Professor Jenny MortonUniversity positionProfessor Professor Jenny Morton is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Physiology, Development and Neuroscience Home pagehttp://www.pdn.cam.ac.uk/staff/m... Research ThemesInterestsOur research is focused on understanding the mechanisms underlying neurodegeneration and on developing strategies to delay or prevent the death of neurones in injured or degenerating brain, particularly in Huntington's disease. We are also interested in the role that changes in synaptic modulators complexin I and complexin II play in neurological illness. We use a number of different models to study HD including excitotoxin and 3-nitropropionic acid models. However, most of our studies use transgenic mouse models of HD. We use fragment (R6/2) and full length models, both of which have an adult-onset progressive phenotype resembling HD. We take a multidiciplinary approach and our work includes behavioural studies, post mortem tissue analysis and pharmacological studies approaches to developing a treatment for HD. We also use tissue culture (primary organotypic cultures, neurospheres and neuronal cell lines) for experiments aimed at understanding the molecular basis of neurodegeneration. Research Focus
EquipmentBehavioural analysis Cell culture Microscopy Pharmacological studies Postmortem tissue analysis Collaborators
Associated News Items
Key publicationsSkene, D.J., Middleton, B., Fraser, C.K., Pennings, J.L., Kuchel, T.R., Rudiger, S.R., Bawden, C.S., Morton, A.J. (2017), “Metabolic profiling of presymptomatic Huntington's disease sheep reveals novel biomarkers” Scientific Reports 7, 43030 Perentos N, Martins AQ, Watson TC, Bartsch U, Mitchell NL, Palmer DN, Jones MW, Morton AJ (2015), “Translational neurophysiology in sheep: measuring sleep and neurological dysfunction in CLN5 Batten disease affected sheep.” Brain 138(Pt 4):862-74 Details Morton AJ, Rudiger SR, Wood NI, Sawiak SJ, Brown GC, Mclaughlan CJ, Kuchel TR, Snell RG, Faull RL, Bawden CS (2014), “Early and progressive circadian abnormalities in Huntington's disease sheep are unmasked by social environment.” Hum Mol Genet 23(13):3375-83 Details Goodman AO, Rogers L, Pilsworth S, McAllister CJ, Shneerson JM, Morton AJ, Barker RA (2011), “Asymptomatic sleep abnormalities are a common early feature in patients with Huntington's disease.” Curr Neurol Neurosci Rep 11(2):211-7 Details Morton AJ, Avanzo L (2011), “Executive decision-making in the domestic sheep.” PLoS One 6(1):e15752 Details Maywood ES, Fraenkel E, McAllister CJ, Wood N, Reddy AB, Hastings MH, Morton AJ (2010), “Disruption of peripheral circadian timekeeping in a mouse model of Huntington's disease and its restoration by temporally scheduled feeding.” J Neurosci 30(30):10199-204 Details Morton AJ, Glynn D, Leavens W, Zheng Z, Faull RL, Skepper JN, Wight JM (2009), “Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.” Neurobiol Dis 33(3):331-41 Details Glynn D, Sizemore RJ, Morton AJ (2007), “Early motor development is abnormal in complexin 1 knockout mice” Neurobiol Dis 25(3):483-95 Details Morton AJ, Skillings E, Bussey TJ, Saksida LM (2006), “Measuring cognitive deficits in disabled mice using an automated interactive touchscreen system” Nat Methods 3(10):767 Details Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005), “Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease” J Neurosci 25(15):3994 Details Publications2017Jacobsen, J.C., Erdin, S., Chiang, C., Hanscom, C., Handley, R.R., Barker, D.D., Stortchevoi, A., Blumenthal, I., Reid, S.J., Snell, R.G., MacDonald, M.E., Morton, A.J., Ernst, C., Gusella, J.F. and Talkowski, M.E. (2017), “Potential molecular consequences of transgene integration: The R6/2 mouse example” Scientific Reports 7, 41120 in pressKantor, S., Varga, J., Kulkarni, S. and Morton, A.J. (in press), “Chronic paroxetine treatment prevents the emergence of abnormal EEG oscillations in Huntington’s disease mice.” Neurotherapeutics 10.1007/s13311-017-0546-7 Knolle, F., Goncalves, R.P. and Morton, A.J. (in press), “Sheep recognize familiar faces and unfamiliar human faces from two-dimensional images” Royal Society Open Science 101098/rsos.171228 2017Knolle, F., McBride, S.D., Stewart, J.E., Goncalves, R.P. and Morton, A.J. (2017), “A stop-signal task for sheep: introduction and validation of a direct measure for the stop-signal reaction time.” Animal Cognition 20 615–626 2016Glynn, D., Skillings, E.A. and Morton A.J. (2016), “A comparison of discrimination learning in Touchscreen and 2-choice swim tank using an allelic series of Huntington's disease mice.” Journal of Neuroscience Methods 265, 56-71 Kantor, S.K., Varga, J. and Morton, A.J. (2016), “A single dose of hypnotic corrects sleep and EEG abnormalities in Huntington’s disease mice. ” Neuropharmacology 105: 298-307 Kumar, A., Zhang, J., Tallaksen-Greene, S., Crowley, M.R., Crossman, D.K., Morton, A.J., van Groen, T., Kadish, I., Albin, R.L., Lesort, M. and Detloff, D.J. (2016), “ Allelic series of Huntington’s disease knock-in mice reveals expression discorrelates. ?” Human Molecular Genetics Vol. 25.8 1619-1636 Kumar, A., Zhang, J., Tallaksen-Greene, S., Crowley, M.R., Crossman, D.K., Morton, A.J., van Groen, T., Kadish, I., Albin, R.L., Lesort, M. and Detloff, D.J. (2016), “Allelic series of Huntington’s disease knock-in mice reveals expression discorrelates. ” Human Molecular Genetics 25(8) 1619-1636 Nicol, A.U., Perentos, N., Martins, A.Q. and Morton, A.J. (2016), “Automated detection and characterisation of rumination in sheep using in vivo electrophysiology” Physiology & Behavior 163, 258-266 Ouk, K., Aungier, J. and Morton, A.J. (2016), “Prolonged day length exposure improves circadian deficits and survival in a transgenic mouse model of Huntington’s disease.” Neurobiology of Sleep and Circadian Rhythms 2, 27–38 Ouk, K., Aungier, J.A. and Morton, A.J. (2016), “Progressive gene dose-dependent loss of the methamphetamine-sensitive circadian oscillator in a knock-in mouse model of Huntington disease.” Human Molecular Genetics 286, 69-82 Ouk, K., Hughes, S., Pothecary, C.A., Peirson, S.N. and Morton, A.J. (2016), “Attenuated pupillary light responses and loss of opsin expression parallels decline in circadian disruption in two different mouse models of Huntington’s disease” Experimental Neurology 25, (24)5418–5432 Perentos, N., Martins, A.Q., Cumming, R., Mitchell, N.L., Palmer, D.N., Sawiak, S.J. and Morton, A.J. (2016), “An EEG investigation of sleep homeostasis in healthy and CLN5 Batten disease affected sheep” Journal of Neuroscience 36, 8238-8249 Sawiak, S.J., Wood, N.I. and Morton, A.J. (2016), “Similar progression of morphological and metabolic phenotype in R6/2 mice with different CAG repeats revealed by in vivo magnetic resonance imaging and spectroscopy” Neurobiology of disease 5, 271-283 Skillings, E.A. and Morton, A.J. (2016), “Delayed onset and reduced cognitive deficits through pre-conditioning with 3-Nitropropionic acid is dependant on sex and CAG repeat length in the R6/2 mouse model of Huntington’s disease” Journal of Huntington’s Disease 5, 19-32 2015Ciamei A, Detloff PJ, Morton AJ (2015), “Progression of behavioural despair in R6/2 and Hdh knock-in mouse models recapitulates depression in Huntington's disease.” Behav Brain Res Details Furmston T, Morton AJ, Hailes S (2015), “A Significance Test for Inferring Affiliation Networks from Spatio-Temporal Data.” PLoS One 10(7):e0132417 Details Glynn D, Skillings EA, Morton AJ (2015), “A comparison of discrimination learning in touchscreen and 2-choice swim tank using an allelic series of Huntington's disease mice.” J Neurosci Methods Details Larson E, Fyfe I, Morton AJ, Monckton DG (2015), “Age-, tissue- and length-dependent bidirectional somatic CAG•CTG repeat instability in an allelic series of R6/2 Huntington disease mice.” Neurobiol Dis 76:98-111 Details McBride SD, Perentos N, Morton AJ (2015), “Understanding the concept of a reflective surface: can sheep improve navigational ability through the use of a mirror?” Anim Cogn 18(1):361-71 Details McLennan, K. M., Skillings, E.A., Rebelo C.J.B., Corke M.J., Pires Moreira, M.A. Morton, A.J. and Constantino-Casas, F (2015), “Validation of an automatic recording system to assess behavioural activity level in sheep (Ovis aries). ” Small Ruminant Research 127, 92-96 Sawiak SJ, Morton AJ (2015), “The Cambridge MRI database for animal models of Huntington disease.” Neuroimage Details Sawiak SJ, Perumal SR, Rudiger SR, Matthews L, Mitchell NL, McLaughlan CJ, Bawden CS, Palmer DN, Kuchel T, Morton AJ (2015), “Rapid and Progressive Regional Brain Atrophy in CLN6 Batten Disease Affected Sheep Measured with Longitudinal Magnetic Resonance Imaging.” PLoS One 10(7):e0132331 Details 2014Buonincontri G, Wood NI, Puttick SG, Ward AO, Carpenter TA, Sawiak SJ, Morton AJ (2014), “Right ventricular dysfunction in the R6/2 transgenic mouse model of Huntington's disease is unmasked by dobutamine.” J Huntingtons Dis 3(1):25-32 Details Cuesta M, Aungier J, Morton AJ (2014), “Behavioral therapy reverses circadian deficits in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 63C:85-91 Details Furmston, T., Hailes, S. and Morton, A.J. (2014), “A bayesian residual-based test for cointegration. ” arXiv :1311.0524v1 [stat.ME] 1311.0524v1 Skillings EA, Wood NI, Morton AJ (2014), “Beneficial effects of environmental enrichment and food entrainment in the R6/2 mouse model of Huntington's disease.” Brain Behav 4(5):675-86 Details 2013Kantor S, Szabo L, Varga J, Cuesta M, Morton AJ (2013), “Progressive sleep and electroencephalogram changes in mice carrying the Huntington's disease mutation.” Brain 136(Pt 7):2147-2158 Details Ma L, Chen K, Clarke DJ, Nortcliffe CP, Wilson GG, Edwardson JM, Morton AJ, Jones AC, Dryden DT (2013), “Restriction endonuclease TseI cleaves A:A and T:T mismatches in CAG and CTG repeats.” Nucleic Acids Res 41(9):4999-5009 Details Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR (2013), “Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.” Hum Mol Genet Details Pouladi MA, Morton AJ, Hayden MR (2013), “Choosing an animal model for the study of Huntington's disease.” Nat Rev Neurosci 14(10):708-21 Details Reid SJ, Patassini S, Handley RR, Rudiger SR, McLaughlan CJ, Osmand A, Jacobsen JC, Morton AJ, Weiss A, Waldvogel HJ, MacDonald ME, Gusella JF, Bawden CS, Faull RL, Snell RG (2013), “Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates.” J Huntingtons Dis 2(3):279-95 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2013), “Voxel-based morphometry with templates and validation in a mouse model of Huntington's disease.” Magn Reson Imaging 31(9):1522-31 Details Wood NI, McAllister CJ, Cuesta M, Aungier J, Fraenkel E, Morton AJ (2013), “Adaptation to Experimental Jet-Lag in R6/2 Mice despite Circadian Dysrhythmia.” PLoS One 8(2):e55036 Details 2012Cuesta M, Aungier J, Morton AJ (2012), “The methamphetamine-sensitive circadian oscillator is dysfunctional in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 45(1):145-55 Details Gong B, Kielar C, Morton AJ (2012), “Temporal separation of aggregation and ubiquitination during early inclusion formation in transgenic mice carrying the Huntington's disease mutation.” PLoS One 7(7):e41450 Details Hobbs-Chell H, King AJ, Sharratt H, Haddadi H, Rudiger SR, Hailes S, Morton AJ, Wilson AM (2012), “Data-loggers carried on a harness do not adversely affect sheep locomotion.” Res Vet Sci 93(1):549-52 Details Kielar C, Sawiak SJ, Navarro Negredo P, Tse DH, Morton AJ (2012), “Tensor-based morphometry and stereology reveal brain pathology in the complexin1 knockout mouse.” PLoS One 7(2):e32636 Details King AJ, Wilson AM, Wilshin SD, Lowe J, Haddadi H, Hailes S, Morton AJ (2012), “Selfish-herd behaviour of sheep under threat.” Curr Biol 22(14):R561-2 Details Morton AJ (2012), “Circadian and sleep disorder in Huntington's disease.” Exp Neurol Details Sawiak SJ, Wood NI, Carpenter TA, Morton AJ (2012), “Huntington's disease mouse models online: high-resolution MRI images with stereotaxic templates for computational neuroanatomy.” PLoS One 7(12):e53361 Details Wishart TM, Rooney TM, Lamont DJ, Wright AK, Morton AJ, Jackson M, Freeman MR, Gillingwater TH (2012), “Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo.” PLoS Genet 8(8):e1002936 Details 2011Duzdevich D, Li J, Whang J, Takahashi H, Takeyasu K, Dryden DT, Morton AJ, Edwardson JM (2011), “Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.” PLoS One 6(2):e17119 Details Williams RH, Morton AJ, Burdakov D (2011), “Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease.” Neurobiol Dis 42(3):438-45 Details Wood NI, Glynn D, Morton AJ (2011), “"Brain training" improves cognitive performance and survival in a transgenic mouse model of Huntington's disease.” Neurobiol Dis 42(3):427-37 Details 2010Glynn D, Gibson HE, Harte MK, Reim K, Jones S, Reynolds GP, Morton AJ (2010), “Clorgyline-mediated reversal of neurological deficits in a Complexin 2 knockout mouse.” Hum Mol Genet 19(17):3402-12 Details Goodman AO, Morton AJ, Barker RA (2010), “Identifying sleep disturbances in Huntington's disease using a simple disease-focused questionnaire.” PLoS Curr 2:RRN1189 Details Wood NI, Carta V, Milde S, Skillings EA, McAllister CJ, Ang YL, Duguid A, Wijesuriya N, Afzal SM, Fernandes JX, Leong TW, Morton AJ (2010), “Responses to environmental enrichment differ with sex and genotype in a transgenic mouse model of Huntington's disease.” PLoS One 5(2):e9077 Details 2009Ciamei A, Morton AJ (2009), “Progressive imbalance in the interaction between spatial and procedural memory systems in the R6/2 mouse model of Huntington's disease.” Neurobiol Learn Mem 92(3):417-28 Details Menalled L, El-Khodor BF, Patry M, Suárez-Fariñas M, Orenstein SJ, Zahasky B, Leahy C, Wheeler V, Yang XW, MacDonald M, Morton AJ, Bates G, Leeds J, Park L, Howland D, Signer E, Tobin A, Brunner D (2009), “Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.” Neurobiol Dis 35(3):319-36 Details Pallier PN, Drew CJ, Morton AJ (2009), “The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function.” Brain Res Bull 78(6):347-55 Details Pallier PN, Morton AJ (2009), “Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease.” Brain Res 1279:90-8 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Voxel-based morphometry in the R6/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry.” Neurobiol Dis 33(1):20-7 Details Sawiak SJ, Wood NI, Williams GB, Morton AJ, Carpenter TA (2009), “Use of magnetic resonance imaging for anatomical phenotyping of the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 33(1):12-9 Details 2008Bussey TJ, Padain TL, Skillings EA, Winters BD, Morton AJ, Saksida LM (2008), “The touchscreen cognitive testing method for rodents: how to get the best out of your rat.” Learn Mem 15(7):516-23 Details Ciamei A, Morton AJ (2008), “Rigidity in social and emotional memory in the R6/2 mouse model of Huntington's disease.” Neurobiol Learn Mem 89(4):533-44 Details Court FA, Gillingwater TH, Melrose S, Sherman DL, Greenshields KN, Morton AJ, Harris JB, Willison HJ, Ribchester RR (2008), “Identity, developmental restriction and reactivity of extralaminar cells capping mammalian neuromuscular junctions.” J Cell Sci 121(Pt 23):3901-11 Details Gong B, Lim MC, Wanderer J, Wyttenbach A, Morton AJ (2008), “Time-lapse analysis of aggregate formation in an inducible PC12 cell model of Huntington's disease reveals time-dependent aggregate formation that transiently delays cell death.” Brain Res Bull 75(1):146-57 Details Goodman AO, Murgatroyd PR, Medina-Gomez G, Wood NI, Finer N, Vidal-Puig AJ, Morton AJ, Barker RA (2008), “The metabolic profile of early Huntington's disease--a combined human and transgenic mouse study.” Exp Neurol 210(2):691-8 Details Michell AW, Goodman AO, Silva AH, Lazic SE, Morton AJ, Barker RA (2008), “Hand tapping: a simple, reproducible, objective marker of motor dysfunction in Huntington's disease.” J Neurol 255(8):1145-52 Details van der Burg JM, Bacos K, Wood NI, Lindqvist A, Wierup N, Woodman B, Wamsteeker JI, Smith R, Deierborg T, Kuhar MJ, Bates GP, Mulder H, Erlanson-Albertsson C, Morton AJ, Brundin P, Petersén A, Björkqvist M (2008), “Increased metabolism in the R6/2 mouse model of Huntington's disease.” Neurobiol Dis 29(1):41-51 Details Wade A, Jacobs P, Morton AJ (2008), “Atrophy and degeneration in sciatic nerve of presymptomatic mice carrying the Huntington's disease mutation.” Brain Res 1188:61-8 Details Wood NI, Goodman AO, van der Burg JM, Gazeau V, Brundin P, Björkqvist M, Petersén A, Tabrizi SJ, Barker RA, Morton AJ (2008), “Increased thirst and drinking in Huntington's disease and the R6/2 mouse.” Brain Res Bull 76(1-2):70-9 Details 2007Drew CJ, Kyd RJ, Morton AJ (2007), “Complexin 1 knockout mice exhibit marked deficits in social behaviours but appear to be cognitively normal.” Hum Mol Genet 16(19):2288-305 Details Glynn D, Reim K, Brose N, Morton AJ (2007), “Depletion of Complexin II does not affect disease progression in a mouse model of Huntington's disease (HD); support for role for complexin II in behavioural pathology in a mouse model of HD.” Brain Res Bull 72(2-3):108-20 Details Kung VW, Hassam R, Morton AJ, Jones S (2007), “Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease.” Neuroscience 146(4):1571-80 Details Lazic SE, Goodman AO, Grote HE, Blakemore C, Morton AJ, Hannan AJ, van Dellen A, Barker RA (2007), “Olfactory abnormalities in Huntington's disease: decreased plasticity in the primary olfactory cortex of R6/1 transgenic mice and reduced olfactory discrimination in patients.” Brain Res 1151:219-26 Details Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ (2007), “Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.” J Neurosci 27(29):7869-78 Details Wanderer J, Morton AJ (2007), “Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington's disease.” Histochem Cell Biol 127(5):473-84 Details Wood NI, Pallier PN, Wanderer J, Morton AJ (2007), “Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice.” Neurobiol Dis 25(2):342-53 Details 2006Hernández-Espinosa D, Morton AJ (2006), “Calcineurin inhibitors cause an acceleration of the neurological phenotype in a mouse transgenic for the human Huntington's disease mutation.” Brain Res Bull 69(6):669-79 Details 2005Gibson HE, Reim K, Brose N, Morton AJ, Jones S (2005), “A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse.” Eur J Neurosci 22(7):1701-12 Details Glynn D, Drew CJ, Reim K, Brose N, Morton AJ (2005), “Profound ataxia in complexin I knockout mice masks a complex phenotype that includes exploratory and habituation deficits.” Hum Mol Genet 14(16):2369-85 Details Hunt MJ, Morton AJ (2005), “Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents.” Exp Brain Res 166(2):220-9 Details Morton AJ, Campbell NB, Gayle JM, Redding WR, Blikslager AT (2005), “Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis.” Res Vet Sci 78(2):189-92 Details Morton AJ, Hunt MJ, Hodges AK, Lewis PD, Redfern AJ, Dunnett SB, Jones L (2005), “A combination drug therapy improves cognition and reverses gene expression changes in a mouse model of Huntington's disease.” Eur J Neurosci 21(4):855-70 Details Morton J (2005), “Ecstasy: pharmacology and neurotoxicity.” Curr Opin Pharmacol 5(1):79-86 Details Phillips W, Morton AJ, Barker RA (2005), “Abnormalities of neurogenesis in the R6/2 mouse model of Huntington's disease are attributable to the in vivo microenvironment.” J Neurosci 25(50):11564-76 Details Wäsle B, Turvey M, Larina O, Thorn P, Skepper J, Morton AJ, Edwardson JM (2005), “Syncollin is required for efficient zymogen granule exocytosis.” Biochem J 385(Pt 3):721-7 Details 2004Freeman W, Morton AJ (2004), “Regional and progressive changes in brain expression of complexin II in a mouse transgenic for the Huntington's disease mutation.” Brain Res Bull 63(1):45-55 Details Freeman W, Morton AJ (2004), “Differential messenger RNA expression of complexins in mouse brain.” Brain Res Bull 63(1):33-44 Details Ribchester RR, Thomson D, Wood NI, Hinks T, Gillingwater TH, Wishart TM, Court FA, Morton AJ (2004), “Progressive abnormalities in skeletal muscle and neuromuscular junctions of transgenic mice expressing the Huntington's disease mutation.” Eur J Neurosci 20(11):3092-114 Details 2003Edwardson JM, Wang CT, Gong B, Wyttenbach A, Bai J, Jackson MB, Chapman ER, Morton AJ (2003), “Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.” J Biol Chem 278(33):30849-53 Details Glynn D, Bortnick RA, Morton AJ (2003), “Complexin II is essential for normal neurological function in mice.” Hum Mol Genet 12(19):2431-48 Details Ma L, Carter RJ, Morton AJ, Nicholson LF (2003), “RAGE is expressed in pyramidal cells of the hippocampus following moderate hypoxic-ischemic brain injury in rats.” Brain Res 966(2):167-74 Details Ma L, Morton AJ, Nicholson LF (2003), “Microglia density decreases with age in a mouse model of Huntington's disease.” Glia 43(3):274-80 Details Wood NI, Morton AJ (2003), “Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation.” Brain Res Bull 61(4):375-83 Details 2002Hickey MA, Reynolds GP, Morton AJ (2002), “The role of dopamine in motor symptoms in the R6/2 transgenic mouse model of Huntington's disease.” J Neurochem 81(1):46-59 Details 2001Carter RJ, Morton J, Dunnett SB (2001), “Motor coordination and balance in rodents.” Curr Protoc Neurosci Chapter 8:Unit 8.12 Details Morton AJ, Edwardson JM (2001), “Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease.” J Neurochem 76(1):166-72 Details Morton AJ, Faull RL, Edwardson JM (2001), “Abnormalities in the synaptic vesicle fusion machinery in Huntington's disease.” Brain Res Bull 56(2):111-7 Details Morton AJ, Hickey MA, Dean LC (2001), “Methamphetamine toxicity in mice is potentiated by exposure to loud music.” Neuroreport 12(15):3277-81 Details 2000Carter RJ, Hunt MJ, Morton AJ (2000), “Environmental stimulation increases survival in mice transgenic for exon 1 of the Huntington's disease gene.” Mov Disord 15(5):925-37 Details Hickey MA, Morton AJ (2000), “Mice transgenic for the Huntington's disease mutation are resistant to chronic 3-nitropropionic acid-induced striatal toxicity.” J Neurochem 75(5):2163-71 Details Morton AJ, Lagan MA, Skepper JN, Dunnett SB (2000), “Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation.” J Neurocytol 29(9):679-702 Details Morton AJ, Leavens W (2000), “Mice transgenic for the human Huntington's disease mutation have reduced sensitivity to kainic acid toxicity.” Brain Res Bull 52(1):51-9 Details Murphy KP, Carter RJ, Lione LA, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (2000), “Abnormal synaptic plasticity and impaired spatial cognition in mice transgenic for exon 1 of the human Huntington's disease mutation.” J Neurosci 20(13):5115-23 Details 1999Carter RJ, Lione LA, Humby T, Mangiarini L, Mahal A, Bates GP, Dunnett SB, Morton AJ (1999), “Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.” J Neurosci 19(8):3248-57 Details Lione LA, Carter RJ, Hunt MJ, Bates GP, Morton AJ, Dunnett SB (1999), “Selective discrimination learning impairments in mice expressing the human Huntington's disease mutation.” J Neurosci 19(23):10428-37 Details 1998Dunnett SB, Carter RJ, Watts C, Torres EM, Mahal A, Mangiarini L, Bates G, Morton AJ (1998), “Striatal transplantation in a transgenic mouse model of Huntington's disease.” Exp Neurol 154(1):31-40 Details Reynolds DS, Carter RJ, Morton AJ (1998), “Dopamine modulates the susceptibility of striatal neurons to 3-nitropropionic acid in the rat model of Huntington's disease.” J Neurosci 18(23):10116-27 Details Reynolds DS, Morton AJ (1998), “Changes in blood-brain barrier permeability following neurotoxic lesions of rat brain can be visualised with trypan blue.” J Neurosci Methods 79(1):115-21 Details 1996Sullivan AM, Morton AJ (1996), “Endothelins induce Fos expression in neurons and glia in organotypic cultures of rat cerebellum.” J Neurochem 67(4):1409-18 Details Sullivan AM, Reynolds DS, Thomas KL, Morton AJ (1996), “Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors.” Neuroreport 8(1):211-6 Details 1995Morton AJ, Williams MN, Emson PC, Faull RL (1995), “The morphology of human neuroblastoma cell grafts in the kainic acid-lesioned basal ganglia of the rat.” J Neurocytol 24(8):568-84 Details Page GK, Morton AJ (1995), “Correlation of neuronal loss with increased expression of NADPH diaphorase in cultured rat cerebellum and cerebral cortex.” Brain Res 697(1-2):157-68 Details Tucker LM, Morton AJ (1995), “A simple method for quantifying changes in neuronal populations in primary cultures of dissociated rat brain.” J Neurosci Methods 59(2):217-23 Details 1994Allanson J, Bond AB, Morton J, Hunt SP (1994), “Transfection of proto oncogene c-jun into a mouse neuroblastoma cell line potentiates differentiation.” Gene Ther 1 Suppl 1:S58 Details 1993Morton AJ, Nicholson LF, Faull RL (1993), “Compartmental loss of NADPH diaphorase in the neuropil of the human striatum in Huntington's disease.” Neuroscience 53(1):159-68 Details 1992Lledo PM, Somasundaram B, Morton AJ, Emson PC, Mason WT (1992), “Stable transfection of calbindin-D28k into the GH3 cell line alters calcium currents and intracellular calcium homeostasis.” Neuron 9(5):943-54 Details Morton AJ, Buss TN (1992), “Accelerated Differentiation in Response to Retinoic Acid After Retrovirally Mediated Gene Transfer of GAP-43 into Mouse Neuroblastoma Cells.” Eur J Neurosci 4(10):910-916 Details Morton AJ, Davenport AP (1992), “Cerebellar neurons and glia respond differentially to endothelins and sarafotoxin S6b.” Brain Res 581(2):299-306 Details Morton AJ, Hammond C, Mason WT, Henderson G (1992), “Characterisation of the L- and N-type calcium channels in differentiated SH-SY5Y neuroblastoma cells: calcium imaging and single channel recording.” Brain Res Mol Brain Res 13(1-2):53-61 Details 1991Davenport AP, Morton AJ (1991), “Binding sites for 125I ET-1, ET-2, ET-3 and vasoactive intestinal contractor are present in adult rat brain and neurone-enriched primary cultures of embryonic brain cells.” Brain Res 554(1-2):278-85 Details Davenport AP, Morton AJ, Brown MJ (1991), “Localization of endothelin-1 (ET-1), ET-2, and ET-3, mouse VIC, and sarafotoxin S6b binding sites in mammalian heart and kidney.” J Cardiovasc Pharmacol 17 Suppl 7:S152-5 Details 1990Morton AJ, Emson PC (1990), “Expression of calbindin D-28K-like immunoreactivity in human SK-N-SH and SH-SY-5Y neuroblastoma cells.” Brain Res 533(1):161-4 Details 1987Morton AJ (1987), “A role for corticosterone in the in vivo regulation of the extraneuronal uptake of [3H]-isoprenaline into rat atria.” Br J Pharmacol 91(2):347-53 Details Morton AJ (1987), “An investigation of the role of adrenergic innervation in the regulation of the extraneuronal uptake of [3H]-isoprenaline into rat vasa deferentia and atria.” Br J Pharmacol 91(2):333-46 Details 1985Morton AJ (1985), “The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.” Br J Pharmacol 86(1):287-95 Details |