Miss Alice White

Interests

I am investigating the neural correlates of decision-making in patients with Huntington's Disease (HD). HD is a genetic neurodegenerative disease in which mutant forms of the huntingtin protein accumulate in the brain. Patients have three main types of symptom: cognitive, psychiatric and motor.

Patients also report difficulties in decision-making. I am creating and using current cognitive tests to quantify decision-making impairments in HD patients. I am also investigating huntingtin aggregates in brain regions implicated in decision-making, as well as the disease-related changes in these circuits with functional imaging.

I am also interested in immune changes in Parkinson's Disease, especially in disease-related thymic and T-cell function.

Research Focus

Equipment

Confocal microscopy

Cross-sectional and cohort studies

Fluorescence microscopy

Immunohistochemistry

Magnetic resonance imaging (MRI)

Microscopy

Neuropsychological testing