Dr Antonina Kouli University positionResearch Associate DepartmentsDepartment of Clinical Neurosciences InstitutesCambridge Centre for Brain Repair Home pagehttp://www.thebarkerwilliamsgraylab.co.uk/ Research ThemesInterestsI am a Research Associate interested in neuroinflammation and its role in neurodegenerative diseases. My research focuses on characterizing the inflammatory changes in PD and evaluating their relationship with dementia and other symptoms. This work involves: (i) a detailed neuropathological investigation in human postmortem PD and control brains, (ii) analysis of peripheral immune markers such as proinflammatory cytokines and Toll-like receptors using flow cytometry and ELISA and (iii) PET neuroimaging with the radioligands 11C-PK11195 (marker of activated microglia) and 18F-AV1451 (marker of tau accumulation) in newly-diagnosed Parkinson's patients. Research Focus
EquipmentFlow cytometry Immunohistochemistry Microscopy Neuropathology Positron Emission Tomography (PET) qPCR Collaborators
Associated News ItemsPublications2021Ameele, J. van den, Hong, Y., Manavaki, R., Kouli, A., Biggs, H., MacIntyre, Z., Horvath, R., Yu-Wai-Man, P., Reid, E., Williams-Gray, C.H., Bullmore, E., Aigbirhio, F., Fryer, T., Chinnery, P. (2021), “[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease. ” Neurology 96, 22. 2020Kouli, A., Camacho, M., Allinson, K., Williams-Gray, C.H. (2020), “Neuroinflammation and protein pathology in Parkinson’s disease dementia.” Acta Neuropathologica Communications 8, 211. Kouli, A., Williams‐Gray, C.H. (2020), “Timing Is Everything: The T-Cell Response to α-Synuclein Is Maximal in Early Parkinson’s” Movement Disorders 35, 1137. 2019Kouli A, Horne CB, Williams-Gray CH (2019), “Toll-like receptors and their therapeutic potential in Parkinson's disease and α-synucleinopathies.” Brain Behav Immun 81, 41-51. Vuono, R., Kouli, A., Legault, E.M., Chagnon, L., Allinson, K.S., Spada, A.L., Biunno, I., Barker, R.A., Drouin‐Ouellet, J. (2019), “Association Between Toll‐Like Receptor 4 (TLR4) and Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Genetic Variants and Clinical Progression of Huntington's Disease.” Movement Disorders 2018Kouli A, Torsney KM, Kuan WL (2018), “Parkinson’s Disease: Etiology, Neuropathology, and Pathogenesis.” Book Chapter In: Stoker TB, Greenland JC, editors. Parkinson’s Disease: Pathogenesis and Clinical Aspects [Internet]. Brisbane (AU): Codon Publications; 2018 Dec 21. Chapter 1. Scott KM, Kouli A, Yeoh SL, Clatworthy MR and Williams-Gray CH (2018), “A Systematic Review and Meta-Analysis of Alpha Synuclein Auto-Antibodies in Parkinson's Disease ” Front Neurol 9:815. 2017Bhosale G, Sharpe JA, Koh A, Kouli A, Szabadkai G, Duchen MR. (2017), “Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics.” Biochim Biophys Acta Mol Cell Res. Volume 1864, Issue 6. |