Audrey Low University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences Home pagehttps://audreylwn.github.io/ (personal home page) Research ThemesInterestsI am a Research Associate studying the role of cerebrovascular dysfunction in dementia and cognitive impairment, with the help of multimodal neuroimaging techniques and clinical data in humans. Currently, my research focuses on the associations between cerebral small vessel disease, inflammation, and blood brain barrier permeability. I am also interested in studying the early risk factors of dementia, and how cerebral small vessel disease is involved in early dementia pathogenesis. In particular, I am interested in how cerebral small vessel disease relates to established dementia risk factors and molecular imaging markers of dementia (e.g., amyloid, tau, neuroinflammation), as a way to further our understanding of how various pathologies interact in their contribution to neurodegeneration and clinical outcomes. Research Focus
EquipmentCross-sectional and cohort studies Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Collaborators
Associated News ItemsPublications2022Dounavi ME, Low A, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT (2022), “Fluid-Attenuated Inversion Recovery MRI textural features as sensitive markers of white matter damage in midlife adults” Brain Commun 4(3): fcac116 Dounavi ME, Newton C, Jenkins N, Mak E, Low A, Muniz-Terrera G, Williams GB, Lawlor B, Naci L, Malhotra P, Mackay C, Koychev I, Ritchie K, Ritchie CW, Su L, O'Brien JT (2022), “Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study” J Neurol 269(8):4299-4309 Low A, Prats-Sedano M, McKiernan E, Carter S, Stefaniak JD, Nannoni S, Su L, Dounavi ME, Muniz-Terrera G, Ritchie K, Lawlor B, Naci L, Malhotra P, MacKay C, Koychev I, Ritchie CW, Markus HS, O’Brien JT (2022), “Modifiable and non-modifiable risk factors of dementia and midlife cerebral small vessel disease in cognitively healthy midlife adults: the PREVENT-Dementia study” Alz Res Therapy 14:154 Low A, Prats-Sedano, MA, Stupart O, Stefaniak JD, McKiernan E, Carter S, Dounavi ME, Mak E, Su L, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT (2022), “CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study” J Neurol Neurosurg Psychiatry 93:481-490 2021Brown R, Low A, Markus HS (2021), “Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design” J Neurol Neurosurg Psychiatry 92(12):1271-1277 Dounavi ME, Low A, McKiernan E, Mak E, Muniz-Terrera G, Ritchie K, Ritchie CW, Su L, O'Brien JT (2021), “Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ?4 carriers: the PREVENT-Dementia study” J Cereb Blood Flow Metab Low A, Su L, Stefaniak JD, Mak E, Dounavi ME, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O'Brien JT (2021), “Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study” Neurobiol Aging 98: 124-133 Mak E, Dounavi M, Low A, Carter SF, McKiernan E, Williams GB, Jones PS, Carriere I, Muniz-Terrera G, Ritchie K, Ritchie C, Su L, O’Brien JT (2021), “Proximity to dementia onset and multi-modal neuroimaging changes: The PREVENT-Dementia Study” NeuroImage 229:117749 Mak E, Holland N, Jones PS, Savulich G, Low A, Malpetti M, Kaalund SS, Passamonti L, Rittman T, Romero-Garcia R, Manavaki R, Williams GB, Hong YT, Fryer TD, Aigbirhio FI, O’Brien JT, Rowe JB (2021), “In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies” Neurobiol Aging 101: 187–198 Vipin A, Wong BYX, Kumar D, Low A, Ng KP, Kandiah N (2021), “Association between white matter hyperintensity load and grey matter atrophy in mild cognitive impairment is not unidirectional” Aging (Albany NY) 13(8): 10973–10988 2020Koh W, Lim L, Low A, Wong B, Lim L, Silva E, Ng KP, Kandiah N (2020), “Development and validation of a brief visual based cognitive screening tool for dementia: the Visual Cognitive Assessment Test short-form (VCAT-S)” J Neurol Neurosurg Psychiatry 91(10):1122-1123 Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT (2020), “In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease” J Neurol Neurosurg Psychiatry 92:45-52 Low A, Mak E, Rowe JB, Markus HS, O’Brien JT. (2020), “Inflammation and cerebral small vessel disease: A systematic review” Ageing Res Rev 53:100916 Low A, Mak E, Stefaniak JD, Malpetti M, Nicastro N, Markus HS, Rowe JB, O’Brien JT. (2020), “Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage” Front Neurosci 14:238 Wong FCC, Yatawara C, Low A, Foo H, Wong BYX, Lim L, Wang B, Kumar D, Ng KP, Kandiah N (2020), “Cerebral Small Vessel Disease Influences Hippocampal Subfield Atrophy in Mild Cognitive Impairment” Transl Stroke Res 1:9 2019Low A, Foo H, Yong T, Tan LCS, Kandiah N (2019), “Hippocampal Subfield Atrophy of CA1 and Subicular Structures Predict Progression to Dementia in Idiopathic Parkinson’s disease” J Neurol Neurosurg Psychiatry 90(6): 681-687 Low A, Lim L, Lim L, Wong B, Silva E, Ng KP, Kandiah N (2019), “Construct Validity of the Visual Cognitive Assessment Test (VCAT): A Cross-Cultural Language-Neutral Cognitive Screening Tool” Int Psychogeriatr 21:1-9 Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Vázquez Rodríguez P, Passamonti L, Bevan-Jones WR, Jones PS, Rowe JB, O'Brien JT (2019), “Asymmetrical Atrophy of Thalamic Subnuclei in Alzheimer’s Disease and Amyloid-Positive Mild Cognitive Impairment is Associated with Key Clinical Features” Alzheimers Dement (Amst). 11: 690-699 Low A, Ng KP, Chander RJ, Wong B, Kandiah N. (2019), “Association of Asymmetrical Distribution of White Matter Hyperintensities and Apolipoprotein E4 on Cognitive Outcomes in Mild Cognitive Impairment and Dementia” J Alzheimers Dis 70(3): 953-964 Low A, Yong T, Chandler RJ, Ng KP, Kandiah N (2019), “Predictors and Patterns of Cognitive Decline Differ between Mild Cognitive Impairment in Parkinson’s disease (PD-MCI) and Alzheimer’s disease (AD-MCI)” J Alzheimers Parkinsonism Dement 3(1): 27 |