EMAIL al857@cam.ac.uk

College St John's College

Department

Institute

Division of Anaesthesia

Information Engineering

Click to view ORCID profile

Research Theme Brains and Machines Neurons, Circuits and Networks Adaptive Brain Computations

Research Focus

Keywords

Consciousness

Functional Connectivity

Receptor

Artificial Neural Network

Complex Science & Network Analysis

Dynamics

Information

Pharmacology

Clinical Conditions

Traumatic brain injury

Equipment & Techniques

Magnetic resonance imaging (MRI)

Positron Emission Tomography (PET)

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Dr Andrea Luppi

University Position

Wellcome Early Career Fellow

Interests

Coming from a background in philosophy and cognitive science, I am interested in the relation between mind and (grey) matter. Specifically, my work aims to characterise how the capacity for cognition and consciousness arises from the complex interactions between brain systems, viewed as a dynamic network. To this end, I combine tools from information theory, network science and whole-brain computational modelling to study the cortical dynamics and connectivity of the brain across multiple scales and modalities (functional MRI, DTI) throughout a variety of states of altered consciousness, such as anaesthesia and disorders of consciousness, but also sleep and psychedelics. Ultimately, I aim to develop a unified understanding of how consciousness is lost, and how we can promote its recovery in patients.

Collaborators

Cambridge

Associated News Items

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Key Publications

Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awad056
Journal: Brain
E-pub date: 1 Aug 2023
Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

A synergistic core for human brain evolution and cognition.

DOI: http://doi.org/10.1038/s41593-022-01070-0
Journal: Nat Neurosci
E-pub date: 1 Jun 2022
Authors: AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O'Brien, JB Rowe, DK Menon, D Bor, EA Stamatakis

Ten simple rules for aspiring graduate students.

DOI: http://doi.org/10.1371/journal.pcbi.1009276
Journal: PLoS Comput Biol
E-pub date: 31 Aug 2021
Authors: AI Luppi, CC Newton, L Folsom, E Galliano, R Romero-Garcia

Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.

DOI: http://doi.org/10.1073/pnas.2026289118
Journal: Proc Natl Acad Sci U S A
E-pub date: 27 Jul 2021
Authors: LRB Spindler, AI Luppi, RM Adapa, MM Craig, P Coppola, ARD Peattie, AE Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

Publications

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

DOI: http://doi.org/10.7554/elife.88173
Journal:
E-pub date: 8 Apr 2024
Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution.

DOI: http://doi.org/10.1177/10738584221138032
Journal: Neuroscientist
E-pub date: 1 Apr 2024
Authors: AI Luppi, FE Rosas, MP Noonan, PAM Mediano, ML Kringelbach, RL Carhart-Harris, EA Stamatakis, AC Vernon, FE Turkheimer

General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species.

DOI: http://doi.org/10.1101/2023.11.08.566332
Journal:
E-pub date: 13 Nov 2023
Authors: AI Luppi, D Golkowski, A Ranft, R Ilg, D Jordan, D Bzdok, AM Owen, L Naci, EA Stamatakis, E Amico, B Misic

Converging on consistent functional connectomics

DOI: http://doi.org/10.1101/2023.06.23.546329
Journal:
E-pub date: 1 Aug 2023
Authors: AI Luppi, HM Gellersen, Z-Q Liu, ARD Peattie, AE Manktelow, R Adapa, AM Owen, L Naci, DK Menon, SI Dimitriadis, EA Stamatakis

A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

DOI: http://doi.org/10.7554/elife.88173.1
Journal:
E-pub date: 25 Jul 2023
Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

Local Orchestration of Global Functional Patterns Supporting Loss and Restoration of Consciousness in the Primate Brain

DOI: http://doi.org/10.1101/2023.06.30.547281
Journal:
E-pub date: 3 Jul 2023
Authors: AI Luppi, L Uhrig, J Tasserie, CM Signorelli, E Stamatakis, A Destexhe, B Jarraya, R Cofre

In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape.

DOI: http://doi.org/10.1126/sciadv.adf8332
Journal: Sci Adv
E-pub date: 16 Jun 2023
Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

Reduced emergent character of neural dynamics in patients with a disrupted connectome.

DOI: http://doi.org/10.1016/j.neuroimage.2023.119926
Journal: Neuroimage
E-pub date: 1 Apr 2023
Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, DK Menon, D Bor, EA Stamatakis

Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

DOI: http://doi.org/10.1038/s42003-023-04474-1
Journal: Commun Biol
E-pub date: 28 Jan 2023
Authors: AI Luppi, J Vohryzek, ML Kringelbach, PAM Mediano, MM Craig, R Adapa, RL Carhart-Harris, L Roseman, I Pappas, ARD Peattie, AE Manktelow, BJ Sahakian, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, S Atasoy, EA Stamatakis

Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape.

DOI: http://doi.org/10.1038/s41467-022-33578-1
Journal: Nat Commun
E-pub date: 3 Oct 2022
Authors: SP Singleton, AI Luppi, RL Carhart-Harris, J Cruzat, L Roseman, DJ Nutt, G Deco, ML Kringelbach, EA Stamatakis, A Kuceyeski

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease.

DOI: http://doi.org/10.1038/s42003-022-03903-x
Journal: Commun Biol
E-pub date: 8 Sep 2022
Authors: A Zarkali, AI Luppi, EA Stamatakis, S Reeves, P McColgan, L-A Leyland, AJ Lees, RS Weil

Reduced emergent character of neural dynamics in patients with a disrupted connectome

DOI: http://doi.org/10.1101/2022.06.16.496445
Journal:
E-pub date: 1 Aug 2022
Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, D Menon, D Bor, E Stamatakis

Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape

DOI: http://doi.org/10.1101/2022.07.12.499688
Journal:
E-pub date: 13 Jul 2022
Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.

DOI: http://doi.org/10.1007/s12028-022-01488-1
Journal: Neurocrit Care
E-pub date: 1 Jun 2022
Authors: AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker, AE Hudson, EN Brown, MN Diringer, RD Stevens, M Massimini, MM Monti, EA Stamatakis, M Boly, Curing Coma Campaign and Its Contributing Collaborators

Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness.

DOI: http://doi.org/10.1038/s42003-022-03330-y
Journal: Commun Biol
E-pub date: 20 Apr 2022
Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

Combining network topology and information theory to construct representative brain networks.

DOI: http://doi.org/10.1162/netn_a_00170
Journal: Netw Neurosci
E-pub date: 1 Aug 2021
Authors: AI Luppi, EA Stamatakis

Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

DOI: http://doi.org/10.1101/2021.02.14.431140
Journal:
E-pub date: 1 Aug 2021
Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, A Owen, L Naci, D Menon, D Bor, E Stamatakis

The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.

DOI: http://doi.org/10.3389/fnins.2021.643871
Journal: Front Neurosci
E-pub date: 1 Aug 2021
Authors: AI Luppi, LRB Spindler, DK Menon, EA Stamatakis

Network dynamics scale with levels of awareness

DOI: http://doi.org/10.1101/2021.04.12.439452
Journal:
E-pub date: 1 Aug 2021
Authors: P Coppola, LRB Spindler, A Luppi, R Adapa, L Naci, J Allanson, P Finoia, G Williams, J Pickard, A Owen, D Menon, E Stamatakis

Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury.

DOI: http://doi.org/10.1016/j.nicl.2021.102682
Journal: Neuroimage Clin
E-pub date: 1 Aug 2021
Authors: AI Luppi, MM Craig, P Coppola, ARD Peattie, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

Searching for Consistent Brain Network Topologies Across the Garden of (Shortest) Forking Paths

DOI: http://doi.org/10.1101/2021.07.13.452257
Journal:
E-pub date: 1 Aug 2021
Authors: A Luppi, H Gellersen, A Peattie, A Manktelow, D Menon, S Dimitriadis, E Stamatakis

What it is like to be a bit: an integrated information decomposition account of emergent mental phenomena.

DOI: http://doi.org/10.1093/nc/niab027
Journal: Neurosci Conscious
E-pub date: 1 Aug 2021
Authors: AI Luppi, PAM Mediano, FE Rosas, DJ Harrison, RL Carhart-Harris, D Bor, EA Stamatakis

Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease

DOI: http://doi.org/10.1101/2021.06.21.449237
Journal:
E-pub date: 1 Aug 2021
Authors: A Zarkali, A Luppi, E Stamatakis, S Reeves, P McColgan, L-A Leyland, A Lees, R Weil

LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory

DOI: http://doi.org/10.1101/2021.05.14.444193
Journal:
E-pub date: 1 Aug 2021
Authors: P Singleton, A Luppi, R Carhart-Harris, J Cruzat, L Roseman, D Nutt, G Deco, M Kringelbach, M Kringelbach, E Stamatakis, A Kuceyeski

Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.

DOI: http://doi.org/10.1007/s12028-021-01281-6
Journal: Neurocrit Care
E-pub date: 1 Jul 2021
Authors: AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker, AE Hudson, EN Brown, MN Diringer, RD Stevens, M Massimini, MM Monti, EA Stamatakis, M Boly, Curing Coma Campaign and Its Contributing Collaborators

Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.

DOI: http://doi.org/10.1002/hbm.25405
Journal: Hum Brain Mapp
E-pub date: 15 Jun 2021
Authors: AI Luppi, D Golkowski, A Ranft, R Ilg, D Jordan, DK Menon, EA Stamatakis

LSD alters dynamic integration and segregation in the human brain.

DOI: http://doi.org/10.1016/j.neuroimage.2020.117653
Journal: Neuroimage
E-pub date: 15 Feb 2021
Authors: AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis

What it is like to be a bit: An Integrated Information Decomposition account of emergent mental phenomena

DOI: http://doi.org/10.31234/osf.io/g9p3r
Journal:
E-pub date: 29 Jan 2021
Authors: AI Luppi, P Mediano, F Rosas, DJ Harrison, R Carhart-Harris, D Bor, EA Stamatakis

A synergistic core for human brain evolution and cognition

DOI: http://doi.org/10.1101/2020.09.22.308981
Journal:
E-pub date: 1 Aug 2020
Authors: A Luppi, PAM Mediano, F Rosas, N Holland, T Fryer, J O’Brien, J Rowe, D Menon, D Bor, E Stamatakis