Dr Amanda Barber
Retinal ganglion cells (RGCs) convey visual signals from the retina to the brain via their axons that forms the optic nerve and the optic tract. Damage to RGC axons, as a result of injury or diseases such as glaucoma, can result in blindness as mammalian RGCs have limited intrinsic ability to regenerate their axons once injured.
The focus of my research is to investigate methods to promote RGC axon regeneration following axonal damage by injury or disease.
Recombinant protein expression
No collaborators listed
Associated News Items
Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA (2013), “Repair of the degenerate retina by photoreceptor transplantation.” Proc Natl Acad Sci U S A 110(1):354-9 Details
Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, Yau KW, Sowden JC, Ali RR (2012), “Restoration of vision after transplantation of photoreceptors.” Nature 485(7396):99-103 Details
Pearson RA, Hippert C, Graca AB, Barber AC (2014), “Photoreceptor replacement therapy: Challenges presented by the diseased recipient retinal environment.” Vis Neurosci :1-12 Details
Warre-Cornish K, Barber AC, Sowden JC, Ali RR, Pearson RA (2013), “Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina.” Stem Cells Dev Details
Lakowski J, Han YT, Pearson RA, Gonzalez-Cordero A, West EL, Gualdoni S, Barber AC, Hubank M, Ali RR, Sowden JC (2011), “Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression.” Stem Cells 29(9):1391-404 Details
Lakowski J, Baron M, Bainbridge J, Barber AC, Pearson RA, Ali RR, Sowden JC (2010), “Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells.” Hum Mol Genet 19(23):4545-59 Details
Pearson RA, Barber AC, West EL, MacLaren RE, Duran Y, Bainbridge JW, Sowden JC, Ali RR (2010), “Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina.” Cell Transplant 19(4):487-503 Details
West EL, Pearson RA, Barker SE, Luhmann UF, Maclaren RE, Barber AC, Duran Y, Smith AJ, Sowden JC, Ali RR (2010), “Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation.” Stem Cells 28(11):1997-2007 Details