Dr Alpar Lazar
My main research area is sleep, circadian rhythm and cognition in neurodegenerative diseases.
My scope is to investigate the deep structure of sleep EEG activity in relation to circadian rhythm, cognition and metabolism and the way it changes over time as patients carrying the HD (Huntington’s disease) gene mutation approach disease onset. For this I use different mathematical procedures which can detect even minor changes in the sleep EEG. We aim to identify sleep related early markers for the onset and prognosis of HD.
I also study the efficacy of non-pharmaceutical approaches to improve sleep quality in manifest patients with HD.
Electrophysiological recording techniques
Associated News Items
Atherton KE, Nobre AC, Lazar AS, Wulff K, Whittaker RG, Dhawan V, Lazar ZI, Zeman AZ, Butler CR (in press), “Slow wave sleep and accelerated forgetting” Cortex
Bartlett DM, Cruickshank TM, Hannan AJ, Eastwood PR, Lazar AS, Ziman MR. (2016), “Neuroendocrine and Neurotrophic Signaling in Huntington's Disease: Implications for Pathogenic Mechanisms and Treatment Strategies” Neurosci Biobehav Rev 2016 Sep 13. pii: S0149-7634(16)30276-7
Santhi N, Lazar AS, McCabe PJ, Lo JC, Groeger JA, Dijk DJ. (2016), “Sex differences in the circadian regulation of sleep and waking cognition in humans.” Proc Natl Acad Sci U S A pii: 201521637. [Epub ahead of print]
Collins LM, Begeti F, Panin F, Lazar AS, Cruickshank T, Ziman M, Mason SL, Barker RA. (2015), “Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease.” PLoS Curr. 2015 Sep 8;7.
Lazar AS, Lazar ZI, Dijk DJ (2015), “Circadian regulation of slow waves in human sleep: Topographical aspects.” Neuroimage 116:123-34 Details
Lazar AS, Panin F, Goodman AO, Lazic SE, Lazar ZI, Mason SL, Rogers L, Murgatroyd PR, Watson LP, Singh P, Borowsky B, Shneerson JM, Barker RA. (2015), “Sleep deficits but no metabolic deficits in premanifest Huntington's disease.” Ann Neurol 78(4):630-48
Mason SL, Zhang J, Begeti F, Guzman NV, Lazar AS, Rowe JB, Barker RA, Hampshire A (2015), “The role of the amygdala during emotional processing in Huntington's disease: From pre-manifest to late stage disease.” Neuropsychologia 70:80-9 Details
Archer SN, Laing EE, Möller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ (2014), “Mistimed sleep disrupts circadian regulation of the human transcriptome.” Proc Natl Acad Sci U S A 111(6):E682-91 Details
Kuan WL, Kasis A, Yuan Y, Mason SL, Lazar AS, Barker RA, Goncalves J (2014), “Modelling the natural history of Huntington's disease progression.” J Neurol Neurosurg Psychiatry Details
Videnovic A, Lazar AS, Barker RA, Overeem S (2014), “'The clocks that time us'--circadian rhythms in neurodegenerative disorders.” Nat Rev Neurol 10(12):683-93 Details
Lazar AS, Santhi N, Hasan S, Lo JC, Johnston J, von Schantz M, Archer SN, Dijk DJ. (2013), “Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory” J Sleep Res Apr;22(2):155-9.
Fornadi K, Lindner A, Czira ME, Szentkiralyi A, Lazar AS, Zoller R, Turanyi CZ, Veber O, Novak M, Mucsi I, Molnar MZ (2012), “Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients.” Int Urol Nephrol 44(2):607-17 Details
Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ (2012), “Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.” FASEB J 26(6):2414-23 Details
Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ (2012), “Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.” Chronobiol Int 29(2):131-46 Details
Lindner A, Fornadi K, Lazar AS, Czira ME, Dunai A, Zoller R, Veber O, Szentkiralyi A, Kiss Z, Toronyi E, Mucsi I, Novak M, Molnar MZ (2012), “Periodic limb movements in sleep are associated with stroke and cardiovascular risk factors in patients with renal failure.” J Sleep Res 21(3):297-307 Details
Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, von Schantz M, Archer SN, Dijk DJ (2012), “Effects of Partial and Acute Total Sleep Deprivation on Performance across Cognitive Domains, Individuals and Circadian Phase.” PLoS One 7(9):e45987 Details
Lázár AS, Lázár ZI, Bíró A, Gyori M, Tárnok Z, Prekop C, Keszei A, Stefanik K, Gádoros J, Halász P, Bódizs R (2010), “Reduced fronto-cortical brain connectivity during NREM sleep in Asperger syndrome: an EEG spectral and phase coherence study.” Clin Neurophysiol 121(11):1844-54 Details
Molnar MZ, Lazar AS, Lindner A, Fornadi K, Czira ME, Dunai A, Zoller R, Szentkiralyi A, Rosivall L, Shapiro CM, Novak M, Mucsi I (2010), “Sleep apnea is associated with cardiovascular risk factors among kidney transplant patients.” Clin J Am Soc Nephrol 5(1):125-32 Details
Bódizs R, Körmendi J, Rigó P, Lázár AS (2009), “The individual adjustment method of sleep spindle analysis: methodological improvements and roots in the fingerprint paradigm.” J Neurosci Methods 178(1):205-13 Details
Bódizs R, Lázár AS, Rigó P (2008), “Correlation of visuospatial memory ability with right parietal EEG spindling during sleep.” Acta Physiol Hung 95(3):297-306 Details
Lázár AS, Bódizs R (2008), “[The structure and patterns of sleep in autism spectrum disorders].” Psychiatr Hung 23(2):109-28 Details
Bódizs R, Lázár AS (2006), “Schizophrenia, slow wave sleep and visuospatial memory: sleep-dependent consolidation or trait-like correlation?” J Psychiatr Res 40(1):89-90 Details
Bódizs R, Kis T, Lázár AS, Havrán L, Rigó P, Clemens Z, Halász P (2005), “Prediction of general mental ability based on neural oscillation measures of sleep.” J Sleep Res 14(3):285-92 Details
Bódizs R, Sverteczki M, Lázár AS, Halász P (2005), “Human parahippocampal activity: non-REM and REM elements in wake-sleep transition.” Brain Res Bull 65(2):169-76 Details