Mr Arshad Haider

Interests

I am interested in understanding the roles of DNA Damage Repair (DDR) in mature neurons and its links to neurodegenerative disorders (including Huntington's and Parkinson's diseases) and ageing. I am utlizting high throughput methods, including whole genome CRISPR-Cas9 screens, scRNAseq, and mass spectrometry in mature neurons, iPSC, mESC and hESC's. In addition, I am utilising and developing organoids as a model to study the aforementioned neurodegenerative disorders. I hope to uncover the mechanisms by which neurons deal with endogenous genotoxic stresses, their contribution to progression of neurodegeneration and ageing, and how to harness this knowledge to inform on key genetic interactions that can be exploited therapeutically.

Research Focus

Equipment

Cell culture

Confocal microscopy

CRISPR-Cas9 screens

Immunohistochemistry

Organoids

scRNAseq