Dr Antonina Kouli

University position

Research Associate

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

ak950@cam.ac.uk

Home page

http://thebarkerlab.co.uk/

Research Themes

Clinical and Veterinary Neuroscience

Cellular and Molecular Neuroscience

The Cambridge Neuroscience Community

Interests

I am a Research Associate interested in neuroinflammation and its role in neurodegenerative diseases. I recently completed my PhD in Clinical Neurosciences at the University of Cambridge, under the supervision of Prof. Roger Barker and Dr. Caroline Williams-Gray.

My current research focuses on characterizing the inflammatory changes in PD and evaluating their relationship with dementia and other symptoms. This work involves:

(i) a detailed neuropathological investigation in human postmortem PD and control brains,

(ii) analysis of peripheral immune markers such as proinflammatory cytokines and Toll-like receptors using flow cytometry and ELISA and

(iii) PET neuroimaging with the radioligands 11C-PK11195 (marker of activated microglia) and 18F-AV1451 (marker of tau accumulation) in newly-diagnosed Parkinson's patients.

Research Focus

Keywords

Parkinson's disease

Dementia

Neuroinflammation

PET imaging

Microglia

Clinical conditions

Cognitive impairment

Dementia

Parkinson's disease

Equipment

Cross-sectional and cohort studies

Flow cytometry

Fluorescence microscopy

Immunohistochemistry

Neuropsychological testing

Positron Emission Tomography (PET)

Collaborators

No collaborators listed

Associated News Items

Publications

2019

Kouli A, Horne CB, Williams-Gray CH (2019), “Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.” Brain Behav Immun pii: S0889-1591(19)30082-0. doi: 10.1016/j.bbi.2019.06.042. [Epub ahead of print]

2018

Kouli A, Torsney KM, Kuan WL (2018), “Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis.” Book Chapter In: Stoker TB, Greenland JC, editors. Parkinson’s Disease: Pathogenesis and Clinical Aspects [Internet]. Brisbane (AU): Codon Publications; 2018 Dec 21. Chapter 1.

Scott KM, Kouli A, Yeoh SL, Clatworthy MR and Williams-Gray CH (2018), “A Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson's Disease ” Front Neurol 9:815.

2017

Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR. (2017), “Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.” Biochim Biophys Acta Mol Cell Res. Volume 1864, Issue 6