Orla Woodward

University position

PhD student
Supervised by Frank Reimann

Departments

Department of Clinical Biochemistry

Institutes

Institute of Metabolic Science

Email

ow264@medschl.cam.ac.uk

Research Themes

Cellular and Molecular Neuroscience

Cognitive and Behavioural Neuroscience

Interests

The number of people living with obesity has tripled worldwide since 1975 with serious implications for public health. As obesity is a consequence of food intake exceeding energy expenditure, efforts are being made to better understand the neuroendocrine mechanisms governing food intake. Peptide hormones secreted from the gastrointestinal tract modulate food intake via interactions with the peripheral and central nervous systems. My research focuses on the gut peptide hormone insulin-like peptide 5 (INSL5), previously shown to increase food intake, and its receptor relaxin/insulin-like family peptide receptor 4 (RXFP4) in the central nervous system. Through this research I aim to elucidate the role of central INSL5-RXFP4 action in the control of food intake and food preference. Expanding understanding of INSL5-RXFP4 action is essential due to the identification of this ligand-receptor pair as a potential therapeutic target for obesity and other food intake-related disorders.

Research Focus

Keywords

metabolism

neuroscience

appetite

Clinical conditions

Diabetes

Eating disorders

Obesity

Equipment

Behavioural analysis

Circuit mapping

Confocal microscopy

Immunohistochemistry

Microscopy

Single cell RNA sequencing

Collaborators

No collaborators listed

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