Dr Antonina Kouli

Interests

I am a Research Associate interested in neuroinflammation and its role in neurodegenerative diseases. My research focuses on characterizing the inflammatory changes in PD and evaluating their relationship with dementia and other symptoms. This work involves:

(i) a detailed neuropathological investigation in human postmortem PD and control brains,

(ii) analysis of peripheral immune markers such as proinflammatory cytokines and Toll-like receptors using flow cytometry and ELISA and

(iii) PET neuroimaging with the radioligands 11C-PK11195 (marker of activated microglia) and 18F-AV1451 (marker of tau accumulation) in newly-diagnosed Parkinson's patients.

Research Focus

Keywords

Parkinson's disease

Dementia

Neuroinflammation

PET imaging

Microglia

Clinical conditions

Cognitive impairment

Dementia

Parkinson's disease

Equipment

Flow cytometry

Immunohistochemistry

Microscopy

Neuropathology

Positron Emission Tomography (PET)

qPCR

Collaborators

Cambridge

Roger Barker

David Klenerman

Caroline Williams-Gray

United Kingdom

Carmen Martin-Ruiz

Associated News Items


    Publications

    2021

    Ameele, J. van den, Hong, Y., Manavaki, R., Kouli, A., Biggs, H., MacIntyre, Z., Horvath, R., Yu-Wai-Man, P., Reid, E., Williams-Gray, C.H., Bullmore, E., Aigbirhio, F., Fryer, T., Chinnery, P. (2021), “[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease. ” Neurology 96, 22.

    2020

    Kouli, A., Camacho, M., Allinson, K., Williams-Gray, C.H. (2020), “Neuroinflammation and protein pathology in Parkinson’s disease dementia.” Acta Neuropathologica Communications 8, 211.

    Kouli, A., Williams‐Gray, C.H. (2020), “Timing Is Everything: The T-Cell Response to α-Synuclein Is Maximal in Early Parkinson’s” Movement Disorders 35, 1137.

    2019

    Kouli A, Horne CB, Williams-Gray CH (2019), “Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.” Brain Behav Immun 81, 41-51.

    Vuono, R., Kouli, A., Legault, E.M., Chagnon, L., Allinson, K.S., Spada, A.L., Biunno, I., Barker, R.A., Drouin‐Ouellet, J. (2019), “Association Between Toll‐Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.” Movement Disorders

    2018

    Kouli A, Torsney KM, Kuan WL (2018), “Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis.” Book Chapter In: Stoker TB, Greenland JC, editors. Parkinson’s Disease: Pathogenesis and Clinical Aspects [Internet]. Brisbane (AU): Codon Publications; 2018 Dec 21. Chapter 1.

    Scott KM, Kouli A, Yeoh SL, Clatworthy MR and Williams-Gray CH (2018), “A Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson's Disease ” Front Neurol 9:815.

    2017

    Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR. (2017), “Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.” Biochim Biophys Acta Mol Cell Res. Volume 1864, Issue 6.