I'm a PhD student studying the development of cellular-scale brain networks in vitro. I grow primary murine neuronal cultures and record spontaneous activity on microelectrode arrays (MEAs). I also analyse MEA recordings of stem-cell-derived human tissue including cerebral organoid slices. I'm interested in network formation, topology and dynamics and currently focus mainly on graph theoretical metrics.
As part of my PhD, I am investigating how networks containing Mecp2-deficient neurons are disrupted. This may have translational implications as Mecp2 mutations cause most cases of Rett Syndtome. Using optognetic manipulation, I am also looking at the role of inhibitory neocortical interneurons in these networks as pathology in these cells is heavily linked to Rett Syndrome.
Electrophysiological recording techniques
Micro/multi electrode arrays
Organoids (cerebral and spinal)
No collaborators listed
Associated News Items