Dr Alexis JoannidesUniversity positionResearch Associate DepartmentsDepartment of Clinical Neurosciences InstitutesCambridge Centre for Brain Repair Research ThemesInterestsWe have established a scaleable and clinically compatible system for generating and propagating neural stem cells from human embryonic stem (ES) cells. Using this platform, and building on our work on mouse ES cells demonstrating a correlation of developmental restriction with the onset of gliogenesis, we are investigating the interplay between extrinsic signals and intrinsic determinants on developmental plasticity in a human context. Research Focus
EquipmentCell culture Confocal microscopy Electrophysiological recording techniques Fluorescence microscopy Immunohistochemistry Microscopy CollaboratorsNo collaborators listed Associated News ItemsKey publicationsJoannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine K, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130:1263-1275 Details Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND (2006), “Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning” Stem Cells 24:1908-1913 Details Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S (2004), “Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells” Lancet 362:172-178 Details |