Miss Alice White

Alice White

University position

PhD student
Supervised by Roger Barker and Sarah Mason

Departments

Department of Clinical Neurosciences

Institutes

Cambridge Centre for Brain Repair

Email

ajw283@cam.ac.uk

Home page

http://thebarkerlab.co.uk/

Research Themes

Clinical and Veterinary Neuroscience

Cognitive and Behavioural Neuroscience

Interests

I am investigating the neural correlates of decision-making in patients with Huntington's Disease (HD). HD is a genetic neurodegenerative disease in which mutant forms of the huntingtin protein accumulate in the brain. Patients have three main types of symptom: cognitive, psychiatric and motor.

Patients also report difficulties in decision-making. I am creating and using current cognitive tests to quantify decision-making impairments in HD patients. I am also investigating huntingtin aggregates in brain regions implicated in decision-making, as well as the disease-related changes in these circuits with functional imaging.

I am also interested in immune changes in Parkinson's Disease, especially in disease-related thymic and T-cell function.

Research Focus

Keywords

Huntington's Disease

Cognition

Decision-Making

Protein Aggregation

Behavioural Economics

Clinical conditions

Cognitive impairment

Dementia

Genetic disorders

Huntington's disease

Movement disorders

Parkinson's disease

Equipment

Confocal microscopy

Cross-sectional and cohort studies

Fluorescence microscopy

Immunohistochemistry

Magnetic resonance imaging (MRI)

Microscopy

Neuropsychological testing

Collaborators

Cambridge

Caroline Williams-Gray

Associated News Items