Dr Tony Coll University positionLecturer Dr Tony Coll is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Biochemistry InstitutesInstitute of Metabolic Science Home pageResearch ThemesInterestsMy current research continues to focus upon the roles of the hypothalamus in the control of energy balance. Our current understanding of the central control of appetite has relied heavily upon mouse models and I continue to utilise the power of both murine genetics and whole animal physiological studies to address these issues. I aim to model disease-related mutations in murine systems and continue the powerful, synergistic relationship between human genetics and murine modelling which has been so fruitful in understanding complex systems biology. Research Focus
EquipmentNo equipment indicated Collaborators
Associated News ItemsKey publicationsColl AP, Farooqi IS, O'Rahilly S (2007), “The hormonal control of food intake” Cell 129(2):251-62 Details Tung YC, Piper SJ, Yeung D, O'Rahilly S, Coll AP (2006), “A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice” Endocrinology 147(12):5940-7 Details Coll AP, Challis BG, Lopez M, Piper S, Yeo GS, O'Rahilly (2005), “S.Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids” Diabetes 54(8):2269-76 Details Publications2013Coll AP (2013), “"Are melanocortin receptors constitutively active in vivo?".” Eur J Pharmacol 719(1-3):202-7 Details Coll AP, Yeo GS (2013), “The hypothalamus and metabolism: integrating signals to control energy and glucose homeostasis.” Curr Opin Pharmacol 13(6):970-6 Details Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS (2013), “Role for the obesity-related FTO gene in the cellular sensing of amino acids.” Proc Natl Acad Sci U S A 110(7):2557-62 Details Roberts EW, Deonarine A, Jones JO, Denton AE, Feig C, Lyons SK, Espeli M, Kraman M, McKenna B, Wells RJ, Zhao Q, Caballero OL, Larder R, Coll AP, O'Rahilly S, Brindle KM, Teichmann SA, Tuveson DA, Fearon DT (2013), “Depletion of stromal cells expressing fibroblast activation protein-? from skeletal muscle and bone marrow results in cachexia and anemia.” J Exp Med 210(6):1137-51 Details 2011Corander MP, Coll AP (2011), “Melanocortins and body weight regulation: glucocorticoids, Agouti-related protein and beyond.” Eur J Pharmacol 660(1):111-8 Details Corander MP, Rimmington D, Challis BG, O'Rahilly S, Coll AP (2011), “Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.” Endocrinology 152(5):1819-28 Details Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP (2011), “Where to go with FTO?” Trends Endocrinol Metab 22(2):53-9 Details 2010Corander MP, Challis BG, Thompson EL, Jovanovic Z, Loraine Tung YC, Rimmington D, Huhtaniemi IT, Murphy KG, Topaloglu AK, Yeo GS, O'Rahilly S, Dhillo WS, Semple RK, Coll AP (2010), “The effects of neurokinin B upon gonadotrophin release in male rodents.” J Neuroendocrinol 22(3):181-7 Details Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS (2010), “Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.” PLoS One 5(1):e8771 Details 2009Corander MP, Fenech M, Coll AP (2009), “Science of self-preservation: how melanocortin action in the brain modulates body weight, blood pressure, and ischemic damage.” Circulation 120(22):2260-8 Details 2008Coll AP, Yeo GS, Farooqi IS, O'Rahilly S (2008), “SnapShot: the hormonal control of food intake.” Cell 135(3):572.e1-2 Details Prieur X, Tung YC, Griffin JL, Farooqi IS, O'Rahilly S, Coll AP (2008), “Leptin regulates peripheral lipid metabolism primarily through central effects on food intake.” Endocrinology 149(11):5432-9 Details 2007Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ (2007), “The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.” Science 318(5855):1469-72 Details Tung YC, Rimmington D, O'Rahilly S, Coll AP (2007), “Pro-opiomelanocortin modulates the thermogenic and physical activity responses to high-fat feeding and markedly influences dietary fat preference.” Endocrinology 148(11):5331-8 Details |