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Research Focus

Keywords

  • Working Memory
  • Executive Function
  • Attention
  • Inhibition
  • Cognitive Function
  • Cognitive Psychopharmacology
  • Clinical Conditions

  • Traumatic brain injury
  • Cognitive impairment
  • Depressive disorders
  • Attention deficit hyperactivity disorder
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Behavioural analysis
  • Statistical analysis
  • Computational modelling
  • Neuropsychological testing
  • Randomised control trials
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    Alexander Peattie

    University Position
    PhD student

    Interests

    My work has focussed on the neurocognitive sequalae of chronic Traumatic Brain Injury (TBI), particularly the domains of response inhibition, working memory, executive function, and sustained attention – and how the pharmacological catecholaminergic stimulant Methylphenidate (MPh) ameliorates cognitive deficits by upregulating synaptic DA/NA concentrations. This research has used both inside-scanner and outside-scanner neuropsychological testing via the CANTAB cognitive assessments. This work has also investigated their cognitive ability and psychiatric status using the NART, MMSE, NPI, BDI, VAS, and SF-36 questionnaires among others. I utilised both task-based and resting-state fMRI as well as DTI approaches to characterise the neurobiological underpinnings of TBI-deficits and MPh’s treatment effects compared to normative healthy control data. I have also collaborated with others in analysing patients with Disorders of Consciousness (DOC), the neurofunctional correlates of anaesthesia, and the effects of psychopharmacological modulators on resting-state fMRI data. TBI, DOC, and depressive conditions share neurological, behavioural, and cognitive deficits due to damage to monoaminergic structures http://anaesthetics.medschl.cam.ac.uk/staff/alex-peattie/

    Key Publications

    Methylphenidate ameliorates behavioural and neurobiological deficits in executive function for patients with chronic Traumatic Brain Injury

    DOI: http://doi.org/10.3390/jcm13030771
    Journal: J Clin Med
    E-pub date: 29 Jan 2024
    Authors: A Peattie, A Manktelow, B Sahakian, D Menon, E Stamatakis

    Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.

    DOI: http://doi.org/10.1073/pnas.2026289118
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 27 Jul 2021
    Authors: LRB Spindler, AI Luppi, RM Adapa, MM Craig, P Coppola, ARD Peattie, AE Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    Publications

    Converging on consistent functional connectomics

    DOI: http://doi.org/10.1101/2023.06.23.546329
    Journal:
    E-pub date: 1 Aug 2023
    Authors: AI Luppi, HM Gellersen, Z-Q Liu, ARD Peattie, AE Manktelow, R Adapa, AM Owen, L Naci, DK Menon, SI Dimitriadis, EA Stamatakis

    In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape.

    DOI: http://doi.org/10.1126/sciadv.adf8332
    Journal: Sci Adv
    E-pub date: 16 Jun 2023
    Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1038/s42003-023-04474-1
    Journal: Commun Biol
    E-pub date: 28 Jan 2023
    Authors: AI Luppi, J Vohryzek, ML Kringelbach, PAM Mediano, MM Craig, R Adapa, RL Carhart-Harris, L Roseman, I Pappas, ARD Peattie, AE Manktelow, BJ Sahakian, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, S Atasoy, EA Stamatakis

    Reduced emergent character of neural dynamics in patients with a disrupted connectome

    DOI: http://doi.org/10.1101/2022.06.16.496445
    Journal:
    E-pub date: 1 Aug 2022
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, D Menon, D Bor, E Stamatakis

    Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape

    DOI: http://doi.org/10.1101/2022.07.12.499688
    Journal:
    E-pub date: 13 Jul 2022
    Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

    Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness.

    DOI: http://doi.org/10.1038/s42003-022-03330-y
    Journal: Commun Biol
    E-pub date: 20 Apr 2022
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

    DOI: http://doi.org/10.1101/2021.02.14.431140
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, A Owen, L Naci, D Menon, D Bor, E Stamatakis

    Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury.

    DOI: http://doi.org/10.1016/j.nicl.2021.102682
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, MM Craig, P Coppola, ARD Peattie, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    Searching for Consistent Brain Network Topologies Across the Garden of (Shortest) Forking Paths

    DOI: http://doi.org/10.1101/2021.07.13.452257
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Luppi, H Gellersen, A Peattie, A Manktelow, D Menon, S Dimitriadis, E Stamatakis

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1101/2020.08.10.244459
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, J Vohryzek, M Kringelbach, PAM Mediano, M Craig, R Adapa, R Carhart-Harris, L Roseman, I Pappas, ARD Peattie, A Manktelow, B Sahakian, P Finoia, G Williams, J Allanson, J Pickard, D Menon, S Atasoy, E Stamatakis