Dr Roberta Cagnetta

Interests

The cue-induced axonal nascent proteome and its translational control mechanisms in neural wiring.

Research Focus

Keywords

Local protein synthesis

Translational control

Unfolded Protein Response

Axon guidance

Neural wiring

Clinical conditions

No direct clinical relevance

Equipment

Cell culture

Confocal microscopy

Fluorescence microscopy

Immunocytochemistry

Collaborators

Cambridge

Giovanna Mallucci

International

Christian Frese

Jeroen Krijgsveld

Hovy Wong

Associated News Items


    Key publications

    Roberta Cagnetta, Christian K Frese, Toshiaki Shigeoka, Jeroen Krijgsveld, Christine E Holt (2018), “Rapid cue-specific remodeling of the nascent axonal proteome” Neuron 99(1): 29-46.e4

    Publications

    2017

    Florian Ströhl, Julie Qiaojin Lin, Romain F Laine, Hovy Ho-Wai Wong, Vasja Urbančič, Roberta Cagnetta, Christine E Holt, Clemens F Kaminski (2017), “Single molecule translation imaging visualizes the dynamics of local β-actin synthesis in retinal axons” Scientific Reports 7(1): 709

    Hovy Ho-Wai Wong, Julie Qiaojin Lin, Florian Ströhl, Cláudio Gouveia Roque, Jean-Michel Cioni, Roberta Cagnetta, Benita Turner-Bridger, Romain F Laine, William A Harris, Clemens F Kaminski, Christine E Holt (2017), “RNA docking and local translation regulate site-specific axon remodeling in vivo” Neuron 95(4): 852-868