Alex Dunn


University position

PhD student
Supervised by Dr Susanna Mierau, Prof Stephen Eglen & Prof Ole Paulsen

Departments

Department of Physiology, Development and Neuroscience

Email

awed2@cam.ac.uk

Home page

https://noggin.pdn.cam.ac.uk/

Research Themes

Developmental Neuroscience

Systems and Computational Neuroscience

Interests

I'm a PhD student studying the development of cellular-scale brain networks in vitro. I grow primary murine neuronal cultures and record spontaneous activity on microelectrode arrays (MEAs). I also analyse MEA recordings of stem-cell-derived human tissue including cerebral organoid slices. I'm interested in network formation, topology and dynamics and currently focus mainly on graph theoretical metrics.

As part of my PhD, I am investigating how networks containing Mecp2-deficient neurons are disrupted. This may have translational implications as Mecp2 mutations cause most cases of Rett Syndtome. Using optognetic manipulation, I am also looking at the role of inhibitory neocortical interneurons in these networks as pathology in these cells is heavily linked to Rett Syndrome.

Research Focus

Keywords

graph theory

Rett Syndrome

MECP2

network

development

Clinical conditions

Rett Syndrome

Equipment

Cell culture

Computational modelling

Electrophysiological recording techniques

Micro/multi electrode arrays

Microscopy

Organoids (cerebral and spinal)

Collaborators

No collaborators listed

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