Professor Tony Holland University positionProfessor Professor Tony Holland is pleased to consider applications from prospective PhD students. DepartmentsHome pagehttp://www.ciddrg.org.uk (personal home page) Research ThemesInterestsThe focus of our interdisciplinary research is on learning disabilities (intellectual disabilities/mental handicap) from different perspectives. Research to date has had the following main themes. First, the relationship between specific genetically determined neurodevelopmental disorders and patterns of development and associated co-morbidities. Research projects have included studies of Prader Willi Syndrome and the associated eating disorder and risks of psychiatric illness; and investigations of the links between Down's syndrome and the high risk for developing Alzheimer's disease. Secondly, studies investigating the interface between people with learning disabilities and the law. This has included research to inform the Mental Capacity Act 2005 and to investigate offending by people with learning disabilies. Thirdly, sociological studies broadly on the theme of 'citizenship' with respect to people with learning disabilities. Since 2008 our group has been part of the NIHR CLAHRC. Research Focus
EquipmentBehavioural analysis Computerised tomography Cross-sectional and cohort studies Electroencephalography (EEG) Magnetic resonance imaging (MRI) Neuropsychological testing Positron Emission Tomography (PET) Collaborators
Associated News ItemsKey publicationsLandt J, D'Abrera JC, Holland AJ, Aigbirhio FI, Fryer TD, Canales R, Hong YT, Menon DK, Baron JC, Zaman SH (2011), “Using Positron Emission Tomography and Carbon 11-Labeled Pittsburgh Compound B to Image Brain Fibrillar {beta}-Amyloid in Adults With Down Syndrome: Safety, Acceptability, and Feasibility.” Arch Neurol Details McAllister CJ, Whittington JE, Holland AJ (2011), “Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding.” Int J Obes (Lond) 35(2):188-97 Details Ball SL, Holland AJ, Watson PC, Huppert FA (2010), “Theoretical exploration of the neural bases of behavioural disinhibition, apathy and executive dysfunction in preclinical Alzheimer's disease in people with Down's syndrome: potential involvement of multiple frontal-subcortical neuronal circuits.” J Intellect Disabil Res 54(4):320-36 Details Publications2019Fonseca LM, Mattar GP, Haddad GG, Gonçalves AS, Miguel ADQC, Guilhoto LM, Zaman S, Holland AJ, de Campos Bottino CM and Hoexter MQ (2019), “Frontal-subcortical behaviours during Alzheimer’s disease in individuals with Down syndrome” Neurobiology of Aging Mak E, Padilla C, Annus T, Wilson LR, Hong YT, Fryer TD, Coles JP, Aigbirhio FI, Menon DK, Nestor PJ, Zaman SH Holland AJ (2019), “Delineating the topography of amyloid-associated cortical atrophy in down’s syndrome” Neurobiology of Aging Raha-Chowdhury R, Henderson JW, Raha AA, Vuono R, Bickerton A, Jones E, Fincham R, Allinson K, Holland A, and Zaman SH (2019), “Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer’s Disease and in Down Syndrome Dementia” Journal of Alzheimer's Disease Wilson LR, Vatansever D, Annus T, Williams GB, Hong YT, Fryer TD, Nestor PJ, Holland AJ, Zaman SH (2019), “Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity” Human Brain Mapping 2018Manning KE, Tait R, Suckling J and Holland AJ (2018), “Grey matter volume and cortical structure in Prader-Willi Syndrome compared to typically developing young adults” NeuroImage: Clinical 17: 899-909 2017Clarke G, Fistein E, Holland AJ, Barclay M, Theimann P, Barclay S (2017), “Preferences for care towards the end of life when decision-making capacity may be impaired: A large scale cross-sectional survey of public attitudes in Great Britain and the United States” PLoS ONE Lautarescu BA, Holland AJ, Zaman SH (2017), “The early presentation of dementia in people with Down syndrome: A systematic review of longitudinal studies” Neuropsychology Review Perez CM, Wagner AP, Ball SL, White SR, Clare ICH, Holland AJ, Redley M (2017), “Prognostic models for identifying adults with intellectual disabilities and mealtime support needs who are at greatest risk of respiratory infection and emergency hospitalisation” Journal of Intellectual Disability Research 2015Manning KE, McAllister CJ, Ring HA, Finer N, Kelly CL, Sylvester KP, Fletcher PC, Morrell NW, Garnett MR, Manford MR, Holland AJ (2015), “Novel insights into maladaptive behaviours in Prader-Willi syndrome: serendipitous findings from an open trial of vagus nerve stimulation.” J Intellect Disabil Res Details 2014Clarke G, Galbraith S, Woodward J, Holland AJ, Barclay S (2014), “Should they have a percutaneous endoscopic gastrostomy? The importance of assessing decision-making capacity and the central role of a multidisciplinary team.” Clinical Medicine 14 (3):245-249 Farrington C, Clare ICH, Holland AJ, Barrett M, & Oborn E (2014), “Knowledge exchange and integrated services: experiences from an integrated community intellectual (learning) disability service for adults” Journal of Intellectual Disability Research DOI: 10.1111/jir.12131 Whittington JE, Holland AJ, Webb T (2014), “Ageing in people with Prader-Willi syndrome: mortality in the UK population cohort and morbidity in an older sample of adults.” Psychol Med :1-7 Details 2013Carroll C, Watson P, Spoudeas HA, Hawkins MM, Walker DA, Clare IC, Holland AJ, Ring HA (2013), “Prevalence, associations, and predictors of apathy in adult survivors of infantile (<5 years of age) posterior fossa brain tumors.” Neuro Oncol 15(4):497-505 Details Clarke G, Harrison K, Holland A, Kuhn I, Barclay S (2013), “How are Treatment Decisions Made about Artificial Nutrition for Individuals at Risk of Lacking Capacity? A Systematic Literature Review.” PLoS One 8(4):e61475 Details d'Abrera JC, Holland AJ, Landt J, Stocks-Gee G, Zaman SH (2013), “A neuroimaging proof of principle study of Down's syndrome and dementia: ethical and methodological challenges in intrusive research.” J Intellect Disabil Res 57(2):105-18 Details de Souza MA, McAllister C, Suttie M, Perrotta C, Mattina T, Faravelli F, Forzano F, Holland A, Hammond P (2013), “Growth hormone, gender and face shape in prader–willi syndrome” American Journal of Medical Genetics Part A 161 (10): 2453–2463 Hempe E-M, Morrison C, Holland A (2013), “Exploring the boundary of a specialist service for adults with intellectual disabilities using a Delphi study: a quantification of stakeholder participation” Health Expectations doi: 10.1111/hex.12107 Holland AJ (2013), “Future challenges for the Journal of Intellectual Disability Research and for research in intellectual disabilities” Journal of Intellectual Disability Research 57 (1):1-2 Larson FV, Whittington J, Webb T, & Holland A J (2013), “A longitudinal follow-up study of people with Prader–Willi syndrome with psychosis and those at increased risk of developing psychosis due to genetic subtype. ” Psychological Medicine DOI: 10.1017/S0033291713002961 . Lindsay WR, Carson D, Holland AJ, Taylor JL, O'Brien G, Wheeler JR, Steptoe L (2013), “Alcohol and its relationship to offence variables in a cohort of offenders with intellectual disability.” J Intellect Dev Disabil 38(4):325-31 Details Lindsay WR, Holland AJ, Carson D, Taylor JL, O'Brien G, Steptoe L, Wheeler J (2013), “Responsivity to criminogenic need in forensic intellectual disability services.” J Intellect Disabil Res 57(2):172-81 Details McAllister CJ, Kelly CL, Manning KE, Holland AJ (2013), “Participant experience of invasive research in adults with intellectual disability.” J Med Ethics Details Phillips AC, Sleigh A, McAllister CJ, Brage S, Carpenter TA, Kemp GJ, Holland AJ (2013), “Defective Mitochondrial Function In Vivo in Skeletal Muscle in Adults with Down's Syndrome: A (31)P-MRS Study.” PLoS One 8(12):e84031 Details Wheeler J R, Clare ICH, Holland AJ (2013), “What can social and environmental factors tell us about the risk of offending by people with intellectual disabilities? ” Psychology, Crime & Law DOI:10.1080/1068316X.2013.854789 Wheeler JR, Clare IC, Holland AJ (2013), “Offending by people with intellectual disabilities in community settings: a preliminary examination of contextual factors.” J Appl Res Intellect Disabil 26(5):370-83 Details Whittington J, Holland AJ (2013), “Traits and Conditions in People with PWS” Prader-Willi Syndrome (Ed.) C Höybe. New York: Nova Biomedical 75-84 Whittington J, Holland AJ (2013), “Behaviour and Psychiatric Conditions in People with PWS” Prader-Willi Syndrome (Ed.) C Höybe. New York: Nova Biomedical 85-94 Whittington J, Holland AJ (2013), “Behaviour and Psychiatric Conditions in People with PWS” Prader-Willi Syndrome: Höybe C (Ed) New York: Nova Biomedical 85-94 Whittington J, Holland AJ (2013), “Traits and Conditions in People with PWS” Prader-Willi Syndrome: Höybe C (Ed). New York: Nova Biomedical 75-84 2012Ball SL, Panter SG, Redley M, Proctor CA, Byrne K, Clare IC, Holland AJ (2012), “The extent and nature of need for mealtime support among adults with intellectual disabilities.” J Intellect Disabil Res 56(4):382-401 Details Carson D, Lindsay W R, Holland A J, Taylor J L, O’Brien G, Wheeler JR, Steptoe L, Johnston S (2012), “Sex offenders with intellectual disability referred to levels of community and secure provision: Comparison and prediction of pathway” Legal and Criminological Psychology doi:10.1111/lcrp.12005 Goldstone AP, Holland AJ, Butler JV, Whittington JE (2012), “Appetite hormones and the transition to hyperphagia in children with Prader-Willi syndrome.” Int J Obes (Lond) 36(12):1564-70 Details Redley M, Banks C, Foody K, Holland A (2012), “Healthcare for men and women with learning disabilities: understanding inequalities in access” Disability & Society 27 (6):747-759 2011Hawkins R, Redley M, Holland AJ (2011), “Duty of care and autonomy: how support workers managed the tension between protecting service users from risk and promoting their independence in a specialist group home.” J Intellect Disabil Res 55(9):873-84 Details Landt J, Ball SL, Holland AJ, Hon J, Owen A, Treppner P, Herbert J (2011), “Age-related changes in plasma dehydroepiandrosterone levels in adults with Down's syndrome and the risk of dementia.” J Neuroendocrinol 23(5):450-5 Details Phillips AC, Holland AJ (2011), “Assessment of objectively measured physical activity levels in individuals with intellectual disabilities with and without Down's syndrome.” PLoS One 6(12):e28618 Details Redley M, Clare ICH, Dunn MC, Platten M, Holland, AJ (2011), “Introducing the Mental Capacity Advocate (IMCA) service and the reform of adult safeguarding procedures” British Journal of Social Work 41 (6):1058-1069 Siaperas P, Ring HA, McAllister CJ, Henderson S, Barnett A, Watson P, Holland AJ (2011), “Atypical Movement Performance and Sensory Integration in Asperger's Syndrome.” J Autism Dev Disord Details Whittington J, Holland A (2011), “Prader-Willi Syndrome” The SAGE Handbook of Developmental Disorders (Eds.) PA Howlin, T Charman, M Ghaziuddin. London: SAGE Publications. 107-123 Whittington J, Holland A (2011), “Prader-Willi Syndrome” The SAGE Handbook of Developmental Disorders: Howlin PA, Charman T, Ghaziuddin M (Eds): London: SAGE Publications 107-123 Whittington J, Holland T (2011), “Recognition of emotion in facial expression by people with Prader-Willi syndrome.” J Intellect Disabil Res 55(1):75-84 Details 2010Butler JV, Whittington JE, Holland AJ, McAllister CJ, Goldstone AP (2010), “The transition between the phenotypes of Prader-Willi syndrome during infancy and early childhood.” Dev Med Child Neurol 52(6):e88-93 Details Carson D, Lindsay WR, O’Brien G, Holland AJ, Taylor JL, Wheeler JR, Middleton C, Price K,Steptoe L, Johnston S (2010), “Referrals into services for offenders with intellectual disabilities: Variables predicting community or secure provision” Criminal Behaviour and Mental Health 20: 39-50 Dunn MC, Clare ICH, Holland AJ (2010), “‘Living a life like ours’: support workers’ accounts of substitute decision-making in residential care homes for adults with intellectual disabilities” Journal of Intellectual Disability Research 54 (2): 144-160 Holland AJ (2010), “The model law of Szmukler, Dawson and Daw – the next stage of a long campaign?” Journal of Mental Health Law (Special Issue: A model law fusing incapacity and mental health legislation – is it viable; is it advisable?) (Ed.) G. Richardson. Newcastle: Northumbria Law Press 63-70 Lindsay WR, Carson D, O’Brien G, Holland AJ, Johnston S, Taylor JL, Young S, Steptoe S, Wheeler JR, Middleton C, Price K (2010), “The relationship between assessed risk & service security level for offenders with intellectual disability” Journal of Forensic Psychiatry & Psychology 21: 537-548 Lindsay WR, O’Brien G, Carson D, Holland A J, Taylor JL, Wheeler JR, Middleton C, Price K, Steptoe L, Johnston S (2010), “Pathways into services for offenders with intellectual disabilities: Childhood experiences, diagnostic information, and offense variables” Criminal Justice & Behaviour 37:678-694 McAllister CJ, Whittington JE, & Holland AJ (2010), “Development of the eating behaviour in Prader-Willi Syndrome: advances in our understanding” International Journal of Obesity 35: 188–197 O'Brien G, Taylor, JL, Lindsay, WR, Holland AJ, Carson D, Steptoe L, Price K, Middleton C, Wheeler, J (2010), “A multi-centre study of adults with learning disabilities referred to services for antisocial or offending behaviour: demographic, individual, offending and service characteristics” Journal of Learning Disabilities and Offending Behaviour 1 (2): 5-15 Redley M, Clare ICH, Luke L, Holland AJ (2010), “Mental Capacity Act (England & Wales) 2005: The emergent Independent Mental Capacity Advocate (IMCA) service” British Journal of Social Work 40 (6): 1812-1828 Redley M, Hughes JC, Holland AJ (2010), “Voting and mental capacity” BMJ 341: c4085 doi:10.1136/bmj.c.4085 Relkovic D, Doe CM, Humby T, Johnstone KA, Resnick JL, Holland AJ, Hagan JJ, Wilkinson LS, Isles AR (2010), “Behavioural and cognitive abnormalities in an imprinting centre deletion mouse model for Prader-Willi syndrome.” Eur J Neurosci 31(1):156-64 Details Whittington J, Holland A (2010), “Neurobehavioral phenotype in Prader-Willi syndrome.” Am J Med Genet C Semin Med Genet 154C(4):438-47 Details 2009Holland A, Whittington J, Cohen O, Curfs L, Delahaye F, Dudley O, Horsthemke B, Lindgren AC, Nourissier C, Sharma N, Vogels A (2009), “The European Prader-Willi Syndrome Clinical Research Database: an aid in the investigation of a rare genetically determined neurodevelopmental disorder.” J Intellect Disabil Res 53(6):538-47 Details Whittington J, Holland A, Webb T (2009), “Relationship between the IQ of people with Prader-Willi syndrome and that of their siblings: evidence for imprinted gene effects.” J Intellect Disabil Res 53(5):411-8 Details 2008Ball SL, Holland AJ, Treppner P, Watson PC, Huppert FA (2008), “Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities.” Br J Clin Psychol 47(Pt 1):1-29 Details Downes EC, Robson J, Grailly E, Abdel-All Z, Xuereb J, Brayne C, Holland A, Honer WG, Mukaetova-Ladinska EB (2008), “Loss of synaptophysin and synaptosomal-associated protein 25-kDa (SNAP-25) in elderly Down syndrome individuals.” Neuropathol Appl Neurobiol 34(1):12-22 Details Goldstone AP, Holland AJ, Hauffa BP, Hokken-Koelega AC, Tauber M, speakers contributors at the Second Expert Meeting of the Comprehensive Care of Patients with PWS (2008), “Recommendations for the diagnosis and management of Prader-Willi syndrome.” J Clin Endocrinol Metab 93(11):4183-97 Details Holland T (2008), “Determining priorities in intellectual disability research.” J Intellect Disabil Res 52(Pt 1):1-2 Details Janicki MP, Henderson CM, Rubin IL, Neurodevelopmental Conditions Study Group (2008), “Neurodevelopmental conditions and aging: report on the Atlanta Study Group Charrette on Neurodevelopmental Conditions and Aging.” Disabil Health J 1(2):116-24 Details Luke L, Redley M, Clare I, Holland A (2008), “Hospital clinicians' attitudes towards a statutory advocacy service for patients lacking mental capacity: implications for implementation.” J Health Serv Res Policy 13(2):73-8 Details Reinders H, Holland T (2008), “Special ethics edition of JIDR.” J Intellect Disabil Res 52(7):563 Details Soni S, Whittington J, Holland AJ, Webb T, Maina EN, Boer H, Clarke D (2008), “The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome.” Psychol Med 38(10):1505-14 Details Webb, T., Maina, E.N., Soni, S., Whittington, J., Boer, H., Clarke, D. and Holland, A. (2008), “In search of the psychosis gene in people with Prader-Willi Syndrome. ” American Journal of Medical Genetics 146A:843-853 Whittington JE, Butler JV, Holland AJ (2008), “Pre-, peri- and postnatal complications in Prader-Willi syndrome in a UK sample.” Early Hum Dev 84(5):331-6 Details 2007Lockstone HE, Harris LW, Swatton JE, Wayland MT, Holland AJ, Bahn S (2007), “Gene expression profiling in the adult Down syndrome brain.” Genomics 90(6):647-60 Details Maina EN, Webb T, Soni S, Whittington J, Boer H, Clarke D, Holland AJ (2007), “Analysis of candidate imprinted genes in PWS subjects with atypical genetics: a possible inactivating mutation in the SNURF/SNRPN minimal promoter” Journal of Human Genetics 52 (4): 297-307 Soni S, Whittington J, Holland AJ, Webb T, Maina E, Boer H, Clarke D (2007), “The course and outcome of psychiatric illness in people with Prader-Willi syndrome: implications for management and treatment.” J Intellect Disabil Res 51(Pt 1):32-42 Details Stansfield AJ, Holland AJ, Clare IC (2007), “The sterilisation of people with intellectual disabilities in England and Wales during the period 1988 to 1999.” J Intellect Disabil Res 51(Pt 8):569-79 Details Whittington JE, Butler JV, Holland AJ (2007), “Changing rates of genetic subtypes of Prader-Willi syndrome in the UK.” Eur J Hum Genet 15(1):127-30 Details 2006Ball SL, Holland AJ, Hon J, Huppert FA, Treppner P, Watson PC (2006), “Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.” Int J Geriatr Psychiatry 21(7):661-73 Details Ball SL, Holland AJ, Huppert F, Treppner P, Dodd K (2006), “The Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and others with Intellectual Disabilities (CAMDEX-DS)” Cambridge University Press ISBN-13 978-0-521-54794-9 and ISBN-10 0-521-54794-6 Hinton EC, Holland AJ, Gellatly MS, Soni S, Owen AM (2006), “An investigation into food preferences and the neural basis of food-related incentive motivation in Prader-Willi syndrome.” J Intellect Disabil Res 50(Pt 9):633-42 Details Hinton EC, Holland AJ, Gellatly MS, Soni S, Patterson M, Ghatei MA, Owen AM (2006), “Neural representations of hunger and satiety in Prader-Willi syndrome.” Int J Obes (Lond) 30(2):313-21 Details Hinton, E.C., Holland, A.J., Gellatly, M.S. Soni, S., Patterson, M., Chatei, M.A. and Owen, A.M. (2006), “Functional neuroimaging in Prader-Willi syndrome. Letter to the Editor,” International Journal of Obesity Webb T, Whittington J, Holland AJ, Soni S, Boer H, Clarke D, Horsthemke B (2006), “CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.” Clin Genet 69(1):26-32 Details 2005Oliver C, Holland AJ, Hall S, Crayton L (2005), “Effects of increasing task load on memory impairment in adults with Down’s syndrome” American Journal on Mental Retardation 110(5):330-345 2004Whittington JE, Holland AJ, Webb T, Butler JV Clarke DJ, Boer H (2004), “Cognitive abilities and genotype in a population-based sample of people with Prader-Willi syndrome” Journal of Intellectual Disability Research 48:172-187 Whittington JE, Holland AJ, Webb T, Butler JV Clarke DJ, Boer H (2004), “Underachievement in Prader Willi Syndrome” Journal of Intellectual Disability Research 48:188-200 Whittington, Joyce and Holland, Tony (2004), “Prader Willi Syndrome Development and Manifestations” Cambridge University Press, Cambridge 2003Goldstone AP, Brynes AE, Thomas EL, Bell JD, Frost G, Holland A, Bloom, S. (2003), “Body composition using whole body magnetic resonance imaging and resting metabolic rate in Prader-Willi Syndrome adults” Journal of Clinical Endocrinology and Metabolism Holland A, Whittington J, Hinton E (2003), “The paradox of Prader-Willi syndrome: a genetic model of starvation.” Lancet 362(9388):989-91 Details Holland AJ, Whittington JE, Butler J, Webb T, Boer H, Clarke DJ (2003), “Behavioural phenotypes associated with specific genetic disorders: evidence from a population-based study of people with Prader-Willi Syndrome” Psychological Medicine 33:141-53 2002Boer H, Holland AJ, Whittington J, Butler J, Webb T, Clarke D (2002), “Psychotic illness in people with Prader Willi Syndrome due to chromosome 15 maternal uniparental disomy” The Lancet 359: 135-136 Butler J, Whittington JE, Holland AJ, Webb T, Clarke D, Boer H (2002), “Prevalence of, and risk factors for, physical ill-health in people with Prader-Willi syndrome: a population-based study” Developmental Medicine and Child Neurology 44:248-255 Clarke DC, Boer H, Whittington JE, Holland AJ, Butler JV, Webb T (2002), “Prader-Willi Syndrome, compulsive and ritualistic behaviours: The first population-based survey” British Journal of Psychiatry 180: 358-362 Holland AJ, Whittington J, Butler J (2002), “Prader-Willi and Angelman Syndromes: from childhood to adult life” Outcomes in neurodevelopmental and genetic disorders (Eds.) P Howlin, O Udwin. Cambridge University Press, Cambridge Holland AJ, Whittington J, Butler J (2002), “Prader-Willi and Angelman Syndromes: from childhood to adult life” Outcomes in neurodevelopmental and genetic disorders: Howlin P, Udwin O (Eds). Cambridge University Press, Cambridge Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2002), “Relationship between clinical and genetic diagnosis of Prader-Willi Syndrome” Journal of Medical Genetics (39):926-32 2001Goldstone AP, Thomas EL, Bryne AE, Bell JD, Frost G, Saeed N, Hajnal, JV, Howard JK, Holland AJ, Bloom SR (2001), “Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi Syndrome female adults: Evidence for novel influences on body fat distribution” Journal of Clinical Endocrinology and Metabolism 86 (9): 4330-38 Whittington JE, Holland AJ, Webb T, Butler JV, Clarke DJ, Boer H (2001), “Population prevalence and estimated birth incidence and mortality rate for people with Prader Willi Syndrome in one health district” Journal of Medical Genetics 38:792-798 2000Crayton L, Oliver C, Holland A, Hall S (2000), “Cognitive deterioration in adults with Down’s Syndrome: Effect on the individual, caregivers, and service use” American Journal of Mental Retardation 105 (6): 455-465 Holland AJ (2000), “Down’s Syndrome and Dementia” Dementia, 2nd edn. (Eds.) J O’Brien, D Ames, A Burns. London: Arnold Holland AJ (2000), “Down’s Syndrome and Dementia” Dementia, 2nd edn: O’Brien J, Ames D, Burns A (Eds). London: Arnold Holland AJ, Hon J, Huppert FA, Stevens F, Watson P (2000), “Incidence and course of dementia in people with Down’s Syndrome: findings from a population-based study” Journal of Intellectual Disability Research 44 (2): 138-146 1999Holland AJ, Wong J (1999), “Genetically determined obesity in Prader-Willi Syndrome: The Ethics and Legality of Treatment” Journal of Medical Ethics 25: 230-236 Hon J, Holland AJ, Huppert FA, Watson P (1999), “Neuropsychological assessment of older adults with Down Syndrome: an epidemiological study using the Cambridge Cognitive Examination (CAMCOG)” British Journal of Clinical Psychology 38: 155-165 Rubinzstein D, Hon J, Stevens F, Pyrah L, Tysoe C, Huppert FA, Easton DF, Holland AJ (1999), “ApoE genotype and risk of dementia in Down’s syndrome” Neuropsychiatric Genetics 88b (4):344-347 1998Crayton L, Oliver C, Holland AJ, Bradbury J, Hall S (1998), “The Neuropsychological assessment of age related cognitive deficits in adults with Down’s Syndrome” Journal of Applied Research in Intellectual Disability 11(3): 255-272 Holland AJ (1998), “Down Syndrome” Mental Retardation, Aging and Dementia (Eds) A Dalton, M Janicki. New York: Taylor and Francis Holland AJ (1998), “Understanding the eating disorder affecting people with Prader-Willi Syndrome” Journal of Applied Research in Intellectual Disability 11(3): 192-206 Holland AJ (1998), “Down Syndrome” Mental Retardation, Aging and Dementia: Dalton A, Janicki M (Eds). New York: Taylor and Francis Holland AJ, Hon J, Huppert FA, Stevens F Watson P (1998), “A population-based study of the prevalence and presentation of dementia in adults with Down Syndrome” British Journal of Psychiatry 172: 493-498 Hon J, Huppert FA, Holland AJ, Watson P (1998), “The value of the Rivermead Behavioural Memory Test (Children’s Version) in an epidemiological study of adults with Down’s Syndrome” British Journal of Clinical Psychology 37:15-29 Oliver C, Crayton L, Holland A, Hall S, Bradbury J (1998), “A four year prospective study of age related cognitive change in adults with Down’s Syndrome” Psychological Medicine 28: 1365-1377 1997Farrer MJ, Crayton L, Davies GE, Oliver C, Powell J, Holland AJ, Kessling AM (1997), “Allelic variablity in D21S11, but not in APP or APOE, is associated with cognitive decline in Down Syndrome” Neuroreport 8:1645-1649 Holland AJ (1997), “The risk of dementia in people with Down’s Syndrome. Research Highlights” Dementia: Challenges and New Directions (Ed.) S Hunter. London: Jessica Kingsley. Holland AJ (1997), “The risk of dementia in people with Down’s Syndrome. Research Highlights” Dementia: Challenges and New Directions: Hunter (Ed). London: Jessica Kingsley 1995Holland AJ, Oliver C (1995), “Down’s Syndrome and the links with Alzheimer’s disease” Journal of Neurology, Neurosurgery and Psychiatry 59:111-114 Holland AJ, Treasure J, Coskeran P, Dallow J (1995), “Characteristics of the eating disorder in the Prader-Willi Syndrome: implications for treatment” Journal of Intellectual Disability Research 39(5):373-381 1994Berg JM, Karlinsky H, Holland AJ (Eds) (1994), “Alzheimer disease Down Syndrome and their relationship” Oxford Medical Publication, Oxford University Press Holland AJ (1994), “Down's Syndrome and dementia of the Alzheimer type” Dementia. (Eds) A Burns, R Levy. London, Chapman and Hall. Holland AJ (1994), “Down's Syndrome and Alzheimer's disease” Mental Health and Mental Retardation (Ed.) N Bouras. Cambridge University Press. Holland AJ (1994), “Down's Syndrome and Alzheimer's disease” Mental Health and Mental Retardation: Bouras N (Ed). Cambridge University Press Holland AJ (1994), “Down's Syndrome and dementia of the Alzheimer type” Dementia: Burns A, Levy R (Eds). London, Chapman and Hall Nicholson LB, Wong FS, Ewins DL, Butler J, Holland AJ, Demaine AG, McGregor AM (1994), “Susceptibility to auto-immune thyroiditis in Down's syndrome is associated with the major histocompatibility class II DQA 0301 allele” Clinical Endocrinology 41:381-383 Richards A, Quaghebeur G, Clift S, Holland A, Dahlitz, M, Parkes D (1994), “The upper airway and sleep apnoea in the the Prader-Willi Syndrome” Clinical Otolaryngo¬logy 19: 193-197 Richards S-J, Holland A, Palmer CR (1994), “Increased risk of Alzheimer's disease in mothers of adults with Down's Syndrome” Lancet 344: 1092-1093 1993Holland AJ, Karlinsky H, Berg JM (1993), “Alzheimer disease in persons with Down syndrome: diagnostic and management considerations” Alzheimer Disease Down Syndrome and their relationship: Berg JM, Karlinsky H, Holland AJ (Eds). Oxford Medical Publication, Oxford University Press Holland AJ, Karlinsky, H, Berg JM (1993), “Alzheimer disease in persons with Down syndrome: diagnostic and management considerations” Alzheimer Disease Down Syndrome and their relationship. (Eds) JM Berg, H Karlinsky, AJ Holland. Oxford Medical Publication, Oxford University Press. Holland AJ, Treasure J, Coskeran P, Dallow J, Milton N, Hillhouse E (1993), “Measurement of excessive appetite and metabolic changes in Prader-Willi Syndrome” International Journal of Obesity 17:527-532 1988Jackson CVE, Holland AJ, Williams CA, Dickerson JWT (1988), “Vitamin E and Alzheimer's disease in subjects with Down's syndrome” J. of Mental Deficiency Research 32: 479-484. 1986Oliver C, Holland AJ (1986), “Down's Syndrome and Alzheimer's Disease: a Review” Psychological Medicine l6, 307-322 |