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Department
  • MRC Mitochondrial Biology Unit
    • Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing Beyond the Neuron
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    Dr Alvaro Sanchez-Martinez

    University Position
    Research Associate

    Interests

    My general research interests are focused on mitochondrial related early-onset and ageing diseases. In particular, how mitochondrial damage/dysfunction and environmental factors, such as stress, may influence ageing and onset as well as progression of these diseases. These interests have lead me to examine the mitochondrial quality control mechanisms, and also how adjusting the organismal/cellular environment, in relation to external/internal stress, may ameliorate the affects of disease and lead to targets for treatment through genetic approaches.

    Key Publications

    FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provide a target for Pink1 phosphorylation in vivo.

    DOI: http://doi.org/10.1371/journal.pbio.3002244
    Journal: PLoS Biol
    E-pub date: 31 Aug 2023
    Authors: A Sanchez-Martinez, A Martinez, AJ Whitworth

    A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins.

    DOI: http://doi.org/10.1126/scitranslmed.abo3823
    Journal: Sci Transl Med
    E-pub date: 1 Mar 2023
    Authors: LM Castelli, Y-H Lin, A Sanchez-Martinez, A Gül, K Mohd Imran, A Higginbottom, SK Upadhyay, NM Márkus, R Rua Martins, J Cooper-Knock, C Montmasson, R Cohen, A Walton, CS Bauer, KJ De Vos, RJ Mead, M Azzouz, C Dominguez, L Ferraiuolo, PJ Shaw, AJ Whitworth, GM Hautbergue

    Parkin drives pS65-Ub turnover independently of canonical autophagy in Drosophila.

    DOI: http://doi.org/10.15252/embr.202153552
    Journal: EMBO Rep
    E-pub date: 6 Dec 2022
    Authors: JL Usher, A Sanchez-Martinez, A Terriente-Felix, P-L Chen, JJ Lee, C-H Chen, AJ Whitworth

    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo.

    DOI: http://doi.org/10.1016/j.celrep.2019.04.033
    Journal: Cell Rep
    E-pub date: 30 Apr 2019
    Authors: R Tufi, TP Gleeson, S von Stockum, VL Hewitt, JJ Lee, A Terriente-Felix, A Sanchez-Martinez, E Ziviani, AJ Whitworth

    Publications

    Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes inPink1/parkinmodels

    DOI: http://doi.org/10.1101/2023.05.14.540700
    Journal:
    E-pub date: 1 Aug 2023
    Authors: A Martinez, A Sanchez-Martinez, J Pickering, M Twyning, A Terriente-Felix, P-L Chen, C-H Chen, A Whitworth

    Activation of the Keap1/Nrf2 pathway suppresses mitochondrial dysfunction in C9orf72 ALS/FTD in vivo models and patient iNeurons

    DOI: http://doi.org/10.1101/2023.10.02.560439
    Journal:
    E-pub date: 1 Aug 2023
    Authors: WH Au, L Miller-Fleming, A Sanchez-Martinez, J Lee, M Twyning, H Prag, S Granger, K Roome, L Ferraiuolo, H Mortiboys, A Whitworth