Dr Alexis Joannides


We have established a scaleable and clinically compatible system for generating and propagating neural stem cells from human embryonic stem (ES) cells. Using this platform, and building on our work on mouse ES cells demonstrating a correlation of developmental restriction with the onset of gliogenesis, we are investigating the interplay between extrinsic signals and intrinsic determinants on developmental plasticity in a human context.

Research Focus


stem cells



Clinical conditions

Alzheimer's disease

Huntington's disease

Multiple sclerosis

Parkinson's disease


Cell culture

Confocal microscopy

Electrophysiological recording techniques

Fluorescence microscopy




No collaborators listed

Associated News Items

    Key publications

    Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine K, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S (2007), “Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells” Brain 130:1263-1275 Details

    Bouhon IA, Joannides A, Kato H, Chandran S, Allen ND (2006), “Embryonic stem cell-derived neural progenitors display temporal restriction to neural patterning” Stem Cells 24:1908-1913 Details

    Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S (2004), “Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells” Lancet 362:172-178 Details