Dr Andrea Santangelo M

Andrea Santangelo

University position

Research Associate

Dr Andrea Santangelo M is pleased to consider applications from prospective PhD students.


Department of Physiology, Development and Neuroscience


Behavioural and Clinical Neuroscience Institute



Research Themes

Cognitive and Behavioural Neuroscience

Cellular and Molecular Neuroscience


My work focuses on gene variation associated to emotional and cognitive behaviour. In particular, I study polymorphisms in the serotonin transporter gene that are linked to vulnerability to early-life stress and the development of affective disorders. Our research includes behavioural testing, brain imaging and molecular studies to understand the neurodevelopmental changes and molecular mechanisms that underlie the individual differences in affective behaviour.

I am available as a consultant.

Reduced serotonin receptor 2A binding potential in the insular cortex correlates with enhanced emotionality.
Reduced Serotonin 2A receptor binding in the anterior insula associated with increased anxiety and genetic variation in the serotonin transporter.
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Research Focus


emotional and cognitive behavior


genetic variation

gene expression regulation

molecular evolution

Clinical conditions

Anxiety disorders


Depressive disorders

Genetic disorders

Panic disorder


Post-traumatic stress disorder

Sleep disorders



Behavioural analysis

Bioinformatics, Gene expression (RT-PCR), DNA-protein interactions (EMSA, ELISA)

Fluorescence microscopy


Magnetic resonance imaging (MRI)

Neuropsychological testing

Positron Emission Tomography (PET)



Shankar Balasubramanian

Anne Ferguson Smith

Mitsuteru Ito

Pierre Murat

Angela Roberts

Yoshiro Shiba


Annabelle Belcher Web: http://irp.drugabuse.gov/NRB/bel...

Chihiro Yokoyama Web: http://clst.riken.jp/bfi/eng...

Jorge Zeredo Web: http:// http://lattes...

Associated News Items

    Key publications

    Shiba Y, Oikonomidis L, Sawiak S, Fryer TD, Hong YT, Cockcroft G, Santangelo AM, Roberts AC. (2017), “Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys ” Biol Psychiatry 82(12):895-903

    Santangelo AM, Ito M, Shiba Y, Clarke HF, Schut EH, Cockcroft G, Ferguson-Smith AC, Roberts AC (2016), “Novel Primate Model of Serotonin Transporter Genetic Polymorphisms Associated with Gene Expression, Anxiety and Sensitivity to Antidepressants” Neuropsychopharmacology 41(9):2366-76



    Oikonomidis L, Santangelo AM, Shiba Y, Clarke FH, Robbins TW, Roberts AC (2017), “A dimensional approach to modeling symptoms of neuropsychiatric disorders in the marmoset monkey” Dev Neurobiol 77(3):328-353


    Shiba Y, Santangelo AM, Roberts AC (2016), “Beyond the Medial Regions of Prefrontal Cortex in the Regulation of Fear and Anxiety” Front Syst Neurosci 10:12


    Shiba Y, Kim C, Santangelo AM, Roberts AC (2015), “Lesions of either anterior orbitofrontal cortex or ventrolateral prefrontal cortex in marmoset monkeys heighten innate fear and attenuate active coping behaviors to predator threat” Front Syst Neurosci 8:250


    Shiba Y, Santangelo AM, Braesicke K, Agustín-Pavón C, Cockcroft G, Haggard M, Roberts AC (2014), “Individual differences in behavioral and cardiovascular reactivity to emotive stimuli and their relationship to cognitive flexibility in a primate model of trait anxiety.” Front Behav Neurosci 8:137 Details


    Agustín-Pavón C, Braesicke K, Shiba Y, Santangelo AM, Mikheenko Y, Cockroft G, Asma F, Clarke H, Man MS, Roberts AC (2012), “Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.” Biol Psychiatry 72(4):266-72 Details


    Bumaschny VF, de Souza FS, López Leal RA, Santangelo AM, Baetscher M, Levi DH, Low MJ, Rubinstein M (2007), “Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence.” Mol Endocrinol 21(11):2738-49 Details

    Santangelo AM, de Souza FS, Franchini LF, Bumaschny VF, Low MJ, Rubinstein M (2007), “Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene.” PLoS Genet 3(10):1813-26 Details


    de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M (2005), “Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting.” Mol Cell Biol 25(8):3076-86 Details


    Overstreet LS, Hentges ST, Bumaschny VF, de Souza FS, Smart JL, Santangelo AM, Low MJ, Westbrook GL, Rubinstein M (2004), “A transgenic marker for newly born granule cells in dentate gyrus.” J Neurosci 24(13):3251-9 Details