Mr Arshad Haider![]() University positionPhD student DepartmentsDepartment of Clinical Neurosciences InstitutesUK Dementia Research Institute at University of Cambridge Research ThemeInterestsI am interested in understanding the roles of DNA Damage Repair (DDR) in mature neurons and its links to neurodegenerative disorders (including Huntington's and Parkinson's diseases) and ageing. I am utlizting high throughput methods, including whole genome CRISPR-Cas9 screens, scRNAseq, and mass spectrometry in mature neurons, iPSC, mESC and hESC's. In addition, I am utilising and developing organoids as a model to study the aforementioned neurodegenerative disorders. I hope to uncover the mechanisms by which neurons deal with endogenous genotoxic stresses, their contribution to progression of neurodegeneration and ageing, and how to harness this knowledge to inform on key genetic interactions that can be exploited therapeutically. Research Focus
EquipmentCell culture Confocal microscopy CRISPR-Cas9 screens Immunohistochemistry Organoids scRNAseq CollaboratorsNo collaborators listed Associated News Items |