Dr Xana Almeida
During neural development the proper number of each specific cell type must be generated at the correct time and place. Thus, a precise balance between cell division, cell survival, cell cycle exit and differentiation must be achieved. However, the mechanisms by which these different processes are coordinated remain poorly understood.
Using the highly structured retina as a model to investigate the mechanisms that regulate cell fate determination, we study how multipotent retinal progenitors give rise to the six retinal neuron types.
Associated News Items
Almeida AD, Boije H, Chow RW, He J, Tham J, Suzuki SC, Harris WA (2014), “Spectrum of Fates: a new approach to the study of the developing zebrafish retina.” Development 141(14):2912
He J, Zhang G, Almeida AD, Cayouette M, Simons BD, Harris WA (2012), “How variable clones build an invariant retina.” Neuron 75(5):786-98 Details
Novorol C, Burkhardt J, Wood KJ, Iqbal A, Roque C, Coutts N, Almeida AD, He J, Wilkinson CJ, Harris WA (2013), “Microcephaly models in the developing zebrafish retinal neuroepithelium point to an underlying defect in metaphase progression.” Open Biol 3(10):130065 Details
Randlett O, MacDonald RB, Yoshimatsu T, Almeida AD, Suzuki SC, Wong RO, Harris WA (2013), “Cellular requirements for building a retinal neuropil.” Cell Rep 3(2):282-90 Details
Jusuf PR, Almeida AD, Randlett O, Joubin K, Poggi L, Harris WA (2011), “Origin and determination of inhibitory cell lineages in the vertebrate retina.” J Neurosci 31(7):2549-62 Details
Almeida AD, Wise HM, Hindley CJ, Slevin MK, Hartley RS, Philpott A (2010), “The F-box protein Cdc4/Fbxw7 is a novel regulator of neural crest development in Xenopus laevis.” Neural Dev 5:1 Details
Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S (2007), “Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation.” PLoS One 2(10):e1004 Details
Grãos M, Almeida AD, Chatterjee S (2005), “Growth-factor-dependent phosphorylation of Bim in mitosis.” Biochem J 388(Pt 1):185-94 Details