Mr Arshad Haider


University position

PhD student
Supervised by Gabriel Balmus

Departments

Department of Clinical Neurosciences

Institutes

UK Dementia Research Institute at University of Cambridge

Research Theme

Cellular and Molecular Neuroscience

Interests

I am interested in understanding the roles of DNA Damage Repair (DDR) in mature neurons and its links to neurodegenerative disorders (including Huntington's and Parkinson's diseases) and ageing. I am utlizting high throughput methods, including whole genome CRISPR-Cas9 screens, scRNAseq, and mass spectrometry in mature neurons, iPSC, mESC and hESC's. In addition, I am utilising and developing organoids as a model to study the aforementioned neurodegenerative disorders. I hope to uncover the mechanisms by which neurons deal with endogenous genotoxic stresses, their contribution to progression of neurodegeneration and ageing, and how to harness this knowledge to inform on key genetic interactions that can be exploited therapeutically.

Research Focus

Keywords

DNA damage

repair

ageing

synthetic lethality

Clinical conditions

Alzheimer's disease

Cancers

Dementia

Huntington's disease

Parkinson's disease

Equipment

Cell culture

Confocal microscopy

CRISPR-Cas9 screens

Immunohistochemistry

Organoids

scRNAseq

Collaborators

No collaborators listed

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