Andrea Loreto

University position

Research Associate


Department of Clinical Neurosciences


Cambridge Centre for Brain Repair


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Research Theme

Cellular and Molecular Neuroscience


Axon degeneration is an early feature of several neurodegenerative diseases, including Parkinson's disease, motor neuron disease, multiple sclerosis and Glaucoma.

My primary area of research focuses on understanding the molecular mechanisms leading to axon degeneration after injury and mitochondrial dysfunction. We aim to identify regulators of axon death and eventually study their involvement in the development of neurodegenerative disorders.

Research Focus


Axon degeneration

Wallerian degeneration


Axonal transport

Mitochondrial dysfunction

Clinical conditions

Alzheimer's disease

Amyotrophic lateral sclerosis



Huntington's disease

Multiple sclerosis

Parkinson's disease

Traumatic brain injury


Calcium imaging

Cell culture

Confocal microscopy

Fluorescence microscopy


Live imaging


Molecular biology

Recombinant protein expression


No collaborators listed

Associated News Items

    Key publications

    Di Stefano M, Loreto A, Orsomando G, Mori V, Zamporlini F, Hulse RP, Webster J, Donaldson LF, Gering M, Raffaelli N, Coleman MP, Gilley J, Conforti L (2017), “NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In Vivo” Curr Biol 27(6):784-794

    Loreto A, Di Stefano M, Gering M, Conforti L (2015), “Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria” Cell Rep 13(11):2539-52



    Rossi F, Geiszler PC, Meng W, Barron MR, Prior M, Herd-Smith A, Loreto A, Lopez MY, Faas H, Pardon MC, Conforti L. (2018), “NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy.” Behav Brain Res. 26;339:140-152.


    Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JR, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L (2015), “A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration” Cell Death Differ 22(5):731-42


    Di Pasquale G, Dicembrini I, Raimondi L, Pagano C, Egan JM, Cozzi A, Cinci L, Loreto A, Manni ME, Berretti S, Morelli A, Zheng C, Michael DG, Maggi M, Vettor R, Chiorini JA, Mannucci E, Rotella CM (2012), “Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes” PLoS One 7(7):e40074