journal: Mov Disord
    E-pub date: 1 Feb 2012
    Authors: SE Winder-Rhodes, P Garcia-Reitböck, M Ban, JR Evans, TS Jacques, A Kemppinen, T Foltynie, CH Williams-Gray, PF Chinnery, G Hudson, DJ Burn, LM Allcock, SJ Sawcer, RA Barker, MG Spillantini

    The natural history of treated Parkinson’s disease in an incident, community based cohort.

    DOI: http://doi.org/10.1136/jnnp.2011.240366
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2011
    Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, C Brayne, TW Robbins, RA Barker

    The factor structure of the UPDRS as an index of disease progression in Parkinson’s disease.

    DOI: http://doi.org/10.3233/JPD-2011-0002
    Journal: J Parkinsons Dis
    E-pub date: 1 Aug 2011
    Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, M Trotter, RA Barker

    A two-stage meta-analysis identifies several new loci for Parkinson’s disease.

    DOI: http://doi.org/10.1371/journal.pgen.1002142
    Journal: PLoS Genet
    E-pub date: 1 Jun 2011
    Authors: International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

    Imputation of sequence variants for identification of genetic risks for Parkinson’s disease: a meta-analysis of genome-wide association studies.

    DOI: http://doi.org/10.1016/S0140-6736(10)62345-8
    Journal: Lancet
    E-pub date: 19 Feb 2011
    Authors: International Parkinson Disease Genomics Consortium, MA Nalls, V Plagnol, DG Hernandez, M Sharma, U-M Sheerin, M Saad, J Simón-Sánchez, C Schulte, S Lesage, S Sveinbjörnsdóttir, K Stefánsson, M Martinez, J Hardy, P Heutink, A Brice, T Gasser, AB Singleton, NW Wood

    Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.

    DOI: http://doi.org/10.1212/WNL.0b013e3181f39d0e
    Journal: Neurology
    E-pub date: 21 Sep 2010
    Authors: D Aarsland, K Bronnick, C Williams-Gray, D Weintraub, K Marder, J Kulisevsky, D Burn, P Barone, J Pagonabarraga, L Allcock, G Santangelo, T Foltynie, C Janvin, JP Larsen, RA Barker, M Emre

    The val158met COMT polymorphism’s effect on atrophy in healthy aging and Parkinson’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2008.07.009
    Journal: Neurobiol Aging
    E-pub date: 1 Jun 2010
    Authors: JB Rowe, L Hughes, CH Williams-Gray, S Bishop, S Fallon, RA Barker, AM Owen

    The genetics of behavior and cognition in Parkinson’s disease

    DOI: http://doi.org/10.1017/CBO9781139856669.004
    Journal:
    E-pub date: 1 Jan 2010
    Authors: CH Williams-Gray, RA Barker

    BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp.2008.154294
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Feb 2009
    Authors: T Foltynie, B Cheeran, CH Williams-Gray, MJ Edwards, SA Schneider, D Weinberger, JC Rothwell, RA Barker, KP Bhatia

    No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-009-0899-x
    Journal: J Neurol
    E-pub date: 1 Jan 2009
    Authors: C Williams-Gray, A Goris, T Foltynie, A Compston, S Sawcer, RA Barker

    Parkinson’s disease and dopaminergic therapy–differential effects on movement, reward and cognition.

    DOI: http://doi.org/10.1093/brain/awn112
    Journal: Brain
    E-pub date: 31 Aug 2008
    Authors: JB Rowe, L Hughes, BCP Ghosh, D Eckstein, CH Williams-Gray, S Fallon, RA Barker, AM Owen

    The Cambridge Behavioural Inventory revised.

    DOI: http://doi.org/10.1590/S1980-57642009DN20200005
    Journal: Dement Neuropsychol
    E-pub date: 1 Aug 2008
    Authors: HJ Wear, CJ Wedderburn, E Mioshi, CH Williams-Gray, SL Mason, RA Barker, JR Hodges

    The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.

    DOI: http://doi.org/10.1136/jnnp.2007.122028
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2008
    Authors: C Wedderburn, H Wear, J Brown, SJ Mason, RA Barker, J Hodges, C Williams-Gray

    Attentional control in Parkinson’s disease is dependent on COMT val 158 met genotype.

    DOI: http://doi.org/10.1093/brain/awm313
    Journal: Brain
    E-pub date: 1 Feb 2008
    Authors: CH Williams-Gray, A Hampshire, RA Barker, AM Owen

    Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson’s disease.

    DOI: http://doi.org/10.1007/s00415-006-0414-6
    Journal: J Neurol
    E-pub date: 1 Jul 2007
    Authors: A Goris, CH Williams-Gray, T Foltynie, J Brown, M Maranian, A Walton, DAS Compston, RA Barker, SJ Sawcer

    Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson’s disease.

    DOI: http://doi.org/10.1523/JNEUROSCI.0774-07.2007
    Journal: J Neurosci
    E-pub date: 2 May 2007
    Authors: CH Williams-Gray, A Hampshire, TW Robbins, AM Owen, RA Barker

    Visual hallucinations predict increased benefits from rivastigmine in Parkinson’s disease dementia.

    DOI: http://doi.org/10.1038/ncpneuro0471
    Journal: Nat Clin Pract Neurol
    E-pub date: 1 May 2007
    Authors: CH Williams-Gray, RA Barker

    Saccadic latency distributions in Parkinson’s disease and the effects of L-dopa.

    DOI: http://doi.org/10.1007/s00221-006-0412-z
    Journal: Exp Brain Res
    E-pub date: 1 Sep 2006
    Authors: AW Michell, Z Xu, D Fritz, SJG Lewis, T Foltynie, CH Williams-Gray, TW Robbins, RHS Carpenter, RA Barker

    Cognitive deficits and psychosis in Parkinson’s disease: a review of pathophysiology and therapeutic options.

    DOI: http://doi.org/10.2165/00023210-200620060-00004
    Journal: CNS Drugs
    E-pub date: 1 Aug 2006
    Authors: CH Williams-Gray, T Foltynie, SJG Lewis, RA Barker

    No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.

    DOI: http://doi.org/10.1086/504726
    Journal: Am J Hum Genet
    E-pub date: 1 Jun 2006
    Authors: A Goris, CH Williams-Gray, T Foltynie, DAS Compston, RA Barker, SJ Sawcer

    Prevalence of the LRRK2 G2019S mutation in a UK community based idiopathic Parkinson’s disease cohort.

    DOI: http://doi.org/10.1136/jnnp.2005.085019
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2006
    Authors: CH Williams-Gray, A Goris, T Foltynie, J Brown, M Maranian, A Walton, DAS Compston, SJ Sawcer, RA Barker

    No alterations in alpha-synuclein gene dosage observed in sporadic Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.20863
    Journal: Mov Disord
    E-pub date: 1 May 2006
    Authors: CH Williams-Gray, A Goris, T Foltynie, J Brown, M Maranian, A Walton, DA Compston, SJ Sawcer, RA Barker

    II.1 Cognitive dysfunction in early Parkinson’s Disease

    DOI: http://doi.org/10.1016/s1353-8020(07)70018-4
    Journal: Parkinsonism & Related Disorders
    E-pub date: 1 May 2006
    Authors: C Williams-Gray, RA Barker, R Swainson, TW Robbins

    Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles.

    DOI: http://doi.org/10.1093/brain/awl027
    Journal: Brain
    E-pub date: 1 Apr 2006
    Authors: BR Underwood, D Broadhurst, WB Dunn, DI Ellis, AW Michell, C Vacher, DE Mosedale, DB Kell, RA Barker, DJ Grainger, DC Rubinsztein