I am studying atypical neuronal development in the autism brain using patient-derived induced pluripotent stem cell (iPSC). The use of iPSC combined with genome editing technologies allows me to investigate the role of an autism high risk gene (Neurexin I) and its role in synaptic transmission in iPSC-derived induced neurons. I am also interested in the contribution of steroid hormones to differential synaptic gene expression during brain development in autism.
Electrophysiological recording techniques
Genome editing (CRISPR-Cas9)
Whole cell patch clamp