Professor Patrice Smith

Patrice Smith

University position

Visiting Professor


Department of Clinical Neurosciences


Cambridge Centre for Brain Repair


Research Theme

Cellular and Molecular Neuroscience


Promoting regeneration and repair of the damaged CNS, with a particular focus on understanding the contribution of neuronal intrinsic mechanisms in axon regeneration.

Research Focus


Axon regeneration

CNS repair

Retinal ganglion cells


Injury response

Clinical conditions

Spinal cord injury, glaucoma


Traumatic brain injury


Cell culture

Confocal microscopy

Fluorescence microscopy


In vivo modeling of CNS damage


Recombinant protein expression



Richard Eva

James Fawcett

Keith Martin

Associated News Items

    Key publications

    Park KK, Liu K, Hu Y, Smith PD, Wang C, Cai B, Xu B, Connolly L, Kramvis I, Sahin M, He Z (2008), “Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.” Science 322(5903):963-6 Details

    Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H, Vincent I, Wang X, Mao Z, Park DS (2006), “Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2.” J Neurosci 26(2):440-7 Details

    Kim RH, Smith PD, Aleyasin H, Hayley S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW (2005), “Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.” Proc Natl Acad Sci U S A 102(14):5215-20 Details

    Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (2004), “BAG5 inhibits parkin and enhances dopaminergic neuron degeneration.” Neuron 44(6):931-45 Details



    Legacy J, Hanea S, Theoret J, Smith PD (2013), “Granulocyte macrophage colony-stimulating factor promotes regeneration of retinal ganglion cells in vitro through a mammalian target of rapamycin-dependent mechanism.” J Neurosci Res 91(6):771-9 Details


    Smith PD, Sun F, Park KK, Cai B, Wang C, Kuwako K, Martinez-Carrasco I, Connolly L, He Z (2009), “SOCS3 deletion promotes optic nerve regeneration in vivo.” Neuron 64(5):617-23 Details


    Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, Park DS (2007), “Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.” J Neurosci 27(12):3328-37 Details


    Crocker SJ, Hayley SP, Smith PD, Mount MP, Lamba WR, Callaghan SM, Slack RS, Park DS (2006), “Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase.” J Neurochem 96(2):489-99 Details


    Hayley S, Crocker SJ, Smith PD, Shree T, Jackson-Lewis V, Przedborski S, Mount M, Slack R, Anisman H, Park DS (2004), “Regulation of dopaminergic loss by Fas in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.” J Neurosci 24(8):2045-53 Details

    Smith PD, O'Hare MJ, Park DS (2004), “CDKs: taking on a role as mediators of dopaminergic loss in Parkinson's disease.” Trends Mol Med 10(9):445-51 Details

    Smith PD, O'Hare MJ, Park DS (2004), “Emerging pathogenic role for cyclin dependent kinases in neurodegeneration.” Cell Cycle 3(3):289-91 Details


    Crocker SJ, Liston P, Anisman H, Lee CJ, Smith PD, Earl N, Thompson CS, Park DS, Korneluk RG, Robertson GS (2003), “Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice.” Neurobiol Dis 12(2):150-61 Details

    Crocker SJ, Smith PD, Jackson-Lewis V, Lamba WR, Hayley SP, Grimm E, Callaghan SM, Slack RS, Melloni E, Przedborski S, Robertson GS, Anisman H, Merali Z, Park DS (2003), “Inhibition of calpains prevents neuronal and behavioral deficits in an MPTP mouse model of Parkinson's disease.” J Neurosci 23(10):4081-91 Details

    Smith PD, Crocker SJ, Jackson-Lewis V, Jordan-Sciutto KL, Hayley S, Mount MP, O'Hare MJ, Callaghan S, Slack RS, Przedborski S, Anisman H, Park DS (2003), “Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.” Proc Natl Acad Sci U S A 100(23):13650-5 Details


    Crocker SJ, Lamba WR, Smith PD, Callaghan SM, Slack RS, Anisman H, Park DS (2001), “c-Jun mediates axotomy-induced dopamine neuron death in vivo.” Proc Natl Acad Sci U S A 98(23):13385-90 Details