Mr Adel Helmy PhD FRCS (SN) University positionLecturer Mr Adel Helmy PhD FRCS (SN) is pleased to consider applications from prospective PhD students. DepartmentsDepartment of Clinical Neurosciences InstitutesHome pagehttp://www.neurosurg.cam.ac.uk/researc... Research ThemeInterestsMy research interests are in Acute Brain Injury (Traumatic Brain Injury (TBI) and Subarachnoid Haemorrhage (SAH)) and in particular the innate inflammatory response following TBI. Inflammation plays a role in secondary injury following TBI, but is also the starting point for reparative processes. I also have an interest in cerebral metabolism multi-modality monitoring as a means of refining and personalising treatment for patients. This includes a collaboration with the MRC Biostatistics Unit on multivariate statistical methods. Research Focus
EquipmentMagnetic resonance imaging (MRI) Microdialysis Collaborators
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Publications2015Carpenter KL, Czosnyka M, Jalloh I, Newcombe VF, Helmy A, Shannon RJ, Budohoski KP, Kolias AG, Kirkpatrick PJ, Carpenter TA, Menon DK, Hutchinson PJ (2015), “Systemic, local, and imaging biomarkers of brain injury: more needed, and better use of those already established?” Front Neurol 6:26 Details Guilfoyle MR, Carpenter KL, Helmy A, Pickard JD, Menon DK, Hutchinson PJ (2015), “Matrix Metalloproteinase Expression in Contusional Traumatic Brain Injury: A Paired Microdialysis Study.” J Neurotrauma Details Jalloh I, Carpenter KL, Grice P, Howe DJ, Mason A, Gallagher CN, Helmy A, Murphy MP, Menon DK, Carpenter TA, Pickard JD, Hutchinson PJ (2015), “Glycolysis and the pentose phosphate pathway after human traumatic brain injury: microdialysis studies using 1,2-(13)C2 glucose.” J Cereb Blood Flow Metab 35(1):111-20 Details Jalloh I, Carpenter KL, Helmy A, Carpenter TA, Menon DK, Hutchinson PJ (2015), “Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings.” Metab Brain Dis 30(3):615-32 Details Young AM, Karri SK, Helmy A, Budohoski KP, Kirollos RW, Bulters DO, Kirkpatrick PJ, Ogilvy CS, Trivedi RA (2015), “Pharmacologic Management of Subarachnoid Hemorrhage.” World Neurosurg 84(1):28-35 Details 2014Budohoski KP, Guilfoyle M, Helmy A, Huuskonen T, Czosnyka M, Kirollos R, Menon DK, Pickard JD, Kirkpatrick PJ (2014), “The pathophysiology and treatment of delayed cerebral ischaemia following subarachnoid haemorrhage.” J Neurol Neurosurg Psychiatry Details Helmy A, Guilfoyle MR, Carpenter KL, Pickard JD, Menon DK, Hutchinson PJ (2014), “Recombinant human interleukin-1 receptor antagonist in severe traumatic brain injury: a phase II randomized control trial.” J Cereb Blood Flow Metab Details Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon D, Carpenter K, Hutchinson P (2014), “Response to letter 'Lactate uptake against a concentration gradient - misinterpretation of analytical imprecision.'” J Neurotrauma Details 2013Carpenter KL, Jalloh I, Gallagher CN, Grice P, Howe DJ, Mason A, Timofeev I, Helmy A, Murphy MP, Menon DK, Kirkpatrick PJ, Carpenter TA, Sutherland GR, Pickard JD, Hutchinson PJ (2013), “13C-labelled microdialysis studies of cerebral metabolism in TBI patients.” Eur J Pharm Sci Details Guilfoyle MR, Helmy A, Duane D, Hutchinson PJ (2013), “Regional scalp block for postcraniotomy analgesia: a systematic review and meta-analysis.” Anesth Analg 116(5):1093-102 Details Helmy A, Agarwal M, Hutchinson PJ (2013), “Concussion and sport.” BMJ 347:f5748 Details Jalloh I, Helmy A, Shannon RJ, Gallagher CN, Menon DK, Carpenter KL, Hutchinson PJ (2013), “Lactate uptake by the injured human brain: evidence from an arteriovenous gradient and cerebral microdialysis study.” J Neurotrauma 30(24):2031-7 Details Kolias AG, Bulters DO, Cowie CJ, Wilson MH, Afshari FT, Helmy A, Broughton E, Joannides AJ, Zebian B, Harrisson SE, Hill CS, Ahmed AI, Barone DG, Thakur B, McMahon CJ, Adlam DM, Bentley RP, Tolias CM, Mitchell PM, Whitfield PC, Critchley GR, Belli A, Brennan PM, Hutchinson PJ, British Neurosurgical Trainee Research Collaborative, British Neurotrauma Group, UKCRR Collaborative Group (2013), “Proposal for establishment of the UK Cranial Reconstruction Registry (UKCRR).” Br J Neurosurg Details Kolias AG, Guilfoyle MR, Helmy A, Allanson J, Hutchinson PJ (2013), “Traumatic brain injury in adults.” Pract Neurol 13(4):228-35 Details Shannon RJ, Carpenter KL, Guilfoyle MR, Helmy A, Hutchinson PJ (2013), “Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.” J Pharmacokinet Pharmacodyn 40(3):343-58 Details 2012Budohoski KP, Czosnyka M, Smielewski P, Kasprowicz M, Helmy A, Bulters D, Pickard JD, Kirkpatrick PJ (2012), “Impairment of cerebral autoregulation predicts delayed cerebral ischemia after subarachnoid hemorrhage: a prospective observational study.” Stroke 43(12):3230-7 Details Helmy A, Antoniades CA, Guilfoyle MR, Carpenter KL, Hutchinson PJ (2012), “Principal component analysis of the cytokine and chemokine response to human traumatic brain injury.” PLoS One 7(6):e39677 Details Helmy A, Kirkpatrick PJ, Seeley HM, Corteen E, Menon DK, Hutchinson PJ (2012), “Fixed, dilated pupils following traumatic brain injury: historical perspectives, causes and ophthalmological sequelae.” Acta Neurochir Suppl 114:295-9 Details 2011Helmy A, Antoun N, Hutchinson P (2011), “Cerebral tuberculoma and magnetic resonance imaging.” J R Soc Med 104(7):299-301 Details Helmy A, Carpenter KL, Menon DK, Pickard JD, Hutchinson PJ (2011), “The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production.” J Cereb Blood Flow Metab 31(2):658-70 Details Helmy A, De Simoni MG, Guilfoyle MR, Carpenter KL, Hutchinson PJ (2011), “Cytokines and innate inflammation in the pathogenesis of human traumatic brain injury.” Prog Neurobiol 95(3):352-72 Details 2010Guilfoyle MR, Khan S, Helmy A, Jalloh I, Trivedi S, Trivedi R, Kirkpatrick PJ (2010), “Spinal intradural haemorrhage in a patient with Wegener's Granulomatosis.” Clin Neurol Neurosurg 112(4):341-3 Details Helmy A, Timofeev I, Palmer CR, Gore A, Menon DK, Hutchinson PJ (2010), “Hierarchical log linear analysis of admission blood parameters and clinical outcome following traumatic brain injury.” Acta Neurochir (Wien) 152(6):953-7 Details Zweifel C, Castellani G, Czosnyka M, Helmy A, Manktelow A, Carrera E, Brady KM, Hutchinson PJ, Menon DK, Pickard JD, Smielewski P (2010), “Noninvasive monitoring of cerebrovascular reactivity with near infrared spectroscopy in head-injured patients.” J Neurotrauma 27(11):1951-8 Details 2009Al-Tamimi YZ, Helmy A, Bavetta S, Price SJ (2009), “Assessment of zero drift in the Codman intracranial pressure monitor: a study from 2 neurointensive care units.” Neurosurgery 64(1):94-8; discussion 98-9 Details Helmy A, Carpenter KL, Skepper JN, Kirkpatrick PJ, Pickard JD, Hutchinson PJ (2009), “Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.” J Neurotrauma 26(4):549-61 Details 2008Lim E, Brown A, Helmy A, Mussa S, Altman DG (2008), “Composite outcomes in cardiovascular research: a survey of randomized trials.” Ann Intern Med 149(9):612-7 Details 2007Helmy A, Carpenter KL, Hutchinson PJ (2007), “Microdialysis in the human brain and its potential role in the development and clinical assessment of drugs.” Curr Med Chem 14(14):1525-37 Details Helmy A, Mellor G (2007), “Spontaneous cervical cord haemorrhage: an unusual presentation.” Emerg Med J 24(3):e16 Details Helmy A, Vizcaychipi M, Gupta AK (2007), “Traumatic brain injury: intensive care management.” Br J Anaesth 99(1):32-42 Details 2006Stoica S, Balaji H, Helmy A, Kitcat J, Freeman C, Sharples L, Nashef SA (2006), “Against the odds: long-term outcome of drastic-risk cardiac surgery.” J Thorac Cardiovasc Surg 132(5):1226-8 Details 2004Evans JR, Helmy AE, Cluroe A, Purushotham AD (2004), “Lymphoma of the breast - case report and review of the literature.” J BUON 9(3):307-11 Details |