Professor Anne Ferguson-Smith

Anne Ferguson-Smith

University position

Head of Department

Professor Anne Ferguson-Smith is pleased to consider applications from prospective PhD students.


Department of Genetics


Home page

Research Theme

Developmental Neuroscience


Genomic imprinting is an epigenetic mechanism causing genes to be expressed depending on their parental origin. Our research investigates the mechanism and evolution of genomic imprinting and the function of imprinted genes in development and disease. Part of this programme considers the implications of epigenetic control in the development and function of the brain. We also use imprinting as a model system for analysing the epigenetic control of genome function and in particular the roles of DNA methylation and histone modifications in the regulation of gene activity and repression. Our work focuses on an imprinted domain that includes genes and non-coding RNAs that are expressed during neural development and in the adult brain. Little is known about the precise roles of these genes. We are taking molecular approaches using mouse genetic models to address the function of these genes.

Research Focus



genomic imprinting

non-coding RNA


stem cells and development

Clinical conditions

Genetic disorders


Cell culture

develomental neurogenetics

Enzyme assays

epigenetic analysis

gene targeting - knockout mice


mouse molecular genetics

transgenic mice


No collaborators listed

Associated News Items



    Charalambous M, da Rocha ST, Hernandez A, Ferguson-Smith AC (2014), “Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting.” Acta Physiol (Oxf) 210(1):174-87 Details

    Cleaton MA, Edwards CA, Ferguson-Smith AC (2014), “Phenotypic Outcomes of Imprinted Gene Models in Mice: Elucidation of Pre- and Postnatal Functions of Imprinted Genes.” Annu Rev Genomics Hum Genet Details

    Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AH, Patti ME, Ferguson-Smith AC (2014), “In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism.” Science Details

    Stridh P, Ruhrmann S, Bergman P, Thessén Hedreul M, Flytzani S, Beyeen AD, Gillett A, Krivosija N, Öckinger J, Ferguson-Smith AC, Jagodic M (2014), “Parent-of-origin effects implicate epigenetic regulation of experimental autoimmune encephalomyelitis and identify imprinted Dlk1 as a novel risk gene.” PLoS Genet 10(3):e1004265 Details


    Aziz A, Baxter EJ, Edwards C, Cheong CY, Ito M, Bench A, Kelley R, Silber Y, Beer PA, Chng K, Renfree MB, McEwen K, Gray D, Nangalia J, Mufti GJ, Hellstrom-Lindberg E, Kiladjian JJ, McMullin MF, Campbell PJ, Ferguson-Smith AC, Green AR (2013), “Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions.” J Clin Invest 123(5):2169-82 Details

    Das R, Lee YK, Strogantsev R, Jin S, Lim YC, Ng PY, Lin XM, Chng K, Yeo GSh, Ferguson-Smith AC, Ding C (2013), “DNMT1 and AIM1 Imprinting in human placenta revealed through a genome-wide screen for allele-specific DNA methylation.” BMC Genomics 14:685 Details

    Driskell RR, Lichtenberger BM, Hoste E, Kretzschmar K, Simons BD, Charalambous M, Ferron SR, Herault Y, Pavlovic G, Ferguson-Smith AC, Watt FM (2013), “Distinct fibroblast lineages determine dermal architecture in skin development and repair.” Nature 504(7479):277-81 Details

    Fogarty NM, Ferguson-Smith AC, Burton GJ (2013), “Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage.” Am J Pathol 183(1):144-52 Details

    Grossniklaus U, Kelly WG, Ferguson-Smith AC, Pembrey M, Lindquist S (2013), “Transgenerational epigenetic inheritance: how important is it?” Nat Rev Genet 14(3):228-35 Details

    Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MF, Ferguson-Smith AC, Dzierzak E, Ottersbach K (2013), “Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.” Haematologica 98(2):163-71 Details

    Padmanabhan N, Jia D, Geary-Joo C, Wu X, Ferguson-Smith AC, Fung E, Bieda MC, Snyder FF, Gravel RA, Cross JC, Watson ED (2013), “Mutation in folate metabolism causes epigenetic instability and transgenerational effects on development.” Cell 155(1):81-93 Details

    Sferruzzi-Perri AN, Vaughan OR, Haro M, Cooper WN, Musial B, Charalambous M, Pestana D, Ayyar S, Ferguson-Smith AC, Burton GJ, Constancia M, Fowden AL (2013), “An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory.” FASEB J 27(10):3928-37 Details

    van der Weyden L, Rust AG, McIntyre RE, Robles-Espinoza CD, del Castillo Velasco-Herrera M, Strogantsev R, Ferguson-Smith AC, McCarthy S, Keane TM, Arends MJ, Adams DJ (2013), “Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity.” Oncogene 32(3):397-402 Details


    An F, Yamanaka S, Allen S, Roberts LR, Gores GJ, Pawlik TM, Xie Q, Ishida M, Mezey E, Ferguson-Smith AC, Mori Y, Selaru FM (2012), “Silencing of miR-370 in human cholangiocarcinoma by allelic loss and interleukin-6 induced maternal to paternal epigenotype switch.” PLoS One 7(10):e45606 Details

    Charalambous M, Ferron SR, da Rocha ST, Murray AJ, Rowland T, Ito M, Schuster-Gossler K, Hernandez A, Ferguson-Smith AC (2012), “Imprinted gene dosage is critical for the transition to independent life.” Cell Metab 15(2):209-21 Details

    Levett DZ, Radford EJ, Menassa DA, Graber EF, Morash AJ, Hoppeler H, Clarke K, Martin DS, Ferguson-Smith AC, Montgomery HE, Grocott MP, Murray AJ, Caudwell Xtreme Everest Research Group (2012), “Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest.” FASEB J 26(4):1431-41 Details

    Lim AL, Ng S, Leow SC, Choo R, Ito M, Chan YH, Goh SK, Tng E, Kwek K, Chong YS, Gluckman PD, Ferguson-Smith AC (2012), “Epigenetic state and expression of imprinted genes in umbilical cord correlates with growth parameters in human pregnancy.” J Med Genet 49(11):689-97 Details

    Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith AC (2012), “An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming.” PLoS Genet 8(4):e1002605 Details

    Strogantsev R, Ferguson-Smith AC (2012), “Proteins involved in establishment and maintenance of imprinted methylation marks.” Brief Funct Genomics 11(3):227-39 Details

    Sun B, Ito M, Mendjan S, Ito Y, Brons IG, Murrell A, Vallier L, Ferguson-Smith AC, Pedersen RA (2012), “Status of genomic imprinting in epigenetically distinct pluripotent stem cells.” Stem Cells 30(2):161-8 Details


    Bartolomei MS, Ferguson-Smith AC (2011), “Mammalian genomic imprinting.” Cold Spring Harb Perspect Biol 3(7) Details

    Ferguson-Smith AC (2011), “Genomic imprinting: the emergence of an epigenetic paradigm.” Nat Rev Genet 12(8):565-75 Details

    Ferguson-Smith AC, Patti ME (2011), “You are what your dad ate.” Cell Metab 13(2):115-7 Details

    Ferrón SR, Charalambous M, Radford E, McEwen K, Wildner H, Hind E, Morante-Redolat JM, Laborda J, Guillemot F, Bauer SR, Fariñas I, Ferguson-Smith AC (2011), “Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis.” Nature 475(7356):381-5 Details

    Fogarty NM, Mayhew TM, Ferguson-Smith AC, Burton GJ (2011), “A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation.” J Anat 219(5):601-10 Details

    Lin S, Ferguson-Smith AC, Schultz RM, Bartolomei MS (2011), “Nonallelic transcriptional roles of CTCF and cohesins at imprinted loci.” Mol Cell Biol 31(15):3094-104 Details

    Radford EJ, Ferrón SR, Ferguson-Smith AC (2011), “Genomic imprinting as an adaptative model of developmental plasticity.” FEBS Lett 585(13):2059-66 Details

    Teperek-Tkacz M, Pasque V, Gentsch G, Ferguson-Smith AC (2011), “Epigenetic reprogramming: is deamination key to active DNA demethylation?” Reproduction 142(5):621-32 Details


    Kagami M, O'Sullivan MJ, Green AJ, Watabe Y, Arisaka O, Masawa N, Matsuoka K, Fukami M, Matsubara K, Kato F, Ferguson-Smith AC, Ogata T (2010), “The IG-DMR and the MEG3-DMR at human chromosome 14q32.2: hierarchical interaction and distinct functional properties as imprinting control centers.” PLoS Genet 6(6):e1000992 Details

    Lim AL, Ferguson-Smith AC (2010), “Genomic imprinting effects in a compromised in utero environment: implications for a healthy pregnancy.” Semin Cell Dev Biol 21(2):201-8 Details

    McEwen KR, Ferguson-Smith AC (2010), “Distinguishing epigenetic marks of developmental and imprinting regulation.” Epigenetics Chromatin 3(1):2 Details

    Meaney MJ, Ferguson-Smith AC (2010), “Epigenetic regulation of the neural transcriptome: the meaning of the marks.” Nat Neurosci 13(11):1313-8 Details

    Rens W, Wallduck MS, Lovell FL, Ferguson-Smith MA, Ferguson-Smith AC (2010), “Epigenetic modifications on X chromosomes in marsupial and monotreme mammals and implications for evolution of dosage compensation.” Proc Natl Acad Sci U S A 107(41):17657-62 Details

    Yamazawa K, Ogata T, Ferguson-Smith AC (2010), “Uniparental disomy and human disease: an overview.” Am J Med Genet C Semin Med Genet 154C(3):329-34 Details


    da Rocha ST, Charalambous M, Lin SP, Gutteridge I, Ito Y, Gray D, Dean W, Ferguson-Smith AC (2009), “Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting.” PLoS Genet 5(2):e1000392 Details

    Ellery PM, Cindrova-Davies T, Jauniaux E, Ferguson-Smith AC, Burton GJ (2009), “Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta.” Placenta 30(4):329-34 Details

    Glass JL, Fazzari MJ, Ferguson-Smith AC, Greally JM (2009), “CG dinucleotide periodicities recognized by the Dnmt3a-Dnmt3L complex are distinctive at retroelements and imprinted domains.” Mamm Genome 20(9-10):633-43 Details

    Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A, Kristinsson KT, Jonasdottir A, Frigge ML, Gylfason A, Olason PI, Gudjonsson SA, Sverrisson S, Stacey SN, Sigurgeirsson B, Benediktsdottir KR, Sigurdsson H, Jonsson T, Benediktsson R, Olafsson JH, Johannsson OT, Hreidarsson AB, Sigurdsson G, DIAGRAM Consortium, Ferguson-Smith AC, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K (2009), “Parental origin of sequence variants associated with complex diseases.” Nature 462(7275):868-74 Details


    Braem C, Recolin B, Rancourt RC, Angiolini C, Barthès P, Branchu P, Court F, Cathala G, Ferguson-Smith AC, Forné T (2008), “Genomic matrix attachment region and chromosome conformation capture quantitative real time PCR assays identify novel putative regulatory elements at the imprinted Dlk1/Gtl2 locus.” J Biol Chem 283(27):18612-20 Details

    Bray SJ, Takada S, Harrison E, Shen SC, Ferguson-Smith AC (2008), “The atypical mammalian ligand Delta-like homologue 1 (Dlk1) can regulate Notch signalling in Drosophila.” BMC Dev Biol 8:11 Details

    Coan PM, Fowden AL, Constancia M, Ferguson-Smith AC, Burton GJ, Sibley CP (2008), “Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.” J Physiol 586(Pt 20):5023-32 Details

    da Rocha ST, Edwards CA, Ito M, Ogata T, Ferguson-Smith AC (2008), “Genomic imprinting at the mammalian Dlk1-Dio3 domain.” Trends Genet 24(6):306-16 Details

    Edwards CA, Mungall AJ, Matthews L, Ryder E, Gray DJ, Pask AJ, Shaw G, Graves JA, Rogers J, SAVOIR consortium, Dunham I, Renfree MB, Ferguson-Smith AC (2008), “The evolution of the DLK1-DIO3 imprinted domain in mammals.” PLoS Biol 6(6):e135 Details

    Kagami M, Sekita Y, Nishimura G, Irie M, Kato F, Okada M, Yamamori S, Kishimoto H, Nakayama M, Tanaka Y, Matsuoka K, Takahashi T, Noguchi M, Tanaka Y, Masumoto K, Utsunomiya T, Kouzan H, Komatsu Y, Ohashi H, Kurosawa K, Kosaki K, Ferguson-Smith AC, Ishino F, Ogata T (2008), “Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes.” Nat Genet 40(2):237-42 Details

    Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC (2008), “A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.” Dev Cell 15(4):547-57 Details

    Nagano T, Mitchell JA, Sanz LA, Pauler FM, Ferguson-Smith AC, Feil R, Fraser P (2008), “The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.” Science 322(5908):1717-20 Details

    Ogata T, Kagami M, Ferguson-Smith AC (2008), “Molecular mechanisms regulating phenotypic outcome in paternal and maternal uniparental disomy for chromosome 14.” Epigenetics 3(4):181-7 Details


    Burdon C, Mann C, Cindrova-Davies T, Ferguson-Smith AC, Burton GJ (2007), “Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta.” Placenta 28(7):724-33 Details

    Charalambous M, da Rocha ST, Ferguson-Smith AC (2007), “Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life.” Curr Opin Endocrinol Diabetes Obes 14(1):3-12 Details

    da Rocha ST, Tevendale M, Knowles E, Takada S, Watkins M, Ferguson-Smith AC (2007), “Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control.” Dev Biol 306(2):810-23 Details

    Edwards CA, Ferguson-Smith AC (2007), “Mechanisms regulating imprinted genes in clusters.” Curr Opin Cell Biol 19(3):281-9 Details

    Edwards CA, Rens W, Clarke O, Mungall AJ, Hore T, Graves JA, Dunham I, Ferguson-Smith AC, Ferguson-Smith MA (2007), “The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals.” BMC Evol Biol 7:157 Details

    Ferguson-Smith AC, Greally JM (2007), “Epigenetics: perceptive enzymes.” Nature 449(7159):148-9 Details

    Kawahara M, Wu Q, Ferguson-Smith AC, Kono T (2007), “Appropriate expression of imprinted genes on mouse chromosome 12 extends development of bi-maternal embryos to term.” FEBS Lett 581(27):5178-84 Details

    Kawahara M, Wu Q, Takahashi N, Morita S, Yamada K, Ito M, Ferguson-Smith AC, Kono T (2007), “High-frequency generation of viable mice from engineered bi-maternal embryos.” Nat Biotechnol 25(9):1045-50 Details

    Lin SP, Coan P, da Rocha ST, Seitz H, Cavaille J, Teng PW, Takada S, Ferguson-Smith AC (2007), “Differential regulation of imprinting in the murine embryo and placenta by the Dlk1-Dio3 imprinting control region.” Development 134(2):417-26 Details

    Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA (2007), “Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines.” Hum Mol Genet 16 Spec No. 2:R243-51 Details


    Coan PM, Conroy N, Burton GJ, Ferguson-Smith AC (2006), “Origin and characteristics of glycogen cells in the developing murine placenta.” Dev Dyn 235(12):3280-94 Details

    Ferguson-Smith AC, Moore T, Detmar J, Lewis A, Hemberger M, Jammes H, Kelsey G, Roberts CT, Jones H, Constancia M (2006), “Epigenetics and imprinting of the trophoblast -- a workshop report.” Placenta 27 Suppl A:S122-6 Details

    Kawahara M, Wu Q, Yaguchi Y, Ferguson-Smith AC, Kono T (2006), “Complementary roles of genes regulated by two paternally methylated imprinted regions on chromosomes 7 and 12 in mouse placentation.” Hum Mol Genet 15(19):2869-79 Details

    Tevendale M, Watkins M, Rasberry C, Cattanach B, Ferguson-Smith AC (2006), “Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting.” Cytogenet Genome Res 113(1-4):215-22 Details

    Tierling S, Dalbert S, Schoppenhorst S, Tsai CE, Oliger S, Ferguson-Smith AC, Paulsen M, Walter J (2006), “High-resolution map and imprinting analysis of the Gtl2-Dnchc1 domain on mouse chromosome 12.” Genomics 87(2):225-35 Details


    Astuti D, Latif F, Wagner K, Gentle D, Cooper WN, Catchpoole D, Grundy R, Ferguson-Smith AC, Maher ER (2005), “Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour.” Br J Cancer 92(8):1574-80 Details

    Coan PM, Burton GJ, Ferguson-Smith AC (2005), “Imprinted genes in the placenta--a review.” Placenta 26 Suppl A:S10-20 Details

    Coan PM, Ferguson-Smith AC, Burton GJ (2005), “Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestation.” J Anat 207(6):783-96 Details

    Henderson P, Ferguson-Smith AC, Johnson MH (2005), “Developing essential professional skills: a framework for teaching and learning about feedback.” BMC Med Educ 5(1):11 Details

    Li J, Bench AJ, Piltz S, Vassiliou G, Baxter EJ, Ferguson-Smith AC, Green AR (2005), “L3mbtl, the mouse orthologue of the imprinted L3MBTL, displays a complex pattern of alternative splicing and escapes genomic imprinting.” Genomics 86(4):489-94 Details

    Reik W, Ferguson-Smith AC (2005), “Developmental biology: the X-inactivation yo-yo.” Nature 438(7066):297-8 Details

    Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA (2005), “Human embryonic stem cells as a model for studying epigenetic regulation during early development.” Cell Cycle 4(10):1323-6 Details

    Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA (2005), “Epigenetic status of human embryonic stem cells.” Nat Genet 37(6):585-7 Details

    Sado T, Ferguson-Smith AC (2005), “Imprinted X inactivation and reprogramming in the preimplantation mouse embryo.” Hum Mol Genet 14 Spec No 1:R59-64 Details

    Youngson NA, Kocialkowski S, Peel N, Ferguson-Smith AC (2005), “A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting.” J Mol Evol 61(4):481-90 Details


    Coan PM, Ferguson-Smith AC, Burton GJ (2004), “Developmental dynamics of the definitive mouse placenta assessed by stereology.” Biol Reprod 70(6):1806-13 Details

    da Rocha ST, Ferguson-Smith AC (2004), “Genomic imprinting.” Curr Biol 14(16):R646-9 Details

    Ferguson-Smith AC (2004), “X inactivation: pre- or post-fertilisation turn-off?” Curr Biol 14(8):R323-5 Details

    Ferguson-Smith AC, Lin SP, Youngson N (2004), “Regulation of gene activity and repression: a consideration of unifying themes.” Curr Top Dev Biol 60:197-213 Details

    Li J, Bench AJ, Vassiliou GS, Fourouclas N, Ferguson-Smith AC, Green AR (2004), “Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies.” Proc Natl Acad Sci U S A 101(19):7341-6 Details

    Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaillé J (2004), “A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain.” Genome Res 14(9):1741-8 Details

    Seitz H, Royo H, Lin SP, Youngson N, Ferguson-Smith AC, Cavaillé J (2004), “Imprinted small RNA genes.” Biol Chem 385(10):905-11 Details

    Sibley CP, Coan PM, Ferguson-Smith AC, Dean W, Hughes J, Smith P, Reik W, Burton GJ, Fowden AL, Constância M (2004), “Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.” Proc Natl Acad Sci U S A 101(21):8204-8 Details


    Ferguson-Smith AC, Reik W (2003), “The need for Eed.” Nat Genet 33(4):433-4 Details

    Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC (2003), “Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12.” Nat Genet 35(1):97-102 Details

    Seitz H, Youngson N, Lin SP, Dalbert S, Paulsen M, Bachellerie JP, Ferguson-Smith AC, Cavaillé J (2003), “Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.” Nat Genet 34(3):261-2 Details


    Cavaillé J, Seitz H, Paulsen M, Ferguson-Smith AC, Bachellerie JP (2002), “Identification of tandemly-repeated C/D snoRNA genes at the imprinted human 14q32 domain reminiscent of those at the Prader-Willi/Angelman syndrome region.” Hum Mol Genet 11(13):1527-38 Details

    Georgiades P, Ferguson-Smith AC, Burton GJ (2002), “Comparative developmental anatomy of the murine and human definitive placentae.” Placenta 23(1):3-19 Details

    Rada C, Ferguson-Smith AC (2002), “Epigenetics: monoallelic expression in the immune system.” Curr Biol 12(3):R108-10 Details

    Takada S, Paulsen M, Tevendale M, Tsai CE, Kelsey G, Cattanach BM, Ferguson-Smith AC (2002), “Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19.” Hum Mol Genet 11(1):77-86 Details

    Tsai CE, Lin SP, Ito M, Takagi N, Takada S, Ferguson-Smith AC (2002), “Genomic imprinting contributes to thyroid hormone metabolism in the mouse embryo.” Curr Biol 12(14):1221-6 Details


    Ferguson-Smith AC, Surani MA (2001), “Imprinting and the epigenetic asymmetry between parental genomes.” Science 293(5532):1086-9 Details

    Ferguson-Smith AC, Tevendale M, Georgiades P, Grandjean V (2001), “Balanced translocations for the analysis of imprinted regions of the mouse genome.” Methods Mol Biol 181:41-54 Details

    Georgiades P, Watkins M, Burton GJ, Ferguson-Smith AC (2001), “Roles for genomic imprinting and the zygotic genome in placental development.” Proc Natl Acad Sci U S A 98(8):4522-7 Details

    Paulsen M, Ferguson-Smith AC (2001), “DNA methylation in genomic imprinting, development, and disease.” J Pathol 195(1):97-110 Details

    Paulsen M, Takada S, Youngson NA, Benchaib M, Charlier C, Segers K, Georges M, Ferguson-Smith AC (2001), “Comparative sequence analysis of the imprinted Dlk1-Gtl2 locus in three mammalian species reveals highly conserved genomic elements and refines comparison with the Igf2-H19 region.” Genome Res 11(12):2085-94 Details

    Westbury J, Watkins M, Ferguson-Smith AC, Smith J (2001), “Dynamic temporal and spatial regulation of the cdk inhibitor p57(kip2) during embryo morphogenesis.” Mech Dev 109(1):83-9 Details


    Ferguson-Smith AC (2000), “Genetic imprinting: silencing elements have their say.” Curr Biol 10(23):R872-5 Details

    Georgiades P, Watkins M, Surani MA, Ferguson-Smith AC (2000), “Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12.” Development 127(21):4719-28 Details

    Grandjean V, Smith J, Schofield PN, Ferguson-Smith AC (2000), “Increased IGF-II protein affects p57kip2 expression in vivo and in vitro: implications for Beckwith-Wiedemann syndrome.” Proc Natl Acad Sci U S A 97(10):5279-84 Details

    Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC (2000), “Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12.” Curr Biol 10(18):1135-8 Details


    Georgiades P, Chierakul C, Ferguson-Smith AC (1998), “Parental origin effects in human trisomy for chromosome 14q: implications for genomic imprinting.” J Med Genet 35(10):821-4 Details

    Hatano N, Eversole-Cire P, Ferguson-Smith AC, Jones PA, Surani MA, Sasaki H (1998), “Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene.” J Biochem 123(5):984-91 Details


    Ferguson-Smith AC (1996), “Imprinting moves to the centre.” Nat Genet 14(2):119-21 Details


    Eversole-Cire P, Ferguson-Smith AC, Surani MA, Jones PA (1995), “Coordinate regulation of Igf-2 and H19 in cultured cells.” Cell Growth Differ 6(3):337-45 Details

    Sasaki H, Ferguson-Smith AC, Shum AS, Barton SC, Surani MA (1995), “Temporal and spatial regulation of H19 imprinting in normal and uniparental mouse embryos.” Development 121(12):4195-202 Details


    Eversole-Cire P, Ferguson-Smith AC, Sasaki H, Brown KD, Cattanach BM, Gonzales FA, Surani MA, Jones PA (1993), “Activation of an imprinted Igf 2 gene in mouse somatic cell cultures.” Mol Cell Biol 13(8):4928-38 Details

    Ferguson-Smith AC, Sasaki H, Cattanach BM, Surani MA (1993), “Parental-origin-specific epigenetic modification of the mouse H19 gene.” Nature 362(6422):751-5 Details

    Surani MA, Sasaki H, Ferguson-Smith AC, Allen ND, Barton SC, Jones PA, Reik W (1993), “The inheritance of germline-specific epigenetic modifications during development.” Philos Trans R Soc Lond B Biol Sci 339(1288):165-72 Details


    Dow E, Ferguson-Smith AC, Caplin B, Williamson R (1992), “Dinucleotide repeat polymorphism at the HOX 2B locus.” Hum Mol Genet 1(3):218 Details

    Ruano G, Rogers J, Ferguson-Smith AC, Kidd KK (1992), “DNA sequence polymorphism within hominoid species exceeds the number of phylogenetically informative characters for a HOX2 locus.” Mol Biol Evol 9(4):575-86 Details

    Sasaki H, Jones PA, Chaillet JR, Ferguson-Smith AC, Barton SC, Reik W, Surani MA (1992), “Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene.” Genes Dev 6(10):1843-56 Details


    Barton SC, Ferguson-Smith AC, Fundele R, Surani MA (1991), “Influence of paternally imprinted genes on development.” Development 113(2):679-87 Details

    Ferguson-Smith AC, Cattanach BM, Barton SC, Beechey CV, Surani MA (1991), “Embryological and molecular investigations of parental imprinting on mouse chromosome 7.” Nature 351(6328):667-70 Details


    Ferguson-Smith AC, Reik W, Surani MA (1990), “Genomic imprinting and cancer.” Cancer Surv 9(3):487-503 Details

    Ruano G, Gray MR, Miki T, Ferguson-Smith AC, Ruddle FH, Kidd KK (1990), “Monomorphism in humans and sequence differences among higher primates for a sequence tagged site (STS) in homeo box cluster 2 as assayed by denaturing gradient electrophoresis.” Nucleic Acids Res 18(5):1314 Details

    Surani MA, Kothary R, Allen ND, Singh PB, Fundele R, Ferguson-Smith AC, Barton SC (1990), “Genome imprinting and development in the mouse.” Dev Suppl :89-98 Details


    Ferguson-Smith AC, Fienberg A, Ruddle FH (1989), “Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.” Genomics 5(2):250-8 Details


    Bentley KL, Ferguson-Smith AC, Ruddle FH (1988), “A review of genomic physical mapping.” Cancer Surv 7(2):267-94 Details

    Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (1988), “Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21.” Genomics 2(3):203-8 Details

    Ferguson-Smith AC, Ruddle FH (1988), “The genomics of human homeobox-containing loci.” Pathol Immunopathol Res 7(1-2):119-26 Details


    Murphy PD, Ferguson-Smith AC, Miki T, Feinberg AA, Ruddle FH, Kidd KK (1987), “A moderately frequent RFLP identified by both SacI and BanII with a probe from the HOX2 locus in man (17q11-17q22).” Nucleic Acids Res 15(15):6311 Details