Dr Arkoprovo Paul

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

MRC Cambridge Stem Cell Institute

Email

ap868@medschl.cam.ac.uk

Home page

http://www.linkedin.com/in/ap86... (personal home page)

Research Themes

Cellular and Molecular Neuroscience

Clinical and Veterinary Neuroscience

The Cambridge Neuroscience Community

Interests

I am investigating functional phenotypes of human induced pluripotent stem cell (iPSC) derived Neurons, Astrocytes and Microglia generated using CRISPR/Cas9 genome editing tools and forward reprogramming technologies. My current research is focussed on understanding neuron-glia interactions in isogenic disease models of neurodevelopment and neurodegeneration using network electrophysiology and single cell transcriptomics; with the aim to establish an optimised platform for discovery and therapeutics.

Research Focus

Keywords

Stem cells

Cellular reprogramming

Neuron-Glia interaction

Neurodevelopment

Neurodegeneration

Clinical conditions

Alzheimer's disease

Autism

Dementia

Huntington's disease

Neuroinflammation

Parkinson's disease

Equipment

Bioinformatics

Calcium imaging

Cell culture

Computational modelling

Confocal microscopy

Electrophysiological recording techniques

Enzyme assays

Fluorescence microscopy

Gene editing

Immunohistochemistry

Microscopy

Multi-electrode arrays

Single cell transcriptomics

Western blotting

Collaborators

Cambridge

Simon Baron-Cohen

Emmanouil Metzakopian

United Kingdom

Jack Price Web: http://www.kcl.ac.uk/ioppn/d...

Deepak Srivastava Web: https://kclpure.kcl.ac.uk/portal/...